| Effects of Mithramycin on BCL11A Gene Expression and on the Interaction of the BCL11A Transcriptional Complex to gamma-Globin Gene Promoter Sequences. | Effects of Mithramycin on BCL11A Gene Expression and on the Interaction of the BCL11A Transcriptional Complex to γ-Globin Gene Promoter Sequences.
Finotti A, Gasparello J, Zuccato C, Cosenza LC, Fabbri E, Bianchi N, Gambari R., Free PMC Article | 10/30/2023 |
| RNA-seq analysis reveals candidate genes associated with proliferation, invasion, and migration in BCL11A knockdown B-NHL cell lines. | RNA-seq analysis reveals candidate genes associated with proliferation, invasion, and migration in BCL11A knockdown B-NHL cell lines.
Yin J, Xie X, Quan Y, Wang Z, Liu S, Su Q, Che F, Wang L. | 06/15/2023 |
| [Genetic analysis of a family with BCL11A-related intellectual disability]. | [Genetic analysis of a family with BCL11A-related intellectual disability].
Liu A, Hu Y, Chong B, Zheng S, Li L. | 02/11/2023 |
| Fetal hemoglobin-boosting haplotypes of BCL11A gene and HBS1L-MYB intergenic region in the prediction of clinical and hematological outcomes in a cohort of children with sickle cell anemia. | Fetal hemoglobin-boosting haplotypes of BCL11A gene and HBS1L-MYB intergenic region in the prediction of clinical and hematological outcomes in a cohort of children with sickle cell anemia.
Sales RR, Nogueira BL, Belisário AR, Faria G, Mendes F, Viana MB, Luizon MR. | 12/3/2022 |
| Three children with different de novo BCL11A variants and diverse developmental phenotypes, but shared global motor discoordination and apraxic speech: Evidence for a functional gene network influencing the developing cerebellum and motor and auditory cortices. | Three children with different de novo BCL11A variants and diverse developmental phenotypes, but shared global motor discoordination and apraxic speech: Evidence for a functional gene network influencing the developing cerebellum and motor and auditory cortices.
Bruce L, Peter B. | 11/19/2022 |
| Bcl11a and the Correlated Key Genes Ascribable to Globin Switching: An In-silico Study. | Bcl11a and the Correlated Key Genes Ascribable to Globin Switching: An In-silico Study.
Motlagh FM, Soleimanpour-Lichaei HR, Emami A, Kadkhoda S, Shamsara M, Rasti A, Modarressi MH. | 11/12/2022 |
| BCL11A Facilitates Cell Proliferation and Metastasis in Neuroblastoma via Regulating the PI3K/Akt Signaling Pathway. | BCL11A Facilitates Cell Proliferation and Metastasis in Neuroblastoma via Regulating the PI3K/Akt Signaling Pathway.
Jin Q, Chen Y, Du S, Xu D, Yue J, Cai L, Yuan X., Free PMC Article | 10/29/2022 |
| MicroRNA-92a-3p-mediated inhibition of BCL11A upregulates gamma-globin expression and inhibits oxidative stress and apoptosis in erythroid precursor cells. | MicroRNA-92a-3p-mediated inhibition of BCL11A upregulates γ-globin expression and inhibits oxidative stress and apoptosis in erythroid precursor cells.
Li H, Lin R, Li H, Ou R, Wang K, Lin J, Li C. | 10/15/2022 |
| HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription. | HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription.
Huang P, Peslak SA, Ren R, Khandros E, Qin K, Keller CA, Giardine B, Bell HW, Lan X, Sharma M, Horton JR, Abdulmalik O, Chou ST, Shi J, Crossley M, Hardison RC, Cheng X, Blobel GA., Free PMC Article | 09/24/2022 |
| Genetic modifiers of fetal hemoglobin affect the course of sickle cell disease in patients treated with hydroxyurea. | Genetic modifiers of fetal hemoglobin affect the course of sickle cell disease in patients treated with hydroxyurea.
Allard P, Alhaj N, Lobitz S, Cario H, Jarisch A, Grosse R, Oevermann L, Hakimeh D, Tagliaferri L, Kohne E, Kopp-Schneider A, Kulozik AE, Kunz JB., Free PMC Article | 07/9/2022 |
| Metabolic sensor O-GlcNAcylation regulates erythroid differentiation and globin production via BCL11A. | Metabolic sensor O-GlcNAcylation regulates erythroid differentiation and globin production via BCL11A.
Luanpitpong S, Kang X, Janan M, Thumanu K, Li J, Kheolamai P, Issaragrisil S., Free PMC Article | 07/2/2022 |
| BCL11A promotes myeloid leukemogenesis by repressing PU.1 target genes. | BCL11A promotes myeloid leukemogenesis by repressing PU.1 target genes.
Sunami Y, Yokoyama T, Yoshino S, Takahara T, Yamazaki Y, Harada H, Nakamura T., Free PMC Article | 04/30/2022 |
| Pathogenic BCL11A variants provide insights into the mechanisms of human fetal hemoglobin silencing. | Pathogenic BCL11A variants provide insights into the mechanisms of human fetal hemoglobin silencing.
Shen Y, Li R, Teichert K, Montbleau KE, Verboon JM, Voit RA, Sankaran VG., Free PMC Article | 12/4/2021 |
| Overproduction of BCL11A in human beta cells inhibits glucose-stimulated insulin secretion, while knockdown of BCL11A in human pseudoislets enhances both basal and glucose-stimulated insulin secretion. | Discovering human diabetes-risk gene function with genetics and physiological assays.
Peiris H, Park S, Louis S, Gu X, Lam JY, Asplund O, Ippolito GC, Bottino R, Groop L, Tucker H, Kim SK, Peiris H, Park S, Louis S, Gu X, Lam JY, Asplund O, Ippolito GC, Bottino R, Groop L, Tucker H, Kim SK, Peiris H, Park S, Louis S, Gu X, Lam JY, Asplund O, Ippolito GC, Bottino R, Groop L, Tucker H, Kim SK., Free PMC Articles: PMC6155000, PMC6155000, PMC6155000 | 06/14/2021 |
| RNA interference-mediated knockdown of the Drosophila ortholog of BCL11A in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. | Discovering human diabetes-risk gene function with genetics and physiological assays.
Peiris H, Park S, Louis S, Gu X, Lam JY, Asplund O, Ippolito GC, Bottino R, Groop L, Tucker H, Kim SK, Peiris H, Park S, Louis S, Gu X, Lam JY, Asplund O, Ippolito GC, Bottino R, Groop L, Tucker H, Kim SK, Peiris H, Park S, Louis S, Gu X, Lam JY, Asplund O, Ippolito GC, Bottino R, Groop L, Tucker H, Kim SK., Free PMC Articles: PMC6155000, PMC6155000, PMC6155000 | 06/14/2021 |
| BCL11A expression in cultured human islets is glucose-regulated, with a 50% increase in mRNA levels in islets cultured in 16 mM glucose as compared to islets cultured at 11 mM glucose. | Discovering human diabetes-risk gene function with genetics and physiological assays.
Peiris H, Park S, Louis S, Gu X, Lam JY, Asplund O, Ippolito GC, Bottino R, Groop L, Tucker H, Kim SK, Peiris H, Park S, Louis S, Gu X, Lam JY, Asplund O, Ippolito GC, Bottino R, Groop L, Tucker H, Kim SK, Peiris H, Park S, Louis S, Gu X, Lam JY, Asplund O, Ippolito GC, Bottino R, Groop L, Tucker H, Kim SK., Free PMC Articles: PMC6155000, PMC6155000, PMC6155000 | 06/14/2021 |
| Transcription factor competition at the gamma-globin promoters controls hemoglobin switching. | Transcription factor competition at the γ-globin promoters controls hemoglobin switching.
Liu N, Xu S, Yao Q, Zhu Q, Kai Y, Hsu JY, Sakon P, Pinello L, Yuan GC, Bauer DE, Orkin SH., Free PMC Article | 04/24/2021 |
| miR-30a regulates gamma-globin expression in erythoid precursors of intermedia thalassemia through targeting BCL11A. | miR-30a regulates γ-globin expression in erythoid precursors of intermedia thalassemia through targeting BCL11A.
Gholampour MA, Asadi M, Naderi M, Azarkeivan A, Soleimani M, Atashi A. | 02/20/2021 |
| miR5745p attenuates proliferation, migration and EMT in triplenegative breast cancer cells by targeting BCL11A and SOX2 to inhibit the SKIL/TAZ/CTGF axis. | miR‑574‑5p attenuates proliferation, migration and EMT in triple‑negative breast cancer cells by targeting BCL11A and SOX2 to inhibit the SKIL/TAZ/CTGF axis.
Zhang KJ, Hu Y, Luo N, Li X, Chen FY, Yuan JQ, Guo L. | 02/13/2021 |
| The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression. | The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression.
Huang P, Peslak SA, Lan X, Khandros E, Yano JA, Sharma M, Keller CA, Giardine B, Qin K, Abdulmalik O, Hardison RC, Shi J, Blobel GA., Free PMC Article | 02/13/2021 |
| The transcriptional repressor BCL11A promotes breast cancer metastasis. | The transcriptional repressor BCL11A promotes breast cancer metastasis.
Seachrist DD, Hannigan MM, Ingles NN, Webb BM, Weber-Bonk KL, Yu P, Bebek G, Singh S, Sizemore ST, Varadan V, Licatalosi DD, Keri RA., Free PMC Article | 01/23/2021 |
| Comparative targeting analysis of KLF1, BCL11A, and HBG1/2 in CD34(+) HSPCs by CRISPR/Cas9 for the induction of fetal hemoglobin. | Comparative targeting analysis of KLF1, BCL11A, and HBG1/2 in CD34(+) HSPCs by CRISPR/Cas9 for the induction of fetal hemoglobin.
Lamsfus-Calle A, Daniel-Moreno A, Antony JS, Epting T, Heumos L, Baskaran P, Admard J, Casadei N, Latifi N, Siegmund DM, Kormann MSD, Handgretinger R, Mezger M., Free PMC Article | 01/16/2021 |
| BCL11A gene over-expression in high risk neuroblastoma. | BCL11A gene over-expression in high risk neuroblastoma.
Sultan I, Tbakhi A. | 01/2/2021 |
| Association between BCL11A, HSB1L-MYB, and XmnI gammaG-158 (C/T) gene polymorphism and hemoglobin F level in Egyptian sickle cell disease patients. | Association between BCL11A, HSB1L-MYB, and XmnI γG-158 (C/T) gene polymorphism and hemoglobin F level in Egyptian sickle cell disease patients.
El-Ghamrawy M, Yassa ME, Tousson AMS, El-Hady MA, Mikhaeil E, Mohamed NB, Khorshied MM. | 10/3/2020 |
| BCL11A: a potential diagnostic biomarker and therapeutic target in human diseases. | BCL11A: a potential diagnostic biomarker and therapeutic target in human diseases.
Yin J, Xie X, Ye Y, Wang L, Che F., Free PMC Article | 09/26/2020 |