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    MMP12 matrix metallopeptidase 12 [ Homo sapiens (human) ]

    Gene ID: 4321, updated on 12-Sep-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    THE ROLE OF POLYMORPHISMS OF MATRIX METALLOPROTEINASES' POLYMORPHISMS 1 AND 12 IN THE FORMATION OF WHEEZING SYNDROME AMONG CHILDREN WITH RECURRENT BRONCHITIS.

    THE ROLE OF POLYMORPHISMS OF MATRIX METALLOPROTEINASES' POLYMORPHISMS 1 AND 12 IN THE FORMATION OF WHEEZING SYNDROME AMONG CHILDREN WITH RECURRENT BRONCHITIS.
    Strelkova MI, Senatorova GS, Polyakov VV.

    09/11/2021
    The association between plasma proteomics and incident cardiovascular disease identifies MMP-12 as a promising cardiovascular risk marker in patients with chronic kidney disease.

    The association between plasma proteomics and incident cardiovascular disease identifies MMP-12 as a promising cardiovascular risk marker in patients with chronic kidney disease.
    Feldreich T, Nowak C, Carlsson AC, Östgren CJ, Nyström FH, Sundström J, Carrero-Roig JJ, Leppert J, Hedberg P, Giedraitis V, Lind L, Cordeiro A, Ärnlöv J.

    06/26/2021
    Estimation of salivary matrix metalloproteinases- 12 (MMP- 12) levels among patients presenting with oral submucous fibrosis and oral squamous cell carcinoma.

    Estimation of salivary matrix metalloproteinases- 12 (MMP- 12) levels among patients presenting with oral submucous fibrosis and oral squamous cell carcinoma.
    Saleem Z, Shaikh AH, Zaman U, Ahmed S, Majeed MM, Kazmi A, Farooqui WA., Free PMC Article

    05/1/2021
    Matrix Metalloproteinase Genes (MMP1, MMP10, MMP12) on Chromosome 11q22 and the Risk of Non-Contact Anterior Cruciate Ligament Ruptures.

    Matrix Metalloproteinase Genes (<i>MMP1, MMP10, MMP12</i>) on Chromosome 11q22 and the Risk of Non-Contact Anterior Cruciate Ligament Ruptures.
    Lulińska E, Gibbon A, Kaczmarczyk M, Maciejewska-Skrendo A, Ficek K, Leońska-Duniec A, Wilk M, Leźnicka K, Michałowska-Sawczyn M, Humińska-Lisowska K, Buryta R, Cięszczyk P, Maculewicz E, Czarny W, September AV, Sawczuk M., Free PMC Article

    03/20/2021
    MMP-12 as a potential biomarker to forecast ischemic stroke in obese patients.

    MMP-12 as a potential biomarker to forecast ischemic stroke in obese patients.
    Wang CY, Zhang CP, Li BJ, Jiang SS, He WH, Long SY, Tian Y.

    01/30/2021
    Revisiting matrix metalloproteinase 12: its role in pathophysiology of asthma and related pulmonary diseases.

    Revisiting matrix metalloproteinase 12: its role in pathophysiology of asthma and related pulmonary diseases.
    Abd-Elaziz K, Jesenak M, Vasakova M, Diamant Z.

    12/19/2020
    Results detected that MMP12 expression is increased in castration-resistant prostate cancer (CRPC) patients tissues, and its knockdown attenuates CRPC cell line invasion. Also, endogenous estrogen produced by aromatase upregulates MMP12 expression via ERalpha. These data suggest that upregulating MMP12 expression may be a crucial mechanism by which aromatase promotes CRPC metastasis.

    Aromatase-induced endogenous estrogen promotes tumour metastasis through estrogen receptor-α/matrix metalloproteinase 12 axis activation in castration-resistant prostate cancer.
    Liang Z, Cao J, Tian L, Shen Y, Yang X, Lin Q, Zhang R, Liu H, Du X, Shi J, Zhang J.

    05/23/2020
    MMP-12 induces pro-osteogenic responses in aortic valve interstitial cells ( AVICs) by activation of p38 MAPK-mediated LRP-6 and beta-catenin signaling pathways.

    MMP-12-Induced Pro-osteogenic Responses in Human Aortic Valve Interstitial Cells.
    Deng XS, Meng X, Li F, Venardos N, Fullerton D, Jaggers J., Free PMC Article

    11/23/2019
    Finding show that increase serum levels of MMP-12 in a multivariate regression model were independent predictors of concomitant COPD and carotid plaque.

    Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking.
    Kraen M, Frantz S, Nihlén U, Engström G, Löfdahl CG, Wollmer P, Dencker M., Free PMC Article

    11/9/2019
    Tumor cell-derived matrix metalloproteinase 12 promotes tumor propagation in the lung.

    Matrix metalloproteinase 12 promotes tumor propagation in the lung.
    Ella E, Harel Y, Abraham M, Wald H, Benny O, Karsch-Bluman A, Vincent D, Laurent D, Amir G, Izhar U, Shapira OM, Yoon D, Lee HS, Sugarbaker DJ, Burt B, Peled A, Wald O.

    09/28/2019
    Results confirm that patients with COPD exhibited more MMP-12 protein, and the -82G allele of SNP rs2276109 was more frequent in controls than in COPD patients group. On the other hand, no relationship between the mentioned genetic polymorphism and MMP-12 level was found. Nevertheless, the data, together with other findings, suggest that MMP-12 affects COPD development.

    The role of MMP-12 gene polymorphism - 82 A-to-G (rs2276109) in immunopathology of COPD in polish patients: a case control study.
    Gilowska I, Majorczyk E, Kasper Ł, Bogacz K, Szczegielniak J, Kasper M, Kaczmarski J, Skomudek A, Czerwinski M, Sładek K., Free PMC Article

    08/24/2019
    In active human systemic lupus erythematosus, MMP12 levels were lower and IFN-gamma higher compared to treated patients or healthy individuals. Hence, macrophage proteolytic truncation of IFN-gamma attenuates classical activation of macrophages as a prelude for resolving inflammation.

    C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease.
    Dufour A, Bellac CL, Eckhard U, Solis N, Klein T, Kappelhoff R, Fortelny N, Jobin P, Rozmus J, Mark J, Pavlidis P, Dive V, Barbour SJ, Overall CM., Free PMC Article

    01/19/2019
    rs3025058 in MMP3 and rs2276109 in MMP12 might not contribute to the risk of developing rheumatic heart disease in a Han population in Southern China.

    Association of matrix metalloprotease 1, 3, and 12 polymorphisms with rheumatic heart disease in a Chinese Han population.
    Hu W, Ye Y, Yin Y, Sang P, Li L, Wang J, Wan W, Li R, Bai X, Xie Y, Meng Z., Free PMC Article

    12/22/2018
    Studied association of matrix metallopeptidase 12 (MMP12) -82 A>G promoter single nucleotide polymorphism (SNP) with bronchial asthma in a Bulgarian population. Results suggest the variant G allele of the MMP12 -82 A>G promoter polymorphism might considered protective for development of bronchial asthma.

    MMP12 -82 A&gt;G Promoter Polymorphism in Bronchial Asthma in a Population of Central Bulgaria.
    Tacheva T, Dimov D, Aleksandrova E, Bialecka M, Gulubova M, Vlaykova T.

    10/27/2018
    that MMP-12 might act as a potential target for the development of novel therapeutics of esophageal squamous cell carcinoma

    The overexpression and predictive significance of MMP-12 in esophageal squamous cell carcinoma.
    Han F, Zhang S, Zhang L, Hao Q.

    08/11/2018
    MMP-12 (-82A/G) polymorphisms associate with obesity risk and its severity.

    Role of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 (Lys45Glu), MMP-7 (-181A/G), and MMP-12 (-82A/G) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population.
    Boumiza S, Bchir S, Ben Nasr H, Abbassi A, Jacob MP, Norel X, Tabka Z, Chahed K., Free PMC Article

    08/4/2018
    Significant association observed for MMP-12 (-1082 A/G) (OR 2.55; 95% CI 1.75 to 3.71) gene polymorphism and risk of ischemic stroke. [meta-analysis]

    Association between matrix metalloproteinase family gene polymorphisms and risk of ischemic stroke: A systematic review and meta-analysis of 29 studies.
    Misra S, Talwar P, Kumar A, Kumar P, Sagar R, Vibha D, Pandit AK, Gulati A, Kushwaha S, Prasad K.

    07/21/2018
    Review/Meta-analysis: MMP-1 -1607 1G/2G and MMP-12 -82 A/G gene polymorphisms are associated with ischemic stroke risk.

    MMP Gene Polymorphisms, MMP-1 -1607 1G/2G, -519 A/G, and MMP-12 -82 A/G, and Ischemic Stroke: A Meta-Analysis.
    Zhang G, Li W, Guo Y, Li D, Liu Y, Xu S.

    07/7/2018
    The MMP12 down regulation by increasing oxygen concentration enables temporal expression control of MMP12 and involves several mechanisms including HIF-1alpha. These findings suggest MMP12 involved in trophoblast invasion during the first trimester.

    Expression of matrix metalloproteinase 12 is highly specific for non-proliferating invasive trophoblasts in the first trimester and temporally regulated by oxygen-dependent mechanisms including HIF-1A.
    Hiden U, Eyth CP, Majali-Martinez A, Desoye G, Tam-Amersdorfer C, Huppertz B, Ghaffari Tabrizi-Wizsy N., Free PMC Article

    05/5/2018
    In the present report, hypoxia is shown to activate a HIF-KDM3A-MMP12 signaling cascade that promotes trophoblast invasion and trophoblast-directed uterine spiral artery remodeling.

    HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia.
    Chakraborty D, Cui W, Rosario GX, Scott RL, Dhakal P, Renaud SJ, Tachibana M, Rumi MA, Mason CW, Krieg AJ, Soares MJ., Free PMC Article

    04/28/2018
    The current results suggest that MMP12 rs652438 but not MMP12 rs2276109 may affect the risk for Parkinson Disease

    Effects of common functional MMP12 gene polymorphisms on PD in a Polish population.
    Białecka M, Kurzawski M, Vlaykova T, Tacheva T, Dziedziejko V, Pierzchlińska A, Droździk M.

    03/24/2018
    The results of this study demonstrate that the gene expression of MMP9, MMP12, TIMP1 and TIMP2 was influenced by the addition of TGF-beta1. These results may be translated to chronic venous insufficiency framework and suggest involvement of TGF-beta1 in the vein wall pathology.

    Effect of TGF-beta1 on MMP/TIMP and TGF-beta1 receptors in great saphenous veins and its significance on chronic venous insufficiency.
    Serralheiro P, Cairrão E, Maia CJ, João M, Almeida CMC, Verde I.

    03/10/2018
    M4 macrophages are a possible source for HDAC9 and MMP12 expression in advanced human carotid plaques.

    Synergistic Expression of Histone Deacetylase 9 and Matrix Metalloproteinase 12 in M4 Macrophages in Advanced Carotid Plaques.
    Oksala NKJ, Seppälä I, Rahikainen R, Mäkelä KM, Raitoharju E, Illig T, Klopp N, Kholova I, Laaksonen R, Karhunen PJ, Hytönen VP, Lehtimäki T.

    01/20/2018
    MMP12 levels were increased in gingival tissue of periodontitis patients. MMP12-producing monocyte-derived cells also had reduced CD200R surface levels. MMP12 production by these cells was induced by CSF2, and treatment with a CD200R ligand reduced CSF2-induced MMP12 production. This novel association of the CD200/CD200R pathway with MMP12 production by monocyte-derived cells may play a key role in PD progression.

    Gingival Tissue Inflammation Promotes Increased Matrix Metalloproteinase-12 Production by CD200R<sup>low</sup> Monocyte-Derived Cells in Periodontitis.
    Björnfot Holmström S, Clark R, Zwicker S, Bureik D, Kvedaraite E, Bernasconi E, Nguyen Hoang AT, Johannsen G, Marsland BJ, Boström EA, Svensson M.

    12/30/2017
    G allele of MMP12 -82 A > G promoter polymorphism as a protective factor for COPD in Bulgarian population

    The G allele of MMP12 -82 A &gt; G promoter polymorphism as a protective factor for COPD in Bulgarian population.
    Tacheva T, Dimov D, Aleksandrova E, Bialecka M, Gulubova M, Vlaykova T.

    10/14/2017
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