A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS. | A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS. Johann L, Soldati S, Müller K, Lampe J, Marini F, Klein M, Schramm E, Ries N, Schelmbauer C, Palagi I, Karram K, Assmann JC, Khan MA, Wenzel J, Schmidt MH, Körbelin J, Schlüter D, van Loo G, Bopp T, Engelhardt B, Schwaninger M, Waisman A., Free PMC Article | 12/27/2023 |
Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunction-associated steatohepatitis. | Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunction-associated steatohepatitis. Provera A, Ramavath NN, Gadipudi LL, Gigliotti CL, Boggio E, Vecchio C, Stoppa I, Rolla R, Boldorini R, Pirisi M, Smirne C, Albano E, Dianzani U, Sutti S., Free PMC Article | 12/20/2023 |
Attenuate ICOSL and IL-27 in Aire-overexpressing DC2.4 cells suppress TFH cell differentiation. | Attenuate ICOSL and IL-27 in Aire-overexpressing DC2.4 cells suppress TFH cell differentiation. Zou X, Zhang Y, Wang S, Wang X, Yang W, Li Y. | 03/19/2022 |
ICOS ligand and IL-10 synergize to promote host-microbiota mutualism. | ICOS ligand and IL-10 synergize to promote host-microbiota mutualism. Landuyt AE, Klocke BJ, Duck LW, Kemp KM, Muir RQ, Jennings MS, Blum SI, Tse HM, Lee G, Morrow CD, Elson CO, Maynard CL., Free PMC Article | 10/23/2021 |
work identified a potentially novel role for ICOSL, which serves as an endogenous alphavbeta3-selective antagonist to maintain glomerular filtration. | Nonimmune cell-derived ICOS ligand functions as a renoprotective αvβ3 integrin-selective antagonist. Koh KH, Cao Y, Mangos S, Tardi NJ, Dande RR, Lee HW, Samelko B, Altintas MM, Schmitz VP, Lee H, Mukherjee K, Peev V, Cimbaluk DJ, Reiser J, Hahm E., Free PMC Article | 02/29/2020 |
study confirms the importance of ICOSL shedding in ICOS/ICOSL function and expression and it identifies ADAM10 as the most important sheddase for controlling ICOSL levels | ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses. Lownik JC, Luker AJ, Damle SR, Cooley LF, El Sayed R, Hutloff A, Pitzalis C, Martin RK, El Shikh MEM, Conrad DH., Free PMC Article | 10/28/2017 |
results showed that monocyte-derived osteoclast (OC)-like cells (MDOCs) express B7h during their differentiation, and that B7h triggering reversibly inhibits OC differentiation and function both in vitro and in vivo | ICOS-Ligand Triggering Impairs Osteoclast Differentiation and Function In Vitro and In Vivo. Gigliotti CL, Boggio E, Clemente N, Shivakumar Y, Toth E, Sblattero D, D'Amelio P, Isaia GC, Dianzani C, Yagi J, Rojo JM, Chiocchetti A, Boldorini R, Bosetti M, Dianzani U. | 08/12/2017 |
study concludse that lymphopenia-driven autoimmunity and the development of Tfh17 cells in Rasgrp1-deficient mice occur independently of CD275(B7-H2) | CD275-Independent IL-17-Producing T Follicular Helper-like Cells in Lymphopenic Autoimmune-Prone Mice. Smith C, Buhlmann JE, Wang X, Bartlett A, Lim B, Barrington RA., Free PMC Article | 08/5/2017 |
The expression of ICOSL in the cornea and the ICOS-mediated induction of Foxp3+ CD4+ regulatory T cells may contribute to successful corneal allograft survival. | Protective Role of ICOS and ICOS Ligand in Corneal Transplantation and in Maintenance of Immune Privilege. Kunishige T, Taniguchi H, Terada M, Akiba H, Yagita H, Abe R, Hori J. | 06/24/2017 |
this study shows that sICOSL in the serum of healthy donors increases in an age-dependent manner and that the matrix metalloproteinase inhibitor (MMPI) could suppress sICOSL production | Development of a novel monoclonal antibody to human inducible co-stimulator ligand (ICOSL): Biological characteristics and application for enzyme-linked immunosorbent assay. Hu X, Wu J, An J, Hu Y, Shen Y, Liu C, Zhang X. | 04/1/2017 |
There was a clearly positive correlation between the presence of IL-17-producing cells and ICOS expression in ICOSL KO mice; it also showed that Th17 was involved in the pathological tissue remodeling in liver fibrosis induced by schistosomiasis. | Th17 down-regulation is involved in reduced progression of schistosomiasis fibrosis in ICOSL KO mice. Wang B, Liang S, Wang Y, Zhu XQ, Gong W, Zhang HQ, Li Y, Xia CM., Free PMC Article | 01/30/2016 |
Selective ablation of ICOSL in CD11c+ cells, but not in B cells, dramatically ameliorates kidney and lung inflammation in lupus-prone transgenic mice. | Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus. Teichmann LL, Cullen JL, Kashgarian M, Dong C, Craft J, Shlomchik MJ., Free PMC Article | 05/16/2015 |
ICOS-ICOS-L interaction promoted cytokine production and survival in type 2 innate lymphoid cells through STAT5 signaling in asthma. | ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity. Maazi H, Patel N, Sankaranarayanan I, Suzuki Y, Rigas D, Soroosh P, Freeman GJ, Sharpe AH, Akbari O., Free PMC Article | 05/16/2015 |
restoring control of the T follicular helper-germinal center B-cell axis by blocking the ICOS-ICOSL pathway reduced the development of atherosclerosis and the formation of tertiary lymphoid organs. | Control of the T follicular helper-germinal center B-cell axis by CD8⁺ regulatory T cells limits atherosclerosis and tertiary lymphoid organ development. Clement M, Guedj K, Andreata F, Morvan M, Bey L, Khallou-Laschet J, Gaston AT, Delbosc S, Alsac JM, Bruneval P, Deschildre C, Le Borgne M, Castier Y, Kim HJ, Cantor H, Michel JB, Caligiuri G, Nicoletti A. | 04/11/2015 |
ICOSL is a molecular linkage between T-B interactional dynamics and positive selection for high-affinity bone-marrow plasma cell formation; study reveals a pathway by which follicular T-helper cells control the quality of long-lived humoral immunity | T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction. Liu D, Xu H, Shih C, Wan Z, Ma X, Ma W, Luo D, Qi H. | 02/21/2015 |
the costimulatory ligand ICOS ligand (ICOSL) is selectively downregulated on the surface of B cells in an ADAM17-specific manner, although it is not proteolitically processed by recombinant ADAM17 in vitro. | The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses. Marczynska J, Ozga A, Wlodarczyk A, Majchrzak-Gorecka M, Kulig P, Banas M, Michalczyk-Wetula D, Majewski P, Hutloff A, Schwarz J, Chalaris A, Scheller J, Rose-John S, Cichy J. | 11/29/2014 |
The need for additional immune suppression in the intestine reflects commensal microbe-driven T-cell activation through the accessory costimulation molecules ICOSL and OX40L in B7 deprived mice. | Commensal microbes drive intestinal inflammation by IL-17-producing CD4+ T cells through ICOSL and OX40L costimulation in the absence of B7-1 and B7-2. Xin L, Jiang TT, Chaturvedi V, Kinder JM, Ertelt JM, Rowe JH, Steinbrecher KA, Way SS., Free PMC Article | 10/4/2014 |
the B7h-ICOS interaction may modulate the spread of cancer metastases | B7h triggering inhibits the migration of tumor cell lines. Dianzani C, Minelli R, Gigliotti CL, Occhipinti S, Giovarelli M, Conti L, Boggio E, Shivakumar Y, Baldanzi G, Malacarne V, Orilieri E, Cappellano G, Fantozzi R, Sblattero D, Yagi J, Rojo JM, Chiocchetti A, Dianzani U. | 06/28/2014 |
Findings indicate the separable roles of delivery of antigens and ICOS-L by cognate B cells for follicular Th (Tfh) cell maturation and function. | B cells in T follicular helper cell development and function: separable roles in delivery of ICOS ligand and antigen. Weinstein JS, Bertino SA, Hernandez SG, Poholek AC, Teplitzky TB, Nowyhed HN, Craft J., Free PMC Article | 06/14/2014 |
Data indicate that the signals provided by ICOSL-expressing B cells to Teff cells and Tfh cells are necessary for the development of arthritis. | B cell-specific expression of inducible costimulator ligand is necessary for the induction of arthritis in mice. Hamel KM, Cao Y, Olalekan SA, Finnegan A. | 03/22/2014 |
ICOS-L maintains tolerance at the fetomaternal interface. | B7h (ICOS-L) maintains tolerance at the fetomaternal interface. Riella LV, Dada S, Chabtini L, Smith B, Huang L, Dakle P, Mfarrej B, D'Addio F, Adams LT, Kochupurakkal N, Vergani A, Fiorina P, Mellor AL, Sharpe AH, Yagita H, Guleria I., Free PMC Article | 11/16/2013 |
In cardiac transplantation apoptosis of CD8(+) T cells in recipient draining lymph nodes was enhanced by pretreatment with donor specific transfusion and impaired ICOS/B7h allorecognition. | Apoptosis of peripheral T cells in rodent cardiac allograft recipients induced by donor-specific transfusion with impaired inducible costimulator/B7 homologous protein allorecognition. Du JF, Shen XF, Ji XQ, Chen G, Bai X, Zuo FY, Yu B. | 08/31/2013 |
Data suggest that knockdown of Icosl in mouse leukemic cells may significantly enhance graft versus leukemia effect after allogeneic bone marrow transplantation. | Effects of ICOSLG expressed in mouse hematological neoplasm cell lines in the GVL reaction. Wang B, Ma N, Cheng H, Zhou H, Qiu H, Yang J, Wang J. | 06/29/2013 |
lineage-specific transgenic expression on dendritic and plasma cells generates different outcome upon ICOS costimulation | B7h-expressing dendritic cells and plasma B cells mediate distinct outcomes of ICOS costimulation in T cell-dependent antibody responses. Larimore K, Liang L, Bakkour S, Sha WC., Free PMC Article | 02/9/2013 |
Results indicate that ICOSLG blockade may enhance cytotoxity in allogeneic mixed lymphocyte-hematologic neoplasm cell reactions. | Expression of ICOSLG on mouse hematologic neoplasm cell lines and their influence on cytotoxicity in allogeneic mixed lymphocyte reactions. Wang B, Cheng H, Wang L, Zhou H, Wang J. | 08/25/2012 |