| Methionine represses the autophagy of gastric cancer stem cells via promoting the methylation and phosphorylation of RAB37. | Methionine represses the autophagy of gastric cancer stem cells via promoting the methylation and phosphorylation of RAB37.
Xin L, Li SH, Liu C, Zeng F, Cao JQ, Zhou LQ, Zhou Q, Yuan YW., Free PMC Article | 12/11/2021 |
| Low RAB37 expression is associated with lung cancer. | Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype.
Tzeng HT, Su CC, Chang CP, Lai WW, Su WC, Wang YC. | 12/14/2019 |
| This study shows that RAB37 hypermethylation is involved in NPC metastasis and chemoresistance, and that our prognostic model can identify patients who are at a high risk of distant metastasis and might benefit from for docetaxel IC. | RAB37 Hypermethylation Regulates Metastasis and Resistance to Docetaxel-Based Induction Chemotherapy in Nasopharyngeal Carcinoma.
Li Y, Yang X, Du X, Lei Y, He Q, Hong X, Tang X, Wen X, Zhang P, Sun Y, Zhang J, Wang Y, Ma J, Liu N. | 11/23/2019 |
| Rab37-mediated SFRP1 secretion suppresses cancer stemness. | Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness.
Cho SH, Kuo IY, Lu PF, Tzeng HT, Lai WW, Su WC, Wang YC., Free PMC Article | 11/23/2019 |
| Findings indicate that patients with low vesicle associated membrane protein 8 (VAMP8)/low rab GTP-binding protein RAB37 (RAB37) expression profile showed significantly high risk of death even after adjusting for tumor metastasis parameter. | VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function.
Wang YS, Tzeng HT, Tsai CH, Cheng HC, Lai WW, Liu HS, Wang YC. | 09/28/2019 |
| results demonstrate a role of RAB37 in autophagosome formation through a molecular connection of RAB37, ATG5-12, ATG16L1 up to LC3B, suggesting an organiser role of RAB37 during autophagosomal membrane biogenesis. | RAB37 interacts directly with ATG5 and promotes autophagosome formation via regulating ATG5-12-16 complex assembly.
Sheng Y, Song Y, Li Z, Wang Y, Lin H, Cheng H, Zhou R., Free PMC Article | 09/21/2019 |
| Our findings suggest that Rab37-mediated TSP1 secretion in cancer cells suppresses metastasis and angiogenesis via a cross-talk with endothelial cells and reveal a novel component of the vesicular exocytic machinery in tumor microenvironment and tumor progression | Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis.
Tzeng HT, Tsai CH, Yen YT, Cheng HC, Chen YC, Pu SW, Wang YS, Shan YS, Tseng YL, Su WC, Lai WW, Wu LW, Wang YC. | 02/24/2018 |
| Results identify Rab37 as an additional component of the machinery governing exocytosis of beta-cells and suggest that impaired expression of this GTPase may contribute to defective insulin release in pre-diabetic and diabetic conditions. | The GTPase Rab37 Participates in the Control of Insulin Exocytosis.
Ljubicic S, Bezzi P, Brajkovic S, Nesca V, Guay C, Ohbayashi N, Fukuda M, Abderrhamani A, Regazzi R., Free PMC Article | 10/14/2017 |
| RAB37 regulates the exocytosis of TIMP1 in a nucleotide-dependent manner to inactivate MMP9 migration axis in vitro and in vivo and to suppress tumor metastasis. | Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis.
Tsai CH, Cheng HC, Wang YS, Lin P, Jen J, Kuo IY, Chang YH, Liao PC, Chen RH, Yuan WC, Hsu HS, Yang MH, Hsu MT, Wu CY, Wang YC. | 10/31/2015 |
| Rab37 mRNA was specifically expressed in some ESCC cell lines but its genetic polymorphisms were not associated with esophageal squamous cell carcinoma. | An association study on genetic polymorphisms of Rab37 gene with the risk of esophageal squamous cell carcinoma in a Chinese Han population.
Xu X, Guan X, Tao H, Yang K, Bai Y., Free PMC Article | 07/13/2013 |
| Promoter/exon1 methylation is the predominant mechanism in down-regulation of the hRAB37, and can serve as a potential prediction biomarker of NSCLC progression. | Frequent down-regulation of hRAB37 in metastatic tumor by genetic and epigenetic mechanisms in lung cancer.
Wu CY, Tseng RC, Hsu HS, Wang YC, Hsu MT. | 01/21/2010 |
| the TMEM22/RAB37 complex is likely to play a crucial role in growth of renal cell carcinoma | Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells.
Dobashi S, Katagiri T, Hirota E, Ashida S, Daigo Y, Shuin T, Fujioka T, Miki T, Nakamura Y. | 01/21/2010 |