| Gbb glutathionylation promotes its proteasome-mediated degradation to inhibit synapse growth. | Gbb glutathionylation promotes its proteasome-mediated degradation to inhibit synapse growth.
Hossain MS, Yao A, Qiao X, Shi W, Xie T, Chen C, Zhang YQ., Free PMC Article | 07/5/2023 |
| The results indicate that high-fat diet-induced Gbb signaling provokes insulin resistance by increasing tribbles expression. | High fat diet-induced TGF-β/Gbb signaling provokes insulin resistance through the tribbles expression.
Hong SH, Kang M, Lee KS, Yu K., Free PMC Article | 04/21/2018 |
| Dpp and Gbb are produced by enterocytes and act in conjunction to promote intestinal stem cell self-renewal by antagonizing Notch signaling. | Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut.
Tian A, Jiang J., Free PMC Article | 11/14/2015 |
| Dpp/Gbb signaling is required for normal intestinal regeneration during infection. | Dpp/Gbb signaling is required for normal intestinal regeneration during infection.
Zhou J, Florescu S, Boettcher AL, Luo L, Dutta D, Kerr G, Cai Y, Edgar BA, Boutros M. | 05/9/2015 |
| propose that Gbb/Cmpy corelease from presynaptic terminals defines a neuronal protransmission signal | Crimpy enables discrimination of presynaptic and postsynaptic pools of a BMP at the Drosophila neuromuscular junction.
James RE, Hoover KM, Bulgari D, McLaughlin CN, Wilson CG, Wharton KA, Levitan ES, Broihier HT., Free PMC Article | 02/28/2015 |
| Klu is expressed specifically in the postmitotic Ap4/FMRFa neuron, promoting its differentiation through the initiation of BMP signaling | Klumpfuss controls FMRFamide expression by enabling BMP signaling within the NB5-6 lineage.
Losada-Pérez M, Gabilondo H, Molina I, Turiegano E, Torroja L, Thor S, Benito-Sipos J. | 06/29/2013 |
| Glial Mav modulates muscle expression of Gbb. | Integration of a retrograde signal during synapse formation by glia-secreted TGF-β ligand.
Fuentes-Medel Y, Ashley J, Barria R, Maloney R, Freeman M, Budnik V., Free PMC Article | 05/4/2013 |
| Data indicate that Gbb38, the large ligand form of the glass bottom boat (Gbb) exhibited greater signaling activity and a longer range than the shorter form Gbb15. | A large bioactive BMP ligand with distinct signaling properties is produced by alternative proconvertase processing.
Akiyama T, Marqués G, Wharton KA., Free PMC Article | 08/11/2012 |
| Studies indicate that glass bottom boat (Gbb) can be processed singly at a prodomain site or a main site to generate two active isoforms, Gbb15 and Gbb38. | You're going to need a bigger (glass bottom) boat.
Peterson AJ, O'Connor MB. | 08/11/2012 |
| Data demonstrate that crimpy (cmpy; CG13253) limits neuronal Gbb activity to permit appropriate regulation of neuromuscular junction growth. | Crimpy inhibits the BMP homolog Gbb in motoneurons to enable proper growth control at the Drosophila neuromuscular junction.
James RE, Broihier HT., Free PMC Article | 09/24/2011 |
| Data show that the expression of tkv correlates with the spatial pattern of BMP signaling. | BMP signaling dynamics in the follicle cells of multiple Drosophila species.
Niepielko MG, Hernáiz-Hernández Y, Yakoby N. | 08/6/2011 |
| The dRich coordinates the Gbb-dependent modulation of synaptic growth and function with postsynaptic development. | The Cdc42-selective GAP rich regulates postsynaptic development and retrograde BMP transsynaptic signaling.
Nahm M, Long AA, Paik SK, Kim S, Bae YC, Broadie K, Lee S., Free PMC Article | 12/11/2010 |
| Study shows that the Daw/Babo pathway acts upstream of gbb, and is involved in maintenance of muscle gbb expression. | Activin signaling functions upstream of Gbb to regulate synaptic growth at the Drosophila neuromuscular junction.
Ellis JE, Parker L, Cho J, Arora K. | 06/14/2010 |
| Gbb/BMP signaling is a new pathway critical for positive regulation of nutrient storage and energy homeostasis during development. | Gbb/BMP signaling is required to maintain energy homeostasis in Drosophila.
Ballard SL, Jarolimova J, Wharton KA., Free PMC Article | 03/1/2010 |
| This present study demonstrates that the central synapses that coordinate motoneuron activation are also reliant on Gbb-dependent retrograde signaling. | Synaptic strengthening mediated by bone morphogenetic protein-dependent retrograde signaling in the Drosophila CNS.
Baines RA., Free PMC Article | 01/21/2010 |
| The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction. | The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction.
McCabe BD, Marqués G, Haghighi AP, Fetter RD, Crotty ML, Haerry TE, Goodman CS, O'Connor MB. | 01/21/2010 |
| the relative contributions of Gbb and Dpp to patterning the wing imaginal disc along its A/P axis, change as a function of distance from the ligand source. | Dpp and Gbb exhibit different effective ranges in the establishment of the BMP activity gradient critical for Drosophila wing patterning.
Bangi E, Wharton K. | 01/21/2010 |
| Gbb globally regulates NMJ function by controlling both the growth and transmitter release properties of the synapse. | Retrograde Gbb signaling through the Bmp type 2 receptor wishful thinking regulates systemic FMRFa expression in Drosophila.
Marqués G, Haerry TE, Crotty ML, Xue M, Zhang B, O'Connor MB. | 01/21/2010 |