| Heparin activation of protein Z-dependent protease inhibitor (ZPI) allosterically blocks protein Z activation through an extended heparin-binding site. | Heparin activation of protein Z-dependent protease inhibitor (ZPI) allosterically blocks protein Z activation through an extended heparin-binding site.
Huang X, Swanson R, Olson ST., Free PMC Article | 07/2/2022 |
| Plasma concentration of protein Z-dependent protease inhibitor and ZPI exon 3 mutations in preeclampsia. | Plasma concentration of protein Z-dependent protease inhibitor and ZPI exon 3 mutations in preeclampsia.
Zhang P, Li YC, Li L, Lu Y. | 01/8/2022 |
| these results suggest an important anticoagulant role for the ZPI-PZ complex in regulating both free FXa generated in the initiation phase of coagulation as well as prothrombinase-bound FXa in the propagation phase that complement prothrombinase regulation by APC. | Protein Z-dependent protease inhibitor (ZPI) is a physiologically significant inhibitor of prothrombinase function.
Huang X, Swanson R, Kroh HK, Bock PE., Free PMC Article | 12/14/2019 |
| PZ/ZPI polymorphisms do not appear to play an active role in the development of prosthesis heart valve thrombosis. | The Role of Protein Z and Protein Z-Dependent Protease Inhibitor Polymorphisms in the Development of Prosthetic Heart Valve Thrombosis.
Karakoyun S, Ozan Gürsoy M, Kalçık M, Yesin M, Gündüz S, Ali Astarcıoğlu M, Bayram Z, Çakal B, Bayam E, Özkan M. | 06/16/2018 |
| Data suggest oxidized lipid vesicles with phosphatidylserine/polyunsaturated fatty acids promote inactivation of ZPI-PZ complex or free ZPI; binding of PZ-complexed or free ZPI to oxidized vesicles mediates inactivation of ZPI (an inhibitor of FXa); blocking heparin- (anticoagulant-)binding site on ZPI interferes with binding to lipid or PZ. (ZPI = protein Z-dependent protease inhibitor; PZ = protein Z; FXa = factor Xa) | Lipid oxidation inactivates the anticoagulant function of protein Z-dependent protease inhibitor (ZPI).
Huang X, Liu B, Wei Y, Beyea R, Yan H, Olson ST., Free PMC Article | 09/30/2017 |
| rs2232710 SNV showed no association with DVT in two Dutch replication cohorts the LETS study and the MEGA study, indicating that the rs2232710 variant is not a risk factor for DVT | Single Nucleotide Variant rs2232710 in the Protein Z-Dependent Protease Inhibitor (ZPI, SERPINA10) Gene Is Not Associated with Deep Vein Thrombosis.
Gorski MM, Lotta LA, Pappalardo E, de Haan HG, Passamonti SM, van Hylckama Vlieg A, Martinelli I, Peyvandi F., Free PMC Article | 07/30/2016 |
| Results show the energetic basis of the Z-dependent protease inhibitor (ZPI)-protein Z (PZ) interaction and suggest an important role for ZPI Lys-239 in PZ catalytic action. | Thermodynamic and kinetic characterization of the protein Z-dependent protease inhibitor (ZPI)-protein Z interaction reveals an unexpected role for ZPI Lys-239.
Huang X, Zhou J, Zhou A, Olson ST., Free PMC Article | 06/27/2015 |
| The unbalance between PZ and ZPI in plasma samples from patients with Colorectal Cancer or Pancreatic Cancer is not only related to an inflammatory state but could also results from an ectopic synthesis of these proteins by the cancer cells. | Unbalance between plasma levels of Protein Z and protein Z-dependent inhibitor in patients with colorectal and pancreatic cancer: a pilot study.
Doat S, Borgel D, François JH, Bianchini E, Botton J, François D, Mitry E, Vasse M. | 09/20/2014 |
| Protein Z EGF2 subdomain constitutes an interactive-site for ZPI protein. | Characterization of the protein Z-dependent protease inhibitor interactive-sites of protein Z.
Qureshi SH, Lu Q, Manithody C, Yang L, Rezaie AR., Free PMC Article | 09/13/2014 |
| Protein Z/protein Z-dependent protease inhibitor and Fxa expression in human gastric cancer cells indicate that these proteins may play a role in anticoagulant events at the tumor tissue. | Protein Z/protein Z-dependent protease inhibitor system in loco in human gastric cancer.
Sierko E, Wojtukiewicz MZ, Zimnoch L, Tokajuk P, Ostrowska-Cichocka K, Kisiel W., Free PMC Article | 05/31/2014 |
| the PZ/ZPI complex may play some modulating role in hemophilia A | Plasma concentration of protein Z and protein Z-dependent protease inhibitor in patients with haemophilia A.
Bolkun L, Galar M, Piszcz J, Lemancewicz D, Kloczko J. | 10/19/2013 |
| structural features within residues of the 39-loop contribute to the resistance of FIXa to inhibition by plasma inhibitors ZPI and TFPI. | Residues of the 39-loop restrict the plasma inhibitor specificity of factor IXa.
Yang L, Rezaie AR., Free PMC Article | 07/13/2013 |
| The study shows by Ala-scanning mutagenesis of the ZPI-binding interface, together with native PAGE and kinetic analyses of PZ binding to ZPI, that Tyr240 and Asp293 of ZPI are crucial hot spots for PZ binding. | Structural basis for catalytic activation of protein Z-dependent protease inhibitor (ZPI) by protein Z.
Huang X, Yan Y, Tu Y, Gatti J, Broze GJ Jr, Zhou A, Olson ST., Free PMC Article | 11/3/2012 |
| Report two missense mutations identified in venous thrombosis patients impair the inhibitory function of the ZPI were not convincingly associted with thrombosis risk. | Two missense mutations identified in venous thrombosis patients impair the inhibitory function of the protein Z dependent protease inhibitor.
Young LK, Birch NP, Browett PJ, Coughlin PB, Horvath AJ, Van de Water NS, Ockelford PA, Harper PL. | 09/1/2012 |
| heparin-binding site of ZPI was mapped: basic residues of both helices C and D of ZPI interact with heparin to modulate the inhibitory function of the serpin. | Characterization of the heparin-binding site of the protein z-dependent protease inhibitor.
Yang L, Ding Q, Huang X, Olson ST, Rezaie AR., Free PMC Article | 08/25/2012 |
| Plasma ZPI levels were unchanged in non-pregnant recurrent miscarriage women, while the plasma PZ level was slightly reduced, a finding consistent with existing reports. | Increase in the plasma levels of protein Z-dependent protease inhibitor in normal pregnancies but not in non-pregnant patients with unexplained recurrent miscarriage.
Souri M, Sugiura-Ogasawara M, Saito S, Kemkes-Matthes B, Meijers JC, Ichinose A. | 08/4/2012 |
| Medium expression of ZPI(IRS=6.5), together with weak expression of PZ(IRS=4), was observed in cancer cells. | Protein Z/protein Z-dependent protease inhibitor system in human non-small-cell lung cancer tissue.
Sierko E, Wojtukiewicz MZ, Zimnoch L, Ostrowska-Cichocka K, Tokajuk P, Ramlau R, Kisiel W. | 07/28/2012 |
| localization of PZ/ZPI and FX in colon cancer cells indicates that PZ/ZPI may contribute to anticoagulant events at the tumor site. | Co-localization of Protein Z, Protein Z-Dependent protease inhibitor and coagulation factor X in human colon cancer tissue: implications for coagulation regulation on tumor cells.
Sierko E, Wojtukiewicz MZ, Zimnoch L, Tokajuk P, Ostrowska-Cichocka K, Kisiel W. | 07/28/2012 |
| The results demonstrate that both ZPI R67X and W303X non-sense variants and specific ZPI haplotypes are significantly associated with recurrent spontaneous miscarriage. | Association of the R67X and W303X non-sense polymorphisms in the protein Z-dependent protease inhibitor gene with idiopathic recurrent miscarriage.
AlShaikh FS, Finan RR, Almawi AW, Mustafa FE, Almawi WY., Free PMC Article | 07/7/2012 |
| heparin activates ZPI to inhibit free factor Xa as well as factor XIa and therefore may play a physiologically and pharmacologically important role in ZPI anticoagulant function. | Heparin is a major activator of the anticoagulant serpin, protein Z-dependent protease inhibitor.
Huang X, Rezaie AR, Broze GJ Jr, Olson ST., Free PMC Article | 05/21/2011 |
| present in loco in human breast cancer tissue | Protein Z-dependent protease inhibitor (ZPI) is present in loco in human breast cancer tissue.
Sierko E, Wojtukiewicz MZ, Ostrowska-Cichocka K, Zimnoch L. | 02/26/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Data show that mutation of four ZPI contact residues eliminated PZ binding and membrane-dependent PZ acceleration of fXa inhibition. | Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa.
Huang X, Dementiev A, Olson ST, Gettins PG., Free PMC Article | 08/30/2010 |
| PROTEIN A AND PZI WERE FOUND IN KIDNEY TUBULES BY IMMUNOHISTOCHEMISTRY | Protein Z and protein Z-dependent protease inhibitor and renal tubules.
Broze GJ Jr, Tu Y., Free PMC Article | 05/31/2010 |
| Data show that the structural model of ZPI/FXa is compatible with available experimental information regarding the importance for the inhibitory action of certain basic residues in FXa. | A computational modeling and molecular dynamics study of the Michaelis complex of human protein Z-dependent protease inhibitor (ZPI) and factor Xa (FXa).
Chandrasekaran V, Lee CJ, Lin P, Duke RE, Pedersen LG., Free PMC Article | 01/21/2010 |