| Bile acids serve as endogenous antagonists of the Leukemia inhibitory factor (LIF) receptor in oncogenesis. | Bile acids serve as endogenous antagonists of the Leukemia inhibitory factor (LIF) receptor in oncogenesis.
Di Giorgio C, Morretta E, Lupia A, Bellini R, Massa C, Urbani G, Bordoni M, Marchianò S, Lachi G, Rapacciuolo P, Finamore C, Sepe V, Chiara Monti M, Moraca F, Natalizi N, Graziosi L, Distrutti E, Biagioli M, Catalanotti B, Donini A, Zampella A, Fiorucci S. | 04/25/2024 |
| Intrahepatic paracrine signaling by cardiotrophin-like cytokine factor 1 ameliorates diet-induced NASH in mice. | Intrahepatic paracrine signaling by cardiotrophin-like cytokine factor 1 ameliorates diet-induced NASH in mice.
Liu T, Wang Q, Zhou L, Zhang P, Mi L, Qiu X, Chen Z, Kuang H, Li S, Lin JD., | 11/13/2023 |
| Interplay of "leukemia inhibitory factor receptor gene" (rs3099124) polymorphism, leukemia inhibitory factor and ovarian steroids with unexplained infertility. | Interplay of "leukemia inhibitory factor receptor gene" (rs3099124) polymorphism, leukemia inhibitory factor and ovarian steroids with unexplained infertility.
Ali R, Iqbal MUN, Rehman R, Khan TA. | 07/26/2023 |
| Role and mechanism of leukemia inhibitory factor receptor in cervical cancer invasion and metastasis. | Role and mechanism of leukemia inhibitory factor receptor in cervical cancer invasion and metastasis.
Hu H, Zhao Q, Sang Y, Xiao Y, Jiang N., Free PMC Article | 06/29/2023 |
| CircLIFR Inhibits Non-small Cell Lung Cancer Progression by Acting as a miR-429 Sponge to Enhance CELF2 Expression. | CircLIFR Inhibits Non-small Cell Lung Cancer Progression by Acting as a miR-429 Sponge to Enhance CELF2 Expression.
Wang J, Lai X, Peng X. | 04/6/2023 |
| Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations in familial vesicoureteral reflux. | Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations in familial vesicoureteral reflux.
Bartik ZI, Sillén U, Djos A, Lindholm A, Fransson S., Free PMC Article | 12/3/2022 |
| The Pleiotropic role, functions and targeted therapies of LIF/LIFR axis in cancer: Old spectacles with new insights. | The Pleiotropic role, functions and targeted therapies of LIF/LIFR axis in cancer: Old spectacles with new insights.
Halder S, Parte S, Kshirsagar P, Muniyan S, Nair HB, Batra SK, Seshacharyulu P., Free PMC Article | 08/13/2022 |
| Malignant transformation of salivary gland pleomorphic adenoma: proof of principle. | Malignant transformation of salivary gland pleomorphic adenoma: proof of principle.
Valstar MH, Mast H, Ten Hove I, Moonen LR, Balm AJ, Smeele LE, Koljenović S, Dinjens WN, van Velthuysen MF., Free PMC Article | 02/19/2022 |
| A targetable LIFR-NF-kappaB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis. | A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis.
Yao F, Deng Y, Zhao Y, Mei Y, Zhang Y, Liu X, Martinez C, Su X, Rosato RR, Teng H, Hang Q, Yap S, Chen D, Wang Y, Chen MM, Zhang M, Liang H, Xie D, Chen X, Zhu H, Chang JC, You MJ, Sun Y, Gan B, Ma L., Free PMC Article | 01/15/2022 |
| CircLIFR synergizes with MSH2 to attenuate chemoresistance via MutSalpha/ATM-p73 axis in bladder cancer. | CircLIFR synergizes with MSH2 to attenuate chemoresistance via MutSα/ATM-p73 axis in bladder cancer.
Zhang H, Xiao X, Wei W, Huang C, Wang M, Wang L, He Y, Sun J, Jiang Y, Jiang G, Zhang X., Free PMC Article | 12/4/2021 |
| Association of novel stop-gained leukaemia inhibitory factor receptor gene (rs121912501) variant, leukaemia inhibitory factor and ovarian steroids with unexplained infertility among Pakistani women. | Association of novel stop-gained leukaemia inhibitory factor receptor gene (rs121912501) variant, leukaemia inhibitory factor and ovarian steroids with unexplained infertility among Pakistani women.
Ali R, Iqbal MUN, Rehman R, Khan TA. | 08/28/2021 |
| Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies. | Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies.
Christians A, Weiss AC, Martens H, Klopf MG, Hennies I, Haffner D, Kispert A, Weber RG. | 08/7/2021 |
| Leukemia inhibitory factor promotes gastric cancer cell proliferation, migration, and invasion via the LIFR-Hippo-YAP pathway. | Leukemia inhibitory factor promotes gastric cancer cell proliferation, migration, and invasion via the LIFR-Hippo-YAP pathway.
Bian SB, Yang Y, Liang WQ, Zhang KC, Chen L, Zhang ZT. | 02/20/2021 |
| EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer. | EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer.
Lin SR, Wen YC, Yeh HL, Jiang KC, Chen WH, Mokgautsi N, Huang J, Chen WY, Liu YN. | 12/19/2020 |
| Study in eight datasets from four public databases revealed that LIF was highly expressed while LIFR was lowly expressed in pancreatic adenocarcinoma (PAAD) tissues compared with adjacent or normal tissues. High LIF expression was associated with shorter overall survival whereas high LIFR expression was associated with longer overall survival confirming significance LIF and LIFR as biomarkers in PAAD. | Prognostic value of leukemia inhibitory factor and its receptor in pancreatic adenocarcinoma.
Wang D, Liu K, Yang Y, Wang T, Rao Q, Guo W, Zhang Z. | 07/18/2020 |
| ERK2/LIFR/AKT axis modulates prostate carcinoma progression and offers a promising therapeutic and diagnostic target for prostate carcinoma | Phosphorylation of LIFR promotes prostate cancer progression by activating the AKT pathway.
Shao J, Zhu W, Ding Y, Zhu H, Jing X, Yu H, Lu M, Qiao Y, Wang X, Ai H, Wang X. | 02/15/2020 |
| The loss of LIFR protein was frequently found in Indian breast cancer patients, and aberrant promoter methylation showed a significant correlation with its downregulation. | Mutation, methylation and expression analysis of LIFR gene in Indian breast cancer patients.
Real SAS, Parveen F, Rehman AU, Shaik R, Deo SVS, Husain SA. | 12/7/2019 |
| LIFR signaling plays a role in the breast cancer tumor progression. LIFR is the receptor for ILEI, which mediates signaling through STAT3 to drive both epithelial-mesenchymal transition and breast cancer stem cells formation. | TGFβ promotes breast cancer stem cell self-renewal through an ILEI/LIFR signaling axis.
Woosley AN, Dalton AC, Hussey GS, Howley BV, Mohanty BK, Grelet S, Dincman T, Bloos S, Olsen SK, Howe PH., Free PMC Article | 12/7/2019 |
| Both in vivo and in vitro experiments revealed that circCRIM1 suppresses the invasion and metastasis of lung adenocarcinoma (LUAC) by promoting the expression of leukemia inhibitory factor receptor, a well-known tumor suppressor, by sponging miR-93 and miR-182. In the clinical and pathological analyses, the downregulation of circCRIM1 in LUAC was significantly correlated with lymphatic metastasis and TNM stage. | Circular RNA circCRIM1 inhibits invasion and metastasis in lung adenocarcinoma through the microRNA (miR)-182/miR-93-leukemia inhibitory factor receptor pathway.
Wang L, Liang Y, Mao Q, Xia W, Chen B, Shen H, Xu L, Jiang F, Dong G., Free PMC Article | 10/5/2019 |
| LIFR may be a novel negative regulator during the early stage of human bone marrow mesenchymal cell osteogenic differentiation. | Effects of Leukaemia Inhibitory Factor Receptor on the Early Stage of Osteogenic Differentiation of Human Bone Marrow Mesenchymal Cells.
Wang T, Yan RQ, Xu XY, Cao LL, Liu JY, Zheng MR, Li WD. | 08/3/2019 |
| Data suggest that mitogen-activated protein kinase kinase 6 (MAP2K6) might be an important regulator of leukemia inhibitory factor receptor (LIFR)-induced radioresistance in nasopharyngeal carcinoma cells (NPC). | Quantitative proteome analysis identifies MAP2K6 as potential regulator of LIFR-induced radioresistance in nasopharyngeal carcinoma cells.
Li Z, Fu J, Li N, Shen L. | 06/1/2019 |
| Mechanistically, nPAK4 promoted the metastasis of ERalpha-positive breast cancer cells by targeting LIFR, a bone metastasis suppressor. Strikingly, the nuclear accumulation of PAK4 might promote aggressive phenotypes, highlighting nPAK4 as a novel predictive biomarker for ERalpha-positive breast cancer bone metastasis. | A mandatory role of nuclear PAK4-LIFR axis in breast-to-bone metastasis of ERα-positive breast cancer cells.
Li Y, Zhang H, Zhao Y, Wang C, Cheng Z, Tang L, Gao Y, Liu F, Li J, Li Y, Li Y, Geng N, Rui X, Teng Y, Liu Y, Cao L, Kumar R, Jin F, Li F., Free PMC Article | 03/2/2019 |
| LncRNA-LOWEG is a tumor suppressor that inhibits Gastric cancer cell invasion. And LIFR gene is up-regulated by lncRNA-LOWEG. | A novel long noncoding RNA-LOWEG is low expressed in gastric cancer and acts as a tumor suppressor by inhibiting cell invasion.
Zhao JH, Sun JX, Song YX, Chen XW, Yang YC, Ma B, Wang J, Gao P, Wang ZN. | 02/28/2019 |
| High levels of LIFR in colorectal cancer (CRC) facilitated proliferation and migration of endothelial cells, resulting in an increase in angiogenic activity. Moreover, IL-8 was found to play a role in the LIFR induced angiogenesis. IL-8 levels were correlated with LIFR levels in CRC tissues, whereas depletion of IL-8 led to a reduced angiogenic activity of LIFR in CRC cells. | LIFR promotes tumor angiogenesis by up-regulating IL-8 levels in colorectal cancer.
Wu HX, Cheng X, Jing XQ, Ji XP, Chen XZ, Zhang YQ, He YG, Liu K, Ye F, Sun HX, Gao HJ, Song ZJ, Wu H, Zhang XJ, Zhang T, Zhao R. | 12/22/2018 |
| These data indicate that miR-377-3p suppressed adipogenesis of human bone marrow mesenchymal stem cells by targeting LIFR, which provides novel insights into the molecular mechanism of miRNA-mediated cellular differentiation. | miR-377-3p regulates adipogenic differentiation of human bone marrow mesenchymal stem cells by regulating LIFR.
Li X, Yang Y, Yan R, Xu X, Gao L, Mei J, Liu J, Wang X, Zhang J, Wu P, Li W, Zhao Z, Xiong J, Wang T. | 12/22/2018 |