| MYO10 regulates genome stability and cancer inflammation through mediating mitosis. | MYO10 regulates genome stability and cancer inflammation through mediating mitosis.
Mayca Pozo F, Geng X, Miyagi M, Amin AL, Huang AY, Zhang Y., Free PMC Article | 06/7/2023 |
| MYO10 contributes to the malignant phenotypes of colorectal cancer via RACK1 by activating integrin/Src/FAK signaling. | MYO10 contributes to the malignant phenotypes of colorectal cancer via RACK1 by activating integrin/Src/FAK signaling.
Ou H, Wang L, Xi Z, Shen H, Jiang Y, Zhou F, Liu Y, Zhou Y., Free PMC Article | 11/12/2022 |
| MYO10-filopodia support basement membranes at pre-invasive tumor boundaries. | MYO10-filopodia support basement membranes at pre-invasive tumor boundaries.
Peuhu E, Jacquemet G, Scheele CLGJ, Isomursu A, Laisne MC, Koskinen LM, Paatero I, Thol K, Georgiadou M, Guzmán C, Koskinen S, Laiho A, Elo LL, Boström P, Hartiala P, van Rheenen J, Ivaska J. | 10/29/2022 |
| MYO10 promotes transzonal projection-dependent germ line-somatic contact during mammalian folliculogenesisdagger. | MYO10 promotes transzonal projection-dependent germ line-somatic contact during mammalian folliculogenesis†.
Granados-Aparici S, Volodarsky-Perel A, Yang Q, Anam S, Tulandi T, Buckett W, Son WY, Younes G, Chung JT, Jin S, Terret ME, Clarke HJ., Free PMC Article | 08/27/2022 |
| Myosin-X and talin modulate integrin activity at filopodia tips. | Myosin-X and talin modulate integrin activity at filopodia tips.
Miihkinen M, Grönloh MLB, Popović A, Vihinen H, Jokitalo E, Goult BT, Ivaska J, Jacquemet G., Free PMC Article | 02/19/2022 |
| Elevated MYO10 Predicts Poor Prognosis and its Deletion Hampers Proliferation and Migration Potentials of Cells Through Rewiring PI3K/Akt Signaling in Cervical Cancer. | Elevated MYO10 Predicts Poor Prognosis and its Deletion Hampers Proliferation and Migration Potentials of Cells Through Rewiring PI3K/Akt Signaling in Cervical Cancer.
He JH, Chen JG, Zhang B, Chen J, You KL, Hu JM, Xu JW, Chen L., Free PMC Article | 11/27/2021 |
| LncRNA SNHG7 enhances chemoresistance in neuroblastoma through cisplatin-induced autophagy by regulating miR-329-3p/MYO10 axis. | LncRNA SNHG7 enhances chemoresistance in neuroblastoma through cisplatin-induced autophagy by regulating miR-329-3p/MYO10 axis.
Wang SY, Wang X, Zhang CY. | 04/3/2021 |
| We demonstrated that circMYO10 is upregulated in OS tissues and cell lines. CircMYO10 activates Wnt/beta-catenin signaling by regulating miR-370-3p/RUVBL1 axis to promote H4K16Ac at the promoter region of beta-catenin/LEF1 target genes. | CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling.
Chen J, Liu G, Wu Y, Ma J, Wu H, Xie Z, Chen S, Yang Y, Wang S, Shen P, Fang Y, Fan S, Shen S, Fang X., Free PMC Article | 04/18/2020 |
| MYO10 represents a new clinical biomarker for this aggressive disease and due to its role in cellular motility and invasion | Expression ratio of the TGFβ-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response.
Dvornikov D, Schneider MA, Ohse S, Szczygieł M, Titkova I, Rosenblatt M, Muley T, Warth A, Herth FJ, Dienemann H, Thomas M, Timmer J, Schilling M, Busch H, Boerries M, Meister M, Klingmüller U., Free PMC Article | 10/26/2019 |
| miR-129 inhibited neuroblastoma growth and potentiated chemosensitivity by targeting MYO10 | miR-129 inhibits tumor growth and potentiates chemosensitivity of neuroblastoma by targeting MYO10.
Wang X, Li J, Xu X, Zheng J, Li Q. | 10/20/2018 |
| In two cohorts with available data, we identified one intronic SNP (rs13361131) in myosin X gene (MYO10) associated with C17:0 level (P = 1.37x10-8), and two intronic SNP (rs12874278 and rs17363566) in deleted in lymphocytic leukemia 1 (DLEU1) region associated with C19:0 level (P = 7.07x10-9) | Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids: Results from the CHARGE Consortium.
de Oliveira Otto MC, Lemaitre RN, Sun Q, King IB, Wu JHY, Manichaikul A, Rich SS, Tsai MY, Chen YD, Fornage M, Weihua G, Aslibekyan S, Irvin MR, Kabagambe EK, Arnett DK, Jensen MK, McKnight B, Psaty BM, Steffen LM, Smith CE, Risérus U, Lind L, Hu FB, Rimm EB, Siscovick DS, Mozaffarian D., Free PMC Article | 08/4/2018 |
| MYO10 (myosin X), a direct miR340 target gene, mediated the migration and invasion of breast cancer cells | MiR-340 suppresses cell migration and invasion by targeting MYO10 in breast cancer.
Chen CP, Sun ZL, Lu X, Wu WX, Guo WL, Lu JJ, Han C, Huang JQ, Fang Y. | 10/1/2016 |
| Results suggest that NF-kappaB-regulated miR-124 targets MYO10, inhibits cell invasion and metastasis, and is down-regulated in node-positive NSCLC. | NF-κB-mediated miR-124 suppresses metastasis of non-small-cell lung cancer by targeting MYO10.
Sun Y, Ai X, Shen S, Lu S., Free PMC Article | 05/21/2016 |
| Myo10 plays a key role in integrating the actin and microtubule cytoskeletons to position centrosomes and mitotic spindles. | Direct Microtubule-Binding by Myosin-10 Orients Centrosomes toward Retraction Fibers and Subcortical Actin Clouds.
Kwon M, Bagonis M, Danuser G, Pellman D., Free PMC Article | 11/14/2015 |
| New research implicates Myo10 in a number of disease states including cancer metastasis and pathogen infection. | Myosin-X and disease.
Courson DS, Cheney RE., Free PMC Article | 08/15/2015 |
| PCTK1 regulates spindle orientation through phosphorylation of Ser83 on KAP0, a regulatory subunit of protein kinase A. | PCTK1 regulates integrin-dependent spindle orientation via protein kinase A regulatory subunit KAP0 and myosin X.
Iwano S, Satou A, Matsumura S, Sugiyama N, Ishihama Y, Toyoshima F., Free PMC Article | 05/30/2015 |
| Elevated MYO10 expression and involvement in invadopodia formation increases the aggressiveness of breast cancer . | Elevated expression of myosin X in tumours contributes to breast cancer aggressiveness and metastasis.
Cao R, Chen J, Zhang X, Zhai Y, Qing X, Xing W, Zhang L, Malik YS, Yu H, Zhu X., Free PMC Article | 09/27/2014 |
| Study demonstrates a novel biological function for Hdl-Myo10 and an important new role for both Myo10 isoforms in the development of dendritic spines and synapses. | Myosin X and its motorless isoform differentially modulate dendritic spine development by regulating trafficking and retention of vasodilator-stimulated phosphoprotein.
Lin WH, Hurley JT, Raines AN, Cheney RE, Webb DJ., Free PMC Article | 07/19/2014 |
| Myo10 upregulation in mutant p53-driven cancers is necessary for invasion and that plasma-membrane protrusions. | Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.
Arjonen A, Kaukonen R, Mattila E, Rouhi P, Högnäs G, Sihto H, Miller BW, Morton JP, Bucher E, Taimen P, Virtakoivu R, Cao Y, Sansom OJ, Joensuu H, Ivaska J., Free PMC Article | 05/10/2014 |
| Phosphorylation of ADD1 at Ser12 and Ser355 by cyclin-dependent kinase 1 enables ADD1 to bind to myosin-X (Myo10). | Adducin-1 is essential for mitotic spindle assembly through its interaction with myosin-X.
Chan PC, Hsu RY, Liu CW, Lai CC, Chen HC., Free PMC Article | 03/22/2014 |
| Authors conclude thatMyo10 generates the force to enhance bacterial-induced cell membrane protrusions by binding its head region to actin filaments and its PH tail domain to the peripheral membrane. | Myosin-X facilitates Shigella-induced membrane protrusions and cell-to-cell spread.
Bishai EA, Sidhu GS, Li W, Dhillon J, Bohil AB, Cheney RE, Hartwig JH, Southwick FS., Free PMC Article | 08/3/2013 |
| Molecular basis by which myosin-X facilitates alternative dual binding to cargos and microtubules. | Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain.
Hirano Y, Hatano T, Takahashi A, Toriyama M, Inagaki N, Hakoshima T., Free PMC Article | 09/17/2011 |
| The structure of the MyoX MyTH4-FERM tandem in complex with the cytoplasmic tail P3 domain of the netrin receptor DCC, is reported. | Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain.
Wei Z, Yan J, Lu Q, Pan L, Zhang M., Free PMC Article | 05/14/2011 |
| Results indicate that PtdIns(3,4,5)P binding to the Myo10-PH2 domain is involved in Myo10 trafficking and regulation of filopodia dynamics. | PtdIns(3,4,5)P₃ is a regulator of myosin-X localization and filopodia formation.
Plantard L, Arjonen A, Lock JG, Nurani G, Ivaska J, Strömblad S. | 01/29/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |