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    INHBB inhibin subunit beta B [ Homo sapiens (human) ]

    Gene ID: 3625, updated on 5-Mar-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Dose inhibin B or anti-Mullerian hormone relate to precocious puberty in girls? result of a systematic review and meta-analysis.

    Dose inhibin B or anti-Müllerian hormone relate to precocious puberty in girls? result of a systematic review and meta-analysis.
    Jiang M, Gao Y, Qu T, Ji Y, Niu Y, Zhang J, Huang L., Free PMC Article

    12/1/2023
    Paracrine activin B-NF-kappaB signaling shapes an inflammatory tumor microenvironment in gastric cancer via fibroblast reprogramming.

    Paracrine activin B-NF-κB signaling shapes an inflammatory tumor microenvironment in gastric cancer via fibroblast reprogramming.
    Jin Y, Cai Q, Wang L, Ji J, Sun Y, Jiang J, Wang C, Wu J, Zhang B, Zhao L, Qi F, Yu B, Zhang J., Free PMC Article

    11/13/2023
    Undetectable anti-Mullerian hormone and inhibin B do not preclude the presence of germ cell tumours in 45,X/46,XY or 46,XY gonadal dysgenesis.

    Undetectable anti-Mullerian hormone and inhibin B do not preclude the presence of germ cell tumours in 45,X/46,XY or 46,XY gonadal dysgenesis.
    Hannema SE, Wolffenbuttel KP, van Bever Y, Brüggenwirth HT, van den Berg SAA, Hersmus R, Oosterhuis JW, Looijenga LHJ.

    06/16/2023
    Downregulated INHBB in endometrial tissue of recurrent implantation failure patients impeded decidualization through the ADCY1/cAMP signalling pathway.

    Downregulated INHBB in endometrial tissue of recurrent implantation failure patients impeded decidualization through the ADCY1/cAMP signalling pathway.
    Zhang H, Wang Z, Zhou Q, Cao Z, Jiang Y, Xu M, Liu J, Zhou J, Yan G, Sun H., Free PMC Article

    06/7/2023
    INHBB promotes tumor aggressiveness and stemness of glioblastoma via activating EGFR signaling.

    INHBB promotes tumor aggressiveness and stemness of glioblastoma via activating EGFR signaling.
    Yang X, Jia Q, Zou Z, Liu X, Li X, Chen H, Ma H, Chen L.

    05/23/2023
    Testicular Sertoli Cell Hormones in Differences in Sex Development.

    Testicular Sertoli Cell Hormones in Differences in Sex Development.
    Lucas-Herald AK, Mitchell RT., Free PMC Article

    08/6/2022
    Human INHBB Gene Variant (c.1079T>C:p.Met360Thr) Alters Testis Germ Cell Content, but Does Not Impact Fertility in Mice.

    Human INHBB Gene Variant (c.1079T>C:p.Met360Thr) Alters Testis Germ Cell Content, but Does Not Impact Fertility in Mice.
    Houston BJ, O'Connor AE, Wang D, Goodchild G, Merriner DJ, Luan H, Conrad DF, Nagirnaja L, Aston KI, Kliesch S, Wyrwoll MJ, Friedrich C, Tüttelmann F, Harrison C, O'Bryan MK, Walton K.

    02/19/2022
    The Activin/FLRG Pathway Associates with Poor COVID-19 Outcomes in Hospitalized Patients.

    The Activin/FLRG Pathway Associates with Poor COVID-19 Outcomes in Hospitalized Patients.
    McAleavy M, Zhang Q, Ehmann PJ, Xu J, Wipperman MF, Ajithdoss D, Pan L, Wakai M, Simonson R, Gadi A, Oyejide A, Hamon SC, Boyapati A, Morton LG, Shavlakadze T, Kyratsous CA, Glass DJ., Free PMC Article

    02/12/2022
    Clinical application value of Inhibin B alone or in combination with other hormone indicators in subfertile men with different spermatogenesis status: A study of 324 Chinese men.

    Clinical application value of Inhibin B alone or in combination with other hormone indicators in subfertile men with different spermatogenesis status: A study of 324 Chinese men.
    Kong X, Ye Z, Chen Y, Zhao H, Tu J, Meng T, Xiong C, Li H, Gong Y, Zheng L, Cheng B, Zhang Z, Xu P., Free PMC Article

    01/15/2022
    Tubule-derived INHBB promotes interstitial fibroblast activation and renal fibrosis.

    Tubule-derived INHBB promotes interstitial fibroblast activation and renal fibrosis.
    Sun Y, Cai H, Ge J, Shao F, Huang Z, Ding Z, Dong L, Chen J, Zhang J, Zang Y.

    01/8/2022
    FSH-stimulated Inhibin B (FSH-iB): A Novel Marker for the Accurate Prediction of Pubertal Outcome in Delayed Puberty.

    FSH-stimulated Inhibin B (FSH-iB): A Novel Marker for the Accurate Prediction of Pubertal Outcome in Delayed Puberty.
    Chaudhary S, Walia R, Bhansali A, Dayal D, Sachdeva N, Singh T, Bhadada SK.

    11/6/2021
    Sox9/INHBB axis-mediated crosstalk between the hepatoma and hepatic stellate cells promotes the metastasis of hepatocellular carcinoma.

    Sox9/INHBB axis-mediated crosstalk between the hepatoma and hepatic stellate cells promotes the metastasis of hepatocellular carcinoma.
    Chen Y, Qian B, Sun X, Kang Z, Huang Z, Ding Z, Dong L, Chen J, Zhang J, Zang Y.

    05/22/2021
    INHBB Is a Novel Prognostic Biomarker Associated with Cancer-Promoting Pathways in Colorectal Cancer.

    INHBB Is a Novel Prognostic Biomarker Associated with Cancer-Promoting Pathways in Colorectal Cancer.
    Yuan J, Xie A, Cao Q, Li X, Chen J., Free PMC Article

    05/15/2021
    Genome-wide association study of semen volume, sperm concentration, testis size, and plasma inhibin B levels.

    Genome-wide association study of semen volume, sperm concentration, testis size, and plasma inhibin B levels.
    Sato Y, Tajima A, Kiguchi M, Kogusuri S, Fujii A, Sato T, Nozawa S, Yoshiike M, Mieno M, Kojo K, Uchida M, Tsuchiya H, Yamasaki K, Imoto I, Iwamoto T.

    11/21/2020
    TGFb/Activin signaling is activated through an ActivinB autocrine mechanism in a subset of Group 3 medulloblastmas.

    An autocrine ActivinB mechanism drives TGFβ/Activin signaling in Group 3 medulloblastoma.
    Morabito M, Larcher M, Cavalli FM, Foray C, Forget A, Mirabal-Ortega L, Andrianteranagna M, Druillennec S, Garancher A, Masliah-Planchon J, Leboucher S, Debalkew A, Raso A, Delattre O, Puget S, Doz F, Taylor MD, Ayrault O, Bourdeaut F, Eychène A, Pouponnot C., Free PMC Article

    05/9/2020
    It concluded that serum INHB as an effective marker for spermatogenesis was a significant predictor of testicular haploid gamete retrieval outcomes in nonobstructive azoospermic men

    Predictive significance of serum inhibin B on testicular haploid gamete retrieval outcomes in nonobstructive azoospermic men.
    Zhu ZG, Zhao ZG, Pang QY, Chen T, Zhang JM, Zhang TJ, Xu C, Zhang HB, Liu W, Xuan XJ., Free PMC Article

    04/11/2020
    Knockdown of the type 2 receptor BMPR2 strongly potentiated activin A- and activin B-induced activation of SMAD1/5/8 and subsequent cell death.

    BMPR2 inhibits activin and BMP signaling via wild-type ALK2.
    Olsen OE, Sankar M, Elsaadi S, Hella H, Buene G, Darvekar SR, Misund K, Katagiri T, Knaus P, Holien T.

    12/7/2019
    three novel MD loci were identified (at P < 5 x 10(- 8)): one for percent dense volume (HABP2) and two for the absolute dense volume (INHBB, LINC01483). INHBB is an established locus for ER-negative breast cancer, and HABP2 and LINC01483 represent putative new breast cancer susceptibility loci

    Common genetic variation and novel loci associated with volumetric mammographic density.
    Brand JS, Humphreys K, Li J, Karlsson R, Hall P, Czene K., Free PMC Article

    03/23/2019
    Results found that INHBB expression was reduced in nasopharyngeal carcinoma (NPC) tissues, and associated with lymph node metastasis. Further data revealed that INHBB could suppress anoikis resistance and migration of NPC cells by the TGF-beta signaling pathway, decrease p53 overexpression, and could serve as a potential biomarker for NPC metastasis and prognosis .

    Inhibin B suppresses anoikis resistance and migration through the transforming growth factor-β signaling pathway in nasopharyngeal carcinoma.
    Zou G, Ren B, Liu Y, Fu Y, Chen P, Li X, Luo S, He J, Gao G, Zeng Z, Xiong W, Li G, Huang Y, Xu K, Zhang W., Free PMC Article

    11/24/2018
    Presence of varicocele was associated with lower serum inhibin B.

    Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries.
    Damsgaard J, Joensen UN, Carlsen E, Erenpreiss J, Blomberg Jensen M, Matulevicius V, Zilaitiene B, Olesen IA, Perheentupa A, Punab M, Salzbrunn A, Toppari J, Virtanen HE, Juul A, Skakkebæk NE, Jørgensen N.

    12/30/2017
    Elevated activin B levels together with normal activin A levels identified patients with the diagnostic symptoms of chronic fatigue syndrome/myalgic encephalomyelitis.

    Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: a cross sectional study.
    Lidbury BA, Kita B, Lewis DP, Hayward S, Ludlow H, Hedger MP, de Kretser DM., Free PMC Article

    11/4/2017
    Results identified Inhbb as one factor mediating the proliferative effect of Pdx-1 on islet cells.

    A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation.
    Hayes HL, Zhang L, Becker TC, Haldeman JM, Stephens SB, Arlotto M, Moss LG, Newgard CB, Hohmeier HE., Free PMC Article

    06/24/2017
    Low activin B level is associated with tubal ectopic pregnancy.

    Serum activin B concentration as predictive biomarker for ectopic pregnancy.
    Dhiman P, Senthilkumar GP, Rajendiran S, Sivaraman K, Soundararaghavan S, Kulandhasamy M.

    02/18/2017
    The Sertoli cell hormones inhibin-B and anti Mullerian hormone have different patterns of secretion in prepubertal cryptorchid boys.

    The Sertoli cell hormones inhibin-B and anti Müllerian hormone have different patterns of secretion in prepubertal cryptorchid boys.
    Cortes D, Clasen-Linde E, Hutson JM, Li R, Thorup J.

    10/29/2016
    Pregnant Han Chinese women carrying the rs7579169 CC genotype and G-G-C haplotype are significantly more likely to develop pre-eclampsia, especially late-onset and multiparous cases.

    Single nucleotide polymorphisms near the inhibin beta B gene on 2q14 are associated with pre-eclampsia in Han Chinese women.
    Wang Q, Wang G, Guo C, Cao X, An L, Du M, Qiu Y, Yang Y, Wang Y, Wang S, Wang X, Ma X.

    06/28/2016
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