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    CASC15 cancer susceptibility 15 [ Homo sapiens (human) ]

    Gene ID: 401237, updated on 20-Nov-2023

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Prognostic value of CASC15 and LINC01600 as competitive endogenous RNAs in lung adenocarcinoma: An observational study.

    Prognostic value of CASC15 and LINC01600 as competitive endogenous RNAs in lung adenocarcinoma: An observational study.
    Zhou F., Free PMC Article

    11/18/2023
    A study of the prognostic value of long non-coding RNA CASC15 in human solid tumors utilizing The Cancer Genome Atlas (TCGA) datasets and a meta-analysis.

    A study of the prognostic value of long non-coding RNA CASC15 in human solid tumors utilizing The Cancer Genome Atlas (TCGA) datasets and a meta-analysis.
    Chen W, Qian W, Nie J, Dai M.

    02/27/2023
    LncRNA-CASC15 knockdown inhibits the progression of esophageal squamous cell carcinoma through targeting miR-33a-5p/PTGS2 axis.

    LncRNA-CASC15 knockdown inhibits the progression of esophageal squamous cell carcinoma through targeting miR-33a-5p/PTGS2 axis.
    Zhou WZ, Wang XW, Zhu J, Chen MZ, Jin H.

    02/24/2023
    CASC15 Gene Polymorphisms and Glioma Susceptibility in Chinese Children.

    CASC15 Gene Polymorphisms and Glioma Susceptibility in Chinese Children.
    Lin HR, Chen YP, Chen HT, Liu XP, Zhou JY, Huang XK, Yuan L, Zhuo ZJ.

    08/20/2022
    [Clinical Significance of Low Expression of LncRNA CASC15 in Acute Myeloid Leukemia with NPM1 Mutations].

    [Clinical Significance of Low Expression of LncRNA CASC15 in Acute Myeloid Leukemia with NPM1 Mutations].
    Xia PH, Xu ZJ, Jin Y, Ma JC, Wen XM, Yuan Q, Leng JY, Qian J, Lin J.

    06/18/2022
    LncRNA CASC15 regulates breast cancer cell stemness via the miR-654-5p/MEF2D axis.

    LncRNA CASC15 regulates breast cancer cell stemness via the miR-654-5p/MEF2D axis.
    Shen P, Yu Y, Yan Y, Yu B, You W.

    05/21/2022
    LncRNA CASC15, MiR-23b Cluster and SMAD3 form a Novel Positive Feedback Loop to promote Epithelial-Mesenchymal Transition and Metastasis in Ovarian Cancer.

    LncRNA CASC15, MiR-23b Cluster and SMAD3 form a Novel Positive Feedback Loop to promote Epithelial-Mesenchymal Transition and Metastasis in Ovarian Cancer.
    Lin H, Xu X, Chen K, Fu Z, Wang S, Chen Y, Zhang H, Niu Y, Chen H, Yu H, Shao JZ, Lu W, Wu Y, Xia D., Free PMC Article

    04/30/2022
    lncRNACASC15 promotes osteosarcoma proliferation and metastasis by regulating epithelialmesenchymal transition via the Wnt/betacatenin signaling pathway.

    lncRNA‑CASC15 promotes osteosarcoma proliferation and metastasis by regulating epithelial‑mesenchymal transition via the Wnt/β‑catenin signaling pathway.
    Wang H, Zhang P., Free PMC Article

    11/6/2021
    Long noncoding RNA CASC15 facilitates esophageal squamous cell carcinoma tumorigenesis via decreasing SIM2 stability via FTOmediated demethylation.

    Long non‑coding RNA CASC15 facilitates esophageal squamous cell carcinoma tumorigenesis via decreasing SIM2 stability via FTO‑mediated demethylation.
    Qin B, Dong M, Wang Z, Wan J, Xie Y, Jiao Y, Yan D., Free PMC Article

    10/23/2021
    The long non-coding RNA <i>Cancer Susceptibility 15</i> (<i>CASC15</i>) is induced by isocitrate dehydrogenase (IDH) mutations and maintains an immature phenotype in adult acute myeloid leukemia.

    The long non-coding RNA Cancer Susceptibility 15 (CASC15) is induced by isocitrate dehydrogenase (IDH) mutations and maintains an immature phenotype in adult acute myeloid leukemia.
    Grasedieck S, Ruess C, Krowiorz K, Lux S, Pochert N, Schwarzer A, Klusmann JH, Jongen-Lavrencic M, Herold T, Bullinger L, Pollack JR, Rouhi A, Kuchenbauer F., Free PMC Article

    05/1/2021
    CASC15 polymorphisms are correlated with cervical cancer susceptibility in Chinese women.

    CASC15 polymorphisms are correlated with cervical cancer susceptibility in Chinese women.
    Gao Z, Xiong Z, Sun Y, Wu J, Liu J, Liu Y, Li H, Li B, Jin T., Free PMC Article

    04/17/2021
    Long Non-Coding RNA (LncRNA) CASC15 Is Upregulated in Diabetes-Induced Chronic Renal Failure and Regulates Podocyte Apoptosis.

    Long Non-Coding RNA (LncRNA) CASC15 Is Upregulated in Diabetes-Induced Chronic Renal Failure and Regulates Podocyte Apoptosis.
    Qin X, Zhu S, Chen Y, Chen D, Tu W, Zou H., Free PMC Article

    12/19/2020
    Long Non-Coding RNA-CASC15 Promotes Cell Proliferation, Migration, and Invasion by Activating Wnt/beta-Catenin Signaling Pathway in Melanoma.

    Long Non-Coding RNA-CASC15 Promotes Cell Proliferation, Migration, and Invasion by Activating Wnt/β-Catenin Signaling Pathway in Melanoma.
    Sheng L, Wei R.

    10/24/2020
    CASC15 contributes to proliferation and invasion through regulating miR-766-5p/ KLK12 axis in lung cancer.

    CASC15 contributes to proliferation and invasion through regulating miR-766-5p/ KLK12 axis in lung cancer.
    Bai Y, Zhang G, Cheng R, Yang R, Chu H., Free PMC Article

    09/5/2020
    Higher lncRNA CASC15 expression predicts poor prognosis and associates with tumor growth in cervical cancer.

    Higher lncRNA CASC15 expression predicts poor prognosis and associates with tumor growth in cervical cancer.
    Shan S, Li HF, Yang XY, Guo S, Guo Y, Chu L, Xu MJ, Xin DM.

    08/15/2020
    CASC15 and miR-124 predict TSCC [tongue squamous cell carcinoma ] patients' survival and CASC15 may downregulate miR-124 to inhibit TSCC cell migration and invasion.

    LncRNA CACS15 regulates tongue squamous cell carcinoma cell behaviors and predicts survival.
    Wu X, Ma J, Chen J, Huang H., Free PMC Article

    02/15/2020
    CASC15 could promote EMT and facilitate malignancy of HCC cells by increasing TWIST1 gene expression via miR-33a-5p sponging

    CASC15 promotes epithelial to mesenchymal transition and facilitates malignancy of hepatocellular carcinoma cells by increasing TWIST1 gene expression via miR-33a-5p sponging.
    Li Y, Chen G, Yan Y, Fan Q.

    01/11/2020
    LncRNA CASC15 could promote the proliferation of gastric cancer cells and was expected to become the molecular marker for prediction and prognosis of gastric cancer, as well as a potential therapeutic target.

    High expression of LncRNA CASC15 is a risk factor for gastric cancer prognosis and promote the proliferation of gastric cancer.
    Yao XM, Tang JH, Zhu H, Jing Y.

    08/24/2019
    the positive feedback loop of KLF5/CASC15/miR-153-3p/KLF5 in the acceleration of breast cancer malignant behaviors and tumorigenesis, is reported.

    LncRNA cancer susceptibility candidate 15 accelerates the breast cancer cells progression via miR-153-3p/KLF5 positive feedback loop.
    Yu L, Xu Q, Yu W, Duan J, Dai G.

    05/18/2019
    the knockdown of CASC15 triggered the silencing of ZEB1 in cytoplasm, which was shown to be associated with the competitive binding of CASC15 to miR-33a-5p.

    Long non-coding RNA CASC15 regulates gastric cancer cell proliferation, migration and epithelial mesenchymal transition by targeting CDKN1A and ZEB1.
    Wu Q, Xiang S, Ma J, Hui P, Wang T, Meng W, Shi M, Wang Y., Free PMC Article

    05/18/2019
    upregulated in tongue squamous cell carcinoma tissues and cell lines; overexpression promoted cell proliferation, cycle, and migration

    Long non-coding RNA CASC15 promotes tongue squamous carcinoma progression through targeting miR-33a-5p.
    Zuo Z, Ma L, Gong Z, Xue L, Wang Q.

    12/29/2018
    knockdown of CASC15 significantly inhibited the proliferation, migration and invasion of colon cancer cells in vitro and in vivo. Following mechanistic experiments, CASC15 was observed to act as a sponge to suppress microRNA (miR)4310 that targeted LGR5.

    LncRNA CASC15 promotes colon cancer cell proliferation and metastasis by regulating the miR‑4310/LGR5/Wnt/β‑catenin signaling pathway.
    Jing N, Huang T, Guo H, Yang J, Li M, Chen Z, Zhang Y.

    11/3/2018
    CASC15 plays an important role in the progression of HCC, acting as an oncogene. High expression of CASC15 is correlated with a poor prognosis.

    Long non-coding RNA CASC15 is upregulated in hepatocellular carcinoma and facilitates hepatocarcinogenesis.
    He T, Zhang L, Kong Y, Huang Y, Zhang Y, Zhou D, Zhou X, Yan Y, Zhang L, Lu S, Zhou J, Wang W., Free PMC Article

    07/28/2018
    CASC15-S is a tumor suppressor lncRNA at the 6p22 neuroblastoma susceptibility locus.CASC15-S is a mediator of neural growth and differentiation, which impacts neuroblastoma initiation and progression.

    CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus.
    Russell MR, Penikis A, Oldridge DA, Alvarez-Dominguez JR, McDaniel L, Diamond M, Padovan O, Raman P, Li Y, Wei JS, Zhang S, Gnanchandran J, Seeger R, Asgharzadeh S, Khan J, Diskin SJ, Maris JM, Cole KA., Free PMC Article

    10/31/2015
    We observed a significant association between neuroblastoma and the common minor alleles of three consecutive single-nucleotide polymorphisms (SNPs) at chromosome band 6p22 and containing the predicted genes FLJ22536 and FLJ44180

    Chromosome 6p22 locus associated with clinically aggressive neuroblastoma.
    Maris JM, Mosse YP, Bradfield JP, Hou C, Monni S, Scott RH, Asgharzadeh S, Attiyeh EF, Diskin SJ, Laudenslager M, Winter C, Cole KA, Glessner JT, Kim C, Frackelton EC, Casalunovo T, Eckert AW, Capasso M, Rappaport EF, McConville C, London WB, Seeger RC, Rahman N, Devoto M, Grant SF, Li H, Hakonarson H., Free PMC Article

    01/21/2010
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