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    OSTN osteocrin [ Homo sapiens (human) ]

    Gene ID: 344901, updated on 5-May-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The correlation of serum musclin with diabetic nephropathy.

    The correlation of serum musclin with diabetic nephropathy.
    Zhang J, Shi J, Cheng Z, Hu W.

    06/2/2023
    Musclin attenuates lipid deposition in hepatocytes through SIRT7/autophagy-mediated suppression of ER stress.

    Musclin attenuates lipid deposition in hepatocytes through SIRT7/autophagy-mediated suppression of ER stress.
    Cho W, Choi SW, Oh H, Baygutalp F, Abd El-Aty AM, Jeong JH, Song JH, Shin YK, Jung TW.

    04/21/2023
    Nestin and osteocrin mRNA increases in human semitendinosus myotendinous junction 7 days after a single bout of eccentric exercise.

    Nestin and osteocrin mRNA increases in human semitendinosus myotendinous junction 7 days after a single bout of eccentric exercise.
    Jakobsen JR, Schjerling P, Kjær M, Mackey AL, Krogsgaard MR.

    07/9/2022
    Skeletal muscle derived Musclin protects the heart during pathological overload.

    Skeletal muscle derived Musclin protects the heart during pathological overload.
    Szaroszyk M, Kattih B, Martin-Garrido A, Trogisch FA, Dittrich GM, Grund A, Abouissa A, Derlin K, Meier M, Holler T, Korf-Klingebiel M, Völker K, Garfias Macedo T, Pablo Tortola C, Boschmann M, Huang N, Froese N, Zwadlo C, Malek Mohammadi M, Luo X, Wagner M, Cordero J, Geffers R, Batkai S, Thum T, Bork N, Nikolaev VO, Müller OJ, Katus HA, El-Armouche A, Kraft T, Springer J, Dobreva G, Wollert KC, Fielitz J, von Haehling S, Kuhn M, Bauersachs J, Heineke J., Free PMC Article

    02/12/2022
    Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.

    Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.
    Wang JS, Kamath T, Mazur CM, Mirzamohammadi F, Rotter D, Hojo H, Castro CD, Tokavanich N, Patel R, Govea N, Enishi T, Wu Y, da Silva Martins J, Bruce M, Brooks DJ, Bouxsein ML, Tokarz D, Lin CP, Abdul A, Macosko EZ, Fiscaletti M, Munns CF, Ryder P, Kost-Alimova M, Byrne P, Cimini B, Fujiwara M, Kronenberg HM, Wein MN., Free PMC Article

    12/25/2021
    This study demonstrated that a female-specific role OSTN in tau pathology

    Sex-specific genetic predictors of Alzheimer's disease biomarkers.
    Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Moghekar A, Del Aguila JL, Fernandez MV, Budde J, Hassenstab J, Fagan AM, Riemenschneider M, Petersen RC, Minthon L, Chao MJ, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Peskind ER, Li G, Davis LK, Sealock JM, Cox NJ, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer Disease Genetics Consortium (ADGC), Goate AM, Bennett DA, Schneider JA, Jefferson AL, Cruchaga C, Hohman TJ., Free PMC Article

    10/12/2019
    The circulating concentration of musclin was significantly increased in type 2 diabetes mellitus patients. Results suggest that musclin has a strong relationship with insulin resistance in type 2 diabetes mellitus.

    Increased circulating levels of musclin in newly diagnosed type 2 diabetic patients.
    Chen WJ, Liu Y, Sui YB, Zhang B, Zhang XH, Yin XH.

    10/14/2017
    findings suggest that, in response to sensory input, OSTN regulates features of neuronal structure and function that are unique to primates

    Evolution of Osteocrin as an activity-regulated factor in the primate brain.
    Ataman B, Boulting GL, Harmin DA, Yang MG, Baker-Salisbury M, Yap EL, Malik AN, Mei K, Rubin AA, Spiegel I, Durresi E, Sharma N, Hu LS, Pletikos M, Griffith EC, Partlow JN, Stevens CR, Adli M, Chahrour M, Sestan N, Walsh CA, Berezovskii VK, Livingstone MS, Greenberg ME., Free PMC Article

    12/17/2016
    Observational study of gene-disease association. (HuGE Navigator)

    High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
    Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, MrOS Research Group., Free PMC Article

    06/24/2009
    Ostn is a naturally occurring ligand of the NPR-C clearance receptor and may act to locally modulate the actions of the natriuretic system in bone by blocking the clearance action of NPR-C, thus locally elevating levels of C-type natriuretic peptide.

    Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth.
    Moffatt P, Thomas G, Sellin K, Bessette MC, Lafrenière F, Akhouayri O, St-Arnaud R, Lanctôt C.

    01/21/2010
    Foxo1 downregulates musclin mRNA expression both in vitro and in vivo, which should explain insulin-mediated upregulation of this gene in muscle cells.

    Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor.
    Yasui A, Nishizawa H, Okuno Y, Morita K, Kobayashi H, Kawai K, Matsuda M, Kishida K, Kihara S, Kamei Y, Ogawa Y, Funahashi T, Shimomura I.

    01/21/2010
    osteocrin represents a novel, unique vitamin D-regulated bone-specific protein that appears to act as a soluble osteoblast regulator

    Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype.
    Thomas G, Moffatt P, Salois P, Gaumond MH, Gingras R, Godin E, Miao D, Goltzman D, Lanctôt C.

    01/21/2010
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