| Impact of Mitochondrial Genetic Variants in ND1, ND2, ND5, and ND6 Genes on Sperm Motility and Intracytoplasmic Sperm Injection (ICSI) Outcomes. | Impact of Mitochondrial Genetic Variants in ND1, ND2, ND5, and ND6 Genes on Sperm Motility and Intracytoplasmic Sperm Injection (ICSI) Outcomes.
Al Smadi MA, Hammadeh ME, Solomayer E, Batiha O, Altalib MM, Jahmani MY, Shboul MA, Nusair B, Amor H., Free PMC Article | 01/29/2022 |
| Analysis of variants in mitochondrial genome and their putative pathogenicity in tuberculosis patients from Mizoram, North east India. | Analysis of variants in mitochondrial genome and their putative pathogenicity in tuberculosis patients from Mizoram, North east India.
Vanlalhruaii Tonsing M, Vanlalbiakdiki Sailo C, Zothansanga, Chhakchhuak L, Chhakchhuak Z, Pandit B, Kumar D, Pratim Mazumder P, Senthil Kumar N. | 04/3/2021 |
| gene variants not associated with total fertilization failure | Association between sperm mitochondrial ND2 gene variants and total fertilization failure.
Zhang JL, Mao GH, Huang XH, Chang HY, Zheng Y, Cao X. | 11/10/2018 |
| The C5263T single-nucleotide mutation of the mitochondrial ND2 gene was observed in 2 young coronary heart disease (CHD) patients in the case group. The premature CHD of these 2 patients followed a pattern of maternal inheritance. | The Association between the C5263T Mutation in the Mitochondrial ND2 Gene and Coronary Heart Disease among Young Chinese Han People.
Han GX, Xia L, Li SS, Jin QH, Song Y, Shen H, Wang LL, Kong LJ, Li TS, Zhu HY. | 08/26/2017 |
| Data show no association between the mitochondrial 5178C/A polymorphism of NADH-dehydrogenase subunit 2 (ND2) gene with type-2 diabetes mellitus (T2DM), however, the polymorphism may affect the development of nephropathy and hypertension complications. | [Effect of mitochondrial DNA 5178 C/A polymorphism on risks for type 2 diabetes mellitus and its complications].
Yang X, Zhang Y, Ma Y, Zhao Q, Lyu J. | 05/28/2016 |
| Study identified cancer-specific somatic variants in the ND2 and ND3 regions, and the presence of these mutated DNAs in the serum during the postoperative period accurately predicted poor prognoses in oral squamous cell carcinomas. | Quantitative detection of circulating tumor-derived mitochondrial NADH subunit variants as a potential prognostic biomarker for oral cancer.
Uzawa K, Kasamatsu A, Baba T, Kimura Y, Nakashima D, Higo M, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H. | 05/21/2016 |
| This study did not show a correlation between ARMS2, C3, MT-NDH2, and CFH alleles in the development of choroid neovascularization associated with ocular histoplasmosis. | Investigation of choroidal neovascularization risk alleles in ocular histoplasmosis.
Wilkes MF, Miller DM, Mitchell MD, Zanke B, Petersen MR, Sisk RA, Riemann CD, Foster RE. | 09/13/2014 |
| The Mt5178 C/A genotype, which results in an amino acid polymorphism in NADH dehydrogenase subunit 2, may modify longitudinal changes in serum total cholesterol and high-density lipoprotein cholesterol levels in middle-aged Japanese men. | Influence of mitochondrial DNA 5178 C/A polymorphism on serum cholesterol changes: a short-term follow-up in middle-aged Japanese men.
Honmyo R, Kokaze A, Karita K, Yoshida M, Ishikawa M, Ohno H., Free PMC Article | 01/26/2013 |
| demethylation of the D-loop plays a key role in regulating ND2 expression during the initiation and/or progression of colorectal cancer. | Correlation between increased ND2 expression and demethylated displacement loop of mtDNA in colorectal cancer.
Feng S, Xiong L, Ji Z, Cheng W, Yang H. | 09/15/2012 |
| For Mt5178C genotypic men, alcohol consumption may reduce the risk of hyper-LDL cholesterolemia | Joint effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on risk of hyper-LDL cholesterolemia in middle-aged Japanese men.
Kawamoto T, Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, Shimada N, Ohtsu T, Shirasawa T, Ochiai H, Ito T, Hoshino H, Takashima Y., Free PMC Article | 11/26/2011 |
| modifies the effects of coffee consumption on blood pressure or the risk of hypertension | NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modulates the effects of coffee consumption on the risk of hypertension in middle-aged Japanese men.
Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, Ohtsu T, Shirasawa T, Sekii H, Ito T, Kawamoto T, Takashima Y., Free PMC Article | 01/21/2010 |
| mitochondrial MTND2 polymorphism may increase susceptibility to nucleoside reverse transcriptase inhibitors associated peripheral neuropathy | The mitochondrial pharmacogenomics of haplogroup T: MTND2*LHON4917G and antiretroviral therapy-associated peripheral neuropathy.
Canter JA, Haas DW, Kallianpur AR, Ritchie MD, Robbins GK, Shafer RW, Clifford DB, Murdock DG, Hulgan T, Canter JA, Haas DW, Kallianpur AR, Ritchie MD, Robbins GK, Shafer RW, Clifford DB, Murdock DG, Hulgan T. | 01/21/2010 |
| Observational study of genotype prevalence. (HuGE Navigator) | Tracking of the genetic deafness associated to the aging in Brazilian patients.
Piatto VB, Pereira MC, da Silva MA, Maniglia JV. | 03/13/2008 |
| Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | The mitochondrial pharmacogenomics of haplogroup T: MTND2*LHON4917G and antiretroviral therapy-associated peripheral neuropathy.
Canter JA, Haas DW, Kallianpur AR, Ritchie MD, Robbins GK, Shafer RW, Clifford DB, Murdock DG, Hulgan T, Canter JA, Haas DW, Kallianpur AR, Ritchie MD, Robbins GK, Shafer RW, Clifford DB, Murdock DG, Hulgan T. | 03/13/2008 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Complex I polymorphisms, bigenomic heterogeneity, and family history in Virginians with Parkinson's disease.
Swerdlow RH, Weaver B, Grawey A, Wenger C, Freed E, Worrall BB., Free PMC Article | 03/13/2008 |
| Observational study of genetic testing. (HuGE Navigator) | Genotyping Parkinson disease-associated mitochondrial polymorphisms.
Jiang Y, Ellis T, Greenlee AR., Free PMC Article | 03/13/2008 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | See all PubMed (6) articlesMitochondrial DNA variant A4917G, smoking and spontaneous preterm birth.
Velez DR, Menon R, Simhan H, Fortunato S, Canter JA, Williams SM. Longevity-associated mitochondrial DNA 5178 C/A polymorphism and its interaction with cigarette consumption are associated with pulmonary function in middle-aged Japanese men.
Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Satoh M, Teruya K, Honmyo R, Shirasawa T, Hoshino H, Takashima Y. NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies the effects of alcohol consumption on risk for hypertension in middle-aged Japanese men.
Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Satoh M, Teruya K, Masuda Y, Honmyo R, Uchida Y, Takashima Y, Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Satoh M, Teruya K, Masuda Y, Honmyo R, Uchida Y, Takashima Y. Associations of MTHFR DNMT3b 4977 bp deletion in mtDNA and GSTM1 deletion, and aberrant CpG island hypermethylation of GSTM1 in non-obstructive infertility in Indian men.
Dhillon VS, Shahid M, Husain SA. Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism influences the effects of alcohol consumption on serum uric acid levels in nonobese Japanese men.
Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Satoh M, Teruya K, Honmyo R, Yorimitsu M, Masuda Y, Uchida Y, Takashima Y. Longevity-associated mitochondrial DNA 5178 A/C polymorphism is associated with intraocular pressure in Japanese men.
Kokaze A, Yoshida M, Ishikawa M, Matsunaga N, Makita R, Satoh M, Sekiguchi K, Masuda Y, Uchida Y, Takashima Y. | 03/13/2008 |
| Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Possible relationship between mitochondrial DNA polymorphisms and lithium response in bipolar disorder.
Washizuka S, Ikeda A, Kato N, Kato T. | 03/13/2008 |
| Observational study of gene-environment interaction. (HuGE Navigator) | See all PubMed (2) articlesInteraction between longevity-associated mitochondrial DNA 5178 C/A polymorphism and cigarette smoking on hematological parameters in Japanese men.
Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Makita R, Satoh M, Teruya K, Sekiguchi K, Masuda Y, Harada M, Uchida Y, Takashima Y. Longevity-associated mitochondrial DNA 5178 A/C polymorphism influences effects of cigarette smoking on serum protein fraction levels in Japanese men.
Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Sekine Y, Sekiguchi K, Satoh M, Harada M, Teruya K, Takeda N, Uchida Y, Takashima Y. | 03/13/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (26) articlesMtSNPscore: a combined evidence approach for assessing cumulative impact of mitochondrial variations in disease.
Bhardwaj A, Mukerji M, Sharma S, Paul J, Gokhale CS, Srivastava AK, Tiwari S. Mitochondrial polymorphisms are associated both with increased and decreased longevity.
Castri L, Melendez-Obando M, Villegas-Palma R, Barrantes R, Raventos H, Pereira R, Luiselli D, Pettener D, Madrigal L. Comprehensive analysis of common mitochondrial DNA variants and colorectal cancer risk.
Webb E, Broderick P, Chandler I, Lubbe S, Penegar S, Tomlinson IP, Houlston RS. Mitochondrial DNA injury and mortality in hemodialysis patients.
Rao M, Li L, Demello C, Guo D, Jaber BL, Pereira BJ, Balakrishnan VS, HEMO Study Group. Novel mutations of mitochondrial DNA associated with type 2 diabetes in Chinese Han population.
Liao WQ, Pang Y, Yu CA, Wen JY, Zhang YG, Li XH. Mitochondrial DNA haplogroup analysis in patients with bipolar disorder.
Kazuno AA, Munakata K, Mori K, Nanko S, Kunugi H, Nakamura K, Mori N, Yamada K, Yoshikawa T, Kato N, Kato T. Quantitative analysis of the 4977-bp common deletion of mitochondrial DNA in postmortem frontal cortex from patients with bipolar disorder and schizophrenia.
Fuke S, Kametani M, Kato T. Mitochondrial DNA polymorphism A4917G is independently associated with age-related macular degeneration.
Canter JA, Olson LM, Spencer K, Schnetz-Boutaud N, Anderson B, Hauser MA, Schmidt S, Postel EA, Agarwal A, Pericak-Vance MA, Sternberg P Jr, Haines JL. Prevalence of 4977bp deletion in mitochondrial DNA from patients with chronic kidney disease receiving conservative treatment or hemodialysis in southern Brazil.
Rossato LB, Nunes AC, Pereira ML, de Souza CF, Dummer C, Milani V, Porsch DB, de Mattos CB, Barros EJ. Specific polymorphic variation in the mitochondrial genome and increased in-hospital mortality after severe trauma.
Canter JA, Norris PR, Moore JH, Jenkins JM, Morris JA. Quantitative analysis of mitochondrial DNA 4977-bp deletion in sporadic breast cancer and benign breast diseases.
Ye C, Shu XO, Wen W, Pierce L, Courtney R, Gao YT, Zheng W, Cai Q. Mitochondrial DNA 4977 BP deletion mutations in lung carcinoma.
Dai JG, Xiao YB, Min JX, Zhang GQ, Yao K, Zhou RJ. ALDH2 polymorphisms and bone mineral density in an elderly Japanese population.
Yamaguchi J, Hasegawa Y, Kawasaki M, Masui T, Kanoh T, Ishiguro N, Hamajima N. Longevity-associated mitochondrial DNA 5178 C/A polymorphism is associated with fasting plasma glucose levels and glucose tolerance in Japanese men.
Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Makita R, Satoh M, Teruya K, Sekiguchi K, Masuda Y, Harada M, Uchida Y, Takashima Y. The association of mitochondrial DNA 5178 C > a polymorphism with plasma lipid levels among three ethnic groups.
Lal S, Madhavan M, Heng CK. Mitochondrial DNA polymorphisms and risk of Parkinson's disease in Spanish population.
Huerta C, Castro MG, Coto E, Blázquez M, Ribacoba R, Guisasola LM, Salvador C, Martínez C, Lahoz CH, Alvarez V. Longevity-associated NADH dehydrogenase subunit-2 polymorphism and serum electrolyte levels in middle-aged obese Japanese men.
Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Makita R, Satoh M, Teruya K, Sekiguchi K, Masuda Y, Harada M, Uchida Y, Takashima Y. Detection of mtDNA with 4977 bp deletion in blood cells and atherosclerotic lesions of patients with coronary artery disease.
Botto N, Berti S, Manfredi S, Al-Jabri A, Federici C, Clerico A, Ciofini E, Biagini A, Andreassi MG. Association of a 5178C-->A (Leu237Met) polymorphism in the mitochondrial DNA with a low prevalence of myocardial infarction in Japanese individuals.
Takagi K, Yamada Y, Gong JS, Sone T, Yokota M, Tanaka M. Mitochondrial DNA polymorphisms and extraversion.
Kato C, Umekage T, Tochigi M, Otowa T, Hibino H, Ohtani T, Kohda K, Kato N, Sasaki T. Longevity-associated mitochondrial DNA 5178 A/C polymorphism and blood pressure in the Japanese population.
Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Sekine Y, Sekiguchi K, Harada M, Satoh M, Teruya K, Takeda N, Fukazawa S, Uchida Y, Takashima Y. Mitochondrial 5178A/C genotype is associated with acute myocardial infarction.
Mukae S, Aoki S, Itoh S, Sato R, Nishio K, Iwata T, Katagiri T. Association of the longevity-associated mitochondrial DNA 5178 A/C polymorphism with serum protein fraction levels in healthy Japanese women.
Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Sekine Y, Teruya K, Takeda N, Satoh M, Sumiya Y, Uchida Y, Takashima Y. Cerebrovascular disorders and genetic polymorphisms: mitochondrial DNA5178C is predominant in cerebrovascular disorders.
Ohkubo R, Nakagawa M, Ikeda K, Kodama T, Arimura K, Akiba S, Saito M, Ookatsu Y, Atsuchi Y, Yamano Y, Osame M. Association of the mitochondrial DNA 5178 A/C polymorphism with serum lipid levels in the Japanese population.
Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Sekine Y, Teruya K, Takeda N, Sumiya Y, Uchida Y, Takashima Y. Association of the mitochondrial DNA 5178A/C polymorphism with maternal inheritance and onset of type 2 diabetes in Japanese patients.
Wang D, Taniyama M, Suzuki Y, Katagiri T, Ban Y. | 03/13/2008 |
| Mutation T4681C disturbs the mitochondrial electron transport complex I assembly pathway and leads to Leigh syndrome. | Mutated ND2 impairs mitochondrial complex I assembly and leads to Leigh syndrome.
Ugalde C, Hinttala R, Timal S, Smeets R, Rodenburg RJ, Uusimaa J, van Heuvel LP, Nijtmans LG, Majamaa K, Smeitink JA. | 01/21/2010 |
| Novel mitochondrial DNA mutations in Parkinson's disease. we report novel homoplasmic base changes. We were unable to detect heteroplasmic base changes. | Novel mitochondrial DNA mutations in Parkinson's disease.
Richter G, Sonnenschein A, Grünewald T, Reichmann H, Janetzky B. | 01/21/2010 |
| results suggest that ND2-237 Leu/Met polymorphism is associated with hypertension and that modification of hypertension risk is dependent on alcohol consumption in middle-aged Japanese men | NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies the effects of alcohol consumption on risk for hypertension in middle-aged Japanese men.
Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Satoh M, Teruya K, Masuda Y, Honmyo R, Uchida Y, Takashima Y, Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Satoh M, Teruya K, Masuda Y, Honmyo R, Uchida Y, Takashima Y. | 01/21/2010 |