| Gain-of-function MYCN causes a megalencephaly-polydactyly syndrome manifesting mirror phenotypes of Feingold syndrome. | Gain-of-function MYCN causes a megalencephaly-polydactyly syndrome manifesting mirror phenotypes of Feingold syndrome.
Nishio Y, Kato K, Tran Mau-Them F, Futagawa H, Quélin C, Masuda S, Vitobello A, Otsuji S, Shawki HH, Oishi H, Thauvin-Robinet C, Takenouchi T, Kosaki K, Takahashi Y, Saitoh S., Free PMC Article | 05/20/2024 |
| Ependymomas of the spinal region in adults: Clinical and pathological features and MYCN expression levels in spinal ependymomas and myxopapillary ependymomas. | Ependymomas of the spinal region in adults: Clinical and pathological features and MYCN expression levels in spinal ependymomas and myxopapillary ependymomas.
Topel G, Dirilenoğlu F, Sevin İE, Kahraman A. | 04/29/2024 |
| Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus. | Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus.
Streeter SA, Williams AG, Evans JR, Wang J, Guarnaccia AD, Florian AC, Al-Tobasei R, Liu Q, Tansey WP, Weissmiller AM., Free PMC Article | 04/29/2024 |
| CKLF instigates a "cold" microenvironment to promote MYCN-mediated tumor aggressiveness. | CKLF instigates a "cold" microenvironment to promote MYCN-mediated tumor aggressiveness.
Qin X, Lam A, Zhang X, Sengupta S, Iorgulescu JB, Ni H, Das S, Rager M, Zhou Z, Zuo T, Meara GK, Floru AE, Kemet C, Veerapaneni D, Kashy D, Lin L, Lloyd K, Kwok L, Smith KS, Nagaraju RT, Meijers R, Ceol C, Liu CT, Alexandrescu S, Wu CJ, Keskin DB, George RE, Feng H., Free PMC Article | 03/20/2024 |
| MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma. | MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma.
Guan J, Li M, Wang Y, Zhang Y, Que Y, Lu S, Wang J, Zhu J, Huang J, Zhen Z, Sun F, Song M, Zhang Y., Free PMC Article | 02/27/2024 |
| MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression. | MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression.
Salib A, Jayatilleke N, Seneviratne JA, Mayoh C, De Preter K, Speleman F, Cheung BB, Carter DR, Marshall GM., Free PMC Article | 01/31/2024 |
| Computational completion of the Aurora interaction region of N-Myc in the Aurora a kinase complex. | Computational completion of the Aurora interaction region of N-Myc in the Aurora a kinase complex.
Altiner P, Çınaroğlu SS, Timucin AC, Timucin E., Free PMC Article | 11/15/2023 |
| Prediction of MYCN Gene Amplification in Pediatric Neuroblastomas: Development of a Deep Learning-Based Tool for Automatic Tumor Segmentation and Comparative Analysis of Computed Tomography-Based Radiomics Features Harmonization. | Prediction of MYCN Gene Amplification in Pediatric Neuroblastomas: Development of a Deep Learning-Based Tool for Automatic Tumor Segmentation and Comparative Analysis of Computed Tomography-Based Radiomics Features Harmonization.
Yeow LY, Teh YX, Lu X, Srinivasa AC, Tan E, Tan TSE, Tang PH, Kn BP. | 11/6/2023 |
| MYCN amplification, TERT rearrangements and ATRX mutations in neuroblastoma: clinicopathological correlates- an Indian perspective. | MYCN amplification, TERT rearrangements and ATRX mutations in neuroblastoma: clinicopathological correlates- an Indian perspective.
Kerkar AN, Chinnam D, Verma A, Peters NJ, Kakkar N, Trehan A, Singh M, Gupta K. | 11/1/2023 |
| LncRNA AC142119.1 facilitates the progression of neuroblastoma by epigenetically initiating the transcription of MYCN. | LncRNA AC142119.1 facilitates the progression of neuroblastoma by epigenetically initiating the transcription of MYCN.
Yang R, Liu N, Li T, Liu F, Zhang J, Zhao H, Zou L, He X., Free PMC Article | 10/25/2023 |
| USP7 Inhibition Suppresses Neuroblastoma Growth via Induction of p53-Mediated Apoptosis and EZH2 and N-Myc Downregulation. | USP7 Inhibition Suppresses Neuroblastoma Growth via Induction of p53-Mediated Apoptosis and EZH2 and N-Myc Downregulation.
Le Clorennec C, Lee K, Huo Y, Zage PE., Free PMC Article | 09/30/2023 |
| A novel MYCN-YTHDF1 cascade contributes to retinoblastoma tumor growth by eliciting m[6]A -dependent activation of multiple oncogenes. | A novel MYCN-YTHDF1 cascade contributes to retinoblastoma tumor growth by eliciting m(6)A -dependent activation of multiple oncogenes.
Luo Y, He M, Yang J, Zhang F, Chen J, Wen X, Fan J, Fan X, Chai P, Jia R. | 09/14/2023 |
| MYCN amplification and International Neuroblastoma Risk Group stratification on fine-needle aspiration biopsy and their correlation to survival in neuroblastoma. | MYCN amplification and International Neuroblastoma Risk Group stratification on fine-needle aspiration biopsy and their correlation to survival in neuroblastoma.
Bhardwaj N, Rohilla M, Trehan A, Bansal D, Kakkar N, Srinivasan R. | 08/22/2023 |
| LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma. | LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma.
Alborzinia H, Chen Z, Yildiz U, Freitas FP, Vogel FCE, Varga JP, Batani J, Bartenhagen C, Schmitz W, Büchel G, Michalke B, Zheng J, Meierjohann S, Girardi E, Espinet E, Flórez AF, Dos Santos AF, Aroua N, Cheytan T, Haenlin J, Schlicker L, Xavier da Silva TN, Przybylla A, Zeisberger P, Superti-Furga G, Eilers M, Conrad M, Fabiano M, Schweizer U, Fischer M, Schulze A, Trumpp A, Friedmann Angeli JP., Free PMC Article | 08/9/2023 |
| The deubiquitinase USP28 maintains the expression of the transcription factor MYCN and is essential in neuroblastoma cells. | The deubiquitinase USP28 maintains the expression of the transcription factor MYCN and is essential in neuroblastoma cells.
Li J, Peng J, Wu L, Shen X, Zhen X, Zhang Y, Ma H, Xu Y, Xiong Q, Zhu Q, Zhang P., Free PMC Article | 08/1/2023 |
| Impaired Antitumor Immune Response in MYCN-amplified Neuroblastoma Is Associated with Lack of CCL2 Secretion and Poor Dendritic Cell Recruitment. | Impaired Antitumor Immune Response in MYCN-amplified Neuroblastoma Is Associated with Lack of CCL2 Secretion and Poor Dendritic Cell Recruitment.
Kacher J, Manches O, Aspord C, Sartelet H, Chaperot L., Free PMC Article | 07/31/2023 |
| CCNB1IP1 prevents ubiquitination-mediated destabilization of MYCN and potentiates tumourigenesis of MYCN-amplificated neuroblastoma. | CCNB1IP1 prevents ubiquitination-mediated destabilization of MYCN and potentiates tumourigenesis of MYCN-amplificated neuroblastoma.
Zhou Y, Yan H, Zhou Q, Wang P, Yang F, Yuan Z, Du Q, Zhai B., Free PMC Article | 07/25/2023 |
| Neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene or MYCN gene. | Neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene or MYCN gene.
Bhardwaj N, Das G, Srinivasan R. | 07/23/2023 |
| Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN. | Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.
Fuchs S, Danßmann C, Klironomos F, Winkler A, Fallmann J, Kruetzfeldt LM, Szymansky A, Naderi J, Bernhart SH, Grunewald L, Helmsauer K, Rodriguez-Fos E, Kirchner M, Mertins P, Astrahantseff K, Suenkel C, Toedling J, Meggetto F, Remke M, Stadler PF, Hundsdoerfer P, Deubzer HE, Künkele A, Lang P, Fuchs J, Henssen AG, Eggert A, Rajewsky N, Hertwig F, Schulte JH., Free PMC Article | 07/7/2023 |
| MYCN Amplification Is Associated with Reduced Expression of Genes Encoding gamma-Secretase Complex and NOTCH Signaling Components in Neuroblastoma. | MYCN Amplification Is Associated with Reduced Expression of Genes Encoding γ-Secretase Complex and NOTCH Signaling Components in Neuroblastoma.
Agarwal P, Glowacka A, Mahmoud L, Bazzar W, Larsson LG, Alzrigat M., Free PMC Article | 06/7/2023 |
| IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression. | IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression.
Hagemann S, Misiak D, Bell JL, Fuchs T, Lederer MI, Bley N, Hämmerle M, Ghazy E, Sippl W, Schulte JH, Hüttelmaier S., Free PMC Article | 05/30/2023 |
| Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine differentiation of castration-resistant prostate cancer. | Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine differentiation of castration-resistant prostate cancer.
Chen WY, Thuy Dung PV, Yeh HL, Chen WH, Jiang KC, Li HR, Chen ZQ, Hsiao M, Huang J, Wen YC, Liu YN., Free PMC Article | 05/28/2023 |
| Genomic profiles of IDH-mutant gliomas: MYCN-amplified IDH-mutant astrocytoma had the worst prognosis. | Genomic profiles of IDH-mutant gliomas: MYCN-amplified IDH-mutant astrocytoma had the worst prognosis.
Lee K, Kim SI, Kim EE, Shim YM, Won JK, Park CK, Choi SH, Yun H, Lee H, Park SH., Free PMC Article | 05/24/2023 |
| HAND2 Assists MYCN Enhancer Invasion to Regulate a Noradrenergic Neuroblastoma Phenotype. | HAND2 Assists MYCN Enhancer Invasion to Regulate a Noradrenergic Neuroblastoma Phenotype.
Xu M, Sun M, Zhang X, Nguyen R, Lei H, Shern JF, Thiele CJ, Liu Z., Free PMC Article | 03/24/2023 |
| Targeting ARHGEF12 promotes neuroblastoma differentiation, MYCN degradation, and reduces tumorigenicity. | Targeting ARHGEF12 promotes neuroblastoma differentiation, MYCN degradation, and reduces tumorigenicity.
Yang Y, Wang S, Cai J, Liang J, Zhang Y, Xie Y, Luo F, Tang J, Gao Y, Shen S, Feng H, Li Y. | 02/28/2023 |