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    ITPKA inositol-trisphosphate 3-kinase A [ Homo sapiens (human) ]

    Gene ID: 3706, updated on 2-Aug-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    ITPKA induces cell senescence, inhibits ovarian cancer tumorigenesis and can be downregulated by miR-203.

    ITPKA induces cell senescence, inhibits ovarian cancer tumorigenesis and can be downregulated by miR-203.
    Shaosheng W, Shaochuang W, Lichun F, Na X, Xiaohong Z., Free PMC Article

    07/31/2021
    TFAP2A Induced ITPKA Serves as an Oncogene and Interacts with DBN1 in Lung Adenocarcinoma.

    TFAP2A Induced ITPKA Serves as an Oncogene and Interacts with DBN1 in Lung Adenocarcinoma.
    Guoren Z, Zhaohui F, Wei Z, Mei W, Yuan W, Lin S, Xiaoyue X, Xiaomei Z, Bo S., Free PMC Article

    01/9/2021
    IP3K-A binds to EB3 and their binding affinity is precisely regulated by protein kinase A (PKA)-dependent phosphorylation of IP3K-A at Ser119 (pSer119). The complex of IP3K-A and EB3 dissociates and reassociates rapidly during chemically induced LTP.

    PKA-dependent phosphorylation of IP3K-A at Ser119 regulates a binding affinity with EB3.
    Mo SJ, Cho Y, Choi BI, Lee D, Kim H.

    06/8/2019
    ITPKA is a potential oncogene that it is overexpressed in most tumors, and its overexpression promotes tumorigenesis; ITPKA gene body methylation regulates its expression and serves as a novel and potential biomarker for early cancer detection

    ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers.
    Wang YW, Ma X, Zhang YA, Wang MJ, Yatabe Y, Lam S, Girard L, Chen JY, Gazdar AF., Free PMC Article

    01/20/2018
    Our data indicated that ITPKA expression was significantly up-regulated in hepatocellular carcinoma and could serve as a potential novel prognostic biomarker

    ITPKA expression is a novel prognostic factor in hepatocellular carcinoma.
    Li J, Zhu YH, Huang P, Zhang B, Sun J, Guan XY., Free PMC Article

    04/2/2016
    describe the crystal structure of the complex between human Ca2+/CaM and the CaM-binding region of human IP3-3K isoform A (residues 158-183)

    A new calmodulin-binding motif for inositol 1,4,5-trisphosphate 3-kinase regulation.
    Franco-Echevarría E, Baños-Sanz JI, Monterroso B, Round A, Sanz-Aparicio J, González B.

    12/20/2014
    we conclude that the observed expression of ITPKA early in tumor development increases the metastatic potential of lung adenocarcinoma cells.

    Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.
    Windhorst S, Kalinina T, Schmid K, Blechner C, Kriebitzsch N, Hinsch R, Chang L, Herich L, Schumacher U, Mayr GW.

    09/24/2011
    Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.

    Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.
    Windhorst S, Fliegert R, Blechner C, Möllmann K, Hosseini Z, Günther T, Eiben M, Chang L, Lin HY, Fanick W, Schumacher U, Brandt B, Mayr GW., Free PMC Article

    03/15/2010
    the morphological changes induced by IP3K-A are mediated by non-enzymatic activities of the protein.

    Ins(1,4,5)P3 3-kinase-A overexpression induces cytoskeletal reorganization via a kinase-independent mechanism.
    Windhorst S, Blechner C, Lin HY, Elling C, Nalaskowski M, Kirchberger T, Guse AH, Mayr GW.

    01/21/2010
    results highlight the potential role of the three isoforms of InsP3 3-kinase as direct InsP3 metabolizing enzymes and direct regulators of Ca2+ responses to extracellular signals

    The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells.
    Dewaste V, Moreau C, De Smedt F, Bex F, De Smedt H, Wuytack F, Missiaen L, Erneux C., Free PMC Article

    01/21/2010
    Data suggest that ITPKA may be related to carcinogenesis by the modulation of inositol polyphosphates and Ca2+ homeostasis and that ITPKA may be a potential novel molecular target and biomarker.

    Down-regulation of 1D-myo-inositol 1,4,5-trisphosphate 3-kinase A protein expression in oral squamous cell carcinoma.
    Kato H, Uzawa K, Onda T, Kato Y, Saito K, Nakashima D, Ogawara K, Bukawa H, Yokoe H, Tanzawa H.

    01/21/2010
    We report the structure of an IPK, the human Ins(1,4,5)P3 3-kinase-A, both free and in complexes with substrates and products.

    Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase.
    González B, Schell MJ, Letcher AJ, Veprintsev DB, Irvine RF, Williams RL.

    01/21/2010
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