MLL1 is regulated by KSHV LANA and is important for virus latency. | MLL1 is regulated by KSHV LANA and is important for virus latency. Tan M, Li S, Juillard F, Chitas R, Custódio TF, Xue H, Szymula A, Sun Q, Liu B, Álvarez ÁL, Chen S, Huang J, Simas JP, McVey CE, Kaye KM., Free PMC Article | 01/15/2022 |
The ORF45 Protein of Kaposi Sarcoma-Associated Herpesvirus Is an Inhibitor of p53 Signaling during Viral Reactivation. | The ORF45 Protein of Kaposi Sarcoma-Associated Herpesvirus Is an Inhibitor of p53 Signaling during Viral Reactivation. Alzhanova D, Meyo JO, Juarez A, Dittmer DP., Free PMC Article | 01/1/2022 |
LANA upregulates let-7a and its primary transcripts in parallel with its reduction of RBPJ expression. | Latency-associated nuclear antigen inhibits lytic replication of Kaposi's sarcoma-associated herpesvirus by regulating let-7a/RBPJ signaling. Qi Y, Zheng G, Di C, Zhang J, Wang X, Hong Y, Song Y, Chen R, Yang Y, Yan Y, Xu L, Tan X, Yang L. | 10/26/2019 |
research shows that intact LANA traffics to the cytoplasm of cells undergoing permissive lytic infections and latently infected cells in which the virus is induced to replicate. This suggests that LANA plays important roles in the cytoplasm and nuclear compartments of the cell during different stages of the life Kaposi's sarcoma-associated herpesvirus cycle. | Full-Length Isoforms of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Accumulate in the Cytoplasm of Cells Undergoing the Lytic Cycle of Replication. Garrigues HJ, Howard K, Barcy S, Ikoma M, Moses AV, Deutsch GH, Wu D, Ueda K, Rose TM., Free PMC Article | 12/16/2017 |
The findings highlight a second point at which cytoplasmic LANA interferes with the innate immune response, as well as the importance of the recently discovered role of cytoplasmic MRN complex members as innate sensors of cytoplasmic DNA for the control of KSHV replication. | Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency. Mariggiò G, Koch S, Zhang G, Weidner-Glunde M, Rückert J, Kati S, Santag S, Schulz TF., Free PMC Article | 09/30/2017 |
the Kaposi Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen (LANA) is capable of supporting Murine Gammaherpesvirus 68 latency in a mouse model of chronic infection but also functions to repress viral replication. | Murine Gammaherpesvirus 68 Expressing Kaposi Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen (LANA) Reveals both Functional Conservation and Divergence in LANA Homologs. Gupta A, Oldenburg DG, Salinas E, White DW, Forrest JC., Free PMC Article | 09/30/2017 |
KSHV LANA recruits host PRCs onto the lytic promoters to suppress lytic gene expression following de novo infection. | LANA-Mediated Recruitment of Host Polycomb Repressive Complexes onto the KSHV Genome during De Novo Infection. Toth Z, Papp B, Brulois K, Choi YJ, Gao SJ, Jung JU., Free PMC Article | 06/24/2017 |
Chimeric proteins constructed by fusion of LANA of Kaposi's sarcoma-associated herpesvirus with the NuMA could bind with ori-P and enhance replication of an ori-P-containing plasmid. | A chimeric protein composed of NuMA fused to the DNA binding domain of LANA is sufficient for the ori-P-dependent DNA replication. Ohsaki E, Ueda K. | 06/24/2017 |
This observation points to a novel function of the cytoplasmic isoforms of LANA during lytic replication and extends the function of LANA from its role during latency to the lytic replication cycle. | Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS. Zhang G, Chan B, Samarina N, Abere B, Weidner-Glunde M, Buch A, Pich A, Brinkmann MM, Schulz TF., Free PMC Article | 07/16/2016 |
The study shows that KSHV LANA and MHV-68 LANA proteins bind terminal repeat viral DNA using strikingly different modes. | KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA. Ponnusamy R, Petoukhov MV, Correia B, Custodio TF, Juillard F, Tan M, Pires de Miranda M, Carrondo MA, Simas JP, Kaye KM, Svergun DI, McVey CE., Free PMC Article | 04/2/2016 |
Bub1 in complex with LANA recruits PCNA to regulate Kaposi's sarcoma-associated herpesvirus latent replication and DNA translesion synthesis. | Bub1 in Complex with LANA Recruits PCNA To Regulate Kaposi's Sarcoma-Associated Herpesvirus Latent Replication and DNA Translesion Synthesis. Sun Z, Jha HC, Robertson ES., Free PMC Article | 12/19/2015 |
Nrf2 interaction with KSHV LANA-1 and the host KAP1 repress viral lytic gene expression. | Activated Nrf2 Interacts with Kaposi's Sarcoma-Associated Herpesvirus Latency Protein LANA-1 and Host Protein KAP1 To Mediate Global Lytic Gene Repression. Gjyshi O, Roy A, Dutta S, Veettil MV, Dutta D, Chandran B., Free PMC Article | 12/12/2015 |
Co-immunoprecipitation demonstrated LANA association with endogenous hSET1 complexes in both lymphoid and endothelial cells suggesting that LANA may contribute to the epigenetic profile of KSHV episomes | LANA binds to multiple active viral and cellular promoters and associates with the H3K4methyltransferase hSET1 complex. Hu J, Yang Y, Turner PC, Jain V, McIntyre LM, Renne R., Free PMC Article | 11/7/2015 |
LANA2 inhibits the modification of p53 by SUMO2 and reduction of p53-SUMO2 conjugation. | KSHV latent protein LANA2 inhibits sumo2 modification of p53. Laura MV, de la Cruz-Herrera CF, Ferreirós A, Baz-Martínez M, Lang V, Vidal A, Muñoz-Fontela C, Rodríguez MS, Collado M, Rivas C., Free PMC Article | 09/26/2015 |
Kaposi's sarcoma-associated herpesvirus - encoded LANA enhances glucocorticoid receptor activation and cell growth suppression in human B-lymphocytes. | Kaposi's sarcoma-associated herpesvirus-encoded LANA associates with glucocorticoid receptor and enhances its transcriptional activities. Togi S, Nakasuji M, Muromoto R, Ikeda O, Okabe K, Kitai Y, Kon S, Oritani K, Matsuda T. | 09/12/2015 |
propose a model for the controlled nucleation of higher-order LANA oligomers that might contribute to the characteristic subnuclear KSHV microdomains ("LANA speckles"), a hallmark of KSHV latency | The 3D structure of Kaposi sarcoma herpesvirus LANA C-terminal domain bound to DNA. Hellert J, Weidner-Glunde M, Krausze J, Lünsdorf H, Ritter C, Schulz TF, Lührs T., Free PMC Article | 08/29/2015 |
LANA recruited cellular proteins including replication factors, chromatin modifying enzymes and cellular mitotic apparatus assembly. [review] | KSHV LANA--the master regulator of KSHV latency. Uppal T, Banerjee S, Sun Z, Verma SC, Robertson ES., Free PMC Article | 07/25/2015 |
the interaction of LANA with RFX proteins interferes with the recruitment of CIITA to MHC-II promoters, resulting in an inhibition of MHC-II gene expression | Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Inhibits Major Histocompatibility Complex Class II Expression by Disrupting Enhanceosome Assembly through Binding with the Regulatory Factor X Complex. Thakker S, Purushothaman P, Gupta N, Challa S, Cai Q, Verma SC., Free PMC Article | 07/25/2015 |
both LANA1 and EBNA1 undergo highly efficient +1/-2 programmed ribosomal frameshifting to generate previously undescribed alternative reading frame (ARF) proteins in their repeat regions. | Human DNA tumor viruses generate alternative reading frame proteins through repeat sequence recoding. Kwun HJ, Toptan T, Ramos da Silva S, Atkins JF, Moore PS, Chang Y., Free PMC Article | 05/2/2015 |
LANA binds host and viral chromatin is highly dynamic and is disrupted in cells undergoing an extensive lytic reactivation. | Site-specific association with host and viral chromatin by Kaposi's sarcoma-associated herpesvirus LANA and its reversal during lytic reactivation. Mercier A, Arias C, Madrid AS, Holdorf MM, Ganem D., Free PMC Article | 10/4/2014 |
LANA of Human herpesvirus 8interacts with Aurora kinase B and induces phosphorylation of survivin at residue T34. | Kaposi's sarcoma-associated herpesvirus-encoded LANA contributes to viral latent replication by activating phosphorylation of survivin. Lu J, Jha HC, Verma SC, Sun Z, Banerjee S, Dzeng R, Robertson ES., Free PMC Article | 06/28/2014 |
Proteomic and co-immunoprecipitation analysis further reveal that the SUMO-2 modified transcription repressor KAP1 is a critical factor recruited by LANA(SIM). | A unique SUMO-2-interacting motif within LANA is essential for KSHV latency. Cai Q, Cai S, Zhu C, Verma SC, Choi JY, Robertson ES., Free PMC Article | 06/28/2014 |
The structural features of LANADBD suggest a novel mechanism of episome maintenance through DNA-binding induced oligomeric assembly. | Molecular basis for oligomeric-DNA binding and episome maintenance by KSHV LANA. Domsic JF, Chen HS, Lu F, Marmorstein R, Lieberman PM., Free PMC Article | 05/31/2014 |
A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins. | A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins. Hellert J, Weidner-Glunde M, Krausze J, Richter U, Adler H, Fedorov R, Pietrek M, Rückert J, Ritter C, Schulz TF, Lührs T., Free PMC Article | 05/31/2014 |
Viral long noncoding RNA promotes LANA-episome disassociation during virus reactivation. | A lytic viral long noncoding RNA modulates the function of a latent protein. Campbell M, Kim KY, Chang PC, Huerta S, Shevchenko B, Wang DH, Izumiya C, Kung HJ, Izumiya Y., Free PMC Article | 04/19/2014 |