| The presence of xanthine dehydrogenase is crucial for the maturation of the rat kidneys. | The presence of xanthine dehydrogenase is crucial for the maturation of the rat kidneys.
Dissanayake LV, Kravtsova O, Lowe M, McCrorey MK, Van Beusecum JP, Palygin O, Staruschenko A. | 02/29/2024 |
| S-allyl cysteine as potent anti-gout drug: Insight into the xanthine oxidase inhibition and anti-inflammatory activity. | S-allyl cysteine as potent anti-gout drug: Insight into the xanthine oxidase inhibition and anti-inflammatory activity.
Johnson P, Loganathan C, Iruthayaraj A, Poomani K, Thayumanavan P. | 12/1/2018 |
| Abdominal paracentesis drainage protects rats against severe acute pancreatitis-associated lung injury by reducing the mobilization of intestinal xanthine dehydrogenase. | Abdominal paracentesis drainage protects rats against severe acute pancreatitis-associated lung injury by reducing the mobilization of intestinal XDH/XOD.
Zhou J, Huang Z, Lin N, Liu W, Yang G, Wu D, Xiao H, Sun H, Tang L. | 01/6/2018 |
| Our results show that XOR is important to the cardiovascular responses to nitrite in 2K1C hypertension, and XOR inhibitors commonly used by patients may cancel this effect. This finding suggests that nitrite treatment may not be effective in patients being treated with XOR inhibitors | Tempol improves xanthine oxidoreductase-mediated vascular responses to nitrite in experimental renovascular hypertension.
Oliveira-Paula GH, Pinheiro LC, Guimaraes DA, Tella SO, Blanco AL, Angelis CD, Schechter AN, Tanus-Santos JE., Free PMC Article | 11/25/2017 |
| Hepatocyte growth factor prevents XO activation following hypoxia/reoxygenation primarily by inhibiting the JAK2 signaling pathway and in turn, inhibiting the increase in cytosolic Calcium. | Hepatocyte growth factor inhibits hypoxia/reoxygenation-induced activation of xanthine oxidase in endothelial cells through the JAK2 signaling pathway.
Zhang YQ, Hu SY, Chen YD, Guo MZ, Wang S., Free PMC Article | 03/11/2017 |
| Treatment with etaftorone decreased expression of inducible NOS and XOR in kidneys, whereas it increased the expression of endothelial NOS. | New 1,4-Dihydropyridines Down-regulate Nitric Oxide in Animals with Streptozotocin-induced Diabetes Mellitus and Protect Deoxyribonucleic Acid against Peroxynitrite Action.
Leonova E, Sokolovska J, Boucher JL, Isajevs S, Rostoka E, Baumane L, Sjakste T, Sjakste N. | 03/11/2017 |
| Results suggest that exaggerated XO activity and resultant increase in oxidative stress contributes to hypertension and xanthine oxidase inhibition could treat treating hypertension and related endothelial dysfunction. | Febuxostat, a novel xanthine oxidoreductase inhibitor, improves hypertension and endothelial dysfunction in spontaneously hypertensive rats.
Shirakura T, Nomura J, Matsui C, Kobayashi T, Tamura M, Masuzaki H., Free PMC Article | 02/25/2017 |
| The results thus demonstrate that XO mediates oxidative stress in MB+PQ-treated rat PMNs via iNOS-independent but cytokine (predominantly IFN-gamma)-dependent mechanism. | IFN-γ regulates xanthine oxidase-mediated iNOS-independent oxidative stress in maneb- and paraquat-treated rat polymorphonuclear leukocytes.
Singh D, Kumar V, Singh C. | 02/18/2017 |
| Transitional cell tumors induced by xanthine oxidase inhibitor topiroxostat in rats were due to physical stimulation to transitional cells of xanthine crystals/calculi. | Xanthine crystals induced by topiroxostat, a xanthine oxidoreductase inhibitor, in rats, cause transitional cell tumors.
Shimo T, Moto M, Ashizawa N, Matsumoto K, Iwanaga T, Saito K. | 05/7/2016 |
| Silencing xanthine oxidase blocked intermittent hypoxia-induced upregulation of HIF-1a demonstrating that HIF-1a activation requires Nox2 activation by xanthine oxidase. | HIF-1α activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase.
Nanduri J, Vaddi DR, Khan SA, Wang N, Makarenko V, Semenza GL, Prabhakar NR., Free PMC Article | 01/16/2016 |
| We have constructed a variant of the liver enzyme that lacks the carboxy-terminal amino acids 1316-1331; it appears to assume an intermediate form, exhibiting a mixture of dehydrogenase and oxidase activities. | The C-terminal peptide plays a role in the formation of an intermediate form during the transition between xanthine dehydrogenase and xanthine oxidase.
Nishino T, Okamoto K, Kawaguchi Y, Matsumura T, Eger BT, Pai EF, Nishino T., Free PMC Article | 12/5/2015 |
| metabolism of sodium metabisulfite in liver tissue increased XO activity, induced ER stress and caused caspase activation which was attenuated by ghrelin treatment | Induction of xanthine oxidase activity, endoplasmic reticulum stress and caspase activation by sodium metabisulfite in rat liver and their attenuation by Ghrelin.
Ercan S, Kencebay C, Basaranlar G, Derin N, Aslan M. | 12/5/2015 |
| Data suggest that, with aging, up-regulation of reactive oxygen species derived from XO down-regulates uric acid excretion via down-regulation of active homodimer breast cancer resistance protein (Bcrp1, uric acid efflux transporter) in ileal mucosa. | Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen.
Ogura J, Kuwayama K, Sasaki S, Kaneko C, Koizumi T, Yabe K, Tsujimoto T, Takeno R, Takaya A, Kobayashi M, Yamaguchi H, Iseki K. | 11/14/2015 |
| These results supported the possibility that XO/XD and AO can contribute to nitric oxide generation. | Nitrite reductase activity of rat and human xanthine oxidase, xanthine dehydrogenase, and aldehyde oxidase: evaluation of their contribution to NO formation in vivo.
Maia LB, Pereira V, Mira L, Moura JJ. | 04/18/2015 |
| Rat Xdh is a moonlighting protein that has two distinct catalytic activities as a dehydrogenase and an oxidase. | Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase: identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant.
Nishino T, Okamoto K, Kawaguchi Y, Hori H, Matsumura T, Eger BT, Pai EF, Nishino T. | 01/22/2014 |
| Allopurinol improves left ventricular contractile function and efficiency possibly by diminishing the known XO-mediated ROS effects on myofilament Ca(2+) sensitivity. | Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload.
Gladden JD, Zelickson BR, Guichard JL, Ahmed MI, Yancey DM, Ballinger S, Shanmugam M, Babu GJ, Johnson MS, Darley-Usmar V, Dell'Italia LJ., Free PMC Article | 01/11/2014 |
| crystal structures of the urate complexes of the demolybdo-form of the D428A mutant of rat xanthine oxidoreductase and of the reduced bovine milk enzyme | Crystal structures of urate bound form of xanthine oxidoreductase: substrate orientation and structure of the key reaction intermediate.
Okamoto K, Kawaguchi Y, Eger BT, Pai EF, Nishino T. | 09/7/2013 |
| 6-mercaptopurine treatment resulted in increased xanthine oxidase (Xdh) expression in the placenta. | 6-Mercaptopurine-induced histopathological changes and xanthine oxidase expression in rat placenta.
Taki K, Fukushima T, Ise R, Horii I, Yoshida T. | 10/20/2012 |
| Data show that aldehyde oxidase (AO) and xanthine oxidase (XO) activities increased significantly after induction of diabetes. | Aldehyde and xanthine oxidase activities in tissues of streptozotocin-induced diabetic rats: effects of vitamin E and selenium supplementation.
Ghaffari T, Nouri M, Saei AA, Rashidi MR. | 10/6/2012 |
| The present study indicates that enhancement of XO activity could be implicated in acrylonitrile-induced gastric damage in rats. | Acrylonitrile-induced gastric toxicity in rats: the role of xanthine oxidase.
Al-Abbasi FA., Free PMC Article | 09/29/2012 |
| inhibition ameliorates sympathetic innervation and arrhythmias | Differential effects of NADPH oxidase and xanthine oxidase inhibition on sympathetic reinnervation in postinfarct rat hearts.
Lee TM, Chen CC, Hsu YJ. | 09/24/2011 |
| Report differential effects of xanthine oxidase inhibition and exercise on albumin concentration in rat tissues. | Differential effects of xanthine oxidase inhibition and exercise on albumin concentration in rat tissues.
Veskoukis AS, Kyparos A, Stagos D, Kouretas D. | 08/30/2010 |
| Xanthine oxidase inhibition can offer protection from radiation-induced endothelial dysfunction and cardiovascular complications. | Dietary inhibition of xanthine oxidase attenuates radiation-induced endothelial dysfunction in rat aorta.
Soucy KG, Lim HK, Attarzadeh DO, Santhanam L, Kim JH, Bhunia AK, Sevinc B, Ryoo S, Vazquez ME, Nyhan D, Shoukas AA, Berkowitz DE. | 08/16/2010 |
| xanthine oxidase and nitric oxide synthase have a role in cocaine-induced oxidative damage to skin | Cocaine induces oxidative damage to skin via xanthine oxidase and nitric oxide synthase.
Portugal-Cohen M, Numa R, Yaka R, Kohen R. | 08/9/2010 |
| Xanthine oxidase contributes to mechanical ventilation-induced diaphragmatic oxidative stress and contractile dysfunction. | Xanthine oxidase contributes to mechanical ventilation-induced diaphragmatic oxidative stress and contractile dysfunction.
Whidden MA, McClung JM, Falk DJ, Hudson MB, Smuder AJ, Nelson WB, Powers SK., Free PMC Article | 01/21/2010 |