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    PAX5 paired box 5 [ Homo sapiens (human) ]

    Gene ID: 5079, updated on 5-May-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    EBF1, PAX5, and MYC: regulation on B cell development and association with hematologic neoplasms.

    EBF1, PAX5, and MYC: regulation on B cell development and association with hematologic neoplasms.
    Li L, Zhang D, Cao X., Free PMC Article

    03/11/2024
    PAX5 fusion genes in acute lymphoblastic leukemia: A literature review.

    PAX5 fusion genes in acute lymphoblastic leukemia: A literature review.
    Fouad FM, Eid JI., Free PMC Article

    06/26/2023
    FOXO1 and PAX5 Rearrangement in Alveolar Rhabdomyosarcoma in Saudi Pediatric Patients.

    FOXO1 and PAX5 Rearrangement in Alveolar Rhabdomyosarcoma in Saudi Pediatric Patients.
    Aljerian K.

    05/30/2023
    PAX5 aberrant expression incorporated in MIPI-SP risk scoring system exhibits additive value in mantle cell lymphoma.

    PAX5 aberrant expression incorporated in MIPI-SP risk scoring system exhibits additive value in mantle cell lymphoma.
    Zhang X, Han Y, Nie Y, Jiang Y, Sui X, Ge X, Liu F, Zhang Y, Wang X.

    05/11/2023
    Functional damaging germline variants in ETV6, IKZF1, PAX5 and RUNX1 predisposing to B-cell precursor acute lymphoblastic leukemia.

    Functional damaging germline variants in ETV6, IKZF1, PAX5 and RUNX1 predisposing to B-cell precursor acute lymphoblastic leukemia.
    Wagener R, Elitzur S, Brozou T, Borkhardt A.

    03/10/2023
    Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets.

    Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets.
    Bacos K, Perfilyev A, Karagiannopoulos A, Cowan E, Ofori JK, Bertonnier-Brouty L, Rönn T, Lindqvist A, Luan C, Ruhrmann S, Ngara M, Nilsson Å, Gheibi S, Lyons CL, Lagerstedt JO, Barghouth M, Esguerra JL, Volkov P, Fex M, Mulder H, Wierup N, Krus U, Artner I, Eliasson L, Prasad RB, Cataldo LR, Ling C., Free PMC Article

    02/23/2023
    PAX5/ITGAX Contributed to the Progression of Atherosclerosis by Regulation of B Differentiation via TNF-alpha Signaling Pathway.

    PAX5/ITGAX Contributed to the Progression of Atherosclerosis by Regulation of B Differentiation via TNF-α Signaling Pathway.
    Wang X, Guan Z, Tang W, Wang X, Xu C, Shan E, Wang W, Gao Y.

    02/18/2023
    PAX5 epigenetically orchestrates CD58 transcription and modulates blinatumomab response in acute lymphoblastic leukemia.

    PAX5 epigenetically orchestrates CD58 transcription and modulates blinatumomab response in acute lymphoblastic leukemia.
    Li Y, Moriyama T, Yoshimura S, Zhao X, Li Z, Yang X, Paietta E, Litzow MR, Konopleva M, Yu J, Inaba H, Ribeiro RC, Pui CH, Yang JJ., Free PMC Article

    12/24/2022
    DNA hypermethylation of CADM1, PAX5, WT1, RARbeta, and PAX6 genes in oropharyngeal cancer associated with human papillomavirus.

    DNA hypermethylation of CADM1, PAX5, WT1, RARβ, and PAX6 genes in oropharyngeal cancer associated with human papillomavirus.
    Birknerová N, Kovaříková H, Baranová I, Přikrylová A, Laco J, Vošmiková H, Gajdošová B, Hodek M, Vošmik M, Palička V, Chmelařová M., Free PMC Article

    10/29/2022
    The utility of PAX8 in comparison with PAX5 immunohistochemical staining in the diagnosis of Hodgkin lymphoma.

    The utility of PAX8 in comparison with PAX5 immunohistochemical staining in the diagnosis of Hodgkin lymphoma.
    Ameli F, Zahavi Z, Kosari F, Soleimani V.

    10/22/2022
    Clinical and immunophenotypic characteristics of familial leukemia predisposition caused by PAX5 germline variants.

    Clinical and immunophenotypic characteristics of familial leukemia predisposition caused by PAX5 germline variants.
    Escudero A, Takagi M, Auer F, Friedrich UA, Miyamoto S, Ogawa A, Imai K, Pascual B, Vela M, Stepensky P, Yasin L, Elitzur S, Borkhardt A, Pérez-Martínez A, Hauer J.

    10/22/2022
    The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa.

    The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa.
    Zhao Y, Song J, Dong W, Liu X, Yang C, Wang D, Xue Y, Ruan X, Liu L, Wang P, Zhang M, Liu Y., Free PMC Article

    09/24/2022
    PAX5 Haploinsufficiency Induces Low T Cell Infiltration in the Cancer Microenvironment via Reduced Chemokines.

    PAX5 Haploinsufficiency Induces Low T Cell Infiltration in the Cancer Microenvironment via Reduced Chemokines.
    Wang L, Liang X, Liang M, Li D, Gu J, Huang W, Zhou J.

    06/25/2022
    Delineation of a novel neurodevelopmental syndrome associated with PAX5 haploinsufficiency.

    Delineation of a novel neurodevelopmental syndrome associated with PAX5 haploinsufficiency.
    Gofin Y, Wang T, Gillentine MA, Scott TM, Berry AM, Azamian MS, Genetti C, Agrawal PB, Picker J, Wojcik MH, Delgado MR, Lynch SA, Scherer SW, Howe JL, Bacino CA, DiTroia S, VanNoy GE, O'Donnell-Luria A, Lalani SR, Graf WD, Rosenfeld JA, Eichler EE, Earl RK, Scott DA., Free PMC Article

    04/9/2022
    Paired box 5 increases the chemosensitivity of esophageal squamous cell cancer cells by promoting p53 signaling activity.

    Paired box 5 increases the chemosensitivity of esophageal squamous cell cancer cells by promoting p53 signaling activity.
    Zhang W, Yan W, Qian N, Han Q, Zhang W, Dai G., Free PMC Article

    03/19/2022
    Pax-5 Protein Expression Is Regulated by Transcriptional 3'UTR Editing.

    Pax-5 Protein Expression Is Regulated by Transcriptional 3'UTR Editing.
    Beauregard AP, Hannay B, Gharib E, Crapoulet N, Finn N, Guerrette R, Ouellet A, Robichaud GA., Free PMC Article

    03/5/2022
    PAX5 haploinsufficiency induced CD8+ T cells dysfunction or exhaustion by high expression of immune inhibitory-related molecules.

    PAX5 haploinsufficiency induced CD8+ T cells dysfunction or exhaustion by high expression of immune inhibitory-related molecules.
    Liang M, Gong D, Wang L, Liang X, Meng J, Huang W, Zhou J.

    02/19/2022
    Distinct clinical characteristics of DUX4- and PAX5-altered childhood B-lymphoblastic leukemia.

    Distinct clinical characteristics of DUX4- and PAX5-altered childhood B-lymphoblastic leukemia.
    Li Z, Lee SHR, Chin WHN, Lu Y, Jiang N, Lim EH, Coustan-Smith E, Chiew KH, Oh BLZ, Koh GS, Chen Z, Kham SKY, Quah TC, Lin HP, Tan AM, Ariffin H, Yang JJ, Yeoh AE., Free PMC Article

    01/15/2022
    DGCR5 is activated by PAX5 and promotes pancreatic cancer via targeting miR-3163/TOP2A and activating Wnt/beta-catenin pathway.

    DGCR5 is activated by PAX5 and promotes pancreatic cancer via targeting miR-3163/TOP2A and activating Wnt/β-catenin pathway.
    Liu SL, Cai C, Yang ZY, Wu ZY, Wu XS, Wang XF, Dong P, Gong W., Free PMC Article

    01/15/2022
    PAX5-induced upregulation of LINC01194 exerts oncogenic properties by regulating GOLPH3 expression via miR-486-5p in prostate cancer.

    PAX5-induced upregulation of LINC01194 exerts oncogenic properties by regulating GOLPH3 expression via miR-486-5p in prostate cancer.
    Song HR, Guo XB, Duan Y, Meng HY, Wang ZY.

    01/8/2022
    PAX5-activated lncRNA ARRDC1-AS1 accelerates the autophagy and progression of DLBCL through sponging miR-2355-5p to regulate ATG5.

    PAX5-activated lncRNA ARRDC1-AS1 accelerates the autophagy and progression of DLBCL through sponging miR-2355-5p to regulate ATG5.
    Xu H, Yu X, Yang Z, Song Q, Cheng S, He Z, Dai L.

    12/4/2021
    Transcription factors Kruppel-like factor 4 and paired box 5 regulate the expression of the Grainyhead-like genes.

    Transcription factors Krüppel-like factor 4 and paired box 5 regulate the expression of the Grainyhead-like genes.
    Kotarba G, Taracha-Wisniewska A, Miller M, Dabrowski M, Wilanowski T., Free PMC Article

    11/27/2021
    Identification of novel, clonally stable, somatic mutations targeting transcription factors PAX5 and NKX2-3, the epigenetic regulator LRIF1, and BRAF in a case of atypical B-cell chronic lymphocytic leukemia harboring a t(14;18)(q32;q21).

    Identification of novel, clonally stable, somatic mutations targeting transcription factors PAX5 and NKX2-3, the epigenetic regulator LRIF1, and BRAF in a case of atypical B-cell chronic lymphocytic leukemia harboring a t(14;18)(q32;q21).
    Burlet B, Ramla S, Fournier C, Abrey-Recalde MJ, Sauter C, Chrétien ML, Rossi C, Duffourd Y, Ragot S, Buriller C, Tournier B, Chapusot C, Nadal N, Racine J, Guy J, Bailly F, Martin L, Casasnovas O, Bastie JN, Caillot D, Albuisson J, Broccardo C, Thieblemont C, Delva L, Maynadié M, Aucagne R, Callanan MB., Free PMC Article

    11/27/2021
    Prognostic significance of p53, Sox11, and Pax5 co-expression in mantle cell lymphoma.

    Prognostic significance of p53, Sox11, and Pax5 co-expression in mantle cell lymphoma.
    Jing C, Zheng Y, Feng Y, Cao X, Xu C., Free PMC Article

    11/13/2021
    PAX5 activates telomerase activity and proliferation in keloid fibroblasts by transcriptional regulation of SND1, thus promoting keloid growth in burn-injured skin.

    PAX5 activates telomerase activity and proliferation in keloid fibroblasts by transcriptional regulation of SND1, thus promoting keloid growth in burn-injured skin.
    Qin G, Sun Y, Guo Y, Song Y.

    11/6/2021
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