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    SERPINA4 serpin family A member 4 [ Homo sapiens (human) ]

    Gene ID: 5267, updated on 5-Mar-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Kallistatin deficiency exacerbates neuronal damage after cardiac arrest.

    Kallistatin deficiency exacerbates neuronal damage after cardiac arrest.
    Kim H, Suh GJ, Kwon WY, Kim KS, Jung YS, Kim T, Park H., Free PMC Article

    02/26/2024
    [Relationship of the kallistatin gene expression with male spermatogenic dysfunction and its possible mechanism].

    [Relationship of the kallistatin gene expression with male spermatogenic dysfunction and its possible mechanism].
    Wang Y, Chen XY, Shang K, Xu Q, Li YX, DU Y, Zhuan L.

    10/25/2023
    Plasma E-selectin and kallistatin as predictive markers of histologic chorioamnionitis in women with preterm premature rupture of membranes.

    Plasma E-selectin and kallistatin as predictive markers of histologic chorioamnionitis in women with preterm premature rupture of membranes.
    Cho I, Lee KN, Joo E, Kim YM, Kim TE, Park KH.

    09/17/2022
    Clinical Significance of Serum Kallistatin and ENOX1 Levels in Patients with Coronary Heart Disease.

    Clinical Significance of Serum Kallistatin and ENOX1 Levels in Patients with Coronary Heart Disease.
    Zhang R, Ji Z, Cai J, Li Y, Ma G., Free PMC Article

    04/2/2022
    Kallistatin in follicular fluid of women with endometriosis and its correlation with IVF outcome.

    Kallistatin in follicular fluid of women with endometriosis and its correlation with IVF outcome.
    Mao Y, Zhan S, Qiao J, Li L, Liu H, Chen R.

    02/12/2022
    Kallistatin limits abdominal aortic aneurysm by attenuating generation of reactive oxygen species and apoptosis.

    Kallistatin limits abdominal aortic aneurysm by attenuating generation of reactive oxygen species and apoptosis.
    Krishna SM, Li J, Wang Y, Moran CS, Trollope A, Huynh P, Jose R, Biros E, Ma J, Golledge J., Free PMC Article

    11/13/2021
    Serum kallistatin level is decreased in women with preeclampsia.

    Serum kallistatin level is decreased in women with preeclampsia.
    Güralp O, Tüten N, Gök K, Hamzaoglu K, Bulut H, Schild-Suhren M, Malik E, Tüten A.

    10/23/2021
    Role of kallistatin in pediatric patients with pulmonary arterial hypertension.

    Role of kallistatin in pediatric patients with pulmonary arterial hypertension.
    Pamukçu Ö, Ay D, Üzüm K, Barlakketi D, Köse M, Baykan A, Sunkak S, Narin N.

    09/25/2021
    Low expression of kallistatin was associated with unfavourable prognosis and platinum resistance in high-grade serous (HGSOC). Overexpression of kallistatin significantly inhibited proliferation and metastasis, and enhanced platinum sensitivity and apoptosis in ovarian cancer cells. These findings demonstrate that kallistatin serves as a prognostic predictor and provide a potential therapeutic target for HGSOC

    Kallistatin inhibits tumour progression and platinum resistance in high-grade serous ovarian cancer.
    Wu H, Li R, Zhang Z, Jiang H, Ma H, Yuan C, Sun C, Li Y, Kong B., Free PMC Article

    05/30/2020
    patients with less severe excretory pancreatic insufficiency and lipid profile disorders had higher kallistatin level than the control group

    Kallistatin level in patients with combination of chronic pancreatitis and aterosclerosis.
    Sirchak ES, Opalenyk SM, Kurchak NY.

    06/8/2019
    These findings provide, for the first time, evidence of a novel role of kallistatin in obesity and its associated comorbidities by limiting adipose tissue inflammation and oxidative stress

    Novel protective role of kallistatin in obesity by limiting adipose tissue low grade inflammation and oxidative stress.
    Frühbeck G, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Valentí V, Moncada R, Becerril S, Unamuno X, Silva C, Salvador J, Catalán V.

    03/30/2019
    Kallistatin levels may provide useful information regarding cardiovascular risk in women with polycystic ovary syndrome

    Association of kallistatin with carotid intima-media thickness in women with polycystic ovary syndrome.
    Calan M, Guler A, Unal Kocabas G, Alarslan P, Bicer M, Imamoglu C, Yuksel A, Bozkaya G, Bilgir O.

    12/1/2018
    Kallistatin functions as an endogenous lymphangiogenesis inhibitor and has an important part in the lymphatic metastasis of gastric cancer.Kallistatin was reduced in the cancer tissue and plasma of gastric cancer patients.

    Kallistatin inhibits lymphangiogenesis and lymphatic metastasis of gastric cancer by downregulating VEGF-C expression and secretion.
    Ma C, Luo C, Yin H, Zhang Y, Xiong W, Zhang T, Gao T, Wang X, Che D, Fang Z, Li L, Xie J, Huang M, Zhu L, Jiang P, Qi W, Zhou T, Yang Z, Wang W, Ma J, Gao G, Yang X.

    10/13/2018
    SNPs rs2093266 in the SERPINA4 is associated with the development of severe acute kidney injury (KDIGO stage 2-3) in critically ill patients with septic shock

    Genetic variants in SERPINA4 and SERPINA5, but not BCL2 and SIK3 are associated with acute kidney injury in critically ill patients with septic shock.
    Vilander LM, Kaunisto MA, Vaara ST, Pettilä V, FINNAKI study group., Free PMC Article

    09/8/2018
    oxidative stress induces down- or upregulation of kallistatin expression, depending on oxygen concentration, and kallistatin plays a novel role in mediating oxygen/exercise-induced HIF-1-eNOS-NO pathway.

    Opposing Effects of Oxygen Regulation on Kallistatin Expression: Kallistatin as a Novel Mediator of Oxygen-Induced HIF-1-eNOS-NO Pathway.
    Chao J, Guo Y, Li P, Chao L., Free PMC Article

    08/18/2018
    These findings reveal novel mechanisms of kallistatin in protection against senescence, aging, and cancer development by modulating miR-34a and miR-21 levels and inhibiting oxidative stress.

    Role of Kallistatin Treatment in Aging and Cancer by Modulating miR-34a and miR-21 Expression.
    Chao J, Guo Y, Li P, Chao L., Free PMC Article

    04/14/2018
    These findings suggested that kallistatin may be a promising agent that could be used to suppress cancer metastasis by inhibiting both angiogenesis and lymphangiogenesis.

    Kallistatin exerts anti-lymphangiogenic effects by inhibiting lymphatic endothelial cell proliferation, migration and tube formation.
    Ma C, Yin H, Zhong J, Zhang Y, Luo C, Che D, Fang Z, Li L, Qin S, Liang J, Qi W, Yang Z, Zhou T, Ma J, Yang X, Gao G., Free PMC Article

    03/3/2018
    generated a meta-marker model made up of SERPINA4 and PON1 that is useful as a differential diagnostic biomarker differentiating lung cancer from other lung diseases.

    Meta-markers for the differential diagnosis of lung cancer and lung disease.
    Kim YI, Ahn JM, Sung HJ, Na SS, Hwang J, Kim Y, Cho JY.

    12/2/2017
    The kallistatin's dual roles in angiogenesis, apoptosis and oxidative stress contribute to its beneficial effects in various diseases.

    Kallistatin: double-edged role in angiogenesis, apoptosis and oxidative stress.
    Chao J, Li P, Chao L.

    11/18/2017
    Our results indicate that during severe sepsis and septic shock, a decrease in plasma concentrations of kallistatin reflects increased severity and poorer outcome of disease.

    Plasma kallistatin in critically ill patients with severe sepsis and septic shock.
    Lin WC, Chen CW, Chao L, Chao J, Lin YS., Free PMC Article

    09/23/2017
    data suggest that overexpression of kallistatin interferes with lymphopoiesis, ultimately impacting the level of circulating CD19(+) B lymphocytes.

    Transgenic expression of a canonical Wnt inhibitor, kallistatin, is associated with decreased circulating CD19(+) B lymphocytes in the peripheral blood.
    McBride JD, Liu X, Berry WL, Janknecht R, Cheng R, Zhou K, Badiavas EV, Ma JX.

    06/24/2017
    Kallistatin levels were correlated with some markers of systemic inflammation in the HIV population.

    Kallistatin levels in HIV-infected patients and effects of statin therapy.
    Eckard AR, Cho S, O'Riordan MA, McComsey GA., Free PMC Article

    02/4/2017
    Increased kallistatin levels in type 1 diabetes and its relation with carotid intima media thickness may reflect vascular dysfunction and suggest a link between micro- and macro-angiopathy.

    Kallistatin as a marker of microvascular complications in children and adolescents with type 1 diabetes mellitus: Relation to carotid intima media thickness.
    El-Asrar MA, Andrawes NG, Ismail EA, Salem SM.

    09/17/2016
    reveal novel mechanisms of kallistatin in inducing apoptosis and autophagy in breast cancer cells

    Kallistatin induces breast cancer cell apoptosis and autophagy by modulating Wnt signaling and microRNA synthesis.
    Li P, Guo Y, Bledsoe G, Yang Z, Chao L, Chao J., Free PMC Article

    08/6/2016
    crystal structure of kallistatin 1.9 A resolution

    Crystallization and crystallographic studies of kallistatin.
    Lin F, Zhou A, Wei Z., Free PMC Article

    07/2/2016
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