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    MUC3A mucin 3A, cell surface associated [ Homo sapiens (human) ]

    Gene ID: 4584, updated on 5-Mar-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy.

    Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy.
    Sotoudeh M, Mansouri V, Shakeri R, Sharififard B, Sajadi N, Haghpanah V, Naderi M.

    01/3/2024
    MUC3A promotes the progression of colorectal cancer through the PI3K/Akt/mTOR pathway.

    MUC3A promotes the progression of colorectal cancer through the PI3K/Akt/mTOR pathway.
    Su W, Feng B, Hu L, Guo X, Yu M., Free PMC Article

    06/11/2022
    MUC3A induces PD-L1 and reduces tyrosine kinase inhibitors effects in EGFR-mutant non-small cell lung cancer.

    MUC3A induces PD-L1 and reduces tyrosine kinase inhibitors effects in EGFR-mutant non-small cell lung cancer.
    Luo Y, Ma S, Sun Y, Peng S, Zeng Z, Han L, Li S, Sun W, Xu J, Tian X, Wang F, Wu Q, Xiao Y, Zhang J, Gong Y, Xie C., Free PMC Article

    04/2/2022
    MUC3A promotes non-small cell lung cancer progression via activating the NFkappaB pathway and attenuates radiosensitivity.

    MUC3A promotes non-small cell lung cancer progression via activating the NFκB pathway and attenuates radiosensitivity.
    Sun Y, Sun X, You C, Ma S, Luo Y, Peng S, Tang F, Tian X, Wang F, Huang Z, Yu H, Xiao Y, Wang X, Zhang J, Gong Y, Xie C., Free PMC Article

    03/19/2022
    KIAA1429 promotes the progression of lung adenocarcinoma by regulating the m6A level of MUC3A.

    KIAA1429 promotes the progression of lung adenocarcinoma by regulating the m6A level of MUC3A.
    Zhao W, Xie Y.

    10/16/2021
    inspection showed that MSLN (Mesothelin), ANTXR1 (TEM8), and MUC3A are the probable targets of CAR T cell therapy in gastric adenocarcinoma.

    MSLN (Mesothelin), ANTXR1 (TEM8), and MUC3A are the potent antigenic targets for CAR T cell therapy of gastric adenocarcinoma.
    Sotoudeh M, Shirvani SI, Merat S, Ahmadbeigi N, Naderi M.

    06/20/2020
    MUC3A may have a role in poor prognosis in localized clear-cell renal cell carcinoma

    Increased expression of MUC3A is associated with poor prognosis in localized clear-cell renal cell carcinoma.
    Niu T, Liu Y, Zhang Y, Fu Q, Liu Z, Wang Z, Fu H, Xu J, Liu K., Free PMC Article

    02/24/2018
    DNA hypomethylation in the 5'-flanking region of the MUC3A gene plays an important role in MUC3A expression in carcinomas of various organs.

    Promoter hypomethylation contributes to the expression of MUC3A in cancer cells.
    Kitamoto S, Yamada N, Yokoyama S, Houjou I, Higashi M, Yonezawa S.

    08/16/2010
    Data show that special stains for mucin did not distinguish pseudocysts from neoplastic mucinous cysts.

    Pseudocyst of the pancreas: the role of cytology and special stains for mucin.
    Gonzalez Obeso E, Murphy E, Brugge W, Deshpande V.

    01/21/2010
    Data show that the diagnostic sensitivity for mucin was 60%, and the specificity for mucin was 100%.

    A technique to improve diagnostic information from fine-needle aspirations: immunohistochemistry on cytoscrape.
    Skov BG, Kiss K, Ramsted J, Linnemann D.

    01/21/2010
    We report the colonic adhesion mechanism of Lactobaillus plantarums LA318 is in part due to GAPDH binding to human ABO-type blood group antigens expressed on human colonic mucin (HCM). [HCM]

    Cell surface glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of Lactobacillus plantarum LA 318 recognizes human A and B blood group antigens.
    Kinoshita H, Wakahara N, Watanabe M, Kawasaki T, Matsuo H, Kawai Y, Kitazawa H, Ohnuma S, Miura K, Horii A, Saito T.

    01/21/2010
    These mucin genes were up-regulated after exposure to low pH in vitro (p < 0.005). Pepsin inhibited this up-regulation (p <0.001). Reflux laryngitis is associated with down-regulation of mucin gene expression.

    Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.
    Samuels TL, Handler E, Syring ML, Pajewski NM, Blumin JH, Kerschner JE, Johnston N.

    01/21/2010
    up-regulated MUC expression by synovial tissue cells and suggest a novel role of MUC3 and MUC5AC in the pathogenesis of arthritis

    Expression of mucin 3 and mucin 5AC in arthritic synovial tissue.
    Volin MV, Shahrara S, Haines GK 3rd, Woods JM, Koch AE.

    01/21/2010
    MUC3 is overexpressed in renal clear cell carcinoma, and the MUC3 expression ratio is greater in nuclear grade 3 than in grades 1 and 2 (low grades) tumor. These findings suggest the implication of MUC3 in renal carcinogenesis.

    Quantitative RT-PCR assay for MUC3 and VEGF mRNA in renal clear cell carcinoma: relationship with nuclear grade and prognosis.
    Leroy X, Gouyer V, Ballereau C, Zerimech F, Huet G, Copin MC, Aubert JP, Porchet N.

    01/21/2010
    has highly conserved amino and carboxyl termini, suggesting a recent duplication of the entire ancestral gene

    Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus.
    Gum JR Jr, Hicks JW, Crawley SC, Dahl CM, Yang SC, Roberton AM, Kim YS.

    01/21/2010
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