| FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters. | FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters.
Li M, Nishimura T, Takeuchi Y, Hongu T, Wang Y, Shiokawa D, Wang K, Hirose H, Sasahara A, Yano M, Ishikawa S, Inokuchi M, Ota T, Tanabe M, Tada KI, Akiyama T, Cheng X, Liu CC, Yamashita T, Sugano S, Uchida Y, Chiba T, Asahara H, Nakagawa M, Sato S, Miyagi Y, Shimamura T, Nagai LAE, Kanai A, Katoh M, Nomura S, Nakato R, Suzuki Y, Tojo A, Voon DC, Ogawa S, Okamoto K, Foukakis T, Gotoh N., Free PMC Article | 11/20/2023 |
| FXYD3 enhances IL-17A signaling to promote psoriasis by competitively binding TRAF3 in keratinocytes. | FXYD3 enhances IL-17A signaling to promote psoriasis by competitively binding TRAF3 in keratinocytes.
Yang W, He R, Qu H, Lian W, Xue Y, Wang T, Lin W, Zhu P, Xia M, Lai L, Wang Q., Free PMC Article | 03/2/2023 |
| FXYD3 facilitates Na(+) and liquid absorption across human airway epithelia by increasing the transport capacity of the Na/K ATPase. | FXYD3 facilitates Na(+) and liquid absorption across human airway epithelia by increasing the transport capacity of the Na/K ATPase.
Cano Portillo C, Villacreses R, Thurman AL, Pezzulo AA, Zabner J, Thornell IM., Free PMC Article | 10/8/2022 |
| Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase. | Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase.
Plain F, Howie J, Kennedy J, Brown E, Shattock MJ, Fraser NJ, Fuller W., Free PMC Article | 06/26/2021 |
| Scn1b and Fxyd1 expression was significantly downregulated in HSCR colon. | Abnormal Scn1b and Fxyd1 gene expression in the pulled-through ganglionic colon may influence functional outcome in patients with Hirschsprung's disease.
O'Donnell AM, Nakamura H, Tomuschat C, Marayati NF, Puri P. | 03/2/2019 |
| Suppression of FXYD3 in MCF-7. | Silencing overexpression of FXYD3 protein in breast cancer cells amplifies effects of doxorubicin and γ-radiation on Na(+)/K(+)-ATPase and cell survival.
Liu CC, Teh R, Mozar CA, Baxter RC, Rasmussen HH. | 10/22/2016 |
| Study demonstrated that the expression of FXYD1, FXYD3 and FXYD5 is elevated in the lungs of Acute respiratory distress syndrome patients | FXYD1 negatively regulates Na(+)/K(+)-ATPase activity in lung alveolar epithelial cells.
Wujak ŁA, Blume A, Baloğlu E, Wygrecka M, Wygowski J, Herold S, Mayer K, Vadász I, Besuch P, Mairbäurl H, Seeger W, Morty RE. | 09/24/2016 |
| All three markers correlated significantly with regional lymph node metastasis: FXYD3 (p = 0.0110), S100A11 (p = 0.0071), and GSTM3 (p = 0.0173) in colon cancer lymphatic metastasis. | Tissue-based proteomics reveals FXYD3, S100A11 and GSTM3 as novel markers for regional lymph node metastasis in colon cancer.
Meding S, Balluff B, Elsner M, Schöne C, Rauser S, Nitsche U, Maak M, Schäfer A, Hauck SM, Ueffing M, Langer R, Höfler H, Friess H, Rosenberg R, Walch A. | 01/10/2015 |
| ExoS facilitates P. aeruginosa penetration through the intestinal epithelial barrier by binding to FXYD3 and thereby impairing the defense function of tight junctions against bacterial penetration. | Translocation of Pseudomonas aeruginosa from the intestinal tract is mediated by the binding of ExoS to an Na,K-ATPase regulator, FXYD3.
Okuda J, Hayashi N, Okamoto M, Sawada S, Minagawa S, Yano Y, Gotoh N., Free PMC Article | 11/13/2010 |
| Up-regulated expression of FXYD-3 protein may be involved in tumourgenesis and invasion of gastric adenocarcinoma. | Expression and significance of FXYD-3 protein in gastric adenocarcinoma.
Zhu ZL, Zhao ZR, Zhang Y, Yang YH, Wang ZM, Cui DS, Wang MW, Kleeff J, Kayed H, Yan BY, Sun XF., Free PMC Article | 07/5/2010 |
| FXYD3 expression is related to several biological variables including ras, p53, legumain and PCNA, and may be involved in the development of the relatively early stages of colorectal cancers | Expression of FXYD3 protein in relation to biological and clinicopathological variables in colorectal cancers.
Widegren E, Onnesjö S, Arbman G, Kayed H, Zentgraf H, Kleeff J, Zhang H, Sun XF. | 03/22/2010 |
| Upregulation of FXYD3 is associated with glioma. | FXYD3 expression in gliomas and its clinicopathological significance.
Wang MW, Gu P, Zhang ZY, Zhu ZL, Geng Y, Kayed H, Zentgraf H, Sun XF. | 03/8/2010 |
| inactivation of FXYD3 through a gene mutation or unknown mechanism could be one cause of the atypical shapes of cancer cells and play a potential role in the progression of lung cancer. | Down-regulation of FXYD3 expression in human lung cancers: its mechanism and potential role in carcinogenesis.
Okudela K, Yazawa T, Ishii J, Woo T, Mitsui H, Bunai T, Sakaeda M, Shimoyamada H, Sato H, Tajiri M, Ogawa N, Masuda M, Sugimura H, Kitamura H., Free PMC Article | 03/1/2010 |
| FXYD3a protein is highly expressed in breast cancers, and responsible for cancer cell proliferation. | FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues.
Yamamoto H, Okumura K, Toshima S, Mukaisho K, Sugihara H, Hattori T, Kato M, Asano S. | 01/21/2010 |
| FXYD3 silencing prevents proper regulation of Na,K-ATPase, which leads to perturbation of cellular Na+ and K+ homeostasis and changes in the expression of Na,K-ATPase isozymes, whose functional properties are incompatible with cell differentiation. | A link between FXYD3 (Mat-8)-mediated Na,K-ATPase regulation and differentiation of Caco-2 intestinal epithelial cells.
Bibert S, Aebischer D, Desgranges F, Roy S, Schaer D, Kharoubi-Hess S, Horisberger JD, Geering K., Free PMC Article | 01/21/2010 |
| structures of the FXYD proteins (with emphasis on 1-4), as well as their dynamics and their associations with the lipid | Structures of the FXYD regulatory proteins in lipid micelles and membranes.
Franzin CM, Gong XM, Teriete P, Marassi FM., Free PMC Article | 01/21/2010 |
| FXYD3 interacts with Na(+)-K(+)-Exchanging ATPase in colorectal neoplasms. | Interaction of Mat-8 (FXYD-3) with Na+/K+-ATPase in colorectal cancer cells.
Arimochi J, Ohashi-Kobayashi A, Maeda M. | 01/21/2010 |
| molecular cloning, protein expression, sequencing and NMR structure determination | Expression and characterization of the FXYD ion transport regulators for NMR structural studies in lipid micelles and lipid bilayers.
Crowell KJ, Franzin CM, Koltay A, Lee S, Lucchese AM, Snyder BC, Marassi FM., Free PMC Article | 01/21/2010 |
| analysis of two human FXYD3 isoforms that are differentially expressed in differentiated and non-differentiated cells with different functional properties | Structural and functional properties of two human FXYD3 (Mat-8) isoforms.
Bibert S, Roy S, Schaer D, Felley-Bosco E, Geering K. | 01/21/2010 |
| overexpression of FXYD3 in pancreatic cancer may contribute to the proliferative activity of this malignancy | FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth.
Kayed H, Kleeff J, Kolb A, Ketterer K, Keleg S, Felix K, Giese T, Penzel R, Zentgraf H, Büchler MW, Korc M, Friess H. | 01/21/2010 |
| Results indicate that the human MAT-8 gene contains the potential to serve as a prostate cancer expression marker and that MAT-8 plays an important role in cellular growth of prostate carcinomas. | Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells.
Grzmil M, Voigt S, Thelen P, Hemmerlein B, Helmke K, Burfeind P. | 01/21/2010 |
| show that the helical regions and connecting segments of FXYD1, FXYD3, and FXYD4 determined in micelles by NMR spectroscopy coincide with the positions of intron-exon junctions in the genes | Correlation of gene and protein structures in the FXYD family proteins.
Franzin CM, Yu J, Thai K, Choi J, Marassi FM., Free PMC Article | 01/21/2010 |