| Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes collagen cross-linking and ECM stiffening to induce liver fibrosis. | Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes collagen cross-linking and ECM stiffening to induce liver fibrosis.
Yue W, Zhang H, Gao Y, Ding J, Xue R, Dong C, Liu F, Yang L, Yang L, Li L. | 05/29/2024 |
| METTL3 facilitates renal cell carcinoma progression by PLOD2 m[6]A-methylation under prolonged hypoxia. | METTL3 facilitates renal cell carcinoma progression by PLOD2 m(6)A-methylation under prolonged hypoxia.
Chen Y, He Y, Li Z, Zhang N, Zhou C, He X, Xue D., Free PMC Article | 01/30/2024 |
| Hypoxia-induced PLOD2 promotes clear cell renal cell carcinoma progression via modulating EGFR-dependent AKT pathway activation. | Hypoxia-induced PLOD2 promotes clear cell renal cell carcinoma progression via modulating EGFR-dependent AKT pathway activation.
Liu T, Xiang W, Chen Z, Wang G, Cao R, Zhou F, Meng Z, Luo Y, Chen L., Free PMC Article | 11/30/2023 |
| Circular RNA circPLOD2 regulates pericyte function by targeting the transcription factor KLF4. | Circular RNA circPLOD2 regulates pericyte function by targeting the transcription factor KLF4.
Glaser SF, Brezski A, Baumgarten N, Klangwart M, Heumüller AW, Maji RK, Leisegang MS, Guenther S, Zehendner CM, John D, Schulz MH, Zarnack K, Dimmeler S. | 09/6/2023 |
| The PLOD2/succinate axis regulates the epithelial-mesenchymal plasticity and cancer cell stemness. | The PLOD2/succinate axis regulates the epithelial-mesenchymal plasticity and cancer cell stemness.
Tong Y, Qi Y, Xiong G, Li J, Scott TL, Chen J, He D, Li L, Wang C, Lane AN, Xu R., Free PMC Article | 05/12/2023 |
| Apelin promotes osteosarcoma metastasis by upregulating PLOD2 expression via the Hippo signaling pathway and hsa_circ_0000004/miR-1303 axis. | Apelin promotes osteosarcoma metastasis by upregulating PLOD2 expression via the Hippo signaling pathway and hsa_circ_0000004/miR-1303 axis.
Trang NTN, Lai CY, Tsai HC, Huang YL, Liu SC, Tsai CH, Fong YC, Tzeng HE, Tang CH., Free PMC Article | 02/15/2023 |
| circRNA PLOD2 promotes tumorigenesis and Warburg effect in colon cancer by the miR-513a-5p/SIX1/LDHA axis. | circRNA PLOD2 promotes tumorigenesis and Warburg effect in colon cancer by the miR-513a-5p/SIX1/LDHA axis.
Li Y, Ma H., Free PMC Article | 11/26/2022 |
| Clinicopathological significances of PLOD2, epithelial-mesenchymal transition markers, and cancer stem cells in patients with esophageal squamous cell carcinoma. | Clinicopathological significances of PLOD2, epithelial-mesenchymal transition markers, and cancer stem cells in patients with esophageal squamous cell carcinoma.
Gong X, Wang A, Song W., Free PMC Article | 09/3/2022 |
| PLOD2 Is a Prognostic Marker in Glioblastoma That Modulates the Immune Microenvironment and Tumor Progression. | PLOD2 Is a Prognostic Marker in Glioblastoma That Modulates the Immune Microenvironment and Tumor Progression.
Kreße N, Schröder H, Stein KP, Wilkens L, Mawrin C, Sandalcioglu IE, Dumitru CA., Free PMC Article | 06/18/2022 |
| Bruck syndrome in 13 new patients: Identification of five novel FKBP10 and PLOD2 variants and further expansion of the phenotypic spectrum. | Bruck syndrome in 13 new patients: Identification of five novel FKBP10 and PLOD2 variants and further expansion of the phenotypic spectrum.
Otaify GA, Abdel-Hamid MS, Hassib NF, Elhossini RM, Abdel-Ghafar SF, Aglan MS. | 05/28/2022 |
| Identification and Validation of PLOD2 as an Adverse Prognostic Biomarker for Oral Squamous Cell Carcinoma. | Identification and Validation of PLOD2 as an Adverse Prognostic Biomarker for Oral Squamous Cell Carcinoma.
Sun Y, Wang S, Zhang X, Wu Z, Li Z, Ding Z, Huang X, Chen S, Jing Y, Zhang X, Ding L, Song Y, Sun G, Ni Y., Free PMC Article | 01/15/2022 |
| FK506 binding protein 10: a key actor of collagen crosslinking in clear cell renal cell carcinoma. | FK506 binding protein 10: a key actor of collagen crosslinking in clear cell renal cell carcinoma.
Zhang Y, Yin Y, Liu S, Yang L, Sun C, An R., Free PMC Article | 01/15/2022 |
| Lysyl hydroxylase 2-induced collagen cross-link switching promotes metastasis in head and neck squamous cell carcinomas. | Lysyl hydroxylase 2-induced collagen cross-link switching promotes metastasis in head and neck squamous cell carcinomas.
Sato K, Parag-Sharma K, Terajima M, Musicant AM, Murphy RM, Ramsey MR, Hibi H, Yamauchi M, Amelio AL., Free PMC Article | 01/1/2022 |
| PLOD2-driven IL-6/STAT3 signaling promotes the invasion and metastasis of oral squamous cell carcinoma via activation of integrin beta1. | PLOD2-driven IL-6/STAT3 signaling promotes the invasion and metastasis of oral squamous cell carcinoma via activation of integrin β1.
Saito K, Mitsui A, Sumardika IW, Yokoyama Y, Sakaguchi M, Kondo E., Free PMC Article | 11/27/2021 |
| PLOD2 Is a Potent Prognostic Marker and Associates with Immune Infiltration in Cervical Cancer. | PLOD2 Is a Potent Prognostic Marker and Associates with Immune Infiltration in Cervical Cancer.
Li G, Wang X, Liu G., Free PMC Article | 09/25/2021 |
| PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43. | PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43.
Guo T, Gu C, Li B, Xu C. | 08/7/2021 |
| The Collagen-Modifying Enzyme PLOD2 Is Induced and Required during L1-Mediated Colon Cancer Progression. | The Collagen-Modifying Enzyme PLOD2 Is Induced and Required during L1-Mediated Colon Cancer Progression.
Cheriyamundath S, Kumar A, Gavert N, Brabletz T, Ben-Ze'ev A., Free PMC Article | 06/5/2021 |
| Involvement of microRNA-124 in biological behaviors of laryngeal carcinoma via PLOD2 signaling pathway. | Involvement of microRNA-124 in biological behaviors of laryngeal carcinoma via PLOD2 signaling pathway.
Huang J, Zhou XH, Huang S, Li S, Wu TT. | 04/3/2021 |
| PLOD2 promotes aerobic glycolysis and cell progression in colorectal cancer by upregulating HK2. | PLOD2 promotes aerobic glycolysis and cell progression in colorectal cancer by upregulating HK2.
Du W, Liu N, Zhang Y, Liu X, Yang Y, Chen W, He Y. | 02/27/2021 |
| KRAB-Induced Heterochromatin Effectively Silences PLOD2 Gene Expression in Somatic Cells and is Resilient to TGFbeta1 Activation. | KRAB-Induced Heterochromatin Effectively Silences PLOD2 Gene Expression in Somatic Cells and is Resilient to TGFβ1 Activation.
Gjaltema RAF, Goubert D, Huisman C, Pilar García Tobilla CD, Koncz M, Jellema PG, Wu D, Brouwer U, Kiss A, Verschure PJ, Bank RA, Rots MG., Free PMC Article | 02/20/2021 |
| Hypoxia-induced PLOD2 regulates invasion and epithelial-mesenchymal transition in endometrial carcinoma cells. | Hypoxia-induced PLOD2 regulates invasion and epithelial-mesenchymal transition in endometrial carcinoma cells.
Wan J, Qin J, Cao Q, Hu P, Zhong C, Tu C. | 10/24/2020 |
| Procollagen-lysine, 2-oxoglutarate 5-dioxygenases 1, 2, and 3 are potential prognostic indicators in patients with clear cell renal cell carcinoma. | Procollagen-lysine, 2-oxoglutarate 5-dioxygenases 1, 2, and 3 are potential prognostic indicators in patients with clear cell renal cell carcinoma.
Xu WH, Xu Y, Wang J, Tian X, Wu J, Wan FN, Wang HK, Qu YY, Zhang HL, Ye DW., Free PMC Article | 09/5/2020 |
| Hypoxia and TGF-beta1 increase PLOD2 expression through HIF and SMAD pathway. | A hierarchical network of hypoxia-inducible factor and SMAD proteins governs procollagen lysyl hydroxylase 2 induction by hypoxia and transforming growth factor β1.
Rosell-García T, Palomo-Álvarez O, Rodríguez-Pascual F., Free PMC Article | 05/23/2020 |
| PLOD2 confers resistance to osimertinib in HCC827 cells by regulating EMT, FAK-PI3K/AKT and MAPK signal pathways. | [Mechanism of PLOD2 induced osimertinib resistance in non-small cell lung cancer HCC827 cells].
Kang XH, Wang K, Wang Y, Zhao HK, Zhang J, Zhao KL, Miao ZH, Xu ZY, Cao F, Gong YB. | 05/16/2020 |
| We found that PLOD2 could serve as a prognostic marker in patients with LSCC and confer drug resistance in LSCC by increasing CSC-like traits; in addition, a Wnt-responsive CSC pathway was identified. | PLOD2 contributes to drug resistance in laryngeal cancer by promoting cancer stem cell-like characteristics.
Sheng X, Li Y, Li Y, Liu W, Lu Z, Zhan J, Xu M, Chen L, Luo X, Cai G, Zhang S., Free PMC Article | 01/25/2020 |