| The genetic association of the transcription factor NPAT with glycemic response to metformin involves regulation of fuel selection. | The genetic association of the transcription factor NPAT with glycemic response to metformin involves regulation of fuel selection.
Chen C, Gallagher JR, Tarlton J, van Aalten L, Bray SE, Ashford MLJ, McCrimmon RJ, Pearson ER, McNeilly AD, Sutherland C., Free PMC Article | 11/6/2021 |
| Structural Analysis of the SANT/Myb Domain of FLASH and YARP Proteins and Their Complex with the C-Terminal Fragment of NPAT by NMR Spectroscopy and Computer Simulations. | Structural Analysis of the SANT/Myb Domain of FLASH and YARP Proteins and Their Complex with the C-Terminal Fragment of NPAT by NMR Spectroscopy and Computer Simulations.
Bucholc K, Skrajna A, Adamska K, Yang XC, Krajewski K, Poznański J, Dadlez M, Domiński Z, Zhukov I., Free PMC Article | 02/20/2021 |
| Cpn10 has a role in the spatial regulation of NPAT signaling | Interaction of Heat Shock Protein Cpn10 with the Cyclin E/Cdk2 Substrate Nuclear Protein Ataxia-Telangiectasia (NPAT) Is Involved in Regulating Histone Transcription.
Ling Zheng L, Wang FY, Cong XX, Shen Y, Rao XS, Huang DS, Fan W, Yi P, Wang XB, Zheng L, Zhou YT, Luo Y., Free PMC Article | 04/23/2016 |
| The conserved C-terminal domain shared by FLASH, YARP, and Mute recognizes the C-terminal sequence of NPAT orthologues, thus acting as a signal targeting proteins to histone locus bodies. | A conserved interaction that is essential for the biogenesis of histone locus bodies.
Yang XC, Sabath I, Kunduru L, van Wijnen AJ, Marzluff WF, Dominski Z., Free PMC Article | 03/7/2015 |
| Genetic variants of NPAT-ATM and AURKA are associated with an individual early adverse reaction in the gastrointestinal tract of patients with cervical cancer treated with pelvic radiation therapy | Genetic variants of NPAT-ATM and AURKA are associated with an early adverse reaction in the gastrointestinal tract of patients with cervical cancer treated with pelvic radiation therapy.
Ishikawa A, Suga T, Shoji Y, Kato S, Ohno T, Ishikawa H, Yoshinaga S, Ohara K, Ariga H, Nomura K, Shibamoto Y, Ishikawa K, Moritake T, Michikawa Y, Iwakawa M, Imai T, Ishikawa A, Suga T, Shoji Y, Kato S, Ohno T, Ishikawa H, Yoshinaga S, Ohara K, Ariga H, Nomura K, Shibamoto Y, Ishikawa K, Moritake T, Michikawa Y, Iwakawa M, Imai T. | 01/7/2012 |
| NPAT is thus far the first gene implicated in nodular lymphocyte predominant Hodgkin lymphoma predisposition. | Exome sequencing reveals germline NPAT mutation as a candidate risk factor for Hodgkin lymphoma.
Saarinen S, Aavikko M, Aittomäki K, Launonen V, Lehtonen R, Franssila K, Lehtonen HJ, Kaasinen E, Broderick P, Tarkkanen J, Bain BJ, Bauduer F, Ünal A, Swerdlow AJ, Cooke R, Mäkinen MJ, Houlston R, Vahteristo P, Aaltonen LA. | 10/8/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| NPAT is essential for histone mRNA 3' end processing and recruits CDK9 to replication-dependent histone genes. | Induced G1 cell-cycle arrest controls replication-dependent histone mRNA 3' end processing through p21, NPAT and CDK9.
Pirngruber J, Johnsen SA. | 06/14/2010 |
| Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells. | Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells.
Becker KA, Ghule PN, Lian JB, Stein JL, van Wijnen AJ, Stein GS., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesGenetic variants of NPAT-ATM and AURKA are associated with an early adverse reaction in the gastrointestinal tract of patients with cervical cancer treated with pelvic radiation therapy.
Ishikawa A, Suga T, Shoji Y, Kato S, Ohno T, Ishikawa H, Yoshinaga S, Ohara K, Ariga H, Nomura K, Shibamoto Y, Ishikawa K, Moritake T, Michikawa Y, Iwakawa M, Imai T, Ishikawa A, Suga T, Shoji Y, Kato S, Ohno T, Ishikawa H, Yoshinaga S, Ohara K, Ariga H, Nomura K, Shibamoto Y, Ishikawa K, Moritake T, Michikawa Y, Iwakawa M, Imai T. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Genetic susceptibility to distinct bladder cancer subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, EPICURO/Spanish Bladder Cancer Study investigators. | 09/20/2009 |
| The subnuclear organization of histone gene regulatory proteins and 3' end processing factors (NPAT/LSM10) of normal somatic and embryonic stem cells is compromised in selected human cancer cell types. | The subnuclear organization of histone gene regulatory proteins and 3' end processing factors of normal somatic and embryonic stem cells is compromised in selected human cancer cell types.
Ghule PN, Dominski Z, Lian JB, Stein JL, van Wijnen AJ, Stein GS., Free PMC Article | 01/21/2010 |
| Results suggest that cyclin-dependent kinase inhibitors selectively control stimulation of the histone H4 gene promoter by the p220(NPAT)/HiNF-P complex. | CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P.
Mitra P, Ghule PN, van der Deen M, Medina R, Xie RL, Holmes WF, Ye X, Nakayama KI, Harper JW, Stein JL, Stein GS, van Wijnen AJ., Free PMC Article | 01/21/2010 |
| Only the number of FLASH/NPAT histone gene locus bodies correlates with ploidy and only these organelles appear to be regulated during the cell cycle. | FLASH and NPAT positive but not Coilin positive Cajal Bodies correlate with cell ploidy.
Bongiorno-Borbone L, De Cola A, Vernole P, Finos L, Barcaroli D, Knight RA, Melino G, De Laurenzi V. | 01/21/2010 |
| NPAT recruits the TRRAP-Tip60 complex to histone gene promoters to coordinate the transcriptional activation of multiple histone genes during the G(1)/S-phase transition | Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition.
DeRan M, Pulvino M, Greene E, Su C, Zhao J., Free PMC Article | 01/21/2010 |
| HiNF-P/P220NPAT regulates expression of nonhistone targets that influence competency for cell cycle progression. | The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes.
Medina R, van der Deen M, Miele-Chamberland A, Xie RL, van Wijnen AJ, Stein JL, Stein GS. | 01/21/2010 |
| Results characterize the functional signals required for NPAT localization to the cell nucleus. | Characterization of functional regions for nuclear localization of NPAT.
Sagara M, Takeda E, Nishiyama A, Utsumi S, Toyama Y, Yuasa S, Ninomiya Y, Imai T. | 01/21/2010 |
| p220 is an essential downstream component of the cyclin E/Cdk2 signaling pathway and functions to coordinate multiple elements of the G1/S transition. | The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells.
Ye X, Wei Y, Nalepa G, Harper JW., Free PMC Article | 01/21/2010 |
| the ability of p220 to promote S phase is independent of its ability to promote histone H4 transcription and p220 may link cyclin E/Cdk2 to multiple independent downstream functions | The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain.
Wei Y, Jin J, Harper JW., Free PMC Article | 01/21/2010 |
| NPAT, together with CUL5 and PPP2R1B, is implicated in the deregulation of the cell-cycle and apoptosis regulators and in the pathogenesis of B-CLL. | Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B.
Kalla C, Scheuermann MO, Kube I, Schlotter M, Mertens D, Döhner H, Stilgenbauer S, Lichter P. | 01/21/2010 |
| NPAT links E2F to the activation of S-phase-specific histone gene transcription. | NPAT expression is regulated by E2F and is essential for cell cycle progression.
Gao G, Bracken AP, Burkard K, Pasini D, Classon M, Attwooll C, Sagara M, Imai T, Helin K, Zhao J., Free PMC Article | 01/21/2010 |
| OCA-S, the multicomponent Oct-1 coactivator, intercts with NPAT. | S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component.
Zheng L, Roeder RG, Luo Y. | 01/21/2010 |