| Hematopoietic Wnts Modulate Endochondral Ossification During Fracture Healing. | Hematopoietic Wnts Modulate Endochondral Ossification During Fracture Healing.
Chua K, Lee VK, Chan C, Yew A, Yeo E, Virshup DM., Free PMC Article | 12/25/2021 |
| Opposing actions of renal tubular- and myeloid-derived porcupine in obstruction-induced kidney fibrosis. | Opposing actions of renal tubular- and myeloid-derived porcupine in obstruction-induced kidney fibrosis.
Lu X, Rudemiller NP, Ren J, Wen Y, Yang B, Griffiths R, Privratsky JR, Madan B, Virshup DM, Crowley SD., Free PMC Article | 11/21/2020 |
| Porcn mosaicism results in reduced fertility. | Regulation of porcupine-dependent Wnt signaling is essential for uterine development and function.
Farah O, Biechele S, Rossant J, Dufort D. | 10/27/2018 |
| This study showed that postnatal ablation of Porcupine in the uterine luminal epithelium alone results in the decrease in endometrial gland number; mutant females are completely infertile. | Porcupine-dependent Wnt activity within the uterine epithelium is essential for fertility.
Farah O, Biechele S, Rossant J, Dufort D. | 08/4/2018 |
| Data suggest that PORCN exhibits substrate specificity that includes a Wnt3a peptide fragment (residues 199-219, with disulfide bonds); recombinant PORCN containing a point mutation (R228C) associated with focal dermal hypoplasia exhibits impaired acylation activity toward Wnt3a peptide fragment. (PORCN = porcupine O-acyltransferase; Wnt3a = Wnt family member 3A) | An in vitro fatty acylation assay reveals a mechanism for Wnt recognition by the acyltransferase Porcupine.
Asciolla JJ, Miele MM, Hendrickson RC, Resh MD., Free PMC Article | 09/9/2017 |
| Porcupine-dependent Wnt signaling, unlike previously reported, is dispensable for postnatal gland formation but is required for post-pubertal gland maintenance as well as for stromal cell proliferation. | Porcupine-dependent Wnt signaling controls stromal proliferation and endometrial gland maintenance through the action of distinct WNTs.
Farah O, Biechele S, Rossant J, Dufort D. | 06/3/2017 |
| Overexpression of PORCN enhances the ability of WLS to promote WNT1 trafficking to the cell surface as well as secretion, but decreases the ability of WLS to activate WNT1 signaling in target cell. | Divergent effects of Porcupine and Wntless on WNT1 trafficking, secretion, and signaling.
Galli LM, Zebarjadi N, Li L, Lingappa VR, Burrus LW., Free PMC Article | 05/20/2017 |
| Inhibition of porcupine abrogates kidney fibrosis not only by overcoming the redundancy of individual Wnt isoforms but also by preventing upstream cytokine-induced Wnt generation. | Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis.
Madan B, Patel MB, Zhang J, Bunte RM, Rudemiller NP, Griffiths R, Virshup DM, Crowley SD., Free PMC Article | 01/28/2017 |
| Conditional PORCN knockout mice exhibit specific changes in AMPAR expression and gating that reduce basal synaptic transmission but leave long-term potentiation intact. | Porcupine Controls Hippocampal AMPAR Levels, Composition, and Synaptic Transmission.
Erlenhardt N, Yu H, Abiraman K, Yamasaki T, Wadiche JI, Tomita S, Bredt DS., Free PMC Article | 10/29/2016 |
| Porcn is required in both extraocular and neuroectodermal tissues to regulate distinct Wnt-dependent processes during morphogenesis of the posterior and anterior segments of the eye | Multiple requirements of the focal dermal hypoplasia gene porcupine during ocular morphogenesis.
Bankhead EJ, Colasanto MP, Dyorich KM, Jamrich M, Murtaugh LC, Fuhrmann S., Free PMC Article | 09/26/2015 |
| Residues in predicted transmembrane domain 9 within Porcupine are essential for palmitoleoylation. | Identification of key residues and regions important for porcupine-mediated Wnt acylation.
Rios-Esteves J, Haugen B, Resh MD., Free PMC Article | 10/25/2014 |
| Data show bronchopneumonia, rhinitis, and otitis media, suggesting a potential link between Porcn function and the normal development of ciliated cells. | Zygotic Porcn paternal allele deletion in mice to model human focal dermal hypoplasia.
Biechele S, Adissu HA, Cox BJ, Rossant J., Free PMC Article | 08/30/2014 |
| Studies highlight the importance of Wnt3 and Wnt7b for embryonic and placental development but suggest that endogenous Porcn-dependent Wnt secretion does not play an essential role in either implantation or blastocyst lineage specification. | Porcn-dependent Wnt signaling is not required prior to mouse gastrulation.
Biechele S, Cockburn K, Lanner F, Cox BJ, Rossant J. | 09/7/2013 |
| an essential regulatory role of PORCN in shaping Wnt signaling gradients. | Precise regulation of porcupine activity is required for physiological Wnt signaling.
Proffitt KD, Virshup DM., Free PMC Article | 01/5/2013 |
| Porcn inactivation in the mouse produces a model for human FDH and that phenotypic features result from defective WNT signaling in ectodermal- and mesenchymal-derived structures. | Deletion of Porcn in mice leads to multiple developmental defects and models human focal dermal hypoplasia (Goltz syndrome).
Liu W, Shaver TM, Balasa A, Ljungberg MC, Wang X, Wen S, Nguyen H, Van den Veyver IB., Free PMC Article | 08/4/2012 |
| Data show that conditional deletion of Porcn provides an experimental model of FDH, as well as a valuable tool to probe Wnt ligand function in vivo. | Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome.
Barrott JJ, Cash GM, Smith AP, Barrow JR, Murtaugh LC., Free PMC Article | 10/29/2011 |
| Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos. | Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos.
Biechele S, Cox BJ, Rossant J. | 09/10/2011 |