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    MMP2 matrix metallopeptidase 2 [ Homo sapiens (human) ]

    Gene ID: 4313, updated on 11-Sep-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Imbalance in the metalloproteinase (MMP2, MMP9) to inhibitor tissue expression (TIMP1, TIMP2) in the vessel wall (the cross-sections of the internal thoracic artery, radial artery, and saphenous vein) might predispose to aortocoronary graft failure after coronary artery bypass grafting. A stronger expression of TIMPs than MMPs in the arterial grafts might explain favourable long-term outcomes.

    Variability in gelatinase expression in the walls of vessels used as aortocoronary conduits may impact long-term graft patency.
    Perek B, Kowalska K, Nowicki M, Kempisty B, Puślecki M, Jankowski M, Jemielity M, Malińska A.

    08/31/2019
    Increasing urinary cadmium concentrations were positively associated with hypertension risk in a Chinese population, and the associations were modified by polymorphism of rs14070 and rs7201 in gene MMP-2.

    Polymorphisms in gene MMP-2 modify the association of cadmium exposure with hypertension risk.
    Wu W, Liu D, Jiang S, Zhang K, Zhou H, Lu Q.

    08/24/2019
    Results found that MMP-2 was responsible for the Naa10p-induced invasive phenotype of human osteosarcoma cells. Naa10p was directly associated with MMP-2 protein through its acetyltransferase domain maintaining MMP-2 protein stability . MMP-2 expression levels were also significantly correlated with Naa10p levels in osteosarcoma tissues.

    N-α-acetyltransferase 10 protein promotes metastasis by stabilizing matrix metalloproteinase-2 protein in human osteosarcomas.
    Chien MH, Lee WJ, Yang YC, Tan P, Pan KF, Liu YC, Tsai HC, Hsu CH, Wen YC, Hsiao M, Hua KT.

    08/24/2019
    Mechano-growth factor regulates cyclic stretch-induced osteogenic differentiation and MMP-1, MMP-2 expression in human periodontal ligament cells by activating MEK/ERK1/2 signaling pathway.

    [Mechano-growth factor regulated cyclic stretch-induced osteogenic differentiation and MMP-1, MMP-2 expression in human periodontal ligament cells by activating the MEK/ERK1/2 pathway].
    Chen JT, Wang Y, Zhou ZF, Wei KW.

    08/24/2019
    This study indicated that the MMP-2 (-1306C/T) polymorphism, in combination with the TIMP-2 (-418G/C) polymorphism, contributes to acne vulgaris susceptibility in the Chinese Han population.

    Role of MMP-2(-1306 C/T) and TIMP-2(-418G/C) Polymorphism in Chinese Han Patients with Acne Vulgaris.
    Gao R, Yu H, Zhao Q, Wang S, Bai B., Free PMC Article

    08/17/2019
    we compared the expression of MMP1, MMP2, MMP7, and MMP9, well known as secreted MMPs, and found that MMP expression varied in lesions with different histological grade,histological subtype, and type of invasion.

    Expression of Matrix Metalloproteinases in Intraductal Papillary Mucinous Neoplasm of the Pancreas.
    Akashi M, Hisaka T, Sakai H, Ishikawa H, Kawahara R, Goto Y, Nomura Y, Yasunaga M, Fujita F, Tanigawa M, Naito Y, Akiba J, Yano H, Tanaka H, Akagi Y, Okuda K.

    08/10/2019
    TLR4 and MMP2 polymorphisms and their complex interactions with cardiovascular risk factors contributed to aortic aneurysmal diseases.

    TLR4 and MMP2 polymorphisms and their associations with cardiovascular risk factors in susceptibility to aortic aneurysmal diseases.
    Li T, Jing J, Sun L, Jiang B, Xin S, Yang J, Yuan Y., Free PMC Article

    07/27/2019
    Rg3 suppressed the expression of EMT-related transcription factors, especially the Zinc Finger E-Box Binding Homeobox 1 (ZEB1). In summary, our data suggested that Rg3 could inhibit migration and invasion of NPC cells. This effect of Rg3 might be mediated through regulating MMP-2 and MMP-9 expressions and suppressing EMT.

    Ginsenoside Rg3 Inhibits Migration and Invasion of Nasopharyngeal Carcinoma Cells and Suppresses Epithelial Mesenchymal Transition.
    Wang D, Wu C, Liu D, Zhang L, Long G, Hu G, Sun W., Free PMC Article

    07/27/2019
    Blood concentrations of MMP2 and MMP7 did not distinguish between different types of endocarditis

    [The study of activity of matrix metalloproteinases abd reactants of inflammation in patients with endocarditis.]
    Bakhareva YS, Poteryaeva ON, Chapaeva NN, Scherbakova LV.

    07/20/2019
    Results suggested that a reduction in CLDN18-dependent ZO-2 expression enhances MMP2 expression in lung adenocarcinoma cells, resulting in the promotion of the cell migration.

    ZO-2 Suppresses Cell Migration Mediated by a Reduction in Matrix Metalloproteinase 2 in Claudin-18-Expressing Lung Adenocarcinoma A549 Cells.
    Akizuki R, Eguchi H, Endo S, Matsunaga T, Ikari A.

    07/13/2019
    In pancreatic cancer (PC) tissue samples expression of TSPAN1 was markedly increased compared to normal samples. siRNA knockdown of TSPAN1 in PC cell lines suppressed PC cell migration and invasion and downregulated MMP2 expression. Transfection with siRNA targeted to PLCgamma revealed that TSPAN1 siRNA suppressed PC cell migration and invasion, and MMP2 expression by blocking the translocation and phosphorylation of P...

    TSPAN1 upregulates MMP2 to promote pancreatic cancer cell migration and invasion via PLCγ.
    Zhang X, Shi G, Gao F, Liu P, Wang H, Tan X., Free PMC Article

    07/6/2019
    MMP2 gene expression is regulated by TFPI-2 in breast cancer cells.

    Localization of TFPI-2 in the nucleus modulates MMP-2 gene expression in breast cancer cells.
    Wang G, Zeng Y, Chen S, Li D, Li W, Zhou Y, Singer RH, Gu W., Free PMC Article

    07/6/2019
    Mesenchymal stem cells and their derived MMP-2 exert neuroprotective properties through proteolysis of aggregated alpha-synuclein in Parkinson's disease-related microenvironments.

    The Cleavage Effect of Mesenchymal Stem Cell and Its Derived Matrix Metalloproteinase-2 on Extracellular α-Synuclein Aggregates in Parkinsonian Models.
    Oh SH, Kim HN, Park HJ, Shin JY, Kim DY, Lee PH., Free PMC Article

    07/6/2019
    PHLPP2 stabilization by p27 mediates its inhibition of bladder cancer invasion by promoting autophagic degradation of MMP2 protein.

    PHLPP2 stabilization by p27 mediates its inhibition of bladder cancer invasion by promoting autophagic degradation of MMP2 protein.
    Peng M, Wang J, Zhang D, Jin H, Li J, Wu XR, Huang C., Free PMC Article

    07/6/2019
    Data suggest that the MMP-2-1306 C/T polymorphism is probably a risk factor for sinus thrombosis in dural arteriovenous fistula patients.

    Polymorphism in dural arteriovenous fistula: matrix metalloproteinase-2-1306 C/T as a potential risk factor for sinus thrombosis.
    Tsuei YS, Chou YE, Chen WH, Luo CB, Yang SF.

    06/29/2019
    aimed to elucidate the carcinogenic effects of insulin and the synergistic effect with the KRAS mutation in the early stage of pancreatic cancer through PI3K/AKT and ERK1/2 activation, with MMP-2 gelatinolytic activity playing a vital role in this process

    Insulin promotes invasion and migration of KRAS<sup>G12D</sup> mutant HPNE cells by upregulating MMP-2 gelatinolytic activity via ERK- and PI3K-dependent signalling.
    Wang G, Yin L, Peng Y, Gao Y, Gao H, Zhang J, Lv N, Miao Y, Lu Z.

    06/22/2019
    our study revealed a novel mechanism of the RBMS3/Twsit1/MMP2 axis in the regulation of invasion and metastasis of breast cancer

    The RNA binding protein RBMS3 inhibits the metastasis of breast cancer by regulating Twist1 expression.
    Zhu L, Xi PW, Li XX, Sun X, Zhou WB, Xia TS, Shi L, Hu Y, Ding Q, Wei JF., Free PMC Article

    06/15/2019
    discriminatory ability in the diagnosis of bladder carcinoma of MMP-2 and MMP-9 expression was confirmed by receiver operating characteristic curve analysis that revealed a sensitivity and specificity of 100%. MMP-2 and MMP-9 levels were not correlated with grade or stage of the tumor

    MMP-2 and MMP-9 as prognostic markers for the early detection of urinary bladder cancer.
    Fouad H, Salem H, Ellakwa DE, Abdel-Hamid M.

    06/8/2019
    Low level of MMP2 and high level of MMP7 in the plasma of gastric adenocarcinoma patients correlated with poor overall survival.

    Clinical Significance of Matrix Metalloproteinases in Blood Plasma of Patients with Gastric Cancer.
    Kushlinskii NE, Gershtein ES, Ivannikov AA, Davydov MM, Chang VL, Ognerubov NA, Stilidi IS.

    06/1/2019
    Treatment with PFOA did not affect cell migration, but enhanced cell invasion, adhesion and activity of MMP-2 in FTC133 cells. PFOA selectively enhanced the phosphorylation of nuclear factor kappa B (NF-kappaB) p65, as well as induced NF-kappaB nuclear translocation.

    Perfluorooctanoic Acid Enhances Invasion of Follicular Thyroid Carcinoma Cells Through NF-κB and Matrix Metalloproteinase-2 Activation.
    Saejia P, Lirdprapamongkol K, Svasti J, Paricharttanakul NM.

    05/25/2019
    The authors' findings suggest that changes in DNA methylation at the promoter region of MMP2 could underlie the changes in its expression in the ectopic endometria from patients with endometriosis.

    The DNA methylation status of genes encoding Matrix metalloproteinases and tissue inhibitors of Matrix metalloproteinases in endometriosis.
    Tang L, Xiang Y, Zhou Y, Mu J, Zai M, Xing Q, Zhao X, He L, Wang L, Dong X, Li Q.

    05/18/2019
    Elevated levels of MMP-2 protein levels were observed in all regions of PT-PE placenta possibly influencing the degradation of placental ECM. Lower mRNA expression of MMP-9 both in PT-PE and T-PE may contribute to a disturbed placental vascularization.

    Matrix metalloproteinases-2 (MMP-2) and matrix metalloproteinases -9 (MMP-9) are differentially expressed in different regions of normal and preeclampsia placentae.
    Sahay AS, Jadhav AT, Sundrani DP, Wagh GN, Mehendale SS, Joshi SR.

    05/18/2019
    IGFBP2 acts as a stimulator of Vasculogenic mimicry formation in glioma cells via enhancing CD144 and MMP2 expression.

    IGFBP2 promotes vasculogenic mimicry formation via regulating CD144 and MMP2 expression in glioma.
    Liu Y, Li F, Yang YT, Xu XD, Chen JS, Chen TL, Chen HJ, Zhu YB, Lin JY, Li Y, Xie XM, Sun XL, Ke YQ.

    05/11/2019
    The expression of the gelatinases MMP 2, MMP 9 and regulators of their activity is aimed at increasing the tumor destructive (invasive) potential and can occur (be induced) in the intact corpus uteri tissue that is morphologically different from cervix uteri tissue with apparent participation of signaling through an epithelial-mesenchymal interaction.

    [Gelatinases A and B and their endogenous regulators in the corpus uteri in squamous cell cervical carcinoma].
    Timoshenko OS, Gureeva TA, Kugaevskaya EV, Zavalishina LE, Andreeva YY, Solovyeva NI.

    05/11/2019
    In both diffuse adenomyosis and adenomyomas, the basal layer of the eutopic and ectopic endometrium differed many (3-8.5) times, showing the higher expression of the enzymes in the epithelial and stromal cells, which affected their invasive activity (moesin, PAK 4, MMP 2 and MMP 9), and the increased number of CD34 cells in its stroma.

    [The expression of moesin, p21-activated kinase 4 (PAK 4), matrix metalloproteinases (MMP 2, MMP 9), and CD34 in the eutopic and ectopic endometrium in adenomyosis].
    Zayratyants OV, Adamyan LV, Manukyan LM, Kalinin DV, Arslanyan KN.

    05/11/2019
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