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    MIR199B microRNA 199b [ Homo sapiens (human) ]

    Gene ID: 406978, updated on 15-Oct-2023

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    hsa-miR-199b-3p suppresses osteosarcoma progression by targeting CCDC88A, inhibiting epithelial-to-mesenchymal transition, and Wnt/beta-catenin signaling pathway.

    hsa-miR-199b-3p suppresses osteosarcoma progression by targeting CCDC88A, inhibiting epithelial-to-mesenchymal transition, and Wnt/beta-catenin signaling pathway.
    Zhu D, Qi H, Zhu H., Free PMC Article

    08/4/2023
    The role of AURKA/miR-199b-3p in hepatocellular carcinoma cells.

    The role of AURKA/miR-199b-3p in hepatocellular carcinoma cells.
    Li G, Tian Y, Gao Z., Free PMC Article

    01/14/2023
    Prognostic and clinicopathological value of miR-199b in cancers: a meta-analysis.

    Prognostic and clinicopathological value of miR-199b in cancers: a meta-analysis.
    Mao Z, Liu R, Zhang M, Liu W, Li D, Li H.

    07/30/2022
    MicroRNA-199b Deregulation Shows Oncogenic Properties and Promising Clinical Value as Circulating Marker in Locally Advanced Rectal Cancer Patients.

    MicroRNA-199b Deregulation Shows Oncogenic Properties and Promising Clinical Value as Circulating Marker in Locally Advanced Rectal Cancer Patients.
    Santos A, Cristóbal I, Rubio J, Caramés C, Luque M, Sanz-Alvarez M, Morales-Gallego M, Madoz-Gúrpide J, Rojo F, García-Foncillas J., Free PMC Article

    05/21/2022
    Role of LINC01133 in Osteogenic Differentiation of Dental Pulp Stem Cells by Targeting miR-199b-5p.

    Role of LINC01133 in Osteogenic Differentiation of Dental Pulp Stem Cells by Targeting miR-199b-5p.
    Shi Q, Zheng M.

    05/7/2022
    Adipose-Derived Stem Cells-Derived Exosomes with High Amounts of Circ_0001747 Alleviate Hypoxia/Reoxygenation-Induced Injury in Myocardial Cells by Targeting MiR-199b-3p/MCL1 Axis.

    Adipose-Derived Stem Cells-Derived Exosomes with High Amounts of Circ_0001747 Alleviate Hypoxia/Reoxygenation-Induced Injury in Myocardial Cells by Targeting MiR-199b-3p/MCL1 Axis.
    Zhou D, Dai Z, Ren M, Yang M.

    04/9/2022
    Identification of miR-199-5p and miR-199-3p Target Genes: Paxillin Facilities Cancer Cell Aggressiveness in Head and Neck Squamous Cell Carcinoma.

    Identification of miR-199-5p and miR-199-3p Target Genes: Paxillin Facilities Cancer Cell Aggressiveness in Head and Neck Squamous Cell Carcinoma.
    Tanaka N, Minemura C, Asai S, Kikkawa N, Kinoshita T, Oshima S, Koma A, Kasamatsu A, Hanazawa T, Uzawa K, Seki N., Free PMC Article

    02/19/2022
    LINC01783 accelerated tongue squamous cell carcinoma progression via inhibiting miR-199b-5p.

    LINC01783 accelerated tongue squamous cell carcinoma progression via inhibiting miR-199b-5p.
    Hu Y, Wang X, Li C, Jiao L, Du Y., Free PMC Article

    02/19/2022
    hsa-miR-199b-3p Prevents the Epithelial-Mesenchymal Transition and Dysfunction of the Renal Tubule by Regulating E-cadherin through Targeting KDM6A in Diabetic Nephropathy.

    hsa-miR-199b-3p Prevents the Epithelial-Mesenchymal Transition and Dysfunction of the Renal Tubule by Regulating E-cadherin through Targeting KDM6A in Diabetic Nephropathy.
    Bai S, Xiong X, Tang B, Ji T, Li X, Qu X, Li W., Free PMC Article

    01/8/2022
    MicroRNA-199b-3p suppresses malignant proliferation by targeting Phospholipase Cepsilon and correlated with poor prognosis in prostate cancer.

    MicroRNA-199b-3p suppresses malignant proliferation by targeting Phospholipase Cε and correlated with poor prognosis in prostate cancer.
    Liu J, Quan Z, Gao Y, Wu X, Zheng Y.

    12/25/2021
    Downregulation of miR-199a-3p in Hepatocellular Carcinoma and Its Relevant Molecular Mechanism via GEO, TCGA Database and In Silico Analyses.

    Downregulation of miR-199a-3p in Hepatocellular Carcinoma and Its Relevant Molecular Mechanism via GEO, TCGA Database and In Silico Analyses.
    Liu AG, Pang YY, Chen G, Wu HY, He RQ, Dang YW, Huang ZG, Zhang R, Ma J, Yang LH., Free PMC Article

    11/27/2021
    miRNA199b3p suppresses growth and progression of ovarian cancer via the CHK1/Ecadherin/EMT signaling pathway by targeting ZEB1.

    miRNA‑199b‑3p suppresses growth and progression of ovarian cancer via the CHK1/E‑cadherin/EMT signaling pathway by targeting ZEB1.
    Wei L, He Y, Bi S, Li X, Zhang J, Zhang S., Free PMC Article

    11/22/2021
    miR-199b-5p promoted chondrogenic differentiation of C3H10T1/2 cells by regulating JAG1.

    miR-199b-5p promoted chondrogenic differentiation of C3H10T1/2 cells by regulating JAG1.
    Zhang M, Yuan SZ, Sun H, Sun L, Zhou D, Yan J.

    10/16/2021
    miR-199b-5p-DDR1-ERK signalling axis suppresses prostate cancer metastasis via inhibiting epithelial-mesenchymal transition.

    miR-199b-5p-DDR1-ERK signalling axis suppresses prostate cancer metastasis via inhibiting epithelial-mesenchymal transition.
    Zhao Z, Zhao S, Luo L, Xiang Q, Zhu Z, Wang J, Liu Y, Luo J., Free PMC Article

    10/2/2021
    Expression and change of miR-199b-5p, s HLA-G in thyroid carcinoma.

    Expression and change of miR-199b-5p, s HLA-G in thyroid carcinoma.
    Tan B, Guo J, Wang L, Wang L, Gan X, Chen B.

    09/4/2021
    miR-101-3p and miR-199b-5p promote cell apoptosis in oral cancer by targeting BICC1.

    miR-101-3p and miR-199b-5p promote cell apoptosis in oral cancer by targeting BICC1.
    Wang H, Guo Y, Mi N, Zhou L.

    06/5/2021
    Aberrant DNA methylation of miRNAs in Fuchs endothelial corneal dystrophy.

    Aberrant DNA methylation of miRNAs in Fuchs endothelial corneal dystrophy.
    Pan P, Weisenberger DJ, Zheng S, Wolf M, Hwang DG, Rose-Nussbaumer JR, Jurkunas UV, Chan MF., Free PMC Article

    10/31/2020
    MiRNA-199 inhibits malignant progression of lung cancer through mediating RGS17.

    MiRNA-199 inhibits malignant progression of lung cancer through mediating RGS17.
    Su WZ, Ren LF.

    09/12/2020
    miR-199a/b-3p was significantly downregulated in metastatic castration-resistant compared with hormone-sensitive prostate cancer tissues. Ectopic expression of miR-199a/b inhibited cancer cell aggressiveness. The gene coding for NCAPH was directly regulated by miR-199a/b-3p. High expression of NCAPH was significantly associated with poor disease-free survival by The Cancer Genome Atlas database analysis.

    Micro-ribonucleic acid expression signature of metastatic castration-resistant prostate cancer: Regulation of NCAPH by antitumor miR-199a/b-3p.
    Arai T, Kojima S, Yamada Y, Sugawara S, Kato M, Yamazaki K, Naya Y, Ichikawa T, Seki N.

    07/18/2020
    this study revealed that miR-199b-5p functions as antioncogene miRNA in papillary thyroid carcinoma cells and that the miR-199b-5p/STON2 axis might be a potential treatment option for papillary thyroid carcinoma

    miR-199b-5p-Stonin 2 axis regulates metastases and epithelial-to-mesenchymal transition of papillary thyroid carcinoma.
    Ren L, Xu Y, Qin G, Liu C, Yan Y, Zhang H.

    12/14/2019
    miR-199b exerts tumor suppressive functions in hepatocellular carcinoma by directly targeting JAG1

    miR-199b exerts tumor suppressive functions in hepatocellular carcinoma by directly targeting JAG1.
    Li GL, Yuan JH, Zhuang GD, Wu DQ.

    11/16/2019
    Study results revealed that miR-199b-5p was significantly downregulated and negatively associated with parathyroid hormone levels in the sporadic but was upregulated in the hereditary parathyroid tumors proposing the potential role of miR-199b-5p as a novel biomarker for distinguishing these two types of parathyroid tumors.

    Differential expression of miRNA199b-5p as a novel biomarker for sporadic and hereditary parathyroid tumors.
    Hwang S, Jeong JJ, Kim SH, Chung YJ, Song SY, Lee YJ, Rhee Y., Free PMC Article

    11/2/2019
    High miR199b expression is associated with osteosarcoma.

    MiR-199b-5p promotes malignant progression of osteosarcoma by regulating HER2.
    Chen Z, Zhao G, Zhang Y, Ma Y, Ding Y, Xu N.

    08/31/2019
    Our findings suggest that mutant K-Ras plays an oncogenic role through downregulating miR-199b in NSCLC and that overexpression of miR-199b is a novel strategy for the treatment of K-Ras-mutated NSCLC.

    Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression.
    Jin H, Jang Y, Cheng N, Li Q, Cui PF, Zhou ZW, Jiang HL, Cho MH, Westover KD, Tan QY, Xu CX., Free PMC Article

    08/10/2019
    Three HPV16 oncoproteins (E5, E6, and E7) downregulate miR-148a-3p, while E6/E7 inhibit miR-199b-5p and miR-190a-5p expression in cervical carcinoma. The three microRNAs, miR-148a-3p, miR-199b-5p, and miR-190a-5p, may be novel diagnostic biomarkers for cervical cancer development in high-risk HPV-positive patients.

    Human Papillomavirus 16 Oncoproteins Downregulate the Expression of miR-148a-3p, miR-190a-5p, and miR-199b-5p in Cervical Cancer.
    Han MS, Lee JM, Kim SN, Kim JH, Kim HS., Free PMC Article

    04/27/2019
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