| PNOC Expressed by B Cells in Cholangiocarcinoma Was Survival Related and LAIR2 Could Be a T Cell Exhaustion Biomarker in Tumor Microenvironment: Characterization of Immune Microenvironment Combining Single-Cell and Bulk Sequencing Technology. | PNOC Expressed by B Cells in Cholangiocarcinoma Was Survival Related and LAIR2 Could Be a T Cell Exhaustion Biomarker in Tumor Microenvironment: Characterization of Immune Microenvironment Combining Single-Cell and Bulk Sequencing Technology.
Chen Z, Yu M, Yan J, Guo L, Zhang B, Liu S, Lei J, Zhang W, Zhou B, Gao J, Yang Z, Li X, Zhou J, Fan J, Ye Q, Li H, Xu Y, Xiao Y., Free PMC Article | 10/2/2021 |
| found differences in Neonatal Abstinence Syndrome outcomes depending on PNOC and COMT SNP genotype. | Association of maternal and infant variants in PNOC and COMT genes with neonatal abstinence syndrome severity.
Wachman EM, Hayes MJ, Sherva R, Brown MS, Shrestha H, Logan BA, Heller NA, Nielsen DA, Farrer LA., Free PMC Article | 12/2/2017 |
| The presence of the PNOC rs732636 A allele was associated with the worse Neonatal abstinence syndrome outcomes in infants. | Neonatal abstinence syndrome: Pharmacologic strategies for the mother and infant.
Kraft WK, Stover MW, Davis JM., Free PMC Article | 12/31/2016 |
| Study presents evidence suggesting that the PNOC and OPRL1 are dysregulated in suicide completers, thereby potentially contributing to impaired emotional and behavioral control and, ultimately, to the suicidal crisis | Decreased expression of nociceptin/orphanin FQ in the dorsal anterior cingulate cortex of suicides.
Lutz PE, Zhou Y, Labbe A, Mechawar N, Turecki G., Free PMC Article | 08/27/2016 |
| findings suggest that SNPs in opioid receptors and the PNOC genes are associated with NAS severity. | Variations in opioid receptor genes in neonatal abstinence syndrome.
Wachman EM, Hayes MJ, Sherva R, Brown MS, Davis JM, Farrer LA, Nielsen DA., Free PMC Article | 05/14/2016 |
| Data suggest that nociceptin/nociceptin receptor signaling in neurons of the hippocampus modulate learning and memory. [REVIEW] | Nociceptin/orphanin-FQ modulation of learning and memory.
Abdel-Mouttalib O. | 09/26/2015 |
| Data suggest that interaction between the nociceptin/nociceptin receptor system and the orexin/orexin receptor system in neurons of the hypothalamus positively and negatively modulate complex and integrated responses to stress. [REVIEW] | The neuronal circuit between nociceptin/orphanin FQ and hypocretins/orexins coordinately modulates stress-induced analgesia and anxiety-related behavior.
Xie XS. | 09/26/2015 |
| Data suggest that the nociceptin/nociceptin receptor system is involved in modulation of psychological and inflammatory stress responses and in pathogenesis of anxiety. [REVIEW] | Endogenous nociceptin system involvement in stress responses and anxiety behavior.
Fulford AJ. | 09/26/2015 |
| Data suggest that the nociceptin/nociceptin receptor system is involved in modulation of the immune response and in pathogenesis of autoimmune diseases. [REVIEW] | Nociceptin/orphanin FQ-NOP receptor system in inflammatory and immune-mediated diseases.
Gavioli EC, de Medeiros IU, Monteiro MC, Calo G, Romão PR. | 09/26/2015 |
| Data suggest that both nociceptin and nocistatin inhibit myometrial contractions and may play roles in perception of pain during delivery. [REVIEW] | Effects of nociceptin and nocistatin on uterine contraction.
Gáspár R, Deák BH, Klukovits A, Ducza E, Tekes K. | 09/26/2015 |
| Opioid neuropeptide systems are important mediators of ovarian steroid signaling that regulate reproduction in female; data suggest that nociceptin and nociceptin receptor system in arcuate nucleus of hypothalamus is such a system. [REVIEW] | Orphanin FQ-ORL-1 regulation of reproduction and reproductive behavior in the female.
Sinchak K, Dalhousay L, Sanathara N. | 09/26/2015 |
| Data suggest that nociceptin plays a crucial role in progress of meiosis during spermatogenesis. [REVIEW] | Nociceptin and meiosis during spermatogenesis in postnatal testes.
Eto K. | 09/26/2015 |
| Data suggest that nociceptin and nociceptin receptor evolved as one of 4 opioid receptor systems in vertebrates; this system exhibits both analgesic and hyperalgesic effects. [REVIEW] | Bioinformatics and evolution of vertebrate nociceptin and opioid receptors.
Stevens CW. | 09/26/2015 |
| REVIEW: intracellular localization and physiological role of nociceptin and nocistatin | Deciphering intracellular localization and physiological role of nociceptin and nocistatin.
Tariq S, Nurulain SM, Tekes K, Adeghate E. | 08/23/2014 |
| Strong expression of PNOC was seen in neoplastic neurons of 7/7 brainstem gangliogliomas, but was significantly weaker in non-brainstem GGs. | Pediatric brainstem gangliogliomas show overexpression of neuropeptide prepronociceptin (PNOC) by microarray and immunohistochemistry.
Chan MH, Kleinschmidt-Demasters BK, Donson AM, Birks DK, Foreman NK, Rush SZ., Free PMC Article | 12/22/2012 |
| The presence of Orphanin, Oxytocin, ANP, eNOS and iNOS proteins was identified in the human umbilical cord.[Orphanin] | Human umbilical cord expresses several vasoactive peptides involved in the local regulation of vascular tone: protein and gene expression of Orphanin, Oxytocin, ANP, eNOS and iNOS.
Mauro A, Buscemi M, Provenzano S, Gerbino A. | 09/13/2012 |
| activation of NFkappaB by OFQ/Nociceptin suggests a likely mechanism for its modulation of the central nervous and immune systems. | Orphanin FQ/nociceptin activates nuclear factor kappa B.
Donica CL, Ramirez VI, Awwad HO, Zaveri NT, Toll L, Standifer KM., Free PMC Article | 03/3/2012 |
| A high expression of nociceptin in adenomyosis may be one of the casual factors of dysmenorrhea. The severity of dysmenorrhea is positively correlated with the expression of nociceptin in eutopic endometrial tissue. | [Expression of orphanin in adenomyosis and its relationship with dysmenorrhea].
Hou R, Zhang WY, Liu LY, Lu J, Zhang WY. | 12/10/2011 |
| chronic ischemic conditions of atherosclerotic origin are associated with significantly lower plasma nociceptin levels | Plasma nociceptin/orphanin FQ levels are lower in patients with chronic ischemic cardiovascular diseases--A pilot study.
Krepuska M, Sótonyi P, Csobay-Novák C, Szeberin Z, Hartyánszky I, Zima E, Szilágyi N, Horkay F, Merkely B, Acsády G, Tekes K. | 10/1/2011 |
| PNOC expression level was 2.99 times higher in vitiligo involved skin when compared to healthy control skin. | Analysis of the expression profile of CRH-POMC system genes in vitiligo skin biopsies.
Reimann E, Kingo K, Karelson M, Salum T, Aunin E, Reemann P, Abram K, Vasar E, Silm H, Kõks S. | 02/5/2011 |
| Results showed that vigorous and prolonged hyperventilation changes plasma nociceptin/orphanin FQ levels due to the direct effects of hypocapnic alkalosis or to different sympatho-adrenergic system responses. | Plasma nociceptin/orphanin FQ levels in response to the hyperventilation test in healthy subjects.
Fontana F, Pizzi C, Bernardi P, Pich EM, Bedini A, Spampinato S. | 07/5/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Our results support the concept postulating that chronic ethanol consumption and withdrawal downregulate the PNOC/OPRL1 system, which critically controls alcohol intake. | Expression of pronociceptin and its receptor is downregulated in the brain of human alcoholics.
Kuzmin A, Bazov I, Sheedy D, Garrick T, Harper C, Bakalkin G., Free PMC Article | 03/8/2010 |
| data obtained from neocortex of epileptic patients provide strong evidence that temporal lobe epilepsy is associated with alterations in mu opioid and nociceptin receptor binding and signal transduction mechanisms downstream of these receptors | Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex.
Rocha L, Orozco-Suarez S, Alonso-Vanegas M, Villeda-Hernandez J, Gaona A, Páldy E, Benyhe S, Borsodi A. | 01/21/2010 |
| Unstable angina is associated with a significant increase in circulating nociceptin/orphanin FQ levels unrelated to intervening transient myocardial ischemia or hemodynamic changes. | Plasma nociceptin/orphanin FQ levels rise after spontaneous episodes of angina, but not during induced myocardial ischemia.
Fontana F, Bernardi P, Pizzi C, Spampinato S, Bedini A, Pich EM. | 01/21/2010 |