| [Methylthioadenosine phosphorylase and p16 as surrogate diagnostic markers for CDKN2A homozygous deletion in brain tumors]. | [Methylthioadenosine phosphorylase and p16 as surrogate diagnostic markers for CDKN2A homozygous deletion in brain tumors].
Wang SN, Wang W, Zhang XW, Zhang YQ, Xiong YL, Liu L, Teng LH. | 05/22/2024 |
| Methylthioadenosine Phosphorylase and Breast Cancer 1 Protein-Associated Protein 1 as Biomarkers for the Peritoneal Mesothelioma. | Methylthioadenosine Phosphorylase and Breast Cancer 1 Protein-Associated Protein 1 as Biomarkers for the Peritoneal Mesothelioma.
Chen Y, Du X, Gao Y, Wu H, Zhao H, Su Y., Free PMC Article | 12/20/2023 |
| MTAP-ANRIL gene fusion promotes melanoma epithelial-mesenchymal transition-like process by activating the JNK and p38 signaling pathways. | MTAP-ANRIL gene fusion promotes melanoma epithelial-mesenchymal transition-like process by activating the JNK and p38 signaling pathways.
Lin Z, Lei Y, Wen M, He Q, Tian D, Xie H., Free PMC Article | 06/13/2023 |
| BAP1 and Claudin-4, But Not MTAP, Reliably Distinguish Borderline and Low-grade Serous Ovarian Tumors From Peritoneal Mesothelioma. | BAP1 and Claudin-4, But Not MTAP, Reliably Distinguish Borderline and Low-grade Serous Ovarian Tumors From Peritoneal Mesothelioma.
Devins KM, Zukerberg L, Watkins JC, Hung YP, Oliva E. | 02/14/2023 |
| MTAP deficiency contributes to immune landscape remodelling and tumour evasion. | MTAP deficiency contributes to immune landscape remodelling and tumour evasion.
Chang WH, Hsu SW, Zhang J, Li JM, Yang DD, Chu CW, Yoo EE, Zhang W, Yu SL, Chen CH., Free PMC Article | 01/21/2023 |
| Correlation of MTAP immunohistochemical deficiency with CDKN2A homozygous deletion and clinicopathological features in pleomorphic xanthoastrocytoma. | Correlation of MTAP immunohistochemical deficiency with CDKN2A homozygous deletion and clinicopathological features in pleomorphic xanthoastrocytoma.
Lou L, Li J, Qin M, Tian X, Guo W, Li Y. | 01/14/2023 |
| Diagnostic capacity of BAP1 and MTAP in cytology from effusions and biopsy in mesothelioma. | Diagnostic capacity of BAP1 and MTAP in cytology from effusions and biopsy in mesothelioma.
Lynggård LA, Panou V, Szejniuk W, Røe OD, Meristoudis C. | 10/29/2022 |
| Deletion of MTAP Highly Sensitizes Osteosarcoma Cells to Methionine Restriction With Recombinant Methioninase. | Deletion of MTAP Highly Sensitizes Osteosarcoma Cells to Methionine Restriction With Recombinant Methioninase.
Aoki Y, Tome Y, Han Q, Yamamoto J, Hamada K, Masaki N, Kubota Y, Bouvet M, Nishida K, Hoffman RM., Free PMC Article | 05/7/2022 |
| Expression and localisation of methylthioadenosine phosphorylase (MTAP) in oral squamous cell carcinoma and their significance in epithelial-to-mesenchymal transition. | Expression and localisation of methylthioadenosine phosphorylase (MTAP) in oral squamous cell carcinoma and their significance in epithelial-to-mesenchymal transition.
Amano Y, Matsubara D, Kihara A, Nishino H, Mori Y, Niki T. | 04/23/2022 |
| Loss of Methylthioadenosine Phosphorylase by Immunohistochemistry Is Common in Pulmonary Sarcomatoid Carcinoma and Sarcomatoid Mesothelioma. | Loss of Methylthioadenosine Phosphorylase by Immunohistochemistry Is Common in Pulmonary Sarcomatoid Carcinoma and Sarcomatoid Mesothelioma.
Terra S, Roden AC, Yi ES, Aubry MC, Boland JM. | 02/5/2022 |
| MTAP Deficiency-Induced Metabolic Reprogramming Creates a Vulnerability to Cotargeting De Novo Purine Synthesis and Glycolysis in Pancreatic Cancer. | MTAP Deficiency-Induced Metabolic Reprogramming Creates a Vulnerability to Cotargeting De Novo Purine Synthesis and Glycolysis in Pancreatic Cancer.
Hu Q, Qin Y, Ji S, Shi X, Dai W, Fan G, Li S, Xu W, Liu W, Liu M, Zhang Z, Ye Z, Zhou Z, Yang J, Zhuo Q, Yu X, Li M, Xu X. | 01/8/2022 |
| Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression. | Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression.
Busacca S, Zhang Q, Sharkey A, Dawson AG, Moore DA, Waller DA, Nakas A, Jones C, Cain K, Luo JL, Salcedo A, Salaroglio IC, Riganti C, Le Quesne J, John T, Boutros PC, Zhang SD, Fennell DA., Free PMC Article | 11/27/2021 |
| Utility of methylthioadenosine phosphorylase immunohistochemical deficiency as a surrogate for CDKN2A homozygous deletion in the assessment of adult-type infiltrating astrocytoma. | Utility of methylthioadenosine phosphorylase immunohistochemical deficiency as a surrogate for CDKN2A homozygous deletion in the assessment of adult-type infiltrating astrocytoma.
Satomi K, Ohno M, Matsushita Y, Takahashi M, Miyakita Y, Narita Y, Ichimura K, Yoshida A. | 11/22/2021 |
| PRMT5 silencing selectively affects MTAP-deleted mesothelioma: In vitro evidence of a novel promising approach. | PRMT5 silencing selectively affects MTAP-deleted mesothelioma: In vitro evidence of a novel promising approach.
Barbarino M, Cesari D, Bottaro M, Luzzi L, Namagerdi A, Bertolino FM, Bellan C, Proietti F, Somma P, Micheli M, de Santi MM, Guazzo R, Mutti L, Pirtoli L, Paladini P, Indovina P, Giordano A., Free PMC Article | 09/11/2021 |
| Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine. | Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine.
Barekatain Y, Ackroyd JJ, Yan VC, Khadka S, Wang L, Chen KC, Poral AH, Tran T, Georgiou DK, Arthur K, Lin YH, Satani N, Ballato ES, Behr EI, deCarvalho AC, Verhaak RGW, de Groot J, Huse JT, Asara JM, Kalluri R, Muller FL., Free PMC Article | 07/24/2021 |
| Loss of 5'-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade Gliomas; Nevertheless, it is Not Associated with Higher Tumor Aggressiveness. | Loss of 5'-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade Gliomas; Nevertheless, it is Not Associated with Higher Tumor Aggressiveness.
Menezes WP, Silva VAO, Gomes INF, Rosa MN, Spina MLC, Carloni AC, Alves ALV, Melendez M, Almeida GC, Silva LSD, Clara C, da Cunha IW, Hajj GNM, Jones C, Bidinotto LT, Reis RM., Free PMC Article | 02/20/2021 |
| MTAP immunohistochemistry is an accurate and reproducible surrogate for CDKN2A fluorescence in situ hybridization in diagnosis of malignant pleural mesothelioma. | MTAP immunohistochemistry is an accurate and reproducible surrogate for CDKN2A fluorescence in situ hybridization in diagnosis of malignant pleural mesothelioma.
Chapel DB, Schulte JJ, Berg K, Churg A, Dacic S, Fitzpatrick C, Galateau-Salle F, Hiroshima K, Krausz T, Le Stang N, McGregor S, Nabeshima K, Husain AN. | 02/2/2021 |
| MTAP-deficiency could predict better treatment response in advanced lung adenocarcinoma patients initially treated with pemetrexed-platinum chemotherapy and bevacizumab. | MTAP-deficiency could predict better treatment response in advanced lung adenocarcinoma patients initially treated with pemetrexed-platinum chemotherapy and bevacizumab.
Jing W, Zhu H, Liu W, Zhai X, Tian H, Yu J., Free PMC Article | 12/5/2020 |
| Authors identified significant associations for rs869330 (in the methylthioadenosine phosphorylase - MTAP gene) with overall survival (hazard ratio = 0.760, P = 0.048, 95% confidence interval: 0.580-0.998) and relapse-free survival (hazard ratio = 0.800, P = 0.020, 95% confidence interval: 0.650-0.970). | Melanoma susceptibility variant rs869330 in the MTAP gene is associated with melanoma outcome.
Marasigan V, Güvenç C, van den Oord JJ, Stas M, Boecxstaens V, Bechter O, Wolter P, Lambrechts D, Garmyn M. | 07/11/2020 |
| Loss of MTAP expression is associated with stemness in Glioblastoma. | MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation.
Hansen LJ, Sun R, Yang R, Singh SX, Chen LH, Pirozzi CJ, Moure CJ, Hemphill C, Carpenter AB, Healy P, Ruger RC, Chen CJ, Greer PK, Zhao F, Spasojevic I, Grenier C, Huang Z, Murphy SK, McLendon RE, Friedman HS, Friedman AH, Herndon JE 2nd, Sampson JH, Keir ST, Bigner DD, Yan H, He Y., Free PMC Article | 04/11/2020 |
| The expression of MTAP in primary liver was positively correlated with metastatic disease in patients with liver metastatic colorectal cancer via EMT. | Characterization of methylthioadenosin phosphorylase (MTAP) expression in colorectal cancer.
Zhong Y, Lu K, Zhu S, Li W, Sun S. | 02/23/2019 |
| melanoma risk alleles correlate with an allele-specific hyper-methylation and down-regulation of gene expression | Melanoma risk alleles are associated with downregulation of the MTAP gene and hypermethylation of a CpG island upstream of the gene in dermal fibroblasts.
Sangalli A, Malerba G, Tessari G, Rodolfo M, Gomez-Lira M. | 04/28/2018 |
| The obtained data suggested a negative association between copy number variation of the MEAP genes and Atherothrombotic stroke. | The research on association of copy number variation in chromosome 9p21 region with atherothrombotic stroke in the Han Chinese population.
Liu H, Yang M, Wang X, Ji Y, Zhao J, Liu W, Zheng J. | 02/24/2018 |
| High MTAP expression is associated with prostate cancer. | The essential role of methylthioadenosine phosphorylase in prostate cancer.
Bistulfi G, Affronti HC, Foster BA, Karasik E, Gillard B, Morrison C, Mohler J, Phillips JG, Smiraglia DJ., Free PMC Article | 01/6/2018 |
| Results indicate complex rearrangements involving CDKN2A locus and frequent occurrence of fusion transcripts involving methylthioadenosine phosphorylase (MTAP) and ANRIL genes. | Mapping of deletion breakpoints at the CDKN2A locus in melanoma: detection of MTAP-ANRIL fusion transcripts.
Xie H, Rachakonda PS, Heidenreich B, Nagore E, Sucker A, Hemminki K, Schadendorf D, Kumar R., Free PMC Article | 12/2/2017 |