| The A96S, G38D, and P88S Cx40 mutations slow conduction and increased the propensity for inducible AF. | Human Connexin40 Mutations Slow Conduction and Increase Propensity for Atrial Fibrillation.
Kanthan A, Fahmy P, Rao R, Pouliopoulos J, Alexander IE, Thomas SP, Kizana E. | 07/21/2018 |
| Lipopolysaccharide impairs permeability of pulmonary microvascular endothelial cells via Connexin40/protein kinase C/nfkappaB pathway. | Lipopolysaccharide impairs permeability of pulmonary microvascular endothelial cells via Connexin40.
Zhou HS, Li M, Sui BD, Wei L, Hou R, Chen WS, Li Q, Bi SH, Zhang JZ, Yi DH. | 07/14/2018 |
| This study demonstrated the Cx40 was upregulated after traumatic brain injury in a linear correlated manner with increased oxidative stress. | Connexin40 correlates with oxidative stress in brains of traumatic brain injury rats.
Chen W, Guo Y, Yang W, Zheng P, Zeng J, Tong W. | 01/13/2018 |
| data are consistent with contributions of G2 and D3 residues to Cx40 channel pore structure, but not with postulated hydrophobic W4 intermolecular interactions; results indicate an absolute requirement for an amphipathic W3/4 residue; alternatively hypothesize that the connexin D2/3-W3/4 locus interacts with the highly conserved FIFR M1 motif to stabilize the NT domain within the pore | Specificity of the connexin W3/4 locus for functional gap junction formation.
Xu Q, Lin X, Matiukas A, Zhang X, Veenstra RD., Free PMC Article | 07/15/2017 |
| Data show that the ratio of peripheral blood CD4(+)/CD8(+) T lymphocytes and the levels of connexin-40 (Cx40), interleukins IL-2, IL-4 and IL-6 are significantly elevated in SH rats. | [An increase in the ratio of peripheral blood CD4+/CD8+ T lymphocytes and the levels of connexin 40 and inflammatory factors in spontaneously hypertensive rats].
Wang A, Zhang H, Zhang L, Li X, Li L, Si J, Ma K. | 07/30/2016 |
| Cx40 expression in mesangial cells is related to mesangial cell regeneration | Glomerular expression of connexin 40 and connexin 43 in rat experimental glomerulonephritis.
Morioka T, Okada S, Nameta M, Kamal F, Yanakieva-Georgieva NT, Yao J, Sato A, Piao H, Oite T. | 12/14/2013 |
| The expressions of Cx40 and HCN4 increase obviously after coculturing bone marrow mesenchymal stem cells with sinoatrial node tissue. | [Expression of connexin 40 and hyperpolarization-activated cyclic nucleotide-gated cation channel 4 in rat bone marrow mesenchymal stem cells cocultured with sinoatrial node tissues in vitro].
Song B, Liao B, Yu F, Xia Z. | 08/31/2013 |
| Valsartan and U0126 were equivalent on attenuating atrial fibrosis and Cx40 remodeling by inhibiting ERK pathways at different levels. | [Effects of valsartan and U0126 on atrial fibrosis and connexin40 remodeling in rats].
Zhang WZ, Wang ZG, Chen YQ, Ma L, Li T, Bao HG, Li PH. | 03/23/2013 |
| three-dimensional molecular topography and calcium-sensitive conformational changes of Connexin40 hemichannels | Atomic force microscopy of Connexin40 gap junction hemichannels reveals calcium-dependent three-dimensional molecular topography and open-closed conformations of both the extracellular and cytoplasmic faces.
Allen MJ, Gemel J, Beyer EC, Lal R., Free PMC Article | 09/3/2011 |
| The demonstrated that in the endothelium of the native vein, the gap-junctional spot numbers (GJSNs) and the total gap-junctional areas (TGJAs) of Cx40 were lower than those of the thoracic aorta. | Differential endothelial gap junction expression in venous vessels exposed to different hemodynamics.
Chang CJ, Wu LS, Hsu LA, Chang GJ, Chen CF, Yeh HI, Ko YS., Free PMC Article | 01/1/2011 |
| Data show heterogeneous expression of the 3 Cx isoforms Cx43, Cx45, and Cx40 in heart. | [Quantitative connexin mRNA detection in posterior nodal extension of adult rat heart].
Ou Y, Niu XL, Han ZH, Ren FX, Huang C. | 06/14/2010 |
| Cx40/43 can regulate the superior mesenteric artery endothelium-dependent vascular contractive response through [Ca2+]i of vascular smooth muscle cells after hemorrhagic shock. | [Relationship between Cx40/43 regulating the intracellular Ca2+ concentration of vascular smooth muscle cell (VSMC) and endothelium-dependent vascular contractive response of superior mesenteric artery in rats].
Ming J, Xu J, Li T, Zhang Y, Yang GM, Liu LM. | 01/21/2010 |
| the selectivities of junctions formed by cells coexpressing Cx40 and Cx43 vary considerably, reflecting both their relative expression levels and phosphorylation-dependent regulation | Regulation of gap junctional charge selectivity in cells coexpressing connexin 40 and connexin 43.
Heyman NS, Kurjiaka DT, Ek Vitorin JF, Burt JM., Free PMC Article | 01/21/2010 |
| Report regulation of connexin 40 gene expression during skeletal muscle regeneration in the adult rat. | Regulation of connexin gene expression during skeletal muscle regeneration in the adult rat.
Trovato-Salinaro A, Belluardo N, Frinchi M, von Maltzahn J, Willecke K, Condorelli DF, Mudò G. | 01/21/2010 |
| Gap junctions, comprising connexins 37 and 40, transduce purinergic signals mediating renal autoregulation. | Connexins 37 and 40 transduce purinergic signals mediating renal autoregulation.
Takenaka T, Inoue T, Kanno Y, Okada H, Hill CE, Suzuki H. | 01/21/2010 |
| a cross-talk between CFTR and a variety of gap junction channels. Cytoskeletal scaffolding proteins and/or other intermediate cytoplasmic proteins are likely to play a role in CFTR-connexins interaction. | Interplay between cystic fibrosis transmembrane regulator and gap junction channels made of connexins 45, 40, 32 and 50 expressed in oocytes.
Kotsias BA, Salim M, Peracchia LL, Peracchia C. | 01/21/2010 |
| Structural remodelling of gap junction connexin proteins may partly underlie electrophysiological defects in STZ-induced diabetic rat sinus atrial node. | Altered expression of gap junction connexin proteins may partly underlie heart rhythm disturbances in the streptozotocin-induced diabetic rat heart.
Howarth FC, Nowotny N, Zilahi E, El Haj MA, Lei M. | 01/21/2010 |
| Renin-angiotensin system blockade corrects decreased expression of Cx37 and Cx40 in arterial endothelial cells of hypertensive rats, partly independently of blood pressure. | Angiotensin II receptor blockade corrects altered expression of gap junctions in vascular endothelial cells from hypertensive rats.
Kansui Y, Fujii K, Nakamura K, Goto K, Oniki H, Abe I, Shibata Y, Iida M. | 01/21/2010 |
| The total amount of connexins and the ratio of phosphorylated/non-phosphorylated isoforms gradually increased during the re-establishment of intercellular communication in heart myocytes. | Expression and regulation of connexins in cultured ventricular myocytes isolated from adult rat hearts.
Polontchouk LO, Valiunas V, Haefliger JA, Eppenberger HM, Weingart R. | 01/21/2010 |
| data suggest that the HKH motif at positions 15-17 is important to the conformational structure of the putative voltage sensor and spermine receptor of Cx40 | An amino-terminal lysine residue of rat connexin40 that is required for spermine block.
Lin X, Fenn E, Veenstra RD., Free PMC Article | 01/21/2010 |
| Adrenergic stimulation of cardiomyocytes can enhance connexin expression thereby increasing cellular coupling, indicating a possible role for catecholamines in the regulation of cardiac gap junction expression in cardiac disease. | Subchronic alpha- and beta-adrenergic regulation of cardiac gap junction protein expression.
Salameh A, Frenzel C, Boldt A, Rassler B, Glawe I, Schulte J, Mühlberg K, Zimmer HG, Pfeiffer D, Dhein S. | 01/21/2010 |
| Kinetics of Cx40 voltage gating. There was a temporal correlation between development of conduction delay or block and the inactivation phase of junctional conductance. | Action potential modulation of connexin40 gap junctional conductance.
Lin X, Veenstra RD. | 01/21/2010 |
| role for Cx40 in EDHF-mediated dilation of rat mesenteric arteries. | Rapid endothelial cell-selective loading of connexin 40 antibody blocks endothelium-derived hyperpolarizing factor dilation in rat small mesenteric arteries.
Mather S, Dora KA, Sandow SL, Winter P, Garland CJ. | 01/21/2010 |