| Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal Cancer Cells by Activating p53. | Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal Cancer Cells by Activating p53.
Jung JH, Lee D, Ko HM, Jang HJ., Free PMC Article | 01/15/2022 |
| CNOT2 haploinsufficiency in a 40-year-old man with intellectual disability, autism, and seizures. | CNOT2 haploinsufficiency in a 40-year-old man with intellectual disability, autism, and seizures.
Royer-Bertrand B, Cisarova K, Niel Bütschi F, Foletti G, Guinchat V, Tran C, Superti-Furga A, Good JM. | 01/15/2022 |
| CCR4NOT transcription complex subunit 2 regulates TRAIL sensitivity in nonsmallcell lung cancer cells via the STAT3 pathway. | CCR4‑NOT transcription complex subunit 2 regulates TRAIL sensitivity in non‑small‑cell lung cancer cells via the STAT3 pathway.
Kim EO, Kang SE, Choi M, Rhee KJ, Yun M., Free PMC Article | 09/12/2020 |
| CNOT2 is a novel negative regulator of the JAK-STAT pathway and supports dengue virus infection. | CNOT2 facilitates dengue virus infection via negatively modulating IFN-Independent Non-Canonical JAK/STAT pathway.
Liu J, Yang L, Liu F, Li H, Tang W, Tong X, Zuo J. | 07/4/2020 |
| Increased expression of MHC II genes after knock-down or knock-out of either CNOT1, CNOT2, or CNOT3 subunit was seen in a variety of cell systems and also in naive macrophages from CNOT3 conditional knock-out mice. | The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription.
Rodríguez-Gil A, Ritter O, Saul VV, Wilhelm J, Yang CY, Grosschedl R, Imai Y, Kuba K, Kracht M, Schmitz ML., Free PMC Article | 05/18/2019 |
| CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells. | CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells.
Sohn EJ, Jung DB, Lee H, Han I, Lee J, Lee H, Kim SH. | 12/9/2017 |
| ERG is recruited to mRNAs via interaction with the RNA-binding protein RBPMS, and it promotes mRNA decay by binding CNOT2, a component of the CCR4-NOT deadenylation complex. | The transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression.
Rambout X, Detiffe C, Bruyr J, Mariavelle E, Cherkaoui M, Brohée S, Demoitié P, Lebrun M, Soin R, Lesage B, Guedri K, Beullens M, Bollen M, Farazi TA, Kettmann R, Struman I, Hill DE, Vidal M, Kruys V, Simonis N, Twizere JC, Dequiedt F. | 06/10/2017 |
| The CNOT2-CNOT3 heterodimer is stabilized and tightly anchored to the surface of CNOT1 through an unexpected intertwined arrangement of peptide regions lacking defined secondary structure. | Structure and assembly of the NOT module of the human CCR4-NOT complex.
Boland A, Chen Y, Raisch T, Jonas S, Kuzuoğlu-Öztürk D, Wohlbold L, Weichenrieder O, Izaurralde E. | 01/4/2014 |
| Cnot1, Cnot2, and Cnot3 represent a novel component of the core self-renewal and pluripotency circuitry conserved in mouse and human ESCs. | Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation.
Zheng X, Dumitru R, Lackford BL, Freudenberg JM, Singh AP, Archer TK, Jothi R, Hu G., Free PMC Article | 08/4/2012 |
| human CNOT2 is important for maintaining the deadenylase activity and structural integrity of the CCR4-NOT complex, thereby affecting cell viability. | CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death.
Ito K, Inoue T, Yokoyama K, Morita M, Suzuki T, Yamamoto T. | 10/1/2011 |
| This study shows that SMRT/NCoR-HDAC3 complex is a cofactor of CNOT2-mediated repression and suggests that transcriptional regulation by the Ccr4-Not complex involves regulation of chromatin modification. | Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex.
Jayne S, Zwartjes CG, van Schaik FM, Timmers HT., Free PMC Article | 12/1/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| These findings suggest that CDK11 may contribute to apoptosis by regulating the activity of NOT2 independent of its kinase activity. | The cyclin-dependent kinase 11 interacts with NOT2.
Shi J, Nelson MA. | 01/21/2010 |
| major repression function of CNOT2 is localized in a specialized protein motif, the Not-Box | Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex.
Zwartjes CG, Jayne S, van den Berg DL, Timmers HT. | 01/21/2010 |