| C-type natriuretic peptide induces inotropic and lusitropic effects in human 3D-engineered cardiac tissue: Implications for the regulation of cardiac function in humans. | C-type natriuretic peptide induces inotropic and lusitropic effects in human 3D-engineered cardiac tissue: Implications for the regulation of cardiac function in humans.
Bachmann JC, Kirchhoff JE, Napolitano JE, Sorota S, Gordon WM, Feric N, Aschar-Sobbi R, Lv J, Cao Z, Coppieters K, Borghetti G, Nyberg M., Free PMC Article | 04/17/2024 |
| A novel variant of NPPC causes abnormal post-translational cleavage: A candidate gene for premature ovarian insufficiency. | A novel variant of NPPC causes abnormal post-translational cleavage: A candidate gene for premature ovarian insufficiency.
Park JY, Go M, Lyu SW, Yoon TK, Kang KM, Kim JW, Shim SH. | 02/12/2022 |
| C-type natriuretic peptide (CNP)/guanylate cyclase B (GC-B) system and endothelin-1(ET-1)/ET receptor A and B system in human vasculature. | C-type natriuretic peptide (CNP)/guanylate cyclase B (GC-B) system and endothelin-1(ET-1)/ET receptor A and B system in human vasculature.
Taura D, Nakao K, Nakagawa Y, Kinoshita H, Sone M, Nakao K. | 07/10/2021 |
| C-type natriuretic peptide plasma levels and whole blood mRNA expression show different trends in adolescents with different degree of endothelial dysfunction. | C-type natriuretic peptide plasma levels and whole blood mRNA expression show different trends in adolescents with different degree of endothelial dysfunction.
Del Ry S, Cabiati M, Bianchi V, Randazzo E, Peroni D, Clerico A, Federico G. | 03/13/2021 |
| CNP, via guanylyl cyclase-B/cyclic GMP signaling, stabilizes resident perivascular mast cells at baseline and prevents their excessive activation under pathological conditions. | Stabilization of Perivascular Mast Cells by Endothelial CNP (C-Type Natriuretic Peptide).
Chen W, Werner F, Illerhaus A, Knopp T, Völker K, Potapenko T, Hofmann U, Frantz S, Baba HA, Rösch M, Zernecke A, Karbach S, Wenzel P, Kuhn M. | 07/18/2020 |
| Data provide evidence that the CNP precursor gene NPPC was 50% less expressed in luteinized granulosa cells from follicles containing mature oocytes than in follicles containing immature oocytes. Further results showed that CNP signaling is downregulated in human ovarian follicles containing mature oocytes. | C-type natriuretic peptide signaling in human follicular environment and its relation with oocyte maturation.
Casalechi M, Dias JA, Pinto LV, Lobach VN, Pereira MT, Cavallo IK, Reis AM, Dela Cruz C, Reis FM. | 06/13/2020 |
| Urine NT-proCNP can serve as a biomarker for chronic kidney disease in diabetes. | Urinary Amino-Terminal Pro-C-Type Natriuretic Peptide: A Novel Marker of Chronic Kidney Disease in Diabetes.
Prickett TCR, Lunt H, Warwick J, Heenan HF, Espiner EA. | 06/6/2020 |
| C-type natriuretic peptide may dampen FGF-23 expression via MAPK signaling pathway in mesangial cells | C-Type Natriuretic Peptide Dampens Fibroblast Growth Factor-23 Expression Through MAPK Signaling Pathway in Human Mesangial Cells.
Wu YF, Zhang DD, Liu SY, Luo HH, Jiang GM, Xu Y, Wu Y, Wang JJ, Liu FF, Samadli S, Wei W, Hu B, Hu P. | 10/26/2019 |
| receptor signaling and NEP are involved in the resistance of CNP to human mesangial proliferation and Col-IV expression. | Receptor signaling and neutral endopeptidase are involved in the resistance of C-type natriuretic peptide to human mesangial proliferation and collagen-IV expression.
Luo HH, Wu C, Hu P, Wu YF, Zhang DD, Liu SY, Jiang GM, Xu Y, Wu Y, Wang JJ, Liu FF, Wei W, Hu B. | 10/5/2019 |
| This review will focus on the novel physiological functions ascribed to CNP, the receptors/signalling mechanisms involved in mediating its cardioprotective effects, and the development of therapeutics targeting CNP signalling pathways in different disease pathologies. | C-type Natriuretic Peptide: A Multifaceted Paracrine Regulator in the Heart and Vasculature.
Moyes AJ, Hobbs AJ., Free PMC Article | 08/31/2019 |
| Community elderly adults with myocardial ageing have lower NTproCNP levels compared to those with preserved myocardial function. Given that impaired myocardial relaxation probably represents early changes within the myocardium with ageing, NTproCNP may be useful as an 'upstream' biomarker useful for charting myocardial ageing | N-Terminal pro C-Type Natriuretic Peptide (NTproCNP) and myocardial function in ageing.
Keng BMH, Gao F, Tan RS, Ewe SH, Teo LLY, Xie BQ, Goh GBB, Koh WP, Koh AS., Free PMC Article | 05/18/2019 |
| A link was found between circulating C-type natriuretic peptide and autonomic dysfunction in chronic kidney disease patients. | Increased circulating bioactive C-type natriuretic peptide is associated with reduced heart rate variability in patients with chronic kidney disease.
Wang L, Liu W, Yu Y, Jiang L, Yang J., Free PMC Article | 03/16/2019 |
| The Post-ictal serum NT-pro CNP levels were lower in epileptic seizures compared to psychogenic non-epileptic seizures as well as healthy controls. | Serum NT-pro CNP levels in epileptic seizure, psychogenic non-epileptic seizure, and healthy subjects.
Ceylan M, Yalcin A, Bayraktutan OF, Laloglu E. | 01/5/2019 |
| two heterozygous NPPC mutations, located in the highly conserved ring, were identified; mutations cause autosomal dominant short stature in humans | Mutations in C-natriuretic peptide (NPPC): a novel cause of autosomal dominant short stature.
Hisado-Oliva A, Ruzafa-Martin A, Sentchordi L, Funari MFA, Bezanilla-López C, Alonso-Bernáldez M, Barraza-García J, Rodriguez-Zabala M, Lerario AM, Benito-Sanz S, Aza-Carmona M, Campos-Barros A, Jorge AAL, Heath KE. | 12/8/2018 |
| This study showed that Plasma concentrations of amino-terminal proCNP are depressed in Parkinson's Disease. | Central and systemic C-type Natriuretic Peptide are both reduced in Parkinson's Disease.
Woodward Z, Prickett TCR, Espiner EA, Anderson TJ. | 06/16/2018 |
| C-type natriuretic peptide (CNP)administration significantly decreased the secretion and expression of MMP-2 and MMP-9 in the cultured mesangial cells ; (2) the secretion and expression of TIMP-1 progressively elevated after treatment with CNP for 24 and 48 h, whereas declined at later time point; (3) CNP expression was negatively correlated with MMP-2 and MMP-9 expression. | C-type natriuretic peptide suppresses mesangial proliferation and matrix expression via a MMPs/TIMPs-independent pathway in vitro.
Huang BY, Hu P, Zhang DD, Jiang GM, Liu SY, Xu Y, Wu YF, Xia X, Wang Y. | 03/10/2018 |
| CNP level in pericardial fluid is a more sensitive marker of LV dysfunction than CNP levels in plasma in coronary artery disease patients undergoing coronary artery bypass grafting. | Evaluation of Pericardial Fluid C-Type Natriuretic Peptide Levels in Patients Undergoing Coronary Bypass Surgery.
Guclu O, Karahan O, Karabacak M, Yuksel V, Huseyin S, Mavitas B. | 09/9/2017 |
| Data suggest mutations in NPR2 in patients with skeletal overgrowth alter conformation: A488P/R655C missense mutations yield conformation mimicking allosterically activated NPR2; A488P mutation sets phosphorylation as requirement for CNP-dependent activation; R655C mutation abrogates need for phosphorylation; ATP analog inhibits mutants. (NPR2 = atrial natriuretic factor receptor B; CNP = C-type natriuretic peptide) | Skeletal overgrowth-causing mutations mimic an allosterically activated conformation of guanylyl cyclase-B that is inhibited by 2,4,6,-trinitrophenyl ATP.
Dickey DM, Otto NM, Potter LR., Free PMC Article | 07/8/2017 |
| CNP may play a more important role than BNP and ANP related peptides, as risk marker of obesity | C-type natriuretic peptide is closely associated to obesity in Caucasian adolescents.
Del Ry S, Cabiati M, Bianchi V, Caponi L, Maltinti M, Caselli C, Kozakova M, Palombo C, Morizzo C, Marchetti S, Randazzo E, Clerico A, Federico G. | 02/4/2017 |
| CNP and FGF-23 act through a close or reciprocal pathway and are in agreement with recent studies demonstrating a down-regulatory role of the mitogen-activated protein kinase activity by CNP | Therapeutic effect of CNP on renal osteodystrophy by antagonizing the FGF-23/MAPK pathway.
Hu P, Huang BY, Xia X, Xuan Q, Hu B, Qin YH. | 11/19/2016 |
| CNP/NPR-B can affect sperm motility and acrosome reaction, thus regulating the reproductive function of males | Role of C-type natriuretic peptide in the function of normal human sperm.
Xia H, Chen Y, Wu KJ, Zhao H, Xiong CL, Huang DH., Free PMC Article | 10/1/2016 |
| CNP levels rose after paroxysmal supraventricular tachycardia and continued to rise after the termination. | Responses of cardiac natriuretic peptides after paroxysmal supraventricular tachycardia: ANP surges faster than BNP and CNP.
Kuo JY, Wang AM, Chang SH, Hung CL, Chen CY, Shih BF, Yeh HI. | 07/30/2016 |
| examined whether CNP reduces hyaluronan production and export via members of the multidrug resistance protein (MRP) and diminishes pro-inflammatory effects in chondrocytes | C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytes.
Peake NJ, Bader DL, Vessillier S, Ramachandran M, Salter DM, Hobbs AJ, Chowdhury TT. | 04/16/2016 |
| Plasma CNP might serve as a useful predictor for the therapeutic efficacy of metoprolol on postural tachycardia syndrome in children. | Plasma C-type natriuretic peptide as a predictor for therapeutic response to metoprolol in children with postural tachycardia syndrome.
Lin J, Han Z, Li H, Chen SY, Li X, Liu P, Wang Y, Tang C, Du J, Jin H., Free PMC Article | 03/5/2016 |
| CNP/proCNP could be new markers in human prostate cancer | C-type natriuretic peptide and its precursor: potential markers in human prostate cancer.
Lippert S, Iversen P, Brasso K, Goetze JP. | 01/16/2016 |