| Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy. | Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy.
Trefny MP, Kirchhammer N, Auf der Maur P, Natoli M, Schmid D, Germann M, Fernandez Rodriguez L, Herzig P, Lötscher J, Akrami M, Stinchcombe JC, Stanczak MA, Zingg A, Buchi M, Roux J, Marone R, Don L, Lardinois D, Wiese M, Jeker LT, Bentires-Alj M, Rossy J, Thommen DS, Griffiths GM, Läubli H, Hess C, Zippelius A., Free PMC Article | 02/10/2023 |
| SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling. | SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling.
Ecker M, Schregle R, Kapoor-Kaushik N, Rossatti P, Betzler VM, Kempe D, Biro M, Ariotti N, Redpath GM, Rossy J., Free PMC Article | 03/19/2022 |
| SNX9 depletion significantly delayed the recycling of integrin beta1 | SNX9 determines the surface levels of integrin β1 in vascular endothelial cells: Implication in poor prognosis of human colorectal cancers overexpressing SNX9.
Tanigawa K, Maekawa M, Kiyoi T, Nakayama J, Kitazawa R, Kitazawa S, Semba K, Taguchi T, Akita S, Yoshida M, Ishimaru K, Watanabe Y, Higashiyama S., Free PMC Article | 06/6/2020 |
| NECAP recruits drivers of late stages of clathrin-coated pit (CCP) formation, including SNX9, via a site distinct from where NECAP binds AP2. | Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation.
Wrobel AG, Kadlecova Z, Kamenicky J, Yang JC, Herrmann T, Kelly BT, McCoy AJ, Evans PR, Martin S, Müller S, Salomon S, Sroubek F, Neuhaus D, Höning S, Owen DJ., Free PMC Article | 05/16/2020 |
| SNX9 knockdown revealed a nonredundant effect on overall ADAM9 protein levels, resulting in increased ADAM9 levels at the cell surface | Sorting nexin 9 (SNX9) regulates levels of the transmembrane ADAM9 at the cell surface.
Mygind KJ, Störiko T, Freiberg ML, Samsøe-Petersen J, Schwarz J, Andersen OM, Kveiborg M., Free PMC Article | 01/26/2019 |
| SNX9 assembles into ring-like structures around the endocytic vesicles | Lipid-mediated PX-BAR domain recruitment couples local membrane constriction to endocytic vesicle fission.
Schöneberg J, Lehmann M, Ullrich A, Posor Y, Lo WT, Lichtner G, Schmoranzer J, Haucke V, Noé F., Free PMC Article | 01/19/2019 |
| In conclusion, the authors identified SNX9 as a facilitator of podocin endocytosis in severe podocyte injury and demonstrated the expression of SNX9 in the podocytes of both nephropathy model mice and human patients with irreversible glomerular disease. | Sorting Nexin 9 facilitates podocin endocytosis in the injured podocyte.
Sasaki Y, Hidaka T, Ueno T, Akiba-Takagi M, Oliva Trejo JA, Seki T, Nagai-Hosoe Y, Tanaka E, Horikoshi S, Tomino Y, Suzuki Y, Asanuma K., Free PMC Article | 11/17/2018 |
| The diversified changes associated with SNX9 expression in cancer highlight its importance as a central regulator of cancer cell behavior. | Sorting nexin 9 negatively regulates invadopodia formation and function in cancer cells.
Bendris N, Stearns CJ, Reis CR, Rodriguez-Canales J, Liu H, Witkiewicz AW, Schmid SL., Free PMC Article | 08/5/2017 |
| reduced levels of SNX9 were observed in blood samples from colorectal cancer patients, emphasizing the feasibility of its use as a diagnostic and prognostic biomarker sensing the host's immune status and inflammatory stage. | Impaired SNX9 Expression in Immune Cells during Chronic Inflammation: Prognostic and Diagnostic Implications.
Ish-Shalom E, Meirow Y, Sade-Feldman M, Kanterman J, Wang L, Mizrahi O, Klieger Y, Baniyash M. | 05/28/2016 |
| this study shows that SNX9 uses a unique mechanism to induce the tubulation of the plasma membrane which mediates proper membrane deformation during clathrin-mediated endocytosis. | The unique mechanism of SNX9 BAR domain for inducing membrane tubulation.
Park J, Zhao H, Chang S., Free PMC Article | 07/25/2015 |
| SNX9 and CHC function in the same molecular pathway for chromosome alignment and segregation, which is dependent on their direct association. | Sorting nexin 9 recruits clathrin heavy chain to the mitotic spindle for chromosome alignment and segregation.
Ma MP, Robinson PJ, Chircop M., Free PMC Article | 02/15/2014 |
| The sorting nexin 9 (SNX9) subfamily members - SNX9, SNX18 and SNX33 - are required for progression and completion of mitosis. | SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis.
Ma MP, Chircop M. | 04/27/2013 |
| study identifies critical amino acids within the BAR domains of SNX9 and SNX33 as determinants for the specificity of BAR domain-mediated interactions and suggests that SNX9 and SNX33 have distinct molecular functions. | Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33.
Dislich B, Than ME, Lichtenthaler SF. | 02/26/2011 |
| Findings suggest that EspF promotes EPEC invasion of intestinal epithelial cells by harnessing the membrane-deforming activity of SNX9. | E. coli secreted protein F promotes EPEC invasion of intestinal epithelial cells via an SNX9-dependent mechanism.
Weflen AW, Alto NM, Viswanathan VK, Hecht G., Free PMC Article | 10/4/2010 |
| The interaction with SNX9 is mediated by the proline-rich domain (PRD) of Itch, a domain distinct from the conventional WW recognition domain, and the SH3 domain of SNX9. | The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain.
Baumann C, Lindholm CK, Rimoldi D, Lévy F. | 07/12/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| SNX9 binding to aldolase is structurally precluded by the binding of substrate to the active site. | Mechanism of aldolase control of sorting nexin 9 function in endocytosis.
Rangarajan ES, Park H, Fortin E, Sygusch J, Izard T., Free PMC Article | 05/10/2010 |
| Tip-to-tip interactions between the BAR domains in a trigonal crystal form of Snx9(PX-BAR) reminiscent of functionally important interactions described for F-BAR domains. | Structure and plasticity of Endophilin and Sorting Nexin 9.
Wang Q, Kaan HY, Hooda RN, Goh SL, Sondermann H. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Genes to diseases (G2D) computational method to identify asthma candidate genes.
Tremblay K, Lemire M, Potvin C, Tremblay A, Hunninghake GM, Raby BA, Hudson TJ, Perez-Iratxeta C, Andrade-Navarro MA, Laprise C., Free PMC Article | 08/20/2008 |
| SNX9 functions in the coordination of membrane remodeling and fission via interactions with actin-regulating proteins, endocytic proteins and PtdIns(4,5)P2-metabolizing enzymes | SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2.
Shin N, Ahn N, Chang-Ileto B, Park J, Takei K, Ahn SG, Kim SA, Di Paolo G, Chang S. | 01/21/2010 |
| crystallization and x-ray diffraction of SNX9 | A combinatorial approach to crystallization of PX-BAR unit of the human Sorting Nexin 9.
Pylypenko O, Ignatev A, Lundmark R, Rasmuson E, Carlsson SR, Rak A. | 01/21/2010 |
| SNX9 PX and BAR domains work in concert in targeting and tubulation of phosphoinositide-containing membranes. | The PX-BAR membrane-remodeling unit of sorting nexin 9.
Pylypenko O, Lundmark R, Rasmuson E, Carlsson SR, Rak A., Free PMC Article | 01/21/2010 |
| SNX9 may function to assist AP-2 in its role at the plasma membrane. | The beta-appendages of the four adaptor-protein (AP) complexes: structure and binding properties, and identification of sorting nexin 9 as an accessory protein to AP-2.
Lundmark R, Carlsson SR., Free PMC Article | 01/21/2010 |
| The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation | The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation.
Lin Q, Lo CG, Cerione RA, Yang W. | 01/21/2010 |
| SNX9-dependent recruitment of Dyn2 to the membrane is regulated by an interaction between SNX9 and aldolase | Regulated membrane recruitment of dynamin-2 mediated by sorting nexin 9.
Lundmark R, Carlsson SR. | 01/21/2010 |