| DMT1 ubiquitination by Nedd4 protects against ferroptosis after intracerebral hemorrhage. | DMT1 ubiquitination by Nedd4 protects against ferroptosis after intracerebral hemorrhage.
Lv B, Fu P, Wang M, Cui L, Bao L, Wang X, Yu L, Zhou C, Zhu M, Wang F, Pang Y, Qi S, Zhang Z, Cui G., Free PMC Article | 05/2/2024 |
| Deoxyribonuclease 1-like 3 inhibits colorectal malignancy through antagonizing NEDD4-triggered CDKN1A ubiquitination. | Deoxyribonuclease 1-like 3 inhibits colorectal malignancy through antagonizing NEDD4-triggered CDKN1A ubiquitination.
Yu L, Huang J. | 02/16/2024 |
| Ubiquitin ligase NEDD4 promotes the proliferation of hepatocellular carcinoma cells through targeting PCDH17 protein for ubiquitination and degradation. | Ubiquitin ligase NEDD4 promotes the proliferation of hepatocellular carcinoma cells through targeting PCDH17 protein for ubiquitination and degradation.
Liu Z, Hu Q, Hu B, Cao K, Xu T, Hou T, Cao T, Wang R, Shi H, Zhang B., Free PMC Article | 02/13/2024 |
| PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer. | PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer.
Xu L, Xiang W, Yang J, Gao J, Wang X, Meng L, Ye K, Zhao XH, Zhang XD, Jin L, Ye Y., Free PMC Article | 01/16/2024 |
| Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2. | Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2.
Rotin D, Prag G. | 12/16/2023 |
| Primate-specific isoform of Nedd4-1 regulates substrate binding via Ser/Thr phosphorylation and 14-3-3 binding. | Primate-specific isoform of Nedd4-1 regulates substrate binding via Ser/Thr phosphorylation and 14-3-3 binding.
Kefalas G, Rotin D., Free PMC Article | 11/1/2023 |
| Oncogenic Role of the NFATC2/NEDD4/FBP1 Axis in Cholangiocarcinoma. | Oncogenic Role of the NFATC2/NEDD4/FBP1 Axis in Cholangiocarcinoma.
Zhao W, Zhao J, Li K, Hu Y, Yang D, Tan B, Shi J. | 09/25/2023 |
| E3 ubiquitin ligase neural precursor cell-expressed developmentally downregulated gene 4 motivates FOXA1 ubiquitination and restrains proliferation of diffuse large B-cell lymphoma cells via the Wnt/beta-Catenin pathway. | E3 ubiquitin ligase neural precursor cell-expressed developmentally downregulated gene 4 motivates FOXA1 ubiquitination and restrains proliferation of diffuse large B-cell lymphoma cells via the Wnt/β-Catenin pathway.
Yang L, Li JN. | 09/18/2023 |
| Nedd4-1 regulates human sodium-dependent vitamin C transporter-2 functional expression in neuronal and epithelial cells. | Nedd4-1 regulates human sodium-dependent vitamin C transporter-2 functional expression in neuronal and epithelial cells.
Teafatiller T, Perez O, Kitazawa M, Agrawal A, Subramanian VS. | 09/15/2023 |
| NEDD4 ameliorates myocardial reperfusion injury by preventing macrophages pyroptosis. | NEDD4 ameliorates myocardial reperfusion injury by preventing macrophages pyroptosis.
Sun W, Lu H, Cui S, Zhao S, Yu H, Song H, Ruan Q, Zhang Y, Chu Y, Dong S., Free PMC Article | 02/11/2023 |
| Unraveling the Potential Role of NEDD4-like E3 Ligases in Cancer. | Unraveling the Potential Role of NEDD4-like E3 Ligases in Cancer.
Jayaprakash S, Hegde M, BharathwajChetty B, Girisa S, Alqahtani MS, Abbas M, Sethi G, Kunnumakkara AB., Free PMC Article | 11/5/2022 |
| N4BP3 promotes breast cancer metastasis via NEDD4-mediated E-cadherin ubiquitination and degradation. | N4BP3 promotes breast cancer metastasis via NEDD4-mediated E-cadherin ubiquitination and degradation.
Luo M, Li J, Yang Q, Xu S, Zhang K, Chen J, Zhang S, Zheng S, Zhou J. | 10/22/2022 |
| Insufficient ablation induces E3-ligase Nedd4 to promote hepatocellular carcinoma progression by tuning TGF-beta signaling. | Insufficient ablation induces E3-ligase Nedd4 to promote hepatocellular carcinoma progression by tuning TGF-β signaling.
Li K, Niu Y, Yuan Y, Qiu J, Shi Y, Zhong C, Qiu Z, Li K, Lin Z, Huang Z, Zhang C, Zuo D, He W, Yuan Y, Li B. | 06/11/2022 |
| NEDD4 degrades TUSC2 to promote glioblastoma progression. | NEDD4 degrades TUSC2 to promote glioblastoma progression.
Rimkus TK, Arrigo AB, Zhu D, Carpenter RL, Sirkisoon S, Doheny D, Regua AT, Wong GL, Manore S, Wagner C, Lin HK, Jin G, Ruiz J, Chan M, Debinski W, Lo HW., Free PMC Article | 04/30/2022 |
| Oncogenic E3 ubiquitin ligase NEDD4 binds to KLF8 and regulates the microRNA-132/NRF2 axis in bladder cancer. | Oncogenic E3 ubiquitin ligase NEDD4 binds to KLF8 and regulates the microRNA-132/NRF2 axis in bladder cancer.
Mao M, Yang L, Hu J, Liu B, Zhang X, Liu Y, Wang P, Li H., Free PMC Article | 04/30/2022 |
| The Roles of NEDD4 Subfamily of HECT E3 Ubiquitin Ligases in Neurodevelopment and Neurodegeneration. | The Roles of NEDD4 Subfamily of HECT E3 Ubiquitin Ligases in Neurodevelopment and Neurodegeneration.
Haouari S, Vourc'h P, Jeanne M, Marouillat S, Veyrat-Durebex C, Lanznaster D, Laumonnier F, Corcia P, Blasco H, Andres CR., Free PMC Article | 04/23/2022 |
| The Ubiquitin E3 Ligase Nedd4 Regulates the Expression and Amyloid-beta Peptide Export Activity of P-Glycoprotein. | The Ubiquitin E3 Ligase Nedd4 Regulates the Expression and Amyloid-β Peptide Export Activity of P-Glycoprotein.
Chai AB, Callaghan R, Gelissen IC., Free PMC Article | 03/12/2022 |
| NEDD4L-induced beta-catenin ubiquitination suppresses the formation and progression of interstitial pulmonary fibrosis via inhibiting the CTHRC1/HIF-1alpha axis. | NEDD4L-induced β-catenin ubiquitination suppresses the formation and progression of interstitial pulmonary fibrosis via inhibiting the CTHRC1/HIF-1α axis.
Chen L, Yang Y, Yan H, Peng X, Zou J., Free PMC Article | 02/26/2022 |
| NEDD4 triggers FOXA1 ubiquitination and promotes colon cancer progression under microRNA-340-5p suppression and ATF1 upregulation. | NEDD4 triggers FOXA1 ubiquitination and promotes colon cancer progression under microRNA-340-5p suppression and ATF1 upregulation.
Yue M, Yun Z, Li S, Yan G, Kang Z., Free PMC Article | 02/26/2022 |
| The E3 Ubiquitin Ligase NEDD4-1 Mediates Temozolomide-Resistant Glioblastoma through PTEN Attenuation and Redox Imbalance in Nrf2-HO-1 Axis. | The E3 Ubiquitin Ligase NEDD4-1 Mediates Temozolomide-Resistant Glioblastoma through PTEN Attenuation and Redox Imbalance in Nrf2-HO-1 Axis.
Chuang HY, Hsu LY, Pan CM, Pikatan NW, Yadav VK, Fong IH, Chen CH, Yeh CT, Chiu SC., Free PMC Article | 10/30/2021 |
| NEDD4 regulates ubiquitination and stability of the cell adhesion molecule IGPR-1 via lysosomal pathway. | NEDD4 regulates ubiquitination and stability of the cell adhesion molecule IGPR-1 via lysosomal pathway.
Sun L, Amraei R, Rahimi N., Free PMC Article | 10/2/2021 |
| NEDD4 E3 ligase: Functions and mechanism in human cancer. | NEDD4 E3 ligase: Functions and mechanism in human cancer.
Wang ZW, Hu X, Ye M, Lin M, Chu M, Shen X. | 09/18/2021 |
| LAPTM4alpha is targeted from the Golgi to late endosomes/lysosomes in a manner dependent on the E3 ubiquitin ligase Nedd4-1 and ESCRT proteins. | LAPTM4α is targeted from the Golgi to late endosomes/lysosomes in a manner dependent on the E3 ubiquitin ligase Nedd4-1 and ESCRT proteins.
Hirota Y, Hayashi M, Miyauchi Y, Ishii Y, Tanaka Y, Fujimoto K. | 07/24/2021 |
| Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy through Deubiquitinating VPS34. | Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy through Deubiquitinating VPS34.
Xie W, Jin S, Wu Y, Xian H, Tian S, Liu DA, Guo Z, Cui J. | 03/20/2021 |
| PRRG4 promotes breast cancer metastasis through the recruitment of NEDD4 and downregulation of Robo1. | PRRG4 promotes breast cancer metastasis through the recruitment of NEDD4 and downregulation of Robo1.
Zhang L, Qin Y, Wu G, Wang J, Cao J, Wang Y, Wu D, Yang K, Zhao Z, He L, Lyu J, Li H, Gu H. | 02/20/2021 |