| Herpesvirus-mediated stabilization of ICP0 expression neutralizes restriction by TRIM23. | Herpesvirus-mediated stabilization of ICP0 expression neutralizes restriction by TRIM23.
Liu X, Acharya D, Krawczyk E, Kangas C, Gack MU, He B., Free PMC Article | 01/15/2022 |
| TRIM23 overexpression is a poor prognostic factor and contributes to carcinogenesis in colorectal cancer. | TRIM23 overexpression is a poor prognostic factor and contributes to carcinogenesis in colorectal cancer.
Han Y, Tan Y, Zhao Y, Zhang Y, He X, Yu L, Jiang H, Lu H, Tian H., Free PMC Article | 09/11/2021 |
| Opposing roles of E3 ligases TRIM23 and TRIM21 in regulation of ion channel ANO1 protein levels. | Opposing roles of E3 ligases TRIM23 and TRIM21 in regulation of ion channel ANO1 protein levels.
Cao X, Zhou Z, Tian Y, Liu Z, Cheng KO, Chen X, Hu W, Wong YM, Li X, Zhang H, Hu R, Huang P., Free PMC Article | 09/4/2021 |
| Data report that the Us11 protein targets TRIM23, which is a key regulator of autophagy-mediated antiviral defense mediated by TBK1. In virus-infected cells, the Us11 protein drastically reduces the formation of autophagosomes mediated by TRIM23 or TBK1. This autophagy-inhibitory effect is attributable to the binding of the Us11 protein to the ARF domain in TRIM23. | Disassembly of the TRIM23-TBK1 Complex by the Us11 Protein of Herpes Simplex Virus 1 Impairs Autophagy.
Liu X, Matrenec R, Gack MU, He B., Free PMC Article | 06/6/2020 |
| Study found that TRIM23 was upregulated in lung adenocarcinoma (LUAD), and elevated TRIM23 expression was correlated with high expression of NF-kappaB, poor cellular differentiation, and adverse overall survival and disease-free survival. Furthermore, TRIM23 acted as an oncogene in LUAD and promoted cisplatin-resistance by regulating glucose metabolism. | Elevated TRIM23 expression predicts cisplatin resistance in lung adenocarcinoma.
Zhang Y, Du H, Li Y, Yuan Y, Chen B, Sun S., Free PMC Article | 02/22/2020 |
| study identifies TRIM27 as a novel positive regulator of HCV replication | TRIM27 Promotes Hepatitis C Virus Replication by Suppressing Type I Interferon Response.
Zheng F, Xu N, Zhang Y. | 01/18/2020 |
| TRIM23 may be associated with progression of gastric cancer | Elevated TRIM23 expression predicts poor prognosis in Chinese gastric cancer.
Yao Y, Liu Z, Guo H, Huang S, Zhong M, Deng J, Xiong J. | 12/22/2018 |
| work identifies the TRIM23-TBK1-p62 axis as a key component of selective autophagy and further reveals a role for K27-linked ubiquitination in GTPase-dependent TBK1 activation | TRIM23 mediates virus-induced autophagy via activation of TBK1.
Sparrer KMJ, Gableske S, Zurenski MA, Parker ZM, Full F, Baumgart GJ, Kato J, Pacheco-Rodriguez G, Liang C, Pornillos O, Moss J, Vaughan M, Gack MU., Free PMC Article | 06/16/2018 |
| Our results indicate that TRIM23 enzymatic activity requires RING dimerization, consistent with the general model of TRIM activation | Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase.
Dawidziak DM, Sanchez JG, Wagner JM, Ganser-Pornillos BK, Pornillos O., Free PMC Article | 10/21/2017 |
| TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARgamma2. | The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARĪ³.
Watanabe M, Takahashi H, Saeki Y, Ozaki T, Itoh S, Suzuki M, Mizushima W, Tanaka K, Hatakeyama S., Free PMC Article | 01/16/2016 |
| conclude that TRIM23-mediated ubiquitin conjugation to NEMO is essential for TLR3- and RIG-I/MDA5-mediated antiviral innate and inflammatory responses | Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense.
Arimoto K, Funami K, Saeki Y, Tanaka K, Okawa K, Takeuchi O, Akira S, Murakami Y, Shimotohno K., Free PMC Article | 10/23/2010 |
| The authors present a novel role for TRIM23 that is specific to UL144-mediated activation of NF-kappaB during the course of virus infection. | Identification of TRIM23 as a cofactor involved in the regulation of NF-kappaB by human cytomegalovirus.
Poole E, Groves I, MacDonald A, Pang Y, Alcami A, Sinclair J., Free PMC Article | 01/21/2010 |
| Data are consistent with a potential function for ADP-ribosylation factor domain protein 1 as an E3 ubiquitin ligase in cells. | E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1).
Vichi A, Payne DM, Pacheco-Rodriguez G, Moss J, Vaughan M., Free PMC Article | 01/21/2010 |