| SIRT5-mediated ME2 desuccinylation promotes cancer growth by enhancing mitochondrial respiration. | SIRT5-mediated ME2 desuccinylation promotes cancer growth by enhancing mitochondrial respiration.
Teng P, Cui K, Yao S, Fei B, Ling F, Li C, Huang Z., | 01/12/2024 |
| Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate. | Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate.
Zhao M, Yao P, Mao Y, Wu J, Wang W, Geng C, Cheng J, Du W, Jiang P. | 04/30/2022 |
| Expression levels of SIX1, ME2, and AP2M1 in adenoid cystic carcinoma and mucoepidermoid carcinoma. | Expression levels of SIX1, ME2, and AP2M1 in adenoid cystic carcinoma and mucoepidermoid carcinoma.
Wu CC, Li H, Xiao Y, Deng WW, Sun ZJ. | 12/26/2020 |
| influences susceptibility to adolescent-onset genetic generalized epilepsy | Replication, reanalysis, and gene expression: ME2 and genetic generalized epilepsy.
Wang M, Greenberg DA, Stewart WCL. | 04/18/2020 |
| ME2 was involved in glioblastoma multiforme growth, invasion, migration, Reactive oxygen species and ATP production. | The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas.
Cheng CP, Huang LC, Chang YL, Hsieh CH, Huang SM, Hueng DY., Free PMC Article | 01/20/2018 |
| The chromosome 18q21 deletion in nearly one third of pancreatic adenocarcinomas eliminates not only the tumor suppressor SMAD4, but also neighboring genes with important cellular roles, such as ME2 | Collateral Lethality in Pancreatic Cancer.
| 11/25/2017 |
| deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer | Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer.
Dey P, Baddour J, Muller F, Wu CC, Wang H, Liao WT, Lan Z, Chen A, Gutschner T, Kang Y, Fleming J, Satani N, Zhao D, Achreja A, Yang L, Lee J, Chang E, Genovese G, Viale A, Ying H, Draetta G, Maitra A, Wang YA, Nagrath D, DePinho RA., Free PMC Article | 06/24/2017 |
| ME1/ME2 expression phenotype may have a potential to be a valuable marker for sebaceous differentiation in sebaceous lesions. | Expression of Malic Enzymes in Sebaceous Lesions.
Su TF, Gao HW. | 01/28/2017 |
| Data indicate that malic enzyme 2 knockdown impacts phosphatidylinositol 3-kinases/proto-oncogene protein akt (PI3K/AKT) signaling. | Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling.
Ren JG, Seth P, Clish CB, Lorkiewicz PK, Higashi RM, Lane AN, Fan TW, Sukhatme VP., Free PMC Article | 10/31/2015 |
| ME2 might be an important factor in melanoma progression and a novel biomarker of invasion. | Human mitochondrial NAD(P)(+)-dependent malic enzyme participates in cutaneous melanoma progression and invasion.
Chang YL, Gao HW, Chiang CP, Wang WM, Huang SM, Ku CF, Liu GY, Hung HC. | 05/9/2015 |
| Three SNP alleles in BRD2, Cx-36, and ME2 and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myclonic epilepsy. | The quest for juvenile myoclonic epilepsy genes.
Delgado-Escueta AV, Koeleman BP, Bailey JN, Medina MT, Durón RM. | 02/1/2014 |
| p53 represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 and ME2 in human and mouse cells | Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence.
Jiang P, Du W, Mancuso A, Wellen KE, Yang X., Free PMC Article | 02/16/2013 |
| Depletion of malic enzyme 2 induced erythroid differentiation in human erythroleukemia cells. | Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2.
Ren JG, Seth P, Everett P, Clish CB, Sukhatme VP., Free PMC Article | 02/26/2011 |
| ME2 activity in Islets of Langerhans cells was measured by a spectrophotometric enzyme assay by utilizing the distinct kinetic properties. | Mitochondrial malic enzyme (ME2) in pancreatic islets of the human, rat and mouse and clonal insulinoma cells.
MacDonald MJ, Longacre MJ, Kendrick MA., Free PMC Article | 01/21/2010 |
| Single nucleotide polymorphism in ME2 gene is associated with acute lymphoblastic leukemia. | Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.
French D, Yang W, Cheng C, Raimondi SC, Mullighan CG, Downing JR, Evans WE, Pui CH, Relling MV., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. Association analysis of malic enzyme 2 gene polymorphisms with idiopathic generalized epilepsy.
Lenzen KP, Heils A, Lorenz S, Hempelmann A, Sander T. | 03/13/2008 |
| Schizophrenic subjects are identified with mitochondrial genes involved in oxidative metabolism as showing consistently decreased expression, including ME2. | Variation in the malic enzyme 2 gene: implications for the pharmacogenomics of psychotic disorders.
Escamilla M. | 01/21/2010 |
| These findings provide a molecular rationale for the role of hS14 in TR-dependent transcriptional activation of the expression of specific genes. | Human spot 14 protein interacts physically and functionally with the thyroid receptor.
Chou WY, Cheng YS, Ho CL, Liu ST, Liu PY, Kuo CC, Chang HP, Chen YH, Chang GG, Huang SM. | 01/21/2010 |
| Site directed mutagenesis was used to detrmine which amino acids in the active site of human mitochondrial NAD+-dependent malic enzyme are necessary for the inhibitory effects of ATP. | Functional roles of ATP-binding residues in the catalytic site of human mitochondrial NAD(P)+-dependent malic enzyme.
Hung HC, Chien YC, Hsieh JY, Chang GG, Liu GY. | 01/21/2010 |
| An ME2-centered nine-SNP haplotype, when present homozygously, increases the risk for IGE (odds ratio 6.1; 95% confidence interval 2.9-12.7) compared with any other genotype | Malic enzyme 2 may underlie susceptibility to adolescent-onset idiopathic generalized epilepsy.
Greenberg DA, Cayanis E, Strug L, Marathe S, Durner M, Pal DK, Alvin GB, Klotz I, Dicker E, Shinnar S, Bromfield EB, Resor S, Cohen J, Moshe SL, Harden C, Kang H., Free PMC Article | 01/21/2010 |