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    MYH10 myosin heavy chain 10 [ Homo sapiens (human) ]

    Gene ID: 4628, updated on 5-Sep-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.

    The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.
    Ke W, Wang B, Hua W, Song Y, Lu S, Luo R, Li G, Wang K, Liao Z, Xiang Q, Li S, Wu X, Zhang Y, Yang C., Free PMC Article

    Network-based analysis reveals novel gene signatures in the peripheral blood of patients with sporadic nonsyndromic thoracic aortic aneurysm.

    Network-based analysis reveals novel gene signatures in the peripheral blood of patients with sporadic nonsyndromic thoracic aortic aneurysm.
    Xu H, Chen S, Zhang H, Zou Y, Zhao J, Yu J, Le S, Cui J, Jiang L, Wu J, Xia J.

    survivin binds to non-muscle myosin II (NMII), regulating its filament assembly.

    A direct interaction between survivin and myosin II is required for cytokinesis.
    Babkoff A, Cohen-Kfir E, Aharon H, Ronen D, Rosenberg M, Wiener R, Ravid S.

    Non-muscle myosin IIA (NMIIA) provides the mechanical tugging force necessary for cell-cell junction reinforcement and maintenance. Non-muscle myosin IIB (NMIIB) is involved in E-cadherin clustering, maintenance of a branched actin layer connecting E-cadherin complexes and perijunctional actin fibers in the biogenesis and integrity of adherens junctions.

    Myosin II isoforms play distinct roles in <i>adherens</i> junction biogenesis.
    Heuzé ML, Sankara Narayana GHN, D'Alessandro J, Cellerin V, Dang T, Williams DS, Van Hest JC, Marcq P, Mège RM, Ladoux B., Free PMC Article

    Nonmuscle myosin II is an actin-based motor that executes numerous mechanical tasks in cells including spatiotemporal organization of the actin cytoskeleton, adhesion, migration, cytokinesis, tissue remodeling, and membrane trafficking. It is ubiquitously expressed in mammalian cells as a tissue-specific combination of three paralogs. (Review)

    Mammalian nonmuscle myosin II comes in three flavors.
    Shutova MS, Svitkina TM., Free PMC Article

    In human glioma cell lines, silencing the MYH10 gene reduced cell migration and invasion, by inhibiting the Wnt/beta-catenin pathway, which may regulate the ECM and inhibit EMT in human glioma.

    Myosin Heavy Chain 10 (MYH10) Gene Silencing Reduces Cell Migration and Invasion in the Glioma Cell Lines U251, T98G, and SHG44 by Inhibiting the Wnt/β-Catenin Pathway.
    Wang Y, Yang Q, Cheng Y, Gao M, Kuang L, Wang C., Free PMC Article

    Myosin IIA and IIB are essential for the formation of transverse arcs and ventral stress fibers, respectively. Furthermore, the study illustrated the roles of both isoforms in lamellar flattening and also raised the possibility that actin filaments in ventral stress fibers are in a stretched conformation.

    Different contributions of nonmuscle myosin IIA and IIB to the organization of stress fiber subtypes in fibroblasts.
    Kuragano M, Uyeda TQP, Kamijo K, Murakami Y, Takahashi M., Free PMC Article

    These distinct functions of NMIIA and NMIIB might promote intrinsic and directed migration of normal human fibroblasts.

    Nonmuscle myosin IIA and IIB differentially contribute to intrinsic and directed migration of human embryonic lung fibroblasts.
    Kuragano M, Murakami Y, Takahashi M.

    cellular quiescence induces Mec17 to couple the production of acetylated microtubules and Myh10, whose accumulation overcomes the inhibitory role of Myh9 and initiates ciliogenesis

    A Mec17-Myosin II Effector Axis Coordinates Microtubule Acetylation and Actin Dynamics to Control Primary Cilium Biogenesis.
    Rao Y, Hao R, Wang B, Yao TP., Free PMC Article

    We identify three mosaic missense and likely-gene disrupting mutations in genes previously implicated in ASD (KMT2C, NCKAP1, and MYH10) in probands but none in siblings. We find a strong ascertainment bias for mosaic mutations in probands relative to their unaffected siblings

    The Contribution of Mosaic Variants to Autism Spectrum Disorder.
    Freed D, Pevsner J., Free PMC Article

    A receptor type-protein tyrosine phosphatase alpha-Src family kinase-Rap1 pathway was identified as responsible for recruiting myosin IIB to the zonula adherens in epithelial cells and supporting contractile tension.

    An RPTPα/Src family kinase/Rap1 signaling module recruits myosin IIB to support contractile tension at apical E-cadherin junctions.
    Gomez GA, McLachlan RW, Wu SK, Caldwell BJ, Moussa E, Verma S, Bastiani M, Priya R, Parton RG, Gaus K, Sap J, Yap AS., Free PMC Article

    myosin IIA and IIB heavy chains play distinct and non-redundant roles in matrix remodeling

    Non-Muscle Myosin II Isoforms Have Different Functions in Matrix Rearrangement by MDA-MB-231 Cells.
    Hindman B, Goeckeler Z, Sierros K, Wysolmerski R., Free PMC Article

    Data show that myosin II supports a stable Rho zone at the at E-cadherin junctions.

    Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions.
    Priya R, Gomez GA, Budnar S, Verma S, Cox HL, Hamilton NA, Yap AS.

    Myosin isoforms impact single-fiber force generation and may lead to alterations in whole skeletal muscle performance.

    Molecular determinants of force production in human skeletal muscle fibers: effects of myosin isoform expression and cross-sectional area.
    Miller MS, Bedrin NG, Ades PA, Palmer BM, Toth MJ., Free PMC Article

    Our results indicate that MYH10 contributes to ciliogenesis in RPE1 cells by promoting cortical actin-dependent centriole migration.

    Myosin heavy chain 10 (MYH10) is required for centriole migration during the biogenesis of primary cilia.
    Hong H, Kim J, Kim J.

    The role of nonmuscle myosin II (NMII)-B in front-back migratory cell polarity is controlled by a short stretch of amino acids containing five serines.

    A regulatory motif in nonmuscle myosin II-B regulates its role in migratory front-back polarity.
    Juanes-Garcia A, Chapman JR, Aguilar-Cuenca R, Delgado-Arevalo C, Hodges J, Whitmore LA, Shabanowitz J, Hunt DF, Horwitz AR, Vicente-Manzanares M., Free PMC Article

    The findings suggest that elevated NMHCIIb levels contribute to meningioma tumor formation and progression.

    miR-200a-mediated suppression of non-muscle heavy chain IIb inhibits meningioma cell migration and tumor growth in vivo.
    Senol O, Schaaij-Visser TB, Erkan EP, Dorfer C, Lewandrowski G, Pham TV, Piersma SR, Peerdeman SM, Ströbel T, Tannous B, Saydam N, Slavc I, Knosp E, Jimenez CR, Saydam O.

    Supervillin concentrates activated and total myosin II at the furrow, and simultaneous knockdown of supervillin and anillin additively increases cell division failure.

    Supervillin binding to myosin II and synergism with anillin are required for cytokinesis.
    Smith TC, Fridy PC, Li Y, Basil S, Arjun S, Friesen RM, Leszyk J, Chait BT, Rout MP, Luna EJ., Free PMC Article

    The data show that although NM IIA and IIB form filaments with similar properties, NM IIC forms filaments that are less well suited to roles such as tension maintenance within the cell.

    Characterization of three full-length human nonmuscle myosin II paralogs.
    Billington N, Wang A, Mao J, Adelstein RS, Sellers JR., Free PMC Article

    The myosin-IIB is unpolarized in cells on soft matrix in 2D and also within soft 3D collagen, with rearward polarization of MIIB emerging only as cells migrate from soft to stiff matrix.

    Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain.
    Raab M, Swift J, Dingal PC, Shah P, Shin JW, Discher DE., Free PMC Article

    MYH10 detection is associated with inherited platelet disorders and myeloid neoplasms with abnormalities in RUNX1 and FLI1.

    MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations.
    Antony-Debré I, Bluteau D, Itzykson R, Baccini V, Renneville A, Boehlen F, Morabito M, Droin N, Deswarte C, Chang Y, Leverger G, Solary E, Vainchenker W, Favier R, Raslova H.

    Increased NMM (nonmuscle myosin II) IIA, NMM IIB and AT expression in keloid fibroblasts compared with scant staining in normal surrounding dermis, is reported.

    Angiotensin-II mediates nonmuscle myosin II activation and expression and contributes to human keloid disease progression.
    Bond JE, Bergeron A, Thurlow P, Selim MA, Bowers EV, Kuang A, Levinson H., Free PMC Article

    Data show that inhibition of non-muscle myosin II ATPase by blebbistatin completely blocks enucleation of human erythroblasts; results suggest that NMMHC-IIB is synthesized in erythroblasts and is required for erythroblast enucleation.

    Enucleation of human erythroblasts involves non-muscle myosin IIB.
    Ubukawa K, Guo YM, Takahashi M, Hirokawa M, Michishita Y, Nara M, Tagawa H, Takahashi N, Komatsuda A, Nunomura W, Takakuwa Y, Sawada K., Free PMC Article

    In the context of inflammation, myeloid cells may limit axonal repair in the central nervous system via a myosin II-dependent mechanism.

    Myeloid lineage cells inhibit neurite outgrowth through a myosin II-dependent mechanism.
    Pool M, Rambaldi I, Durafourt BA, Wright MC, Antel JP, Bar-Or A, Fournier AE.

    Results suggest that IIA and IIB can form hetero-filaments in an isoform-independent manner, and that a factor like Mts1 can remove one isoform from the hetero-filament, resulting in a formation of homo-filaments consisting of another isoform.

    Dynamic assembly properties of nonmuscle myosin II isoforms revealed by combination of fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy.
    Mitsuhashi M, Sakata H, Kinjo M, Yazawa M, Takahashi M.

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