| CREG1 deficiency impaired myoblast differentiation and skeletal muscle regeneration. | CREG1 deficiency impaired myoblast differentiation and skeletal muscle regeneration.
Song H, Tian X, He L, Liu D, Li J, Mei Z, Zhou T, Liu C, He J, Jia X, Yang Z, Yan C, Han Y., Free PMC Article | 04/11/2024 |
| The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes. | The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes.
Liu D, Xing R, Zhang Q, Tian X, Qi Y, Song H, Liu Y, Yu H, Zhang X, Jing Q, Yan C, Han Y., Free PMC Article | 10/4/2023 |
| CREG Protects Retinal Ganglion Cells loss and Retinal Function Impairment Against ischemia-reperfusion Injury in mice via Akt Signaling Pathway. | CREG Protects Retinal Ganglion Cells loss and Retinal Function Impairment Against ischemia-reperfusion Injury in mice via Akt Signaling Pathway.
Zeng S, Du L, Lu G, Xing Y. | 09/6/2023 |
| The role of CREG1 in megakaryocyte maturation and thrombocytopoiesis. | The role of CREG1 in megakaryocyte maturation and thrombocytopoiesis.
Song H, Li J, Peng C, Liu D, Mei Z, Yang Z, Tian X, Zhang X, Jing Q, Yan C, Han Y., Free PMC Article | 08/3/2023 |
| CREG1 stimulates AMPK phosphorylation and glucose uptake in skeletal muscle cells. | CREG1 stimulates AMPK phosphorylation and glucose uptake in skeletal muscle cells.
Goto A, Endo Y, Yamashita H. | 01/21/2023 |
| CREG ameliorates the phenotypic switching of cardiac fibroblasts after myocardial infarction via modulation of CDC42. | CREG ameliorates the phenotypic switching of cardiac fibroblasts after myocardial infarction via modulation of CDC42.
Liu D, Tian X, Liu Y, Song H, Cheng X, Zhang X, Yan C, Han Y., Free PMC Article | 09/25/2021 |
| Effects of CREG1 on Age-Associated Metabolic Phenotypes and Renal Senescence in Mice. | Effects of CREG1 on Age-Associated Metabolic Phenotypes and Renal Senescence in Mice.
Hashimoto M, Goto A, Endo Y, Sugimoto M, Ueda J, Yamashita H., Free PMC Article | 09/11/2021 |
| The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases. | The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases.
Gomez-Auli A, Hillebrand LE, Christen D, Günther SC, Biniossek ML, Peters C, Schilling O, Reinheckel T., Free PMC Article | 02/27/2021 |
| findings demonstrate that CREG1 stimulates brown adipocyte formation and browning, ameliorating obesity and its related pathology in vivo. | CREG1 stimulates brown adipocyte formation and ameliorates diet-induced obesity in mice.
Hashimoto M, Kusudo T, Takeuchi T, Kataoka N, Mukai T, Yamashita H. | 05/23/2020 |
| effect of CREG1 on Ucp1 promoter activity was also stimulated by retinoic acid. These results strongly suggest that CREG1 plays an important role on the regulation of UCP1 expression and brown adipogenesis | CREG1 promotes uncoupling protein 1 expression and brown adipogenesis in vitro.
Kusudo T, Hashimoto M, Kataoka N, Li Y, Nozaki A, Yamashita H. | 01/26/2019 |
| Transplantation of CREG-modified embryonic stem cells exhibits a favorable survival pattern in infarcted hearts, which translates into a substantial preservation of cardiac function after acute myocardial infarction. | Transplantation of CREG modified embryonic stem cells improves cardiac function after myocardial infarction in mice.
Zhang J, Tian X, Peng C, Yan C, Li Y, Sun M, Kang J, Gao E, Han Y. | 12/22/2018 |
| CREG protects heart against MI/R injury-induced cardiomyocytes apoptosis by activating lysosomal autophagy. | CREG protects from myocardial ischemia/reperfusion injury by regulating myocardial autophagy and apoptosis.
Song H, Yan C, Tian X, Zhu N, Li Y, Liu D, Liu Y, Liu M, Peng C, Zhang Q, Gao E, Han Y. | 11/24/2018 |
| CREG1 interacts with Sec8 to promote cardiomyogenic differentiation and cell-cell adhesion. | CREG1 Interacts with Sec8 to Promote Cardiomyogenic Differentiation and Cell-Cell Adhesion.
Liu J, Qi Y, Li S, Hsu SC, Saadat S, Hsu J, Rahimi SA, Lee LY, Yan C, Tian X, Han Y. | 01/27/2018 |
| Study demonstrated that haplodeficiency of Creg1 exacerbated high fat diet-induced obesity, insulin resistance and dyslipidemia. In addition, Creg1+/- mice showed increased systemic and adipose tissue inflammation, possibly through activation of the NF-kappaB pathway. | CREG1 heterozygous mice are susceptible to high fat diet-induced obesity and insulin resistance.
Tian X, Yan C, Liu M, Zhang Q, Liu D, Liu Y, Li S, Han Y., Free PMC Article | 09/9/2017 |
| CREG is a novel mediator of vascular remodeling in response to Ang II. | Cellular Repressor of E1A-Stimulated Genes Is a Critical Determinant of Vascular Remodeling in Response to Angiotensin II.
Li Y, Liu Y, Tian X, Zhang Y, Song H, Liu M, Zhang X, Liu H, Zhang J, Zhang Q, Liu D, Peng C, Yan C, Han Y. | 06/24/2017 |
| CREG inhibits inflammation and promotes autophagy mediated by lysosome formation; it might be a potential therapeutic target in atherosclerosis. | Cellular repressor of E1A-stimulated genes inhibits inflammation to decrease atherosclerosis in ApoE(-/-) mice.
Sun M, Tian X, Liu Y, Zhu N, Li Y, Yang G, Peng C, Yan C, Han Y. | 05/28/2016 |
| CREG1 deficiency influenced the maturation of lysosomes and reduced the espression of Rab7, which might be involved in CREG1-induced cardiomyocyte autophagy. | CREG1 ameliorates myocardial fibrosis associated with autophagy activation and Rab7 expression.
Yan CH, Li Y, Tian XX, Zhu N, Song HX, Zhang J, Sun MY, Han YL. | 04/18/2015 |
| Data indicate cellular repressor of E1A-stimulated gene (CREG) as a factor in regulating endothelial differentiation and vasculogenesis via VEGF/PI3K/Akt pathway. | CREG promotes vasculogenesis by activation of VEGF/PI3K/Akt pathway.
Tian X, Zhang N, Yan C, Nelsen J, Liu S, Kang J, Zhang J, Peng C, Tao J, Sun M, Li Y, Li S, Wang H, Han Y. | 02/14/2015 |
| Suggest that CREG is a novel adventitial fibroblast phenotypic modulator in a p38MAPK-dependent manner. | Cellular repressor E1A-stimulated genes controls phenotypic switching of adventitial fibroblasts by blocking p38MAPK activation.
Li Y, Tao J, Zhang J, Tian X, Liu S, Sun M, Zhang X, Yan C, Han Y. | 05/4/2013 |
| CREG plays a critical role in protecting the vascular endothelium from apoptosis, and the protective effort of CREG against ECs apoptosis is through the activation of the VEGF/PI3K/AKT signaling pathway | Overexpression of CREG attenuates atherosclerotic endothelium apoptosis via VEGF/PI3K/AKT pathway.
Wang N, Han Y, Tao J, Huang M, You Y, Zhang H, Liu S, Zhang X, Yan C. | 04/14/2012 |
| These results indicate that CREG is expressed during mouse embryogenesis and might participate in the differentiation of these organs during embryogenesis. | Pattern of expression of the CREG gene and CREG protein in the mouse embryo.
Yang G, Han Y, Tian X, Tao J, Sun M, Kang J, Yan C. | 05/28/2011 |
| Secreted Creg inhibits cell proliferation mediated by mannose-6-phosphate/insulin-like growth factor II receptor in NIH 3T3 fibroblasts. | Secreted CREG inhibits cell proliferation mediated by mannose 6-phosphate/insulin-like growth factor II receptor in NIH3T3 fibroblasts.
Han YL, Guo P, Sun MY, Guo L, Luan B, Kang J, Yan CH, Li SH. | 01/21/2010 |
| Results show that CREG is a lysosomal protein that undergoes proteolytic maturation during biosynthesis, carries the mannose 6-phosphate recognition marker and depends on the interaction with M-6-P receptors for efficient delivery to lysosomes. | Cellular repressor of E1A-stimulated genes is a bona fide lysosomal protein which undergoes proteolytic maturation during its biosynthesis.
Schähs P, Weidinger P, Probst OC, Svoboda B, Stadlmann J, Beug H, Waerner T, Mach L. | 01/21/2010 |