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    LGALS7 galectin 7 [ Homo sapiens (human) ]

    Gene ID: 3963, updated on 11-Sep-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Herein, the authors first revealed that Galectin-7 was one of the Tid1-interacting client proteins. An inverse association of protein expression profile between Tid1 and Galectin-7 was determined in head and neck squamous cell carcinoma patients. Low Tid1 and high Galectin-7 expression predicted poor overall survival in head and neck squamous cell carcinoma.

    HSP40 co-chaperone protein Tid1 suppresses metastasis of head and neck cancer by inhibiting Galectin-7-TCF3-MMP9 axis signaling.
    Chen YS, Chang CW, Tsay YG, Huang LY, Wu YC, Cheng LH, Yang CC, Wu CH, Teo WH, Hung KF, Huang CY, Lee TC, Lo JF., Free PMC Article

    We further demonstrated using the NMR-based hydrogen-deuterium exchange (HDX) that lactose binding increases the exchange rates of residues located on the opposite side of the ligand-binding pocket for hGal1 and hGal8(NTD), indicative of allostery. Additionally, lactose binding induces significant stabilisation of hGal8(CTD) across the entire domain

    Lactose Binding Induces Opposing Dynamics Changes in Human Galectins Revealed by NMR-Based Hydrogen-Deuterium Exchange.
    Chien CH, Ho MR, Lin CH, Hsu SD., Free PMC Article

    Increased O-linked N-Acetyl-glucosamine (O-GlcNAc) is responsible for reduced Gal-7 expression in cultured human keratinocytes exposed to high glucose environment.

    High-glucose environment induced intracellular O-GlcNAc glycosylation and reduced galectin-7 expression in keratinocytes: Implications on impaired diabetic wound healing.
    Huang SM, Wu CS, Chiu MH, Yang HJ, Chen GS, Lan CE.

    We observed a significantly reduced overall survival for cases with high Gal-7 expression and a better survival for Gal-7 negative cases, when compared to cases with low expression of Gal-7.

    Galectins-1, -3, and -7 Are Prognostic Markers for Survival of Ovarian Cancer Patients.
    Schulz H, Schmoeckel E, Kuhn C, Hofmann S, Mayr D, Mahner S, Jeschke U., Free PMC Article

    Data suggest that evaluation of galectin-7 could help guide postsurgical management for non-metastatic clear cell renal cell carcinoma (ccRCC).

    High expression of galectin-7 associates with poor overall survival in patients with non-metastatic clear-cell renal cell carcinoma.
    Wang J, Liu Y, Yang Y, Xu Z, Zhang G, Liu Z, Fu H, Wang Z, Liu H, Xu J., Free PMC Article

    these findings reveal the existence of a positive self-amplification pathway that regulates intracellular gal-7 expression in breast and ovarian cancer cells.

    Intracellular galectin-7 expression in cancer cells results from an autocrine transcriptional mechanism and endocytosis of extracellular galectin-7.
    Bibens-Laulan N, St-Pierre Y., Free PMC Article

    Gal-7 re-expression affects the regulation of molecular networks in cervical cancer that are involved in diverse cancer hallmarks, such as metabolism, growth control, invasion and evasion of apoptosis

    Systems-level effects of ectopic galectin-7 reconstitution in cervical cancer and its microenvironment.
    Higareda-Almaraz JC, Ruiz-Moreno JS, Klimentova J, Barbieri D, Salvador-Gallego R, Ly R, Valtierra-Gutierrez IA, Dinsart C, Rabinovich GA, Stulik J, Rösl F, Rincon-Orozco B., Free PMC Article

    Measurement of scGal-7 content in tape-stripped samples was useful for the evaluation of the skin barrier function in dry skin conditions such as AD

    Galectin-7 in the stratum corneum: a biomarker of the skin barrier function.
    Niiyama S, Yoshino T, Yasuda C, Yu X, Izumi R, Ishiwatari S, Matsukuma S, Mukai H.

    It is a beta-galactose-binding animal lectin and known to be distributed throughout the body.

    Tissue- and cell-specific localization of galectins, β-galactose-binding animal lectins, and their potential functions in health and disease.
    Nio-Kobayashi J.

    Data indicate that the galectin inhibitor specifically binds galectin-7 (hGal-7), disrupts the formation of homodimers, and inhibits the pro-apoptotic activity of hGal-7 on Jurkat T cells.

    Design of a peptidic inhibitor that targets the dimer interface of a prototypic galectin.
    Vladoiu MC, Labrie M, Létourneau M, Egesborg P, Gagné D, Billard É, Grosset AA, Doucet N, Chatenet D, St-Pierre Y., Free PMC Article

    Galectin-7 regulates keratinocytes proliferation and differentiation through JNK1 pathway.

    Galectin-7 Regulates Keratinocyte Proliferation and Differentiation through JNK-miR-203-p63 Signaling.
    Chen HL, Chiang PC, Lo CH, Lo YH, Hsu DK, Chen HY, Liu FT., Free PMC Article

    The assessment of a carbohydrate-recognition domain (CRD)-defective mutant form of gal-7 (R7S) showed that the ability of this protein to modulate apoptosis was independent of its CRD activity.

    A Mutation in the Carbohydrate Recognition Domain Drives a Phenotypic Switch in the Role of Galectin-7 in Prostate Cancer.
    Labrie M, Vladoiu M, Leclerc BG, Grosset AA, Gaboury L, Stagg J, St-Pierre Y., Free PMC Article

    our study validates the clinical significance of gal-7 overexpression in ovarian cancer

    Expression and functions of galectin-7 in ovarian cancer.
    Labrie M, Vladoiu MC, Grosset AA, Gaboury L, St-Pierre Y., Free PMC Article

    Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells.

    Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells.
    Grosset AA, Labrie M, Gagné D, Vladoiu MC, Gaboury L, Doucet N, St-Pierre Y., Free PMC Article

    Galectin-7 is produced by the premenstrual and menstrual endometrium, where it accumulates in menstrual fluid and likely acts as a paracrine factor to facilitate post-menstrual endometrial re-epithelialization.

    Galectin-7 is important for normal uterine repair following menstruation.
    Evans J, Yap J, Gamage T, Salamonsen L, Dimitriadis E, Menkhorst E.

    Understanding how these dendrimeric compounds interact with hGal-7 would help in the design of new tools to investigate the recognition of carbohydrates by lectins.

    Structural basis of multivalent galactose-based dendrimer recognition by human galectin-7.
    Ramaswamy S, Sleiman MH, Masuyer G, Arbez-Gindre C, Micha-Screttas M, Calogeropoulou T, Steele BR, Acharya KR.

    galectin-7 is a potential predictive marker of chemotherapy and/or radiotherapy resistance in patients with oral squamous cell carcinoma

    Galectin-7 as a potential predictive marker of chemo- and/or radio-therapy resistance in oral squamous cell carcinoma.
    Matsukawa S, Morita K, Negishi A, Harada H, Nakajima Y, Shimamoto H, Tomioka H, Tanaka K, Ono M, Yamada T, Omura K., Free PMC Article

    Results suggest that galectin-3, -4, -7 and -9 could be involved in the biology of inverted papillomas.

    Galectin fingerprinting in naso-sinusal diseases.
    Duray A, De Maesschalck T, Decaestecker C, Remmelink M, Chantrain G, Neiveyans J, Horoi M, Leroy X, Gabius HJ, Saussez S., Free PMC Article

    galectin-7 may have a role in amyloidogenesis of primary localized cutaneous amyloidosis

    In vitro amyloidogenic peptides of galectin-7: possible mechanism of amyloidogenesis of primary localized cutaneous amyloidosis.
    Ono K, Fujimoto E, Fujimoto N, Akiyama M, Satoh T, Maeda H, Fujii N, Tajima S., Free PMC Article

    C/EBPbeta is an important mediator of galectin-7 gene activation in breast cancer cells

    The CCAAT/enhancer-binding protein beta-2 isoform (CEBPβ-2) upregulates galectin-7 expression in human breast cancer cells.
    Campion CG, Labrie M, Grosset AA, St-Pierre Y., Free PMC Article

    Galectin-7 is produced by endometrial epithelium. It is elevated in the endometrium of women with history of miscarriage. We suggest that galectin-7 facilitates adhesion of embryo to endometrium. Elevated galectin-7 may result in abnormal adhesion.

    Galectin-7 acts as an adhesion molecule during implantation and increased expression is associated with miscarriage.
    Menkhorst EM, Gamage T, Cuman C, Kaitu'u-Lino TJ, Tong S, Dimitriadis E.

    galectin-7 may play important roles in downregulating the functions of T lymphocytes after UVB irradiation

    Galectin-7, induced by cis-urocanic acid and ultraviolet B irradiation, down-modulates cytokine production by T lymphocytes.
    Yamaguchi T, Hiromasa K, Kabashima-Kubo R, Yoshioka M, Nakamura M.

    galectin-7 has a tumor suppressive function, and that the gene is epigenetically modified by DNA methylation and significantly down-regulated in gastric cancer.

    Galectin-7 is epigenetically-regulated tumor suppressor in gastric cancer.
    Kim SJ, Hwang JA, Ro JY, Lee YS, Chun KH., Free PMC Article

    Suggest that the differences in galectin-7 expression and subcellular and extracellular distribution may be crucially involved in the pathogenic process of hypertrophic scars.

    Decreased tissue and serum expression of galectin-7 in patients with hypertrophic scars.
    Cho SB, Kim JS, Zheng Z, Choi MJ, Choi IG, Oh HS, Ahn KJ.

    galectin-7 could be part of a common pathway used by mutant p53 to promote cancer progression

    Expression of galectin-7 is induced in breast cancer cells by mutant p53.
    Campion CG, Labrie M, Lavoie G, St-Pierre Y., Free PMC Article

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