| Genetic Variants in WNT16 and PKD2L1 Locus Affect Heel Ultrasound Bone Stiffness: Analyses from the General Population and Patients Evaluated for Osteoporosis. | Genetic Variants in WNT16 and PKD2L1 Locus Affect Heel Ultrasound Bone Stiffness: Analyses from the General Population and Patients Evaluated for Osteoporosis.
Kragl A, Hannemann A, Nauck M, Völker U, Siggelkow H, Teumer A, Tzvetkov MV., Free PMC Article | 11/2/2023 |
| Whole-genome sequencing identifies rare missense variants of WNT16 and ERVW-1 causing the systemic lupus erythematosus. | Whole-genome sequencing identifies rare missense variants of WNT16 and ERVW-1 causing the systemic lupus erythematosus.
Chen J, Zhang P, Chen H, Wang X, He X, Zhong J, Zheng H, Li X, Jakovlić I, Zhang Y, Chen Y, Shen B, Deng C, Wu Y. | 12/31/2022 |
| Associations between WNT signaling pathway-related gene polymorphisms and risks of osteoporosis development in Chinese postmenopausal women: a case-control study. | Associations between WNT signaling pathway-related gene polymorphisms and risks of osteoporosis development in Chinese postmenopausal women: a case-control study.
Yang Z, Liu J, Fu J, Li S, Chai Z, Sun Y. | 05/21/2022 |
| WNT16 from decidual stromal cells regulates HTR8/SVneo trophoblastic cell function via AKT/beta-catenin pathway. | WNT16 from decidual stromal cells regulates HTR8/SVneo trophoblastic cell function via AKT/beta-catenin pathway.
Li X, Shi J, Zhao W, Huang X, Cui L, Liu L, Jin X, Li D, Zhang X, Du M. | 04/2/2022 |
| Bone mineral density in high-level endurance runners: Part B-genotype-dependent characteristics. | Bone mineral density in high-level endurance runners: Part B-genotype-dependent characteristics.
Herbert AJ, Williams AG, Lockey SJ, Erskine RM, Sale C, Hennis PJ, Day SH, Stebbings GK., Free PMC Article | 03/19/2022 |
| WNT16 elevation induced cell senescence of osteoblasts in ankylosing spondylitis. | WNT16 elevation induced cell senescence of osteoblasts in ankylosing spondylitis.
Jo S, Weon S, Nam B, Jang MA, Kang H, Kim TJ, Park YS, Kim TH., Free PMC Article | 12/18/2021 |
| Lower WNT16 expression in patients with adolescent idiopathic scoliosis - potential link to lower bone mass in AIS? | Lower WNT16 expression in patients with adolescent idiopathic scoliosis - potential link to lower bone mass in AIS?
Cheng KL, Li QQ, Wang Y, Zhang J, Lam TP, Hung A, Cheng J, Lee W. | 07/3/2021 |
| Short Communication: The Association of WNT16 Polymorphisms with the CD4(+) T Cell Count in the HIV-Infected Population. | Short Communication: The Association of WNT16 Polymorphisms with the CD4(+) T Cell Count in the HIV-Infected Population.
Xie L, Huang Y, Zhong J, Wei H, Chen S, Jiang K, Li S, Qin X. | 01/16/2021 |
| significant differences in the polymorphisms of the WNT16 rs2908004 genetic variant contributes to the pathogenesis of osteoporosis | Genetic Predisposition for Osteoporosis and Fractures in Postmenopausal Women.
Mitek T, Nagraba Ł, Deszczyński J, Stolarczyk M, Kuchar E, Stolarczyk A. | 11/30/2019 |
| Study identified two rare variants in functional regions of WNT16 (rs190011371 in WNT16b 3'UTR and rs570754792 in the SOST TATA box) found present in women with low BMD. | Common and rare variants of WNT16, DKK1 and SOST and their relationship with bone mineral density.
Martínez-Gil N, Roca-Ayats N, Monistrol-Mula A, García-Giralt N, Díez-Pérez A, Nogués X, Mellibovsky L, Grinberg D, Balcells S., Free PMC Article | 10/19/2019 |
| there was a significant difference in the genotypic frequencies of rs2707466 between hypertrophic and atrophic hip OA in males, with overrepresentation of G alleles in the hypertrophic phenotype. An association in the same direction was observed between these alleles and the type of knee OA, with G alleles being more common in the hypertrophic than in atrophic knee phenotypes | Non-synonymous WNT16 polymorphisms alleles are associated with different osteoarthritis phenotypes.
García-Ibarbia C, Neila S, Garcés C, Alonso MA, Zarrabeitia MT, Valero C, Ortiz F, Riancho JA. | 07/21/2018 |
| WNT16B recognizes cancer cell surface receptors including frizzled (FZD) 3/4/6, a process enhanced by SFRP2, coordinated by the co-receptor LRP6 but subject to abrogation by DKK1. | SFRP2 augments WNT16B signaling to promote therapeutic resistance in the damaged tumor microenvironment.
Sun Y, Zhu D, Chen F, Qian M, Wei H, Chen W, Xu J., Free PMC Article | 09/2/2017 |
| PRKX, WNT3 and WNT16 genes, belonging to the WNT signaling pathway, are involved in the tumorigenic process of nodular basal cell carcinoma | Altered Expression of PRKX, WNT3 and WNT16 in Human Nodular Basal Cell Carcinoma.
DO Carmo NG, Sakamoto LH, Pogue R, DO Couto Mascarenhas C, Passos SK, Felipe MS, DE Andrade RV. | 02/18/2017 |
| ThE findingS suggests that WNT16 might be an important genetic factor in determining peak bone mass acquisition. | Polymorphisms of the WNT16 gene are associated with the heel ultrasound parameter in young adults.
Correa-Rodríguez M, Schmidt Rio-Valle J, Rueda-Medina B. | 12/17/2016 |
| Although in vitro studies demonstrated no differences in expressions of wild-type and mutant forms of IDUA and WNT16B proteins, in silico analyses predicts that WNT16 rs2707466 directly abolishes a phosphorylation site, which could cause a deleterious effect on WNT16 protein. | Identification of IDUA and WNT16 Phosphorylation-Related Non-Synonymous Polymorphisms for Bone Mineral Density in Meta-Analyses of Genome-Wide Association Studies.
Niu T, Liu N, Yu X, Zhao M, Choi HJ, Leo PJ, Brown MA, Zhang L, Pei YF, Shen H, He H, Fu X, Lu S, Chen XD, Tan LJ, Yang TL, Guo Y, Cho NH, Shen J, Guo YF, Nicholson GC, Prince RL, Eisman JA, Jones G, Sambrook PN, Tian Q, Zhu XZ, Papasian CJ, Duncan EL, Uitterlinden AG, Shin CS, Xiang S, Deng HW., Free PMC Article | 11/5/2016 |
| MicroRNA-374b Suppresses Proliferation and Promotes Apoptosis in T-cell Lymphoblastic Lymphoma by Repressing AKT1 and Wnt-16 | MicroRNA-374b Suppresses Proliferation and Promotes Apoptosis in T-cell Lymphoblastic Lymphoma by Repressing AKT1 and Wnt-16.
Qian D, Chen K, Deng H, Rao H, Huang H, Liao Y, Sun X, Lu S, Yuan Z, Xie D, Cai Q. | 08/20/2016 |
| Data indicate that WNT16 is critical for positive regulation of both cortical and trabecular bone mass and structure. WNT16-TG mice exhibited significantly higher whole-body areal bone mineral density and bone mineral content. | Osteoblast-Specific Overexpression of Human WNT16 Increases Both Cortical and Trabecular Bone Mass and Structure in Mice.
Alam I, Alkhouli M, Gerard-O'Riley RL, Wright WB, Acton D, Gray AK, Patel B, Reilly AM, Lim KE, Robling AG, Econs MJ., Free PMC Article | 06/28/2016 |
| ALL cells expressing WNT16 are sensitive to endoplasmic reticulum stress, and show enhanced killing after addition of chloroquine. | WNT16-expressing Acute Lymphoblastic Leukemia Cells are Sensitive to Autophagy Inhibitors after ER Stress Induction.
Verras M, Papandreou I, Denko NC., Free PMC Article | 04/30/2016 |
| loss of endogenous WNT16 results specifically in cortical bone loss, whereas overexpression of WNT16 surprisingly increases mainly trabecular bone mass. | The bone-sparing effects of estrogen and WNT16 are independent of each other.
Movérare-Skrtic S, Wu J, Henning P, Gustafsson KL, Sjögren K, Windahl SH, Koskela A, Tuukkanen J, Börjesson AE, Lagerquist MK, Lerner UH, Zhang FP, Gustafsson JÅ, Poutanen M, Ohlsson C., Free PMC Article | 04/16/2016 |
| Describe TGFbeta-Wnt16-Notch signaling conduit in the chondrocyte-like transformation of VSMCs and identify endogenous TGFbeta activity in MGP-null VSMCs as a critical mediator of chondrogenesis. | Wnt16 attenuates TGFβ-induced chondrogenic transformation in vascular smooth muscle.
Beazley KE, Nurminsky D, Lima F, Gandhi C, Nurminskaya MV., Free PMC Article | 04/16/2016 |
| variants at WNT16 were more strongly related to upper limb-bone mineral density, than to bone mineral density at the other sites. | Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
Kemp JP, Medina-Gomez C, Estrada K, St Pourcain B, Heppe DH, Warrington NM, Oei L, Ring SM, Kruithof CJ, Timpson NJ, Wolber LE, Reppe S, Gautvik K, Grundberg E, Ge B, van der Eerden B, van de Peppel J, Hibbs MA, Ackert-Bicknell CL, Choi K, Koller DL, Econs MJ, Williams FM, Foroud T, Zillikens MC, Ohlsson C, Hofman A, Uitterlinden AG, Davey Smith G, Jaddoe VW, Tobias JH, Rivadeneira F, Evans DM., Free PMC Article | 06/27/2015 |
| Osteoblast-derived WNT16 is a previously unreported key regulator of osteoclastogenesis and fracture susceptibility. | Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures.
Movérare-Skrtic S, Henning P, Liu X, Nagano K, Saito H, Börjesson AE, Sjögren K, Windahl SH, Farman H, Kindlund B, Engdahl C, Koskela A, Zhang FP, Eriksson EE, Zaman F, Hammarstedt A, Isaksson H, Bally M, Kassem A, Lindholm C, Sandberg O, Aspenberg P, Sävendahl L, Feng JQ, Tuckermann J, Tuukkanen J, Poutanen M, Baron R, Lerner UH, Gori F, Ohlsson C., Free PMC Article | 01/24/2015 |
| Increased translation of WNT16 can thus lead to an increased inhibitory action of WNT16 on canonical WNT signaling. | Variation in the Kozak sequence of WNT16 results in an increased translation and is associated with osteoporosis related parameters.
Hendrickx G, Boudin E, Fijałkowski I, Nielsen TL, Andersen M, Brixen K, Van Hul W. | 09/13/2014 |
| Common missense polymorphisms of the WNT16 gene are associated with bone mineral density at the hip, calcaneal ultrasound and the buckling ratio of the femoral neck, as well as with hip fractures in individuals under 80 years of age. | Missense polymorphisms of the WNT16 gene are associated with bone mass, hip geometry and fractures.
García-Ibarbia C, Pérez-Núñez MI, Olmos JM, Valero C, Pérez-Aguilar MD, Hernández JL, Zarrabeitia MT, González-Macías J, Riancho JA. | 03/15/2014 |
| Estrogen/progesterone treatment of mature myometrial cells induced expression of WNT11 and WNT16, which remained constitutively elevated in leiomyoma tissues. | Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth.
Ono M, Yin P, Navarro A, Moravek MB, Coon JS 5th, Druschitz SA, Serna VA, Qiang W, Brooks DC, Malpani SS, Ma J, Ercan CM, Mittal N, Monsivais D, Dyson MT, Yemelyanov A, Maruyama T, Chakravarti D, Kim JJ, Kurita T, Gottardi CJ, Bulun SE., Free PMC Article | 12/14/2013 |