| Biochemical Activity of 17 Cancer-Associated Variants of DNA Polymerase Kappa Predicted by Electrostatic Properties. | Biochemical Activity of 17 Cancer-Associated Variants of DNA Polymerase Kappa Predicted by Electrostatic Properties.
Pathira Kankanamge LS, Mora A, Ondrechen MJ, Beuning PJ., | 11/22/2023 |
| Miscoding and DNA Polymerase Stalling by Methoxyamine-Adducted Abasic Sites. | Miscoding and DNA Polymerase Stalling by Methoxyamine-Adducted Abasic Sites.
Yudkina AV, Zharkov DO. | 03/12/2022 |
| Cryo-EM structure of human Pol kappa bound to DNA and mono-ubiquitylated PCNA. | Cryo-EM structure of human Pol κ bound to DNA and mono-ubiquitylated PCNA.
Lancey C, Tehseen M, Bakshi S, Percival M, Takahashi M, Sobhy MA, Raducanu VS, Blair K, Muskett FW, Ragan TJ, Crehuet R, Hamdan SM, De Biasio A., Free PMC Article | 12/4/2021 |
| DNA polymerases eta and kappa bypass N(2)-guanine-O(6)-alkylguanine DNA alkyltransferase cross-linked DNA-peptides. | DNA polymerases η and κ bypass N(2)-guanine-O(6)-alkylguanine DNA alkyltransferase cross-linked DNA-peptides.
Ghodke PP, Guengerich FP., Free PMC Article | 11/27/2021 |
| Regulation of the error-prone DNA polymerase Polkappa by oncogenic signaling and its contribution to drug resistance. | Regulation of the error-prone DNA polymerase Polκ by oncogenic signaling and its contribution to drug resistance.
Temprine K, Campbell NR, Huang R, Langdon EM, Simon-Vermot T, Mehta K, Clapp A, Chipman M, White RM., Free PMC Article | 11/6/2021 |
| Translesion synthesis of 6-nitrochrysene-derived 2'-deoxyadenosine adduct in human cells. | Translesion synthesis of 6-nitrochrysene-derived 2'-deoxyadenosine adduct in human cells.
Powell BV, Bacurio JHT, Basu AK., Free PMC Article | 04/3/2021 |
| Kinetic Investigation of Translesion Synthesis across a 3-Nitrobenzanthrone-Derived DNA Lesion Catalyzed by Human DNA Polymerase Kappa. | Kinetic Investigation of Translesion Synthesis across a 3-Nitrobenzanthrone-Derived DNA Lesion Catalyzed by Human DNA Polymerase Kappa.
Phi KK, Smith MC, Tokarsky EJ, Suo Z., Free PMC Article | 10/3/2020 |
| The polymorphisms (rs3213801 and rs5744533) of DNA polymerase kappa gene are not related with glioma risk and prognosis: A case-control study. | The polymorphisms (rs3213801 and rs5744533) of DNA polymerase kappa gene are not related with glioma risk and prognosis: A case-control study.
Wu Y, Zhou L, Deng Y, Li N, Yang P, Dong S, Yang S, Zheng Y, Yao L, Zhang M, Zhai Z, Dai Z, Wu Y., Free PMC Article | 09/26/2020 |
| pol kappa has roles both in maintaining and compromising genomic integrity. The expression of pol kappa is altered in several different cancer types, which can lead to genome instability. In addition, many cancer-associated single-nucleotide polymorphisms have been reported in the POLK gene, some of which are associated with poor survival and altered chemotherapy response | Mammalian DNA Polymerase Kappa Activity and Specificity.
Stern HR, Sefcikova J, Chaparro VE, Beuning PJ., Free PMC Article | 01/11/2020 |
| observations from molecular dynamics simulations suggest a possible explanation for the observed experimental results that pol kappa adopts specific active and inactive conformations that depend on both the protein variant and the identity of the DNA adduct | Characterization of Nine Cancer-Associated Variants in Human DNA Polymerase κ.
Antczak NM, Walker AR, Stern HR, Leddin EM, Palad C, Coulther TA, Swett RJ, Cisneros GA, Beuning PJ., Free PMC Article | 07/6/2019 |
| Biochemical and structural work provides the basis for the mechanism by which polkappa performs the error-free and efficient replication across the major cisplatin lesion at the second insertion and extension stages. Polkappa accommodates the highly flexible Pt-GG adduct in a stable conformation, which minimizes the instability of the replicating base pair. | Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender.
Jha V, Ling H. | 05/18/2019 |
| These results suggest that POLK genetic polymorphism rs73120833 plays an important role on the prognosis of small cell lung cancer patients, which can be potential genetic biomarker for small cell lung cancer personalized treatment. | [Genetic variation in DNA polymerase kappa gene is associated with the prognosis after platinum-based chemotherapy in small cell lung cancer patients].
Chen JN, Feng T, Yang J, Li HM, Yuan P, Ma F, Yin LL, Lin DX, Xu BH, Tan W. | 03/30/2019 |
| This study found that human DNA Polymerase kappa is more tolerant to changes in the active site loop than E. coli DinB. [DinB] | Human Y-Family DNA Polymerase κ Is More Tolerant to Changes in Its Active Site Loop than Its Ortholog Escherichia coli DinB.
Antczak NM, Packer MR, Lu X, Zhang K, Beuning PJ. | 12/30/2017 |
| Two X-ray crystal structures of POLK provide mechanistic insights into the error-free lucidin-N(2)-dG DNA adduct bypass catalyzed by POLK. | Mechanism of Error-Free DNA Replication Past Lucidin-Derived DNA Damage by Human DNA Polymerase κ.
Yockey OP, Jha V, Ghodke PP, Xu T, Xu W, Ling H, Pradeepkumar PI, Zhao L., Free PMC Article | 12/30/2017 |
| POLH & POLK are both able to exchange with PolD1 stalled at repetitive CFS (common fragile sites) sequences. POLD1 synthesis was inhibited by replication stress caused by aphidicolin, preventing any replication past CFS. Importantly, POLH & POLK were still proficient in rescuing this stalled POLD1 synthesis. POLD1 stalling at CFSs allows for free exchange with specialized polymerase that is not driven by PCNA. | DNA polymerases eta and kappa exchange with the polymerase delta holoenzyme to complete common fragile site synthesis.
Barnes RP, Hile SE, Lee MY, Eckert KA., Free PMC Article | 12/30/2017 |
| Data suggest that error-free DNA replication through 3-deaza-3-methyladenine adduct is mediated via three different pathways dependent upon POL-iota/POL-kappa, POL-theta, and POL-zeta. | Translesion synthesis DNA polymerases promote error-free replication through the minor-groove DNA adduct 3-deaza-3-methyladenine.
Yoon JH, Roy Choudhury J, Park J, Prakash S, Prakash L., Free PMC Article | 12/23/2017 |
| The structure of polK captured at the lesion-extension stage is reported: the enzyme is extending the primer strand after the base pair containing the BP-dG adduct in the template strand at the -1 position. PolK accommodates the BP adduct in the nascent DNA's minor groove and keeps the adducted DNA helix in a B-form. | Structural basis of accurate replication beyond a bulky major benzo[a]pyrene adduct by human DNA polymerase kappa.
Jha V, Ling H. | 07/29/2017 |
| A report on the structure of human polkappa in complex with a major benzo[a]pyrene adduct reveal a unique mechanism for accurate replication by translesion synthesis past the major bulky adduct. | Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ.
Jha V, Bian C, Xing G, Ling H., Free PMC Article | 05/27/2017 |
| These studies revealed that POLK is a crucial host factor required for covalently closed circular DNA formation during a de novo HBV infection | DNA Polymerase κ Is a Key Cellular Factor for the Formation of Covalently Closed Circular DNA of Hepatitis B Virus.
Qi Y, Gao Z, Xu G, Peng B, Liu C, Yan H, Yao Q, Sun G, Liu Y, Tang D, Song Z, He W, Sun Y, Guo JT, Li W., Free PMC Article | 05/20/2017 |
| DNA polymerases eta and kappa are capable of bypassing of a bulky guanine lesion during DNA replication. | Pre-steady-state kinetic investigation of bypass of a bulky guanine lesion by human Y-family DNA polymerases.
Tokarsky EJ, Gadkari VV, Zahurancik WJ, Malik CK, Basu AK, Suo Z., Free PMC Article | 05/20/2017 |
| POLK protein polymorphisms may influence the risk of developing breast cancer among Chinese women. | Association Between Single Nucleotide Polymorphisms in DNA Polymerase Kappa Gene and Breast Cancer Risk in Chinese Han Population: A STROBE-Compliant Observational Study.
Dai ZJ, Liu XH, Ma YF, Kang HF, Jin TB, Dai ZM, Guan HT, Wang M, Liu K, Dai C, Yang XW, Wang XJ., Free PMC Article | 06/4/2016 |
| Somatic Mutations in Catalytic Core of POLK Reported in Prostate Cancer Alter Translesion DNA Synthesis | Somatic Mutations in Catalytic Core of POLK Reported in Prostate Cancer Alter Translesion DNA Synthesis.
Yadav S, Mukhopadhyay S, Anbalagan M, Makridakis N., Free PMC Article | 05/14/2016 |
| POLK not only protects cells from genotoxic DNA lesions via DNA polymerase activities, but also contributes to genome integrity by acting as a non-catalytic protein against oxidative damage caused by hydrogen peroxide and menadione. | Catalytic and non-catalytic roles of DNA polymerase κ in the protection of human cells against genotoxic stresses.
Kanemaru Y, Suzuki T, Niimi N, Grúz P, Matsumoto K, Adachi N, Honma M, Nohmi T. | 04/30/2016 |
| The steric gate is crucial for rNTP discrimination because of its role in specifically promoting a dNTP-induced conformational change and that rNTP discrimination occurs in a relatively closed state of the polymerases. | Steric gate residues of Y-family DNA polymerases DinB and pol kappa are crucial for dNTP-induced conformational change.
Nevin P, Engen JR, Beuning PJ., Free PMC Article | 02/13/2016 |
| The structural dynamics of DinB1 changes upon substrate binding, noncognate DNA damage prevents the formation of the active conformation of DINB1. | Noncognate DNA damage prevents the formation of the active conformation of the Y-family DNA polymerases DinB and DNA polymerase κ.
Nevin P, Lu X, Zhang K, Engen JR, Beuning PJ., Free PMC Article | 10/31/2015 |