| OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1Induced Jak1Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis. | OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1‒Induced Jak1‒Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis.
Huang YZ, Zheng YX, Zhou Y, Xu F, Cui YZ, Chen XY, Wang ZY, Yan BX, Zheng M, Man XY. | 10/15/2022 |
| Long noncoding RNA SATB1-AS1 contributes to the chemotherapy resistance through the microRNA-580/ 2'-5'-oligoadenylate synthetase 2 axis in acute myeloid leukemia. | Long noncoding RNA SATB1-AS1 contributes to the chemotherapy resistance through the microRNA-580/ 2'-5'-oligoadenylate synthetase 2 axis in acute myeloid leukemia.
Zhou H, Jia X, Yang F, Shi P., Free PMC Article | 01/15/2022 |
| Structural and Hydrodynamic Characterization of Dimeric Human Oligoadenylate Synthetase 2. | Structural and Hydrodynamic Characterization of Dimeric Human Oligoadenylate Synthetase 2.
Koul A, Gemmill D, Lubna N, Meier M, Krahn N, Booy EP, Stetefeld J, Patel TR, McKenna SA., Free PMC Article | 06/12/2021 |
| Quantitative Proteomic Profile of Psoriatic Epidermis Identifies OAS2 as a Novel Biomarker for Disease Activity. | Quantitative Proteomic Profile of Psoriatic Epidermis Identifies OAS2 as a Novel Biomarker for Disease Activity.
Zhou Y, Wang P, Yan BX, Chen XY, Landeck L, Wang ZY, Li XX, Zhang J, Zheng M, Man XY., Free PMC Article | 04/13/2021 |
| The OAS2 showed a marked increase in activity with increasing dsRNA length with a minimum requirement of 35 bp. | Impact of double-stranded RNA characteristics on the activation of human 2'-5'-oligoadenylate synthetase 2 (OAS2).
Koul A, Deo S, Booy EP, Orriss GL, Genung M, McKenna SA. | 04/11/2020 |
| Low OAS2 expression is associated with colorectal cancer metastasis, mediating perineural and lymphovascular invasion. | Opposite functions of GSN and OAS2 on colorectal cancer metastasis, mediating perineural and lymphovascular invasion, respectively.
Kim JC, Ha YJ, Tak KH, Roh SA, Kwon YH, Kim CW, Yoon YS, Lee JL, Park Y, Kim SK, Kim SY, Cho DH, Kim YS., Free PMC Article | 02/23/2019 |
| OAS2 rs739901 5'-flanking C/A genetic polymorphisms involve the susceptibility to EV71 infection, and A allele might be a risk factor of the susceptibility to EV-71 infection. | Polymorphism of OAS2 rs739901 C/A Involves the Susceptibility to EV71 Infection in Chinese Children.
Tan YX, Wang H, Lv H, Liu PP, Xia SG, Wang Y, Wang GY, Guo Y, Liu YD, Yang CQ, Chen LP, Chen ZB. | 11/3/2018 |
| Mx1 and OAS1-2 polymorphisms were associated with the severity of liver disease in HIV/HCV-coinfected patients, suggesting a significant role in the progression of hepatic fibrosis. | Mx1, OAS1 and OAS2 polymorphisms are associated with the severity of liver disease in HIV/HCV-coinfected patients: A cross-sectional study.
García-Álvarez M, Berenguer J, Jiménez-Sousa MA, Pineda-Tenor D, Aldámiz-Echevarria T, Tejerina F, Diez C, Vázquez-Morón S, Resino S., Free PMC Article | 10/27/2018 |
| Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites. | Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites.
Gu X, Boldrup L, Coates PJ, Fahraeus R, Nylander E, Loizou C, Olofsson K, Norberg-Spaak L, Gärskog O, Nylander K., Free PMC Article | 05/19/2018 |
| we characterized the functional consequences of the Neandertal haplotype in the transcriptional regulation of OAS genes at baseline and infected conditions. We found that cells from people with the Neandertal-like haplotype express lower levels of OAS3 upon infection, as well as distinct isoforms of OAS1 and OAS2 | Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.
Sams AJ, Dumaine A, Nédélec Y, Yotova V, Alfieri C, Tanner JE, Messer PW, Barreiro LB., Free PMC Article | 06/24/2017 |
| Suggest 2'5'-oligoadenylate synthetase 2 mediates T-cell receptor CD3-zeta chain down-regulation via caspase-3 activation in oral cancer. | Extracellular 2'5'-oligoadenylate synthetase 2 mediates T-cell receptor CD3-ζ chain down-regulation via caspase-3 activation in oral cancer.
Dar AA, Pradhan TN, Kulkarni DP, Shah SU, Rao KV, Chaukar DA, D'Cruz AK, Chiplunkar SV., Free PMC Article | 06/4/2016 |
| Data obtained suggest that the OAS2 rs1293762 and CD209 rs2287886 SNPs are associated with predisposition to chronic hepatitis C in Russian population. | Association between polymorphisms in OAS2 and CD209 genes and predisposition to chronic hepatitis C in Russian population.
Barkhash AV, Kochneva GV, Chub EV, Mikhailova SV, Romaschenko AG. | 01/31/2015 |
| Primary mononuclear cells from patients with systemic sclerosis have increased basal levels of OASL and OAS2 genes. | Differential upregulation of human 2'5'OAS genes on systemic sclerosis: Detection of increased basal levels of OASL and OAS2 genes through a qPCR based assay.
de Freitas Almeida GM, Oliveira DB, Botelho LM, Silva LK, Guedes AC, Santos FP, Bonjardim CA, Ferreira PC, Kroon EG. | 10/4/2014 |
| The results suggest that OAS1-OAS3-OAS2 haplotypes are associated with differential susceptibility to clinical outcomes of dengue infection. | Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus infection.
Alagarasu K, Honap T, Damle IM, Mulay AP, Shah PS, Cecilia D. | 08/31/2013 |
| The data suggest a possible association between OAS2 and OAS3 single nucleotide polymorphisms and the outcome of tick-borne encephalitis virus infection in a Russian population. | Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease.
Barkhash AV, Perelygin AA, Babenko VN, Myasnikova NG, Pilipenko PI, Romaschenko AG, Voevoda MI, Brinton MA, Barkhash AV, Perelygin AA, Babenko VN, Myasnikova NG, Pilipenko PI, Romaschenko AG, Voevoda MI, Brinton MA. | 01/1/2011 |
| 2'-5'-oligoadenylate synthetase type 2 (OAS2), a dsRNA binding protein involved in the pathway that activates RNase-L, is identified as a new binding partner for NOD2. | Nucleotide oligomerization domain-2 interacts with 2'-5'-oligoadenylate synthetase type 2 and enhances RNase-L function in THP-1 cells.
Dugan JW, Albor A, David L, Fowlkes J, Blackledge MT, Martin TM, Planck SR, Rosenzweig HL, Rosenbaum JT, Davey MP., Free PMC Article | 01/21/2010 |
| Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | A pharmacogenetic study of polymorphisms in interferon pathway genes and response to interferon-alpha treatment in chronic hepatitis B patients.
Wu X, Zhu X, Zhu S, Li J, Ma J, Li Z, Li H, Liu Y. | 08/12/2009 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesVariability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease.
Barkhash AV, Perelygin AA, Babenko VN, Myasnikova NG, Pilipenko PI, Romaschenko AG, Voevoda MI, Brinton MA, Barkhash AV, Perelygin AA, Babenko VN, Myasnikova NG, Pilipenko PI, Romaschenko AG, Voevoda MI, Brinton MA. Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF, Goddard KA, Barreto ML, Reis MG, Teixeira MG. Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype?
Tessier MC, Qu HQ, Fréchette R, Bacot F, Grabs R, Taback SP, Lawson ML, Kirsch SE, Hudson TJ, Polychronakos C. | 03/13/2008 |
| Observational study of gene-environment interaction. (HuGE Navigator) | Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study.
King JK, Yeh SH, Lin MW, Liu CJ, Lai MY, Kao JH, Chen DS, Chen PJ. | 03/13/2008 |