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    MIF macrophage migration inhibitory factor [ Homo sapiens (human) ]

    Gene ID: 4282, updated on 11-Sep-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The increased MIF secretion by the A549R and H460R cells could be suppressed by a multiple kinase inhibitor, dasatinib, which resulted in the decreased of oncogenic network of Src, CD155 and MIF expression

    Cisplatin resistant lung cancer cells promoted M2 polarization of tumor-associated macrophages via the Src/CD155/MIF functional pathway.
    Huang WC, Kuo KT, Wang CH, Yeh CT, Wang Y., Free PMC Article

    09/7/2019
    MIF has a dual role in kidney diseases, promoting (auto)immune glomerular diseases and limiting tubular cell injury in the setting of acute and chronic kidney diseases. These data suggest potential safety issues of systemic MIF targeted therapies, but also open new therapeutic options by targeting MIF or its analogues to tubular cells.

    MIF in kidney diseases : A story of Dr. Jekyll and Mr. Hyde.
    Boor P.

    08/24/2019
    Similar to the MIF-knockout mice, treatment with RPS19, but not the mutant RPS19, suppressed cisplatin-induced acute kidney injury (AKI). Mechanistically, we found that both genetic knockout and pharmacological inhibition of MIF protected against AKI by inactivating the CD74-nuclear factor kappaB (NF-kappaB) signaling.

    Blocking Macrophage Migration Inhibitory Factor Protects Against Cisplatin-Induced Acute Kidney Injury in Mice.
    Li J, Tang Y, Tang PMK, Lv J, Huang XR, Carlsson-Skwirut C, Da Costa L, Aspesi A, Fröhlich S, Szczęśniak P, Lacher P, Klug J, Meinhardt A, Fingerle-Rowson G, Gong R, Zheng Z, Xu A, Lan HY.,

    08/17/2019
    MIF levels in STEMI patients with or without diabetes can reflect acute cardiac function.

    Correlation between Plasma Macrophage Migration Inhibitory Factor Levels and Long-Term Prognosis in Patients with Acute Myocardial Infarction Complicated with Diabetes.
    Yu H, Wang X, Deng X, Zhang Y, Gao W., Free PMC Article

    08/10/2019
    MIF -173 G > C (rs755622) Gene Polymorphism is associated with Tuberculosis Risk.

    MIF -173 G > C (rs755622) Gene Polymorphism Modulates Tuberculosis Risk: Evidence from a Meta-analysis and Trial Sequential Analysis.
    Areeshi MY, Mandal RK, Dar SA, Jawed A, Wahid M, Lohani M, Panda AK, Mishra BN, Akhter N, Haque S., Free PMC Article

    08/10/2019
    Patients with granulomatosis with polyangiitis have an increased frequency of high MIF expression CATT alleles. Higher Mif expression increases the incidence of mortality and pulmonary granulomas in Mif lung-Tg2.1 mice, while anti-MIF treatment protects these mice against death.

    Role of Macrophage Migration Inhibitory Factor in Granulomatosis With Polyangiitis.
    Sreih AG, Ezzedine R, Leng L, Fan J, Yao J, Reid D, Piecychna M, Carette S, Cuthbertson D, Dellaripa P, Hoffman GS, Khalidi NA, Koening CL, Langford CA, Mahr A, McAlear CA, Maksimowicz-Mckinnon K, Monach PA, Seo P, Specks U, St Clair EW, Stone JH, Ytterberg SR, Edberg J, Merkel PA, Bucala R.,

    08/3/2019
    Results suggest that transcriptional regulation of macrophage migration inhibitory factor (MIF) and pursuing pituitary-specific positive transcription factor 1 (Pit-1) as a therapeutic target to treat MIF-mediated inflammatory disorders.

    Biochemical and structural characterization of a novel cooperative binding mode by Pit-1 with CATT repeats in the macrophage migration inhibitory factor promoter.
    Agarwal S, Cho TY., Free PMC Article

    07/27/2019
    Results indicated that MIF-CD74 interaction directly regulated the expression of PD-L1 and helps melanoma tumor cells escape from antitumorigenic immune responses.

    Macrophage migration inhibitory factor-CD74 interaction regulates the expression of programmed cell death ligand 1 in melanoma cells.
    Imaoka M, Tanese K, Masugi Y, Hayashi M, Sakamoto M., Free PMC Article

    07/20/2019
    Overexpression of miR-451a can inhibit cell proliferation and colony formation by inhibiting MIF expression in HepG2 cells.

    [Overexpression of miR-451a inhibits cell proliferation by targeted macrophage migration inhibitory factor in HepG2 cells].
    Dong H, Wang J, Yang Y, Zhang X, Yu M, Xu G, Jian P.

    07/20/2019
    Our data suggest that MIF-173 polymorphisms may be associated with a higher incidence of prostate cancer compared to controls. We believe that MIF-173 GC+CC genotype can be used as a predictive factor for aggressive behavior of prostate cancer including pathological stage and Gleason scores as well as metastatic potential.

    Association of macrophage inhibitory factor -173 gene polymorphism with biological behavior of prostate cancer.
    Razzaghi MR, Mazloomfard MM, Malekian S, Razzaghi Z.

    07/13/2019
    This study investigated a bypass mechanism of resistance to MEK inhibition in KRAS colorectal cancer (CRC). KRAS mutant colorectal cancer cells with refametinib, MEK inhibitor, induced MIF secretion and resulted in activation of STAT3 and MAPK.

    Macrophage migration inhibitory factor promotes resistance to MEK blockade in KRAS mutant colorectal cancer cells.
    Cheon SK, Kim HP, Park YL, Jang JE, Lim Y, Song SH, Han SW, Kim TY., Free PMC Article

    07/6/2019
    Serum level of MIF was a better biomarker than C-reactive protein or IL-6 for predicting death in pulmonary tuberculosis patients.

    Prognostic value of serum macrophage migration inhibitory factor levels in pulmonary tuberculosis.
    Wang Q, Han W, Niu J, Sun B, Dong W, Li G., Free PMC Article

    06/29/2019
    MIF intragroup comparisons between fluids demonstrated significant high levels of MIF in saliva compared with GCF and serum in both study groups (p<0.05). A positive correlation was found between clinical signs and MIF concentration in GCF (p<0.05).

    Macrophage Migration Inhibitory Factor Levels in Gingival Crevicular Fluid, Saliva, and Serum of Chronic Periodontitis Patients.
    Ortiz-García YM, García-Iglesias T, Morales-Velazquez G, Lazalde-Ramos BP, Zúñiga-González GM, Ortiz-García RG, Zamora-Perez AL., Free PMC Article

    06/23/2019
    MIF inhibits mutant SOD1 nuclear clearance when overexpressed in motor neuron-like NSC-34 cells.

    MIF inhibits the formation and toxicity of misfolded SOD1 amyloid aggregates: implications for familial ALS.
    Shvil N, Banerjee V, Zoltsman G, Shani T, Kahn J, Abu-Hamad S, Papo N, Engel S, Bernhagen J, Israelson A., Free PMC Article

    06/22/2019
    Molecular dynamics (MD) simulations up to one microsecond revealed dynamical correlation between a residue located at the opening of one end of the MIF solvent channel, previously thought to be a consequence of homotrimerization, and residues in a distal region responsible for CD74 activation. Experiments verified the allosteric regulatory site .

    Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74.
    Pantouris G, Ho J, Shah D, Syed MA, Leng L, Bhandari V, Bucala R, Batista VS, Loria JP, Lolis EJ., Free PMC Article

    05/18/2019
    the contribution of MIF to the pathogenesis of BLEL of the lacrimal gland

    Macrophage migration inhibitory factor contributes to the pathogenesis of benign lymphoepithelial lesion of the lacrimal gland.
    Adzavon YM, Zhao P, Ma J, Zhang X, Zhang X, Zhang M, Liu M, Wang L, Chen D, Abisso TG, Lv B, Wang L, Xie F, Ma X., Free PMC Article

    05/11/2019
    The meta-analysis indicated the MIF-794 allele CATT7 and CATT8 may be a risk factor to increase the susceptibility of tuberculosis, which was confirmed by trial sequential analysis.

    Macrophage migration inhibitory factor-794 CATT microsatellite polymorphism and risk of tuberculosis: a meta-analysis.
    Ma M, Tao L, Liu A, Liang Z, Yang J, Peng Y, Dai X, Bai R, Ji Z, Jian M, Bao F., Free PMC Article

    04/20/2019
    Study found that plasma MIF and CCL3 were significantly elevated in nasopharyngeal carcinoma (NPC) patients and identified plasma MIF and CCL3 as a promising and potential complementary biomarkers to EBV viral capsid antigen (VCA-IgA) for more effective detection of NPC. The combination of MIF, CCL3 with the traditional NPC tumor marker VCA-IgA may significantly improve the specificity of detection of NPC.

    Plasma Macrophage Migration Inhibitory Factor and CCL3 as Potential Biomarkers for Distinguishing Patients with Nasopharyngeal Carcinoma from High-Risk Individuals Who Have Positive Epstein-Barr Virus Capsid Antigen-Specific IgA.
    Xue N, Lin JH, Xing S, Liu D, Li SB, Lai YZ, Wang XP, Mao MJ, Zhong Q, Zeng MS, Liu WL., Free PMC Article

    04/20/2019
    As the CD138+ multiple myeloma (MM) cell is chemosensitive, targeting MIF-1 and/or the pathways that it regulates could be a viable way to modulate stemness and chemosensitivity, which could in turn transform the treatment of MM.

    Macrophage Inhibitory Factor-1 (MIF-1) controls the plasticity of multiple myeloma tumor cells.
    Joseph D, Gonsky JP, Blain SW., Free PMC Article

    04/20/2019
    MIF, through CD74, constitutively activates NF-kappaB to control mitochondrial dynamics and stability for promoting carcinogenesis via averting apoptosis

    Macrophage migration inhibitory factor regulates mitochondrial dynamics and cell growth of human cancer cell lines through CD74-NF-κB signaling.
    De R, Sarkar S, Mazumder S, Debsharma S, Siddiqui AA, Saha SJ, Banerjee C, Nag S, Saha D, Pramanik S, Bandyopadhyay U.,

    04/20/2019
    Youth carrying the MIF-173*C and CATT7 alleles displayed attenuated cortisol reactivity when compared with non-carriers. Children with the CATT7-173*C haplotype displayed lower cortisol reactivity to the stressor compared to those without this haplotype. Additionally, the CATT5-173*C and CATT6-173*C haplotypes were associated with lower self-reported anxiety ratings across the stressor.

    Macrophage migration inhibitory factor (MIF) gene is associated with adolescents' cortisol reactivity and anxiety.
    Lipschutz R, Bick J, Nguyen V, Lee M, Leng L, Grigorenko E, Bucala R, Mayes LC, Crowley MJ.

    04/13/2019
    Blocking of MIF and CD74 signaling in B cells triggered CXCR4 expression.

    The macrophage migration inhibitory factor pathway in human B cells is tightly controlled and dysregulated in multiple sclerosis.
    Rijvers L, Melief MJ, van der Vuurst de Vries RM, Stéphant M, van Langelaar J, Wierenga-Wolf AF, Hogervorst JM, Geurts-Moespot AJ, Sweep FCGJ, Hintzen RQ, van Luijn MM., Free PMC Article

    04/13/2019
    An inverse correlation between miR-451 and macrophage migration inhibitory protein (MIF) protein expression occurred in colon cancer cells.

    The tumour suppressor effects and regulation of cancer stem cells by macrophage migration inhibitory factor targeted miR-451 in colon cancer.
    Mamoori A, Wahab R, Vider J, Gopalan V, Lam AK.

    04/13/2019
    Basement membrane protein ladinin-1 and the MIF-CD44-beta1 integrin signaling axis are implicated in laryngeal cancer metastasis

    Basement membrane protein ladinin-1 and the MIF-CD44-β1 integrin signaling axis are implicated in laryngeal cancer metastasis.
    Klobučar M, Sedić M, Gehrig P, Grossmann J, Bilić M, Kovač-Bilić L, Pavelić K, Kraljević Pavelić S.

    03/30/2019
    Study found that the expression of MIF in lepromatous leprosy (LL) patients is similar to healthy subjects both in serum and in skin. However, the expression of CD74 is significantly increased in the skin lesions of LL patients, although its participation in the physiopathology leprosy remains unclear.

    Serum Levels of Migration Inhibitory Factor (MIF) and <i>In Situ</i> Expression of MIF and Its Receptor CD74 in Lepromatous Leprosy Patients: A Preliminary Report.
    Martinez-Guzman MA, Alvarado-Navarro A, Delgado-Rizo V, Garcia-Orozco A, Mayorga-Rodríguez JA, Pereira-Suarez AL, Fafutis-Morris M., Free PMC Article

    03/30/2019
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