| Epidermal growth factor receptor signaling protects epithelia from morphogenetic instability and tissue damage in Drosophila. | Epidermal growth factor receptor signaling protects epithelia from morphogenetic instability and tissue damage in Drosophila.
Yoshida K, Hayashi S., Free PMC Article | 03/20/2023 |
| EGFR-dependent suppression of synaptic autophagy is required for neuronal circuit development. | EGFR-dependent suppression of synaptic autophagy is required for neuronal circuit development.
Dutta SB, Linneweber GA, Andriatsilavo M, Hiesinger PR, Hassan BA. | 02/12/2023 |
| Distinct roles of Bendless in regulating FSC niche competition and daughter cell differentiation. | Distinct roles of Bendless in regulating FSC niche competition and daughter cell differentiation.
Tatapudy S, Peralta J, Nystul T., Free PMC Article | 02/12/2022 |
| Egfr Signaling Is a Major Regulator of Ecdysone Biosynthesis in the Drosophila Prothoracic Gland. | Egfr Signaling Is a Major Regulator of Ecdysone Biosynthesis in the Drosophila Prothoracic Gland.
Cruz J, Martín D, Franch-Marro X. | 07/17/2021 |
| Quantitative analyses of EGFR localization and trafficking dynamics in the follicular epithelium. | Quantitative analyses of EGFR localization and trafficking dynamics in the follicular epithelium.
Revaitis NT, Niepielko MG, Marmion RA, Klein EA, Piccoli B, Yakoby N., Free PMC Article | 03/27/2021 |
| Mitochondrial fission regulates germ cell differentiation by suppressing ROS-mediated activation of Epidermal Growth Factor Signaling in the Drosophila larval testis. | Mitochondrial fission regulates germ cell differentiation by suppressing ROS-mediated activation of Epidermal Growth Factor Signaling in the Drosophila larval testis.
Sênos Demarco R, Jones DL., Free PMC Article | 11/21/2020 |
| EGFR Signaling Stimulates Autophagy to Regulate Stem Cell Maintenance and Lipid Homeostasis in the Drosophila Testis. | EGFR Signaling Stimulates Autophagy to Regulate Stem Cell Maintenance and Lipid Homeostasis in the Drosophila Testis.
Sênos Demarco R, Uyemura BS, Jones DL., Free PMC Article | 10/24/2020 |
| Ectopic Dpp signaling promotes stem cell competition through EGFR signaling in the Drosophila testis. | Ectopic Dpp signaling promotes stem cell competition through EGFR signaling in the Drosophila testis.
Lu Y, Yao Y, Li Z., Free PMC Article | 10/24/2020 |
| Data suggest that the discs large 1 protein (Dlg) and the clathrin-mediated endocytic (CME) machinery downregulate epidermal growth factor receptor (EGFR) signaling. | The Dlg Module and Clathrin-Mediated Endocytosis Regulate EGFR Signaling and Cyst Cell-Germline Coordination in the Drosophila Testis.
Papagiannouli F, Berry CW, Fuller MT., Free PMC Article | 05/2/2020 |
| Regulation of cell growth by ROS is independent of the highly conserved TSC-TOR pathway. | ROS Inhibits Cell Growth by Regulating 4EBP and S6K, Independent of TOR, during Development.
Toshniwal AG, Gupta S, Mandal L, Mandal S., Free PMC Article | 01/11/2020 |
| In segmentation mutants, where specific peaks of EGFR ligands fail to form, gaps in signaling activity appear, leading to coincident hid up-regulation and subsequent cell death. In wild-type embryos, the segmentation cascade elicits the segmental production of several epidermal growth factor receptor (EGFR) ligands, including the transforming growth factor Spitz (TGFalpha), and the neuregulin, Vein. | EGFR signaling coordinates patterning with cell survival during Drosophila epidermal development.
Crossman SH, Streichan SJ, Vincent JP., Free PMC Article | 05/11/2019 |
| In this study, whole genome expression analysis was performed to identify genes activated by JAK/STAT and/or EGFR..AdamTS-A mRNA becomes enriched at the anterior and posterior poles of the egg chamber at stages 6 to 7 and is regulated by JAK/STAT. | A Gene Expression Screen in Drosophila melanogaster Identifies Novel JAK/STAT and EGFR Targets During Oogenesis.
Wittes J, Schüpbach T., Free PMC Article | 05/4/2019 |
| Wnt signaling functions genetically upstream of EGFR signaling by activating the expression of the EGFR ligand, Spitz. | Wingless promotes EGFR signaling in follicle stem cells to maintain self-renewal.
Kim-Yip RP, Nystul TG., Free PMC Article | 04/13/2019 |
| The somatic EGFR-ERK activity appeared to regulate the termination of Bam expression in the germline and promote subsequent differentiation to the spermatocyte stage. | Somatic ERK activation during transit amplification is essential for maintaining the synchrony of germline divisions in Drosophila testis.
Gupta S, Varshney B, Chatterjee S, Ray K., Free PMC Article | 03/23/2019 |
| stress-dependent EGFR/MAPK promotes gut regeneration via a novel mechanism that operates independently of Insulin/Pi3K/TOR signaling. | EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration.
Xiang J, Bandura J, Zhang P, Jin Y, Reuter H, Edgar BA., Free PMC Article | 11/17/2018 |
| EGFR/ARF6 regulation of Hh signaling stimulates oncogenic Ras tumor overgrowth in Drosophila. | EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth.
Chabu C, Li DM, Xu T., Free PMC Article | 11/17/2018 |
| Graf functions to downregulate EGFR signaling. | Graf regulates hematopoiesis through GEEC endocytosis of EGFR.
Kim S, Nahm M, Kim N, Kwon Y, Kim J, Choi S, Choi EY, Shim J, Lee C, Lee S. | 12/2/2017 |
| Data show that EGFR controls the proper formation of brain neuroblasts by regulating the number, survival and proneural gene expression of neuroectodermal progenitor cells which suggest that EGFR signalling is crucially important for patterning and early neurogenesis of the brain. | Genetic regulation and function of epidermal growth factor receptor signalling in patterning of the embryonic Drosophila brain.
Jussen D, von Hilchen J, Urbach R., Free PMC Article | 11/18/2017 |
| The activity of Gro is antagonized by EGFR signaling, which inhibits Gro-dependent repression via p-ERK mediated phosphorylation. | Phosphorylated Groucho delays differentiation in the follicle stem cell lineage by providing a molecular memory of EGFR signaling in the niche.
Johnston MJ, Bar-Cohen S, Paroush Z, Nystul TG., Free PMC Article | 09/16/2017 |
| These results reveal that ESCRT-0 (ESCRT-0 components stam and hrs)mutants inhibit EGFR signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells. | ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling.
Sheng Z, Yu L, Zhang T, Pei X, Li X, Zhang Z, Du W., Free PMC Article | 08/5/2017 |
| we find that EGFR regulates the apical determinant Crb and the extracellular matrix regulator Serp, two factors previously known to control tube length. EGFR regulates the organisation of endosomes in which Crb and Serp proteins are loaded | EGFR controls Drosophila tracheal tube elongation by intracellular trafficking regulation.
Olivares-Castiñeira I, Llimargas M., Free PMC Article | 08/5/2017 |
| Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr) pathway in the lateral epidermis for sustained dpp expression in the LE. Specifically, we demonstrate that Egfr pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling | Novel interplay between JNK and Egfr signaling in Drosophila dorsal closure.
Kushnir T, Mezuman S, Bar-Cohen S, Lange R, Paroush Z, Helman A., Free PMC Article | 07/22/2017 |
| Loss of Usp5 results in upregulation of Notch signaling and downregulation of RTK signaling by EGF receptor (EGFR) and Sevenless (Sev), leading to impaired photoreceptor development. | The deubiquitinating enzyme Usp5 regulates Notch and RTK signaling during Drosophila eye development.
Ling X, Huang Q, Xu Y, Jin Y, Feng Y, Shi W, Ye X, Lin Y, Hou L, Lin X. | 06/3/2017 |
| These data demonstrate a strong genetic link between dG9a and the EGFR signaling pathway. | Genome-wide genetic screen identified the link between dG9a and epidermal growth factor receptor signaling pathway in vivo.
Shimaji K, Konishi T, Yoshida H, Kimura H, Yamaguchi M. | 05/20/2017 |
| Avermectin directly interacts with EGFR and leads to the activation of the EGFR/AKT/ERK pathway. | Direct interaction of avermectin with epidermal growth factor receptor mediates the penetration resistance in Drosophila larvae.
Chen LP, Wang P, Sun YJ, Wu YJ., Free PMC Article | 12/31/2016 |