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    SERPINB2 serpin family B member 2 [ Homo sapiens (human) ]

    Gene ID: 5055, updated on 11-Sep-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The expression of SERPINB2 can be induced by diverse AhR ligands, the induction appears to rely on synthesis of a yet unknown protein, and no direct binding of AhR to sequences preceding SERPINB2 is necessary for the process. However, additional work is needed to unravel the complex interplay between AhR and diverse signal transduction pathways in the regulation of SERPINB2 expression.

    Expression of Serpin Peptidase Inhibitor B2 (SERPINB2) is regulated by Aryl hydrocarbon receptor (AhR).
    Brauze D, Kiwerska K, Bednarek K, Grenman R, Janiszewska J, Giefing M, Jarmuz-Szymczak M.

    Our data suggest that PAI2 inhibits invasive potential of HCC cells via uPA- and RB/E2F1-related mechanisms.

    Plasminogen activator inhibitor 2 (PAI2) inhibits invasive potential of hepatocellular carcinoma cells in vitro via uPA- and RB/E2F1-related mechanisms.
    Jin Y, Liang ZY, Zhou WX, Zhou L.

    our results provide additional details to the role of TGF-beta intracellular signalling pathway in OS and AD differentiation of hBMSC and identify SERPINB2 as a negative regulator of these effects

    SERPINB2 is a novel TGFβ-responsive lineage fate determinant of human bone marrow stromal cells.
    Elsafadi M, Manikandan M, Atteya M, Abu Dawud R, Almalki S, Ali Kaimkhani Z, Aldahmash A, Alajez NM, Alfayez M, Kassem M, Mahmood A., Free PMC Article

    the expression level of SERPINB2 gene significantly correlated with the severity of bronchial asthma

    Association between SERPINB2 Gene Expression by Real Time PCR in Respiratory Epithelial Cells and Atopic Bronchial Asthma Severity.
    ELBadawy NE, Abdel-Latif RS, El-Hady HA.

    miR-15a was identified as a downregulated miRNA in CCFs. Moreover, PAI-2 was identified as a novel target gene of miR-15a.

    The microRNA-15a-PAI-2 axis in cholangiocarcinoma-associated fibroblasts promotes migration of cancer cells.
    Utaijaratrasmi P, Vaeteewoottacharn K, Tsunematsu T, Jamjantra P, Wongkham S, Pairojkul C, Khuntikeo N, Ishimaru N, Sirivatanauksorn Y, Pongpaibul A, Thuwajit P, Thuwajit C, Kudo Y., Free PMC Article

    Single nucleotide polymorphisms in ICAM1 (rs1799969) and SERPINB2 (rs6103) genes were found to be protective against thalidomide-induced peripheral neuropathy (TiPN). In children with inflammatory bowel disease, TiPN is common but mild and generally reversible. Cumulative dose seems to be the most relevant risk factor, whereas polymorphisms in genes involved in neuronal inflammation may be protective.

    Risk Factors and Outcomes of Thalidomide-induced Peripheral Neuropathy in a Pediatric Inflammatory Bowel Disease Cohort.
    Bramuzzo M, Stocco G, Montico M, Arrigo S, Calvi A, Lanteri P, Costa S, Pellegrino S, Magazzù G, Barp J, Ghione S, Lionetti P, Zuin G, Fontana M, Di Chio T, Maggiore G, Lazzerini M, Lucafò M, Udina C, Pellegrin MC, Chicco A, Carrozzi M, Decorti G, Ventura A, Martelossi S.

    serpinB2 bound to and stabilized p21 to mediate senescence in a proteasome-independent manner, indicating that serpinB2 has a direct role in senescence. Thus, this study reveals a unique mechanism by which serpinB2 maintains senescence through stabilization of p21 protein levels.

    The serine protease inhibitor serpinB2 binds and stabilizes p21 in senescent cells.
    Hsieh HH, Chen YC, Jhan JR, Lin JJ.

    findings demonstrate the prospective role of SerpinB2 as a novel biomarker for acquired gefitinib resistance and a potential target for non-small cell lung cancer treatment.

    Down-regulation of SerpinB2 is associated with gefitinib resistance in non-small cell lung cancer and enhances invadopodia-like structure protrusions.
    Bae SY, Park HJ, Hong JY, Lee HJ, Lee SK., Free PMC Article

    SerpinB2 promotes miR-200c/141 cluster overexpression-induced breast cancer cell metastasis

    microRNA-200c/141 upregulates SerpinB2 to promote breast cancer cell metastasis and reduce patient survival.
    Jin T, Suk Kim H, Ki Choi S, Hye Hwang E, Woo J, Suk Ryu H, Kim K, Moon A, Kyung Moon W., Free PMC Article

    The current study revealed a significant increase level of TAFI and PAI-1, coupled with a decrease in PAI-2 in women with severe preeclampsia in comparison with the control group.

    Fibrinolysis parameters in Sudanese women with severe preeclampsia.
    Elzein HO, Muddathir AR, Rida M, Rayis DA, Elhassan EM, Adam I.

    PAI-2 likely plays a key role in cardiovascular disease through multiple pathophysiologic processes including racial dependency, platelet clot initiation and propagation, oxidative stress, inflammation effects on HDL metabolism and coagulation

    Influences on plasminogen activator inhibitor-2 polymorphism-associated recurrent cardiovascular disease risk in patients with high HDL cholesterol and inflammation.
    Corsetti JP, Salzman P, Ryan D, Moss AJ, Zareba W, Sparks CE.

    This study is the first to associate enhancer RNAs with SERPINB2 and is the first demonstration of acquisition of NELF binding by enhancer RNAs on chromatin.

    SERPINB2 is regulated by dynamic interactions with pause-release proteins and enhancer RNAs.
    Shii L, Song L, Maurer K, Zhang Z, Sullivan KE., Free PMC Article

    This study establishes a novel role for SerpinB2 in the stromal compartment in pancreatic ductal adenocarcinoma invasion through regulation of stromal remodelling

    SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer.
    Harris NLE, Vennin C, Conway JRW, Vine KL, Pinese M, Cowley MJ, Shearer RF, Lucas MC, Herrmann D, Allam AH, Pajic M, Morton JP, Australian Pancreatic Cancer Genome Initiative., Biankin AV, Ranson M, Timpson P, Saunders DN., Free PMC Article

    The variant of PAI-2 gene was associated with coronary artery disease and recurrent coronary event risk in Chinese Han population, in Xinjiang.

    Variant of PAI-2 gene is associated with coronary artery disease and recurrent coronary event risk in Chinese Han population.
    Li X, Luo JY, Zhang L, Yang YN, Xie X, Liu F, Chen BD, Ma YT., Free PMC Article

    SerpinB2 plays an important role in proteostas

    SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation.
    Lee JA, Yerbury JJ, Farrawell N, Shearer RF, Constantinescu P, Hatters DM, Schroder WA, Suhrbier A, Wilson MR, Saunders DN, Ranson M., Free PMC Article

    a total of 500 ESCC cases and 500 matched controls in a Southwest China population were evaluated for six SNPs in the exons of three Serpin genes (SerpinB5, SerpinB2, and SerpinE1).

    Association between SNPs in Serpin gene family and risk of esophageal squamous cell carcinoma.
    Meng H, Guan X, Guo H, Xiong G, Yang K, Wang K, Bai Y.

    Polymorphisms in this fibrinolytic system gene are associated with recurrent spontaneous abortion in Sinhalese women, probably through impaired implantation.

    Polymorphisms in the fibrinolytic pathway genes and the risk of recurrent spontaneous abortion.
    Andraweera PH, Dekker GA, Thompson SD, Nowak RC, Jayasekara RW, Dissanayake VH, Roberts CT.

    PAI-2 was up-regulated in tensioned keloid fibroblasts and normal fibroblasts, but more so in keloid cells. Knockdown of PAI2 reduced cell proliferation in fibroblasts under tension.

    Skin equivalent tensional force alters keloid fibroblast behavior and phenotype.
    Suarez E, Syed F, Rasgado TA, Walmsley A, Mandal P, Bayat A.

    Soluble guanylate cyclase activators might alleviate or reverse vascular remodeling in pulmonary hypertension through the up-regulation of PAI-2.

    The sGC activator inhibits the proliferation and migration, promotes the apoptosis of human pulmonary arterial smooth muscle cells via the up regulation of plasminogen activator inhibitor-2.
    Zhang S, Zou L, Yang T, Yang Y, Zhai Z, Xiao F, Wang C.

    We found no association between allele frequency and risk of multiples sclerosis for any single nucleotide polymorphism investigated for serpinb2

    Common genetic variants in the plasminogen activation pathway are not associated with multiple sclerosis.
    Cox MB, Bowden NA, Scott RJ, Lechner-Scott J.

    A role for SERPINB2 in patients with head and neck squamous cell carcinoma.

    SERPINB2 down-regulation contributes to chemoresistance in head and neck cancer.
    Huang Z, Li H, Huang Q, Chen D, Han J, Wang L, Pan C, Chen W, House MG, Nephew KP, Guo Z.

    Plasminogen activator inhibitor-2 polymorphism associates with recurrent coronary event risk in patients with high HDL and C-reactive protein levels.

    Plasminogen activator inhibitor-2 polymorphism associates with recurrent coronary event risk in patients with high HDL and C-reactive protein levels.
    Corsetti JP, Salzman P, Ryan D, Moss AJ, Zareba W, Sparks CE., Free PMC Article

    PSMB1 is part of the transcriptional machinery required for gastrin stimulated expression of PAI-2 and Reg1.

    The role of proteasome beta subunits in gastrin-mediated transcription of plasminogen activator inhibitor-2 and regenerating protein1.
    O'Hara A, Howarth A, Varro A, Dimaline R., Free PMC Article

    SerpinB2 can be induced by lentiviral infection in vivo.

    Induction of SerpinB2 and Th1/Th2 modulation by SerpinB2 during lentiviral infections in vivo.
    Major LD, Partridge TS, Gardner J, Kent SJ, de Rose R, Suhrbier A, Schroder WA., Free PMC Article

    Low expression of PAI-2 serves as a novel marker of portal vein tumor embolism and poor prognosis for hepatocellular cancer.

    Low expression of PAI-2 as a novel marker of portal vein tumor thrombosis and poor prognosis in hepatocellular carcinoma.
    Zhou L, Jin Y, Cui QC, Jin KM, Zhou WX, Xing BC.

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