| IL-27/IL-27R Mediates Protective Immunity against Chlamydial Infection by Suppressing Excessive Th17 Responses and Reducing Neutrophil Inflammation. | IL-27/IL-27R Mediates Protective Immunity against Chlamydial Infection by Suppressing Excessive Th17 Responses and Reducing Neutrophil Inflammation.
Zha X, Yang S, Niu W, Tan L, Xu Y, Zeng J, Tang Y, Sun L, Pang G, Qiao S, Zhang H, Liu T, Zhao H, Zheng N, Zhang Y, Bai H. | 08/28/2021 |
| Deficiency of IL-27 Signaling Exacerbates Experimental Autoimmune Uveitis with Elevated Uveitogenic Th1 and Th17 Responses. | Deficiency of IL-27 Signaling Exacerbates Experimental Autoimmune Uveitis with Elevated Uveitogenic Th1 and Th17 Responses.
Wu S, Ma R, Zhong Y, Chen Z, Zhou H, Zhou M, Chong W, Chen J., Free PMC Article | 07/31/2021 |
| IL-27 Ralpha(+) cells promoted allorejection via enhancing STAT1/3/5 phosphorylation. | IL-27 Rα(+) cells promoted allorejection via enhancing STAT1/3/5 phosphorylation.
Zhao S, Liang T, Zhang C, Shi D, Jiang W, Su C, Hou G., Free PMC Article | 05/15/2021 |
| Loss of IL-27Ralpha Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses. | Loss of IL-27Rα Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses.
Coppock GM, Aronson LR, Park J, Qiu C, Park J, DeLong JH, Radaelli E, Suszták K, Hunter CA., Free PMC Article | 03/20/2021 |
| Aging-induced IL27Ra signaling impairs hematopoietic stem cells. | Aging-induced IL27Ra signaling impairs hematopoietic stem cells.
He H, Xu P, Zhang X, Liao M, Dong Q, Cong T, Tang B, Yang X, Ye M, Chang Y, Liu W, Wang X, Ju Z, Wang J. | 02/27/2021 |
| Impaired Interleukin-27-Mediated Control of CD4+ T Cell Function Impact on Ectopic Lymphoid Structure Formation in Patients With Sjogren's Syndrome. | Impaired Interleukin-27-Mediated Control of CD4+ T Cell Function Impact on Ectopic Lymphoid Structure Formation in Patients With Sjögren's Syndrome.
Lucchesi D, Coleby R, Pontarini E, Prediletto E, Rivellese F, Hill DG, Derrac Soria A, Jones SA, Humphreys IR, Sutcliffe N, Tappuni AR, Pitzalis C, Jones GW, Bombardieri M. | 01/16/2021 |
| IL-27Ralpha: A Novel Molecular Imaging Marker for Allograft Rejection. | IL-27Rα: A Novel Molecular Imaging Marker for Allograft Rejection.
Zhao S, Shi D, Su C, Jiang W, Zhang C, Liang T, Hou G., Free PMC Article | 11/28/2020 |
| IL-27 production was elevated during Clostridium difficile infection in humans and mice. Infected WSX-1-/- mice experienced increased weight loss, enhanced colonic histology damage, less Clostridium difficile clearance, and decreased survival compared to wild-type controls during Clostridium difficile infection. | IL-27/IL-27 Receptor Signaling Provides Protection in Clostridium difficile-Induced Colitis.
Wang L, Cao J, Li C, Zhang L. | 04/13/2019 |
| this paper shows that the increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-alpha-deficient mice is supported by IL-17A and is associated with the IL-17A-induced expansion of multifunctional T cells | The increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-alpha-deficient mice is supported by IL-17A and is associated with the IL-17A-induced expansion of multifunctional T cells.
Erdmann H, Behrends J, Ritter K, Hölscher A, Volz J, Rosenkrands I, Hölscher C. | 01/12/2019 |
| show that IL-27R signaling controls endothelial cells activation and myeloid cell recruitment at early and advanced stages of atherosclerosis. In the absence of IL-27R myeloid cells become hyperactivated, produce pro-inflammatory cytokines and act as more potent antigen presenting cells. | IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis.
Peshkova IO, Fatkhullina AR, Mikulski Z, Ley K, Koltsova EK., Free PMC Article | 12/22/2018 |
| data suggested that IL-27/IL-27R expression induced by Toxoplasma gondii infection may regulate mast cell-mediated immune response during acute ocular toxoplasmosis in mouse model | Increased IL-27/IL-27R expression in association with the immunopathology of murine ocular toxoplasmosis.
Tong X, Chen S, Zheng H, Huang S, Lu F. | 12/8/2018 |
| Study reports a high-incidence, low-variation spontaneous mouse model of spondyloarthropathy that delineates how the combination of inflammatory cytokine interleukin-27 (IL-27) signaling deficiency and mitogenic signaling (mutant p53R172H) in vivo, leads to bone loss in the vertebral bodies and ossification of the cartilage in the intervertebral discs. | A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53.
Dibra D, Xia X, Gagea M, Lozano G, Li S., Free PMC Article | 07/7/2018 |
| IL-27 signaling in Foxp3(+) Tregs essential for Tregs to control autoimmune inflammation in the central nervous system | Treg-specific IL-27Rα deletion uncovers a key role for IL-27 in Treg function to control autoimmunity.
Do J, Kim D, Kim S, Valentin-Torres A, Dvorina N, Jang E, Nagarajavel V, DeSilva TM, Li X, Ting AH, Vignali DAA, Stohlman SA, Baldwin WM 3rd, Min B., Free PMC Article | 06/9/2018 |
| The combination of mutant p53 & IL27RA(-/-) causes spontaneous liver inflammation, steatosis, and fibrosis, whereas either gene alone has no effects on the liver. | Mutant p53 in concert with an interleukin-27 receptor alpha deficiency causes spontaneous liver inflammation, fibrosis, and steatosis in mice.
Dibra D, Xia X, Mitra A, Cutrera JJ, Lozano G, Li S., Free PMC Article | 07/16/2016 |
| IL-10 production by CD4(+) YFP(+) T cells is controlled systemically during malaria infection through IL-27 receptor signaling that is supported after CD4(+) T cell priming by ICOS signaling. | Parasite-Specific CD4+ IFN-γ+ IL-10+ T Cells Distribute within Both Lymphoid and Nonlymphoid Compartments and Are Controlled Systemically by Interleukin-27 and ICOS during Blood-Stage Malaria Infection.
Villegas-Mendez A, Shaw TN, Inkson CA, Strangward P, de Souza JB, Couper KN., Free PMC Article | 05/28/2016 |
| The significant expression of IL-27 in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor pair is detrimental in TB. | Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection.
Torrado E, Fountain JJ, Liao M, Tighe M, Reiley WW, Lai RP, Meintjes G, Pearl JE, Chen X, Zak DE, Thompson EG, Aderem A, Ghilardi N, Solache A, McKinstry KK, Strutt TM, Wilkinson RJ, Swain SL, Cooper AM., Free PMC Article | 11/7/2015 |
| IL-27R-mediated regulation of IL-17 controls the development of respiratory syncytial virus-associated pathogenesis. | IL-27R-mediated regulation of IL-17 controls the development of respiratory syncytial virus-associated pathogenesis.
de Almeida Nagata DE, Demoor T, Ptaschinski C, Ting HA, Jang S, Reed M, Mukherjee S, Lukacs NW., Free PMC Article | 01/3/2015 |
| CCL4 and CCL5 expression was higher in livers of infected WSX-1(-/-) mice than infected WT mice, and hepatic CD4 T cells from WSX-1(-/-) mice expressed higher levels of CCR5 than cells from WT mice | WSX-1 signalling inhibits CD4⁺ T cell migration to the liver during malaria infection by repressing chemokine-independent pathways.
Villegas-Mendez A, Gwyer Findlay E, de Souza JB, Grady LM, Saris CJ, Lane TE, Riley EM, Couper KN., Free PMC Article | 07/26/2014 |
| The loss of IL-27R signaling across the whole mouse resulted in reduced viral control and a slight increase in the number of virus-specific CD4 T cells at early stages of viral infection. | Cell-intrinsic IL-27 and gp130 cytokine receptor signaling regulates virus-specific CD4⁺ T cell responses and viral control during chronic infection.
Harker JA, Dolgoter A, Zuniga EI., Free PMC Article | 11/23/2013 |
| Diminution of the Th1 response in infected Il27ra mice in vivo by neutralization of IL-12p40 attenuated CCR5 expression. | IL-27 receptor signaling regulates CD4+ T cell chemotactic responses during infection.
Gwyer Findlay E, Villegas-Mendez A, de Souza JB, Inkson CA, Shaw TN, Saris CJ, Hunter CA, Riley EM, Couper KN., Free PMC Article | 08/3/2013 |
| These findings establish a novel antiatherogenic role for IL-27 receptor signaling, which acts to suppress the production of proinflammatory cytokines and chemokines and to curb the recruitment of inflammatory myeloid cells into atherosclerotic aortas. | Interleukin-27 receptor limits atherosclerosis in Ldlr-/- mice.
Koltsova EK, Kim G, Lloyd KM, Saris CJ, von Vietinghoff S, Kronenberg M, Ley K., Free PMC Article | 01/12/2013 |
| In Th1-dependent autoinflammatory lesions, IL-27Ralpha has a biphasic role in vivo, initially pathogenic, but ultimately playing a protective role by regulating immune responses and attenuating disease. | The IL-27 receptor has biphasic effects in crescentic glomerulonephritis mediated through Th1 responses.
Summers SA, Phoon RK, Ooi JD, Holdsworth SR, Kitching AR., Free PMC Article | 05/28/2011 |
| Data show that the deletion of Il27ra ameliorates pathology in the pristane-induced SLE model. | IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells.
Batten M, Ramamoorthi N, Kljavin NM, Ma CS, Cox JH, Dengler HS, Danilenko DM, Caplazi P, Wong M, Fulcher DA, Cook MC, King C, Tangye SG, de Sauvage FJ, Ghilardi N., Free PMC Article | 02/5/2011 |
| Findings demonstrate the essential role of IL-27R signaling in regulating effector T cell function during malaria infection and reveal a novel pathway that might be amenable to manipulation by drugs or vaccines. | Essential role for IL-27 receptor signaling in prevention of Th1-mediated immunopathology during malaria infection.
Findlay EG, Greig R, Stumhofer JS, Hafalla JC, de Souza JB, Saris CJ, Hunter CA, Riley EM, Couper KN. | 09/27/2010 |
| an alternatively spliced WSX-1 isoform enables humanine to rescue Alzheimer's disease relevant neuronal death. | Identification of soluble WSX-1 not as a dominant-negative but as an alternative functional subunit of a receptor for an anti-Alzheimer's disease rescue factor Humanin.
Hashimoto Y, Kurita M, Matsuoka M. | 01/21/2010 |