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    KRT4 keratin 4 [ Homo sapiens (human) ]

    Gene ID: 3851, updated on 23-Nov-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer.

    CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer.
    Takashima K, Fujii S, Komatsuzaki R, Komatsu M, Takahashi M, Kojima T, Daiko H, Minashi K, Chiwaki F, Muto M, Sasaki H, Yano T.

    Study indicated the mutated KRT4 gene may play important roles in the pathogenesis of white sponge nevus.

    Keratin 4 regulates the development of human white sponge nevus.
    Zhang J, Quan J, Ren Y, Chen M, Yang J, Zhang X.

    The aim of the study was to determine whether KRT4 or KRT13 gene mutation was the molecular basis of oral white sponge nevus. Deletion in the KRT4 gene was found to be a common polymorphism reflecting a high allele frequency of 31.25% in the Turkish population

    Clinical features and molecular genetic analysis in a Turkish family with oral white sponge nevus.
    Kürklü E, Öztürk Ş, Cassidy AJ, Ak G, Koray M, Çefle K, Palandüz Ş, Güllüoğlu MG, Tanyeri H, McLean WH., Free PMC Article

    The crystal structure of recombinant Srr-1-K4BD(485-642) and its possible mode of interaction with K4 through docking studies, are reported.

    Structure of KRT4 binding domain of Srr-1 from Streptococcus agalactiae reveals a novel β-sheet complementation.
    Sundaresan R, Samen U, Ponnuraj K.

    Identification of a mutation of the keratin 4 gene recurrent in a family affected by white sponge nevus.

    Mutation of keratin 4 gene causing white sponge nevus in a Japanese family.
    Kimura M, Nagao T, Machida J, Warnakulasuriya S.

    The aberrant expression of K4 and K13 and concomitant up-regulation of the other keratins may be one of the causative factors for morphological alterations in the affected epithelium.

    Down-regulation of keratin 4 and keratin 13 expression in oral squamous cell carcinoma and epithelial dysplasia: a clue for histopathogenesis.
    Sakamoto K, Aragaki T, Morita K, Kawachi H, Kayamori K, Nakanishi S, Omura K, Miki Y, Okada N, Katsube K, Takizawa T, Yamaguchi A.

    Fascin has a potential role as an early detection biomarker and CK4 as a tumor marker in esophageal squamous cell carcinoma.

    Fascin and CK4 as biomarkers for esophageal squamous cell carcinoma.
    Takikita M, Hu N, Shou JZ, Giffen C, Wang QH, Wang C, Hewitt SM, Taylor PR., Free PMC Article

    Infection by HPV stimulates the expression of cytokeratin 4

    Comparative analysis of the expression of cytokeratins (1, 10, 14, 16, 4), involucrin, filaggrin and e-cadherin in plane warts and epidermodysplasia verruciformis plane wart-type lesions.
    Barcelos AC, Sotto MN.

    Data found that Plk1 binds and directly phosphorylates the HsCYK-4 at the midzone and this modification creates a major docking site for the tandem BRCT repeats of the Rho GTP exchange factor Ect2.

    Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.
    Burkard ME, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat KM, Carr SA, Yaffe MB, Jallepalli PV., Free PMC Article

    Failure to phosphorylate HsCyk-4 blocks Ect2 recruitment to the central spindle and the subsequent induction of furrowing.

    Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation.
    Wolfe BA, Takaki T, Petronczki M, Glotzer M., Free PMC Article

    2 new mutations were found in the keratin 4 gene, the heterozygous missense mutation 1829G-->A in exon 2B, and 2324A-->G in non-coding region, which may be related with the development of WSN.

    Two new mutations in the keratin 4 gene causing oral white sponge nevus in Chinese family.
    Zhang JM, Yang ZW, Chen RY, Gao P, Zhang YR, Zhang LF.

    Deletion of the srr-1 gene in the genome of S. agalactiae revealed that this gene plays a role in bacterial binding to human K4 and that it is involved in adherence to epithelial HEp-2 cells.

    The surface protein Srr-1 of Streptococcus agalactiae binds human keratin 4 and promotes adherence to epithelial HEp-2 cells.
    Samen U, Eikmanns BJ, Reinscheid DJ, Borges F., Free PMC Article

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