| RUNX1-IT1 acts as a scaffold of STAT1 and NuRD complex to promote ROS-mediated NF-kappaB activation and ovarian cancer progression. | RUNX1-IT1 acts as a scaffold of STAT1 and NuRD complex to promote ROS-mediated NF-κB activation and ovarian cancer progression.
Yu X, Zhao P, Luo Q, Wu X, Wang Y, Nan Y, Liu S, Gao W, Li B, Liu Z, Cui Z. | 02/5/2024 |
| Novel NFKB2 Pathogenic Variants in Two Unrelated Patients with Common Variable Immunodeficiency. | Novel NFKB2 Pathogenic Variants in Two Unrelated Patients with Common Variable Immunodeficiency.
Sundaram K, Ferro M, Inborn Errors of Immunity Functional Diagnostics Consortium, Hayman G, Ibrahim MAA. | 07/24/2023 |
| NF-kappaB/p52 augments ETS1 binding genome-wide to promote glioma progression. | NF-κB/p52 augments ETS1 binding genome-wide to promote glioma progression.
Sim N, Li Y., Free PMC Article | 05/4/2023 |
| Analysis of NFKB1 and NFKB2 gene expression in the blood of patients with sudden sensorineural hearing loss. | Analysis of NFKB1 and NFKB2 gene expression in the blood of patients with sudden sensorineural hearing loss.
Jabbari Moghadam Y, Asadi MR, Abbaszadeh V, Gharesouran J, Dehghani H, Sabaie H, Hussen BM, Taheri M, Akbari Dilmaghnai N, Rezazadeh M. | 03/15/2023 |
| How do nuclear factor kappa B (NF-kappaB)1 and NF-kappaB2 defects lead to the incidence of clinical and immunological manifestations of inborn errors of immunity? | How do nuclear factor kappa B (NF-κB)1 and NF-κB2 defects lead to the incidence of clinical and immunological manifestations of inborn errors of immunity?
Fathi N, Mojtahedi H, Nasiri M, Abolhassani H, Yousefpour Marzbali M, Esmaeili M, Salami F, Biglari F, Rezaei N. | 02/24/2023 |
| NFKB2 inhibits NRG1 transcription to affect nucleus pulposus cell degeneration and in fl ammation in intervertebral disc degeneration. | NFKB2 inhibits NRG1 transcription to affect nucleus pulposus cell degeneration and inflammation in intervertebral disc degeneration.
Wang X, Wu H, Zhang Q, Liu F, Wang J, Wei C, Liu F, Li J. | 01/22/2022 |
| An epithelial Nfkb2 pathway exacerbates intestinal inflammation by supplementing latent RelA dimers to the canonical NF-kappaB module. | An epithelial Nfkb2 pathway exacerbates intestinal inflammation by supplementing latent RelA dimers to the canonical NF-κB module.
Chawla M, Mukherjee T, Deka A, Chatterjee B, Sarkar UA, Singh AK, Kedia S, Lum J, Dhillon MK, Banoth B, Biswas SK, Ahuja V, Basak S., Free PMC Article | 12/4/2021 |
| A Nonsense N -Terminus NFKB2 Mutation Leading to Haploinsufficiency in a Patient with a Predominantly Antibody Deficiency. | A Nonsense N -Terminus NFKB2 Mutation Leading to Haploinsufficiency in a Patient with a Predominantly Antibody Deficiency.
Kuehn HS, Bernasconi A, Niemela JE, Almejun MB, Gallego WAF, Goel S, Stoddard JL, Sánchez RGP, Franco CAA, Oleastro M, Grunebaum E, Ballas Z, Cunningham-Rundles C, Fleisher TA, Franco JL, Danielian S, Rosenzweig SD., Free PMC Article | 10/16/2021 |
| Fetal lung C4BPA induces p100 processing in human placenta. | Fetal lung C4BPA induces p100 processing in human placenta.
Ithier MC, Parobchak N, Yadava S, Cheng J, Wang B, Rosen T., Free PMC Article | 10/10/2020 |
| Preventing abnormal NF-kappaB activation and autoimmunity by Otub1-mediated p100 stabilization. | Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization.
Li Y, Yang JY, Xie X, Jie Z, Zhang L, Shi J, Lin D, Gu M, Zhou X, Li HS, Watowich SS, Jain A, Yun Jung S, Qin J, Cheng X, Sun SC., Free PMC Article | 09/12/2020 |
| this study shows fatal enteroviral encephalitis in a patient with common variable immunodeficiency harbouring a novel mutation in NFKB2 | Fatal Enteroviral Encephalitis in a Patient with Common Variable Immunodeficiency Harbouring a Novel Mutation in NFKB2.
Slade CA, McLean C, Scerri T, Giang TB, Megaloudis S, Strathmore A, Tempany JC, Nicholls K, D'Arcy C, Bahlo M, Hodgkin PD, Douglass JA, Bryant VL. | 07/11/2020 |
| Impaired B-cell differentiation and hypogammaglobinemia were consistent features of NFKB2-associated disease. | Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in NFKB2.
Klemann C, Camacho-Ordonez N, Yang L, Eskandarian Z, Rojas-Restrepo JL, Frede N, Bulashevska A, Heeg M, Al-Ddafari MS, Premm J, Seidl M, Ammann S, Sherkat R, Radhakrishnan N, Warnatz K, Unger S, Kobbe R, Hüfner A, Leahy TR, Ip W, Burns SO, Fliegauf M, Grimbacher B., Free PMC Article | 05/30/2020 |
| this study shows that pathogenic NFKB2 variant in the ankyrin repeat domain (R635X) causes a variable antibody deficiency | Pathogenic NFKB2 variant in the ankyrin repeat domain (R635X) causes a variable antibody deficiency.
Tuijnenburg P, Lango Allen H, de Bree GJ, Savic S, Jansen MH, Stockdale C, Simeoni I, Ten Berge IJM, van Leeuwen EMM, NIHR BioResource, Thaventhiran JE, Kuijpers TW. | 04/4/2020 |
| This study suggests that NF-kB2 genetic variations, rs7897947 and rs12769316 are involved in Non-Small Cell Lung Cancer susceptibility, in treatment response and in clinical outcome. | NF-kB2 Genetic Variations are Significantly Associated with Non-Small Cell Lung Cancer Risk and Overall Survival.
Dimitrakopoulos FD, Antonacopoulou AG, Kottorou AE, Maroussi S, Panagopoulos N, Koukourikou I, Scopa C, Kalofonou M, Koutras A, Makatsoris T, Papadaki H, Dougenis D, Brock M, Kalofonos HP., Free PMC Article | 10/12/2019 |
| Using gene expression and patient information from The Cancer Genome Atlas (TCGA) database, this study found that expression of p52-associated genes was increased in lung adenocarcinomas and correlated with reduced survival, even in early stage disease. | p52 expression enhances lung cancer progression.
Saxon JA, Yu H, Polosukhin VV, Stathopoulos GT, Gleaves LA, McLoed AG, Massion PP, Yull FE, Zhao Z, Blackwell TS., Free PMC Article | 10/12/2019 |
| With a heterozygous NFKB2 mutation. | Anticytokine autoantibodies in a patient with a heterozygous NFKB2 mutation.
Ramakrishnan KA, Rae W, Barcenas-Morales G, Gao Y, Pengelly RJ, Patel SV, Kumararatne DS, Ennis S, Döffinger R, Faust SN, Williams AP. | 08/3/2019 |
| NFKB2 SNPs may be a possible marker of non-small cell lung carcinoma in Polish males. | ECCR1 and NFKB2 Polymorphisms as Potential Biomarkers of Non-small Cell Lung Cancer in a Polish Population.
Chaszczewska-Markowska M, Kosacka M, Chryplewicz A, Dyła T, Brzecka A, Bogunia-Kubik K. | 06/22/2019 |
| These data uncovered a previously unknown role of the human cytomegalovirus protein US31 in inducing NF-kappaB-mediated mono-macrophage inflammation in the pathogenesis and development of systemic lupus erythematosus. | The cytomegalovirus protein US31 induces inflammation through mono-macrophages in systemic lupus erythematosus by promoting NF-κB2 activation.
Guo G, Ye S, Xie S, Ye L, Lin C, Yang M, Shi X, Wang F, Li B, Li M, Chen C, Zhang L, Zhang H, Xue X., Free PMC Article | 06/15/2019 |
| we report a novel heterozygous mutation c.2601_2602delGCinsA (p.Tyr867*) in NFKB2 resulted in early-onset CVID, ACTH deficiency and autoimmune features. | A novel NFKB2 mutation in a Chinese patient with DAVID syndrome.
Xiao B, Fang D, Liu H, Wang L, Qiu W. | 04/6/2019 |
| Expression of NFKB P52 by cells of colorectal cancer patients is associated with poor survival | Alternative NF-κB signaling promotes colorectal tumorigenesis through transcriptionally upregulating Bcl-3.
Tao Y, Liu Z, Hou Y, Wang S, Liu S, Jiang Y, Tan D, Ge Q, Li C, Hu Y, Liu Z, Chen X, Wang Q, Wang M, Zhang X. | 03/2/2019 |
| Study found that non-canonical NF-kappaB p52 levels are inversely proportional to IotaKappaKappaepsilon, and growth of triple negative breast cancer cells in anchorage supportive, high-attachment conditions requires IKKepsilon and activated MEK. IKKepsilon and MEK cooperate to support overall viability whereas the p52 transcription factor is only required for viability in low attachment conditions, underscoring the con... | IΚΚε cooperates with either MEK or non-canonical NF-kB driving growth of triple-negative breast cancer cells in different contexts.
House CD, Grajales V, Ozaki M, Jordan E, Wubneh H, Kimble DC, James JM, Kim MK, Annunziata CM., Free PMC Article | 01/19/2019 |
| Data show that nuclear factor kappa B subunit 2 (NF-kappaB2) regulates intracellular cholesterol transport by controlling Niemann Pick type C2 protein (NPC2) expression. | The non-canonical NF-κB pathway promotes NPC2 expression and regulates intracellular cholesterol trafficking.
Liao Y, Wei J, Wang J, Shi X, Luo J, Song BL. | 01/12/2019 |
| the mutant TERT promoter is reactivated by cooperative binding of p52 and ETS1 | Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1.
Xu X, Li Y, Bharath SR, Ozturk MB, Bowler MW, Loo BZL, Tergaonkar V, Song H., Free PMC Article | 01/12/2019 |
| Functional evaluation of natural killer cell cytotoxic activity in NFKB2-mutated patients. | Functional evaluation of natural killer cell cytotoxic activity in NFKB2-mutated patients.
Montin D, Licciardi F, Giorgio E, Ciolfi A, Pizzi S, Mussa A, Meazza R, Tartaglia M, Brusco A, Pende D, Ferrero GB. | 12/22/2018 |
| the present study demonstrated that NFKB2 may be involved in the development of HL by interacting with several genes and miRNAs, including BCL2L1, CSF2, miR-135a-5p, miR-155-5p and miR-9-5p. | Analysis of NFKB2‑mediated regulation of mechanisms underlying the development of Hodgkin's lymphoma.
Zhang Y, Tong L, Chen S, Wu W, Wang L., Free PMC Article | 09/29/2018 |