| New insights into the substrate inhibition of human 17beta-hydroxysteroid dehydrogenase type 1. | New insights into the substrate inhibition of human 17β-hydroxysteroid dehydrogenase type 1.
Li T, Song X, Stephen P, Yin H, Lin SX. | 03/14/2023 |
| Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice. | Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice.
Heinosalo T, Rytkönen KT, Saarinen N, Järvensivu P, Damdimopoulou P, Strauss L, Orasniemi S, Horshauge P, Gabriel M, Koskimies P, Ohlsson C, Kronqvist P, Poutanen M., Free PMC Article | 05/21/2022 |
| Steroid Metabolism in Children and Adolescents With Obesity and Insulin Resistance: Altered SRD5A and 20alpha/20betaHSD Activity. | Steroid Metabolism in Children and Adolescents With Obesity and Insulin Resistance: Altered SRD5A and 20α/20βHSD Activity.
Sumińska M, Podgórski R, Fichna P, Fichna M., Free PMC Article | 02/19/2022 |
| Hydroxysteroid 17-beta dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease. | Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease.
Luukkonen PK, Tukiainen T, Juuti A, Sammalkorpi H, Haridas PAN, Niemelä O, Arola J, Orho-Melander M, Hakkarainen A, Kovanen PT, Dwivedi O, Groop L, Hodson L, Gastaldelli A, Hyötyläinen T, Orešič M, Yki-Järvinen H., Free PMC Article | 06/26/2021 |
| G protein coupled oestrogen receptor 1, aromatase, 17beta-HSD and cAMP level in mutational falsetto. | G protein coupled oestrogen receptor 1, aromatase, 17β-HSD and cAMP level in mutational falsetto.
Sagiroglu S, Kılınc M, Doganer A, Bilal N, Orhan I, Kılıc MA. | 05/8/2021 |
| Altered expression of 17betahydroxysteroid dehydrogenase type 2 and its prognostic significance in nonsmall cell lung cancer. | Altered expression of 17‑β‑hydroxysteroid dehydrogenase type 2 and its prognostic significance in non‑small cell lung cancer.
Drzewiecka H, Jarmołowska-Jurczyszyn D, Kluk A, Gałęcki B, Dyszkiewicz W, Jagodziński PP., Free PMC Article | 01/23/2021 |
| a new inhibitor is proposed that may inhibit 17b-HSD1 through the formation of a dead-end complex. This finding indicates a simple mechanism of enzyme regulation in the physiological background and introduces a pioneer inhibitor of 17b-HSD1 based on the dead-end inhibition model for efficiently targeting estrogen-dependent diseases | Crystal structures of human 17β-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP(+) reveal the mechanism of substrate inhibition.
Li T, Stephen P, Zhu DW, Shi R, Lin SX. | 05/16/2020 |
| Aberrant ERRgamma expression may contribute to the pathogenesis of FGR by regulating the transcriptional activity of HSD17B1. | Estrogen-related receptor γ regulates expression of 17β-hydroxysteroid dehydrogenase type 1 in fetal growth restriction.
Zhu H, Huang L, He Z, Zou Z, Luo Y. | 08/31/2019 |
| Our genetic study demonstrated HSD17B1 937 G variant as a risk factor for infertility in women with stage I and II endometriosis in Polish Caucasian patients. | Involvement of 17β-hydroxysteroid dehydrogenase type gene 1 937 A>G polymorphism in infertility in Polish Caucasian women with endometriosis.
Osiński M, Mostowska A, Wirstlein P, Skrzypczak J, Jagodziński PP, Szczepańska M., Free PMC Article | 01/20/2018 |
| HSD17B1 is a promising marker to predict EC prognosis. | High mRNA levels of 17β-hydroxysteroid dehydrogenase type 1 correlate with poor prognosis in endometrial cancer.
Cornel KM, Krakstad C, Delvoux B, Xanthoulea S, Jori B, Bongers MY, Konings GF, Kooreman LF, Kruitwagen RF, Salvesen HB, ENITEC, Romano A. | 11/4/2017 |
| Macronutrient intakes were associated with serum estradiol level, and these associations may be modified by HSD17B1 polymorphism in postmenopausal Japanese women. | Macronutrient intakes and serum oestrogen, and interaction with polymorphisms in CYP19A1 and HSD17B1 genes: a cross-sectional study in postmenopausal Japanese women.
Takagi S, Naito M, Kawai S, Okada R, Nagata C, Hosono S, Nishida Y, Takashima N, Suzuki S, Shimoshikiryo I, Mikami H, Uemura H, Kuriyama N, Ohnaka K, Kubo M, Hamajima N, Tanaka H, Wakai K. | 10/14/2017 |
| the effect of 17beta-HSD1 expression on breast cancer cell transcript profile in steroid-deprived condition, was investigated. | Estradiol-independent modulation of breast cancer transcript profile by 17beta-hydroxysteroid dehydrogenase type 1.
Aka JA, Calvo EL, Lin SX. | 09/30/2017 |
| Mutation in the 17-beta-hydroxysteroid dehydrogenase gene is associated with congenital adrenal hyperplasia. | Adrenarche unmasks compound heterozygous 3β-hydroxysteroid dehydrogenase deficiency: c.244G>A (p.Ala82Thr) and the novel 931C>T (p.Gln311*) variant in a non-salt wasting, severely undervirilised 46XY.
Teasdale SL, Morton A. | 08/26/2017 |
| Substrate inhibition of 17beta-HSD1 in tumor epithelial cells and regulation of 17beta-HSD7 by 17beta-HSD1 knockdown has been demonstrated. | Substrate inhibition of 17β-HSD1 in living cells and regulation of 17β-HSD7 by 17β-HSD1 knockdown.
Han H, Thériault JF, Chen G, Lin SX. | 08/26/2017 |
| 10 natural products were evaluated leading to inhibition of the activity of 17beta-HSD1 at the concentration of 25 muM, and six of them inhibit the activity over 50%. | Covalent Immobilization of Human Placental 17β-Hydroxysteroid Dehydrogenase Type 1 onto Glutaraldehyde Activated Silica Coupled with LC-TOF/MS for Anti-Cancer Drug Screening Applications.
Bai Y, Zhou WD, Mu XM, Zhang Q, Yu C, Di B, Su MX. | 06/24/2017 |
| The structure of human 17beta-HSD1 and biological function have been studied extensively in the last two decades. In humans, the enzyme is expressed in placenta, ovary, endometrium and breast; high activity of estrogen activation provides the basis of 17beta-HSD1's implication in estrogen-dependent diseases, such as breast cancer, endometriosis and non-small cell lung carcinomas. [Review] | Current knowledge of the multifunctional 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1).
He W, Gauri M, Li T, Wang R, Lin SX., Free PMC Article | 01/28/2017 |
| These findings suggested that the HSD17B1 Ser312Gly polymorphism might confer genetic cancer susceptibility in an ethnic-dependent manner, especially among Caucasians. | Polymorphism of HSD17B1 Ser312Gly with Cancer Risk: Evidence from 66,147 Subjects.
Shi L, Yang X, Dong X, Zhang B. | 12/17/2016 |
| The rs605059 polymorphism of the HSD17B1 gene is associated with increased risk of recurrent spontaneous abortion. | Evidence for association of the rs605059 polymorphism of HSD17B1 gene with recurrent spontaneous abortions.
Ntostis P, Agiannitopoulos K, Tsaousis G, Pantos K, Lamnissou K. | 07/16/2016 |
| Review/Meta-analysis: HSD17B1 rs605059 polymorphisms were not associated with the risks of endometrial cancer or endometriosis. | Association between HSD17B1 rs605059 polymorphisms and the risk of uterine diseases: a systemic review and meta-analysis.
Mu X, Du X, Yao K, Zhao J, Bian C, Wang Q, Ma H, Yi T, Wu Y, Zhao X., Free PMC Article | 05/28/2016 |
| the HSD17B1 transcript and protein were identified in HeLa, SiHa, Ca Ski and C-33A cervical cancer cells. | Increased 17ß-hydroxysteroid dehydrogenase type 1 levels in primary cervical cancer.
Tomaszewska A, Roszak A, Pawlik P, Sajdak S, Jagodziński PP. | 03/19/2016 |
| Increased expression of HSD17B1 in NSCLC may contribute to an elevated intratissue level of E2 and consequently may support the development and spread of cancer. | Increased expression of 17-beta-hydroxysteroid dehydrogenase type 1 in non-small cell lung cancer.
Drzewiecka H, Gałęcki B, Jarmołowska-Jurczyszyn D, Kluk A, Dyszkiewicz W, Jagodziński PP. | 02/27/2016 |
| The key enzymes of ovarian steroidogenesis, CYP 19 and 17beta-HSD, are active in the ovaries of postmenopausal women. | Immunoexpression of aromatase cytochrome P450 and 17β-hydroxysteroid dehydrogenase in women's ovaries after menopause.
Brodowska A, Brodowski J, Laszczyńska M, Słuczanowska-Głąbowska S, Rumianowski B, Rotter I, Starczewski A, Ratajczak MZ., Free PMC Article | 10/24/2015 |
| 17beta-HSD1 and 17beta-HSD7 are principal reductive 17beta-hydroxysteroid dehydrogenases and major players in the viability of estrogen-dependent breast cancer cells. | Reductive 17beta-hydroxysteroid dehydrogenases which synthesize estradiol and inactivate dihydrotestosterone constitute major and concerted players in ER+ breast cancer cells.
Zhang CY, Wang WQ, Chen J, Lin SX. | 07/25/2015 |
| E1-induced ERELuc activity in the inhibitor-treated uterus was reduced by the HSD17B1 inhibitor. | HSD17B1 expression enhances estrogen signaling stimulated by the low active estrone, evidenced by an estrogen responsive element-driven reporter gene in vivo.
Järvensivu P, Saloniemi-Heinonen T, Awosanya M, Koskimies P, Saarinen N, Poutanen M. | 07/4/2015 |
| Single nucleotide polymorphism in HSD17B1 gene is associated with hepatocellular carcinoma. | Association of genetic polymorphisms in HSD17B1, HSD17B2 and SHBG genes with hepatocellular carcinoma risk.
Zhang LS, Yuan F, Guan X, Li J, Liu XL, Sun J, Liu B, Ma W, Deng FM. | 02/28/2015 |