| PAIP1 regulates the translation of YBX2-masked mRNAs during spermiogenesis and this YBX2-PAIP1 interaction may play an important role in male germ cell development. | Murine PAIP1 stimulates translation of spermiogenic mRNAs stored by YBX2 via its interaction with YBX2†.
He Y, Lin Y, Zhu Y, Ping P, Wang G, Sun F. | 04/4/2020 |
| Ybx2 is a novel regulator that controls brown adipose tissue activation by regulating mRNA stability. | RNA Binding Protein Ybx2 Regulates RNA Stability During Cold-Induced Brown Fat Activation.
Xu D, Xu S, Kyaw AMM, Lim YC, Chia SY, Chee Siang DT, Alvarez-Dominguez JR, Chen P, Leow MK, Sun L. | 12/9/2017 |
| mRNAs, possibly in a complex with MSY2 and PADI6, are bound in the cytoplasmic lattices (CPLs) and may play a role in securing the mRNA-MSY2 complex to the CPLs. | Role for PADI6 in securing the mRNA-MSY2 complex to the oocyte cytoplasmic lattices.
Liu X, Morency E, Li T, Qin H, Zhang X, Zhang X, Coonrod S., Free PMC Article | 06/24/2017 |
| YBX2 has the important role of coordinating the storage of translationally repressed mRNAs in round spermatids by inhibiting translational activity and the degradation of transcripts via translation-dependent deadenylation. | Position-dependent interactions of Y-box protein 2 (YBX2) with mRNA enable mRNA storage in round spermatids by repressing mRNA translation and blocking translation-dependent mRNA decay.
Kleene KC. | 12/17/2016 |
| homozygous double mutants could not be generated as haploinsufficiency of both Ybx2 and Ybx3 caused sterility characterized by extensive defects in spermatid differentiation. | Compound Heterozygosity for Y Box Proteins Causes Sterility Due to Loss of Translational Repression.
Snyder E, Soundararajan R, Sharma M, Dearth A, Smith B, Braun RE., Free PMC Article | 06/11/2016 |
| central role in regulating mRNA stability | Absence of MSY2 in mouse oocytes perturbs oocyte growth and maturation, RNA stability, and the transcriptome.
Medvedev S, Pan H, Schultz RM., Free PMC Article | 01/14/2012 |
| Results show that MSY-RNAs are in both nuclei and cytoplasm. | MIWI-independent small RNAs (MSY-RNAs) bind to the RNA-binding protein, MSY2, in male germ cells.
Xu M, Medvedev S, Yang J, Hecht NB., Free PMC Article | 01/21/2010 |
| Study reports that CDC2A (CDK1)-mediated phosphorylation of MSY2 triggers an abrupt transition in which most maternal mRNAs are significantly degraded. | CDC2A (CDK1)-mediated phosphorylation of MSY2 triggers maternal mRNA degradation during mouse oocyte maturation.
Medvedev S, Yang J, Hecht NB, Schultz RM., Free PMC Article | 01/21/2010 |
| data suggest that MSY2 packages mRNAs in vivo with relatively little sequence specificity, which may lead to both stabilization and translation repression of maternal mRNAs | RNA-binding properties and translation repression in vitro by germ cell-specific MSY2 protein.
Yu J, Hecht NB, Schultz RM. | 01/21/2010 |
| role for MSY2 in stabilizing maternal mRNAs in growing oocytes | Transgenic RNAi-mediated reduction of MSY2 in mouse oocytes results in reduced fertility.
Yu J, Deng M, Medvedev S, Yang J, Hecht NB, Schultz RM. | 01/21/2010 |
| Results suggest that Msy2 represents one of a small number of germ-cell-specific genes whose deletion leads to the disruption of both spermatogenesis and oogenesis. | Absence of the DNA-/RNA-binding protein MSY2 results in male and female infertility.
Yang J, Medvedev S, Yu J, Tang LC, Agno JE, Matzuk MM, Schultz RM, Hecht NB., Free PMC Article | 01/21/2010 |
| mRNA instability is a likely cause of the male infertility in Msy2-null mice. | In the absence of the mouse DNA/RNA-binding protein MSY2, messenger RNA instability leads to spermatogenic arrest.
Yang J, Morales CR, Medvedev S, Schultz RM, Hecht NB. | 01/21/2010 |
| MSY2 marks specific mRNAs in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay in meiotic and postmeiotic male germ cells of the mouse. | The DNA/RNA-binding protein MSY2 marks specific transcripts for cytoplasmic storage in mouse male germ cells.
Yang J, Medvedev S, Reddi PP, Schultz RM, Hecht NB., Free PMC Article | 01/21/2010 |
| binding of intact maternal mRNA by MSY2 is required for its cytoplasmic retention in oocytes | Requirement for RNA-binding activity of MSY2 for cytoplasmic localization and retention in mouse oocytes.
Yu J, Hecht NB, Schultz RM. | 01/21/2010 |
| MSY2 and MSY4 bind a conserved sequence in the 3' untranslated region of protamine 1 mRNA in vitro and in vivo | MSY2 and MSY4 bind a conserved sequence in the 3' untranslated region of protamine 1 mRNA in vitro and in vivo.
Giorgini F, Davies HG, Braun RE., Free PMC Article | 10/18/2001 |