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    ITGAV integrin subunit alpha V [ Homo sapiens (human) ]

    Gene ID: 3685, updated on 13-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    A decrease in integrin alpha5beta1/FAK is associated with increased apoptosis of aortic smooth muscle cells in acute type a aortic dissection.

    A decrease in integrin α5β1/FAK is associated with increased apoptosis of aortic smooth muscle cells in acute type a aortic dissection.
    Xue M, Xing L, Yang Y, Shao M, Liao F, Xu F, Chen Y, Wang S, Chen B, Yao C, Gu G, Tong C., Free PMC Article

    03/29/2024
    Novel prognostic marker TGFBI affects the migration and invasion function of ovarian cancer cells and activates the integrin alphavbeta3-PI3K-Akt signaling pathway.

    Novel prognostic marker TGFBI affects the migration and invasion function of ovarian cancer cells and activates the integrin αvβ3-PI3K-Akt signaling pathway.
    Wang H, Xu YH, Guo Y., Free PMC Article

    03/8/2024
    Matrix metalloproteinase-2 inducing COL1A1 synthesis via integrin alpha promotes invasion and metastasis of cholangiocarcinoma cells.

    Matrix metalloproteinase-2 inducing COL1A1 synthesis via integrin alpha Ⅴ promotes invasion and metastasis of cholangiocarcinoma cells.
    Pan S, Hu Y, Gan L, Lai J, Zheng P, Zhang Y, Shuai L, Jiang Y, Chen M, Wang J, He Y.

    03/6/2024
    Integrin alphavbeta1 facilitates ACE2-mediated entry of SARS-CoV-2.

    Integrin αvβ1 facilitates ACE2-mediated entry of SARS-CoV-2.
    Cai Z, Bai H, Ren D, Xue B, Liu Y, Gong T, Zhang X, Zhang P, Zhu J, Shi B, Zhang C., Free PMC Article

    01/3/2024
    Integrin-alphavbeta3 is a Therapeutically Targetable Fundamental Factor in Medulloblastoma Tumorigenicity and Radioresistance.

    Integrin-αvβ3 is a Therapeutically Targetable Fundamental Factor in Medulloblastoma Tumorigenicity and Radioresistance.
    Echavidre W, Durivault J, Gotorbe C, Blanchard T, Pagnuzzi M, Vial V, Raes F, Broisat A, Villeneuve R, Amblard R, Garnier N, Ortholan C, Faraggi M, Serrano B, Picco V, Montemagno C., Free PMC Article

    12/21/2023
    Combined inhibition of surface CD51 and gamma-secretase-mediated CD51 cleavage improves therapeutic efficacy in experimental metastatic hepatocellular carcinoma.

    Combined inhibition of surface CD51 and γ-secretase-mediated CD51 cleavage improves therapeutic efficacy in experimental metastatic hepatocellular carcinoma.
    Cai J, Wang J, Jiang C, Ye L, He X, Huang J, Sun X, Ren Z, Lai X, Qiu Y, Wang H, Lv G, Zheng J, Lu T, Chen H, Liu Y, Chen H, Guan Y, Wang Y, Wang T, Yao J, Sui X, Kang Y, Zhang Y, Li H, Wang J, Li W, Chen G, Yang Y, Xiang AP.

    12/1/2023
    Interaction of Integrin alphavbeta8 With Type I Collagen Promotes Squamous Cell Carcinoma Cell Motility via RAC1 Activation.

    Interaction of Integrin αvβ8 With Type I Collagen Promotes Squamous Cell Carcinoma Cell Motility via RAC1 Activation.
    Ishida Y, Shintani T, Nobumoto T, Sakurai S, Hamana T, Yanamoto S, Hayashido Y.

    11/3/2023
    Regulation of the integrin alphaVbeta3- actin filaments axis in early osteogenic differentiation of human mesenchymal stem cells under cyclic tensile stress.

    Regulation of the integrin αVβ3- actin filaments axis in early osteogenic differentiation of human mesenchymal stem cells under cyclic tensile stress.
    Peng Y, Qu R, Yang Y, Fan T, Sun B, Khan AU, Wu S, Liu W, Zhu J, Chen J, Li X, Dai J, Ouyang J., Free PMC Article

    11/1/2023
    Molecular basis for the recognition of 24-(S)-hydroxycholesterol by integrin alphavbeta3.

    Molecular basis for the recognition of 24-(S)-hydroxycholesterol by integrin αvβ3.
    Gc JB, Chen J, Pokharel SM, Mohanty I, Mariasoosai C, Obi P, Panipinto P, Bandyopadhyay S, Bose S, Natesan S., Free PMC Article

    06/8/2023
    Dysregulation of integrin alphavbeta3 and alpha5beta1 impedes migration of placental endothelial cells in fetal growth restriction.

    Dysregulation of integrin αvβ3 and α5β1 impedes migration of placental endothelial cells in fetal growth restriction.
    Gumina DL, Ji S, Flockton A, McPeak K, Stich D, Moldovan R, Su EJ., Free PMC Article

    10/15/2022
    Specificity of TGF-beta1 signal designated by LRRC33 and integrin alphaVbeta8.

    Specificity of TGF-β1 signal designated by LRRC33 and integrin α(V)β(8).
    Duan Z, Lin X, Wang L, Zhen Q, Jiang Y, Chen C, Yang J, Lee CH, Qin Y, Li Y, Zhao B, Wang J, Zhang Z., Free PMC Article

    09/3/2022
    The clinical significance of integrin subunit alpha V in cancers: from small cell lung carcinoma to pan-cancer.

    The clinical significance of integrin subunit alpha V in cancers: from small cell lung carcinoma to pan-cancer.
    Tang YL, Li GS, Li DM, Tang D, Huang JZ, Feng H, He RQ, Huang ZG, Dang YW, Kong JL, Gan TQ, Zhou HF, Zeng JJ, Chen G., Free PMC Article

    08/20/2022
    Integrin alphaV Mediates the Effects of Irisin on Human Mature Adipocytes.

    Integrin αV Mediates the Effects of Irisin on Human Mature Adipocytes.
    Fu T, Li C, Sun Z, Yan B, Wu Y, Huang Z, Yin X., Free PMC Article

    05/28/2022
    Human Adenovirus Type 26 Induced IL-6 Gene Expression in an alphavbeta3 Integrin- and NF-kappaB-Dependent Manner.

    Human Adenovirus Type 26 Induced IL-6 Gene Expression in an αvβ3 Integrin- and NF-κB-Dependent Manner.
    Nestić D, Božinović K, Drašković I, Kovačević A, van den Bosch J, Knežević J, Custers J, Ambriović-Ristov A, Majhen D., Free PMC Article

    05/7/2022
    MiR-139 inhibits proliferation, migration and invasion of osteosarcoma cell line MG63 via down-regulating integrin subunit alpha V(ITGAV).

    MiR-139 inhibits proliferation, migration and invasion of osteosarcoma cell line MG63 via down-regulating integrin subunit alpha V(ITGAV).
    Li Z, Deng L, Li Y, Wang Y.

    04/23/2022
    Yin Yang 1 regulates ITGAV and ITGB1, contributing to improved prognosis of colorectal cancer.

    Yin Yang 1 regulates ITGAV and ITGB1, contributing to improved prognosis of colorectal cancer.
    Sato N, Sakai N, Furukawa K, Takayashiki T, Kuboki S, Takano S, Ohira G, Matsubara H, Ohtsuka M., Free PMC Article

    03/19/2022
    Angiopoietin-like 3 (ANGPTL3) drives cell proliferation, migration and angiogenesis in cervical cancer via binding to integrin alpha v beta 3.

    Angiopoietin-like 3 (ANGPTL3) drives cell proliferation, migration and angiogenesis in cervical cancer via binding to integrin alpha v beta 3.
    Zhong L, Tang L, He X., Free PMC Article

    03/12/2022
    The Effects of alphavbeta3 Integrin Blockage in Breast Tumor and Endothelial Cells under Hypoxia In Vitro.

    The Effects of αvβ3 Integrin Blockage in Breast Tumor and Endothelial Cells under Hypoxia In Vitro.
    Casali BC, Gozzer LT, Baptista MP, Altei WF, Selistre-de-Araújo HS., Free PMC Article

    03/5/2022
    The VWF/LRP4/alphaVbeta3-axis represents a novel pathway regulating proliferation of human vascular smooth muscle cells.

    The VWF/LRP4/αVβ3-axis represents a novel pathway regulating proliferation of human vascular smooth muscle cells.
    Lagrange J, Worou ME, Michel JB, Raoul A, Didelot M, Muczynski V, Legendre P, Plénat F, Gauchotte G, Lourenco-Rodrigues MD, Christophe OD, Lenting PJ, Lacolley P, Denis CV, Regnault V.

    03/5/2022
    Integrin alphavbeta6 contributes to the development of intestinal fibrosis via the FAK/AKT signaling pathway.

    Integrin αvβ6 contributes to the development of intestinal fibrosis via the FAK/AKT signaling pathway.
    Xie H, Jiao Y, Zhou X, Liao X, Chen J, Chen H, Chen L, Yu S, Deng Q, Sun L, Xu X, Wang J.

    02/12/2022
    Genetic and epigenetic changes in the eutopic endometrium of women with endometriosis: association with decreased endometrial alphavbeta3 integrin expression.

    Genetic and epigenetic changes in the eutopic endometrium of women with endometriosis: association with decreased endometrial αvβ3 integrin expression.
    Joshi NR, Kohan-Ghadr HR, Roqueiro DS, Yoo JY, Fru K, Hestermann E, Yuan L, Ho SM, Jeong JW, Young SL, Lessey BA, Fazleabas AT., Free PMC Article

    01/22/2022
    Integrin alpha-V is an important driver in pancreatic adenocarcinoma progression.

    Integrin alpha-V is an important driver in pancreatic adenocarcinoma progression.
    Kemper M, Schiecke A, Maar H, Nikulin S, Poloznikov A, Galatenko V, Tachezy M, Gebauer F, Lange T, Riecken K, Tonevitsky A, Aigner A, Izbicki J, Schumacher U, Wicklein D., Free PMC Article

    12/11/2021
    Overexpression and Activation of alphavbeta3 Integrin Differentially Affects TGFbeta2 Signaling in Human Trabecular Meshwork Cells.

    Overexpression and Activation of αvβ3 Integrin Differentially Affects TGFβ2 Signaling in Human Trabecular Meshwork Cells.
    Filla MS, Meyer KK, Faralli JA, Peters DM., Free PMC Article

    12/4/2021
    Exploring Single Nucleotide Polymorphisms in ITGAV for Gastric, Pancreatic and Liver Malignancies: An Approach Towards the Discovery of Biomarker.

    Exploring Single Nucleotide Polymorphisms in ITGAV for Gastric, Pancreatic and Liver Malignancies: An Approach Towards the Discovery of Biomarker.
    Bhattacharya S, Sah PP, Banerjee A, Ray S.

    12/4/2021
    Cartilage oligomeric matrix protein fine-tunes disturbed flow-induced endothelial activation and atherogenesis.

    Cartilage oligomeric matrix protein fine-tunes disturbed flow-induced endothelial activation and atherogenesis.
    Lv H, Wang H, Quan M, Zhang C, Fu Y, Zhang L, Lin C, Liu X, Yi X, Chen J, Wang X, Cheng T, Ai D, Kong W, Zhu Y.

    10/30/2021
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