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    WWOX WW domain containing oxidoreductase [ Homo sapiens (human) ]

    Gene ID: 51741, updated on 7-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Mechanistic Investigation of WWOX Function in NF-kB-Induced Skin Inflammation in Psoriasis.

    Mechanistic Investigation of WWOX Function in NF-kB-Induced Skin Inflammation in Psoriasis.
    Shin MJ, Kim HS, Lee P, Yang NG, Kim JY, Eun YS, Lee W, Kim D, Lee Y, Jung KE, Hong D, Shin JM, Lee SH, Lee SY, Kim CD, Kim JE., Free PMC Article

    01/16/2024
    Remote modulation of WWOX by an intronic variant associated with survival of Chinese gastric cancer patients.

    Remote modulation of WWOX by an intronic variant associated with survival of Chinese gastric cancer patients.
    Cheng L, Chang Y, Xia Z, Liu Y, Liu X, Xiong L, Liu C, Zhu X, Wang M, Qiu L.

    11/27/2023
    Identification of compound heterozygous deletion of the WWOX gene in WOREE syndrome.

    Identification of compound heterozygous deletion of the WWOX gene in WOREE syndrome.
    Dong XS, Wen XJ, Zhang S, Wang DG, Xiong Y, Li ZM., Free PMC Article

    11/21/2023
    Loss of fragile WWOX gene leads to senescence escape and genome instability.

    Loss of fragile WWOX gene leads to senescence escape and genome instability.
    Cheng HC, Huang PH, Lai FJ, Jan MS, Chen YL, Chen SY, Chen WL, Hsu CK, Huang W, Hsu LJ., Free PMC Article

    10/30/2023
    WWOX binds MERIT40 and modulates its function in homologous recombination, implications in breast cancer.

    WWOX binds MERIT40 and modulates its function in homologous recombination, implications in breast cancer.
    Taouis K, Vacher S, Guirouilh-Barbat J, Camonis J, Formstecher E, Popova T, Hamy AS, Petitalot A, Lidereau R, Caputo SM, Zinn-Justin S, Bièche I, Driouch K, Lallemand F., Free PMC Article

    08/20/2023
    WWOX Polymorphisms as Predictors of the Biochemical Recurrence of Localized Prostate Cancer after Radical Prostatectomy.

    WWOX Polymorphisms as Predictors of the Biochemical Recurrence of Localized Prostate Cancer after Radical Prostatectomy.
    Lin CY, Wang CL, Wang SS, Yang CK, Li JR, Chen CS, Hung SC, Chiu KY, Cheng CL, Ou YC, Yang SF., Free PMC Article

    06/24/2023
    Neurological Disorders Associated with WWOX Germline Mutations-A Comprehensive Overview.

    Neurological Disorders Associated with WWOX Germline Mutations-A Comprehensive Overview.
    Banne E, Abudiab B, Abu-Swai S, Repudi SR, Steinberg DJ, Shatleh D, Alshammery S, Lisowski L, Gold W, Carlen PL, Aqeilan RI., Free PMC Article

    06/15/2023
    WWOX Modulates ROS-Dependent Senescence in Bladder Cancer.

    WWOX Modulates ROS-Dependent Senescence in Bladder Cancer.
    Liu CW, Chen PH, Yu TJ, Lin KJ, Chang LC., Free PMC Article

    01/28/2023
    Loss of tumor suppressor WWOX accelerates pancreatic cancer development through promotion of TGFbeta/BMP2 signaling.

    Loss of tumor suppressor WWOX accelerates pancreatic cancer development through promotion of TGFβ/BMP2 signaling.
    Husanie H, Abu-Remaileh M, Maroun K, Abu-Tair L, Safadi H, Atlan K, Golan T, Aqeilan RI., Free PMC Article

    01/11/2023
    WWOX and metabolic regulation in normal and pathological conditions.

    WWOX and metabolic regulation in normal and pathological conditions.
    Baryła I, Kośla K, Bednarek AK., Free PMC Article

    12/3/2022
    WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and viability of neuronal cells exposed to high glucose.

    WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and viability of neuronal cells exposed to high glucose.
    Carvalho C, Correia SC, Seiça R, Moreira PI.

    08/27/2022
    WWOX Controls Cell Survival, Immune Response and Disease Progression by pY33 to pS14 Transition to Alternate Signaling Partners.

    WWOX Controls Cell Survival, Immune Response and Disease Progression by pY33 to pS14 Transition to Alternate Signaling Partners.
    Liu TY, Nagarajan G, Chiang MF, Huang SS, Lin TC, Chen YA, Sze CI, Chang NS., Free PMC Article

    08/13/2022
    TGFalpha-EGFR pathway in breast carcinogenesis, association with WWOX expression and estrogen activation.

    TGFα-EGFR pathway in breast carcinogenesis, association with WWOX expression and estrogen activation.
    Pospiech K, Orzechowska M, Nowakowska M, Anusewicz D, Płuciennik E, Kośla K, Bednarek AK., Free PMC Article

    04/16/2022
    Recently defined epileptic encephalopathy related to WWOX gene mutation: six patients and new mutations.

    Recently defined epileptic encephalopathy related to WWOX gene mutation: six patients and new mutations.
    Havali C, Ekici A, Dorum S, Görükmez Ö, Topak A.

    03/5/2022
    Association between WWOX/MAF variants and dementia-related neuropathologic endophenotypes.

    Association between WWOX/MAF variants and dementia-related neuropathologic endophenotypes.
    Dugan AJ, Nelson PT, Katsumata Y, Shade LMP, Teylan MA, Boehme KL, Mukherjee S, Kauwe JSK, Hohman TJ, Schneider JA, Fardo DW, Alzheimer's Disease Genetics Consortium., Free PMC Article

    02/26/2022
    Expression of WW domain-containing oxidoreductase and its clinical implication in endometrial adenocarcinoma patients with metabolic syndrome.

    Expression of WW domain-containing oxidoreductase and its clinical implication in endometrial adenocarcinoma patients with metabolic syndrome.
    Shen Y, Gao L, Jiang S, Liu J, Cheng W, Shou H.

    02/12/2022
    Effect of WW Domain-Containing Oxidoreductase Gene Polymorphism on Clinicopathological Characteristics of Patients with EGFR Mutant Lung Adenocarcinoma in Taiwan.

    Effect of WW Domain-Containing Oxidoreductase Gene Polymorphism on Clinicopathological Characteristics of Patients with EGFR Mutant Lung Adenocarcinoma in Taiwan.
    Li JP, Chang JT, Ju PC, Hsieh MH, Chao YH, Tsao TC, Hsieh MJ, Yang SF., Free PMC Article

    01/8/2022
    RHBDD2WWOX protein interaction during proliferative and differentiated stages in normal and breast cancer cells.

    RHBDD2‑WWOX protein interaction during proliferative and differentiated stages in normal and breast cancer cells.
    Ferretti VA, Canzoneri R, Palma S, Lacunza E, Aldaz CM, Abba MC.

    12/4/2021
    LncRNA WWOX-AS1 sponges miR-20b-5p in hepatocellular carcinoma and represses its progression by upregulating WWOX.

    LncRNA WWOX-AS1 sponges miR-20b-5p in hepatocellular carcinoma and represses its progression by upregulating WWOX.
    Xu D, Liu X, Wu J, Wang Y, Zhou K, Chen W, Chen J, Chen C, Chen L., Free PMC Article

    10/23/2021
    Pleiotropic tumor suppressor functions of WWOX antagonize metastasis.

    Pleiotropic tumor suppressor functions of WWOX antagonize metastasis.
    Khawaled S, Nigita G, Distefano R, Oster S, Suh SS, Smith Y, Khalaileh A, Peng Y, Croce CM, Geiger T, Seewaldt VL, Aqeilan RI., Free PMC Article

    10/16/2021
    Methylation of WWOX gene promotes proliferation of osteosarcoma cells.

    Methylation of WWOX gene promotes proliferation of osteosarcoma cells.
    Liu Y, Wang Q, Yu P, Miao W, Liu C, Pu Y, Zhang C.

    09/11/2021
    In vitro and in silico assessment of the effect of WWOX expression on invasiveness pathways associated with AP-2 transcription factors in bladder cancer.

    In vitro and in silico assessment of the effect of WWOX expression on invasiveness pathways associated with AP-2 transcription factors in bladder cancer.
    Kałuzińska Ż, Kołat D, Kośla K, Orzechowska M, Bednarek AK, Płuciennik E., Free PMC Article

    08/7/2021
    Analysis of WWOX gene expression and protein levels in pterygium.

    Analysis of WWOX gene expression and protein levels in pterygium.
    Bozkurt N, Ates O.

    07/31/2021
    Associations between TUBB-WWOX SNPs, their haplotypes, gene-gene, and gene-environment interactions and dyslipidemia.

    Associations between TUBB-WWOX SNPs, their haplotypes, gene-gene, and gene-environment interactions and dyslipidemia.
    Liu CX, Yin RX, Shi ZH, Zheng PF, Deng GX, Guan YZ, Wei BL., Free PMC Article

    07/24/2021
    MiR-214 Mediates Cell Proliferation and Apoptosis of Nasopharyngeal Carcinoma Through Targeting Both WWOX and PTEN.

    MiR-214 Mediates Cell Proliferation and Apoptosis of Nasopharyngeal Carcinoma Through Targeting Both WWOX and PTEN.
    Han JB, Huang ML, Li F, Yang R, Chen SM, Tao ZZ., Free PMC Article

    07/3/2021
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